Tumor necrosis factor alpha gene regulation: Enhancement of C/EBPβ- induced activation by c-Jun

Molecular and Cellular Biology

Volumn 18, Issue 5, 1998, Pages 2815-2824

  Zagariya, Alexander ^a   Mungre, Shubhangee ^a   Lovis, Rosa ^a   Birrer, Michael ^b   Ness, Scott ^c   Thimmapaya, Bayar ^c   Pope, Richard ^a,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL SPECIFICITY; CHRONIC INFLAMMATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION;

EID: 0031895658     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.5.2815     Document Type: Article

References (55)

1. Akira S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBPβ family. EMBO J. 9:1897-1906.
2. Alani, R., P. Brown, B. Binétruy, H. Dosaka, R. Rosenberg, P. Angel, M. Karin, and M. J. Birrer. 1991. The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol. Cell. Biol. 11:6286-6295.
3. Angel P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
4. Arias, J., A. S. Alperts, P. Brindle, F. X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226-229.
5. Bannister, A. J., T. Oehler, D. Whilhelm, P. Angel, and T. Kouzarides. 1995. Stimulation of c-Jun activity by CBP:c-Jun residues Ser 63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11:2509-2514.
6. Brown, P. H., R. Alani, L. H. Preis, E. Szabo, and M. J. Birrer. 1992. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 8:877-886.
7. Burk, O., S. Mink, M. Ringwald, and K. H. Klempnauer. 1993. Synergistic activation of the chicken mim-1 gene by v-myb and C/EBPβ transcription factors. EMBO J. 12:2027-2038.
8. Callahan, M., R. M. Lovis, C. Rammohan, Y. Lu, and R. M. Pope. 1996. Autocrine regulation of collagenase gcnc expression by TNF-α in U937 cells. J. Leukocyte Biol. 59:125-132.
9. Cao, Z., R. M. Umek, and S. L. McNight. 1991. Regulated expression of three C/EBPβ isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538-1552.
10. Chrivia, J. C., R. P. S. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB hinds specifically to the nuclear protein CBP. Nature 365:855-859.
11. Doyle, G. A. R., R. A. Pierce, and W. C. Parks. 1997. Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-β site. J. Biol. Chem. 272:11840-11649.
12. Eckner R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8:869-884.
13. Economou, J. S., K. Rhoades, R. Essner, W. H. McBride, J. C. Gassonand, and D. L. Morton. 1989. Genetic analysis of the human tumor necrosis factor α/cachectin promoter region in a macrophage cell line. J. Exp. Med. 170: 321-326.
14. Elliot M. J., R. N. Maini, M. Feldman, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, and J. N. Woody. 1994. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110.
15. Goldfeld, A. E., P. G. McCaffrey, J. L. Strominger, and A. Rao. 1993. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor a gene promoter. J. Exp. Med. 178:1365-1379.
16. Gonzalez-Amaro, R., C. Garcia-Monzon, L. Garcia-Buey, R. Moreno-Otero, J. L. Alonso, E. Yague, J. P. Pivel, M. Lopez-Cabrera, E. Fernandez-Ruiz, and F. Sanchez-Madrid. 1994. Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J. Exp. Med. 179:841-848.
17. Grove, M., and M. Plumb. 1993. C/EBPβ, NF-κB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1α immediate-early gene. Mol. Cell. Biol. 13:5276-5289.
18. Grant S. A. J. Freemerman, M. J. Birrer, H. A. Martin, A. J. Turner, E. Szabo, J. Chelliah, and W. D. Jarvis. 1996. Effect of 1-β-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing c-Jun dominant-negative mutant protein (TAM67). Cell Growth Differ. 7:603-610.
19. Hotamisligil, G. S., P. Arner, J. F. Caro, R. L. Atkinson, and B. M. Spiegelman. 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95:2409-2415.
20. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91.
21. Hsu, W., T. K. Kerpolla, P.-L. Chen, T. Curran, and S. Chen-Kiang. 1994. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol. Cell. Biol. 14:268-276.
22. Kern, P. A., M. Saghizadeh, J. M. Ong, R. J. Bosch, and R. Deem. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95:2111-2119.
23. Klampfer, L., T. H. Lee, W. Hsu, J. Vilcek, and S. Chen-Kiang. 1994. NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol. Cell. Biol. 14:6561-6569.
24. Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz. 1994. Novel mechanism of C/EBPβ (NF-M) transcriptional control: activation through derepression. Genes Dev. 8:2781-2791.
25. Kramer, B., K. Wiegmann, and M. Kronke. 1995. Regulation of the human TNFα promoter by the transcription factor Ets. J. Biol. Chem. 270:6577-6583.
26. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145-8149.
27. MacNaul, K. L., N. I. Hutchinson, J. N. Parson, E. K. Bayne, and M. J. Tocci. 1990. Analysis of IL-1 and TNFα-gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization. J. Immunol. 145:4154-4166.
28. Metcalf, J. P. 1996. Adenovirus E1A 13S gene product upregulates tumor necrosis factor gene. Am. J. Physiol. 270:L535-L540.
29. Mink, S., B. Haenig, and K. H. Klempnauer. 1997. Interaction and functional collaboration of p300 and C/EBPβ. Mol. Cell. Biol. 17:6609-6617.
30. Miyazaki, Y., K. Araki, C. Vesin, I. Garcia, Y. Kapanci, J. A. Whitsett, P. F. Piguet, and P. Vassalli. 1995. Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J. Clin. Invest. 96:250-259.
31. Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207-2211.
32. Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto. 1991. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79:460-466.
33. Ness, S. A., E. Kowenz-Leutz, T. Casini, T. Graf, and A. Leutz. 1993. Myb and MF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749-759.
34. Newell, C. L., A. B. Deisseroth, and G. Lopez-Berestein. 1994. Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNFα gene. J. Leukocyte Biol. 56:27-35.
35. Nguyen, D. T., M. K. Eskandari, L. E. DeFore, C. L. Raiford, R. M. Strieter, S. L. Kunkel, and D. G. Remick. 1990. Cyclosporin A modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. J. Immunol. 144:3822-3828.
36. Nishio, Y., H. Isshiki, T. Kishimoto, and S. Akira. 1993. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat 1-acid glycoprotein gene via direct protein-protein interaction. Mol. Cell. Biol. 13:1854-1862.
37. Petrak, D., S. A. Memon, M. J. Birrer, J. D. Ashwell, and C. M. Zacharchuk. 1994. Dominant negative mutant of c7-jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J. Immunol. 153:2046-2051.
38. Plevy, S. E., J. H. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572-4588.
39. Pope, R. M., A. Leutz, and S. Ness. 1994. C/EBPβ regulation of the tumor necrosis factor alpha gene. J. Clin. Invest. 94:1449-1455.
40. Rhoads, K. L., S. H. Golub, and J. S. Economou. 1992. The regulation of the human tumor necrosis factor a promoter region in macrophage, T cell and B cell lines. J. Biol. Chem. 267:22102-22107.
41. Saisanit, S., and X.-H. Sun. 1997. Regulation of the pro-B-cell-specific enhancer of the Idl gene involves the C/EBP family of proteins. Mol. Cell. Biol. 17:844-850.
42. Sears, R. C., and L. Sealy. 1994. Multiple forms of C/EBPβ bind the EFH enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol. Cell. Biol. 14:4855-4871.
43. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBPβ family members: a Rel domain-bZip interaction. Mol. Cell. Biol. 13:3964-3974.
44. Sterneck, E., M. Christine, S. Katz, and A. Leutz. 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBPβ-like factor. EMBO J. 11:115-126.
45. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736.
46. Szabo, E., L. H. Preis, and M. J. Birrer. 1994. Constitutive cJun expression induces partial macrophage differentiation in U-937 cells. Cell Growth Differ 5:439-446.
47. Trautwein, C., C. Caelles, P. van der Geer, T. Hunter, M. Karin, and M. Chojkier. 1993. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364:544-547.
48. Trautwein, C., P. van der Geer, M. Karin, T. Hunter, and M. Chojkier. 1994. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J. Clin. Invest. 93:2554-2561.
49. Tsai, E. Y., J. Jain, P. A. Pesavento, A. Rao, and A. F. Goldfeld. 1996. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2 Jun and NFATp. Mol. Cell. Biol. 16:459-467.
50. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411-452.
51. Wedel, A., G. Sulski, and H. W. L. Ziegler-Heitbrock. 1996. CCAAT enhanced binding protein is involved in the expression of the tumor necrosis factor gene in human monocytes. Cytokine 8:335-341.
52. Wegner, M., Z. Cao, and M. G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256:370-373.
53. Williams, S. C., M. Baer, A. J. Dillner, and P. F. Johnson. 1995. CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J. 14:3170-3183.
54. Yang, X. D., R. Tisch. S. M. Singer, Z. A. Cao, R. S. Liblau, R. D. Schreiber, and H. O. McDevitt. 1994. Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med. 180:995-1004.
55. Zhang, Y., T. C. Lee, B. Guillemin, M. C. Yu, and W. N. Rom. 1993. Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J. Immunol. 150:4188-4196.