The role of MAPK pathways in the action of chemotherapeutic drugs

Carcinogenesis

Volumn 23, Issue 11, 2002, Pages 1831-1838

  Boldt, Simone ^a   Weidle, Ulrich H ^b   Kolch, Walter ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; ANTINEOPLASTIC AGENT; CERAMIDE; ETOPOSIDE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PACLITAXEL; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANALYTICAL PARAMETERS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARCINOMA CELL; CELL CYCLE PARAMETERS; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME KINETICS; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA;

EID: 0036848491     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.11.1831     Document Type: Article

References (62)

1. Oakes,S.G., Schlager,J.J., Santone,K.S., Abraham,R.T. and Powis,G. (1990) Doxorubicin blocks the increase in intracellular Ca+ +, part of a second messenger system in N1E-115 murine neuroblastoma. cells. J. Phamacol. Exp. Ther., 252, 979-983.
2. Barry,M.A., Behnke,C.A. and Eastman,A. (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem. Pharmacol., 40, 2353-2362.
3. Kaufmann,S.H. (1998) Cell death induced by topoisomerase-targeted drugs: more questions than answers. Biochim. Biophys. Acta, 1400, 195-211.
4. Rafter,J. and Glinghammar,B. (1998) Interactions between the environment and genes in the colon. Eur. J. Cancer Prev., 7 (Suppl. 2), S69-S74.
5. de Gruijl,F.R. (1999) Skin cancer and solar UV radiation. Eur. J. Cancer, 35, 2003-2009.
6. Jamerson,M.H., Johnson,M.D. and Dickson,R.B. (2000) Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models. Oncogene, 19, 1065-1071.
7. Pelengaris,S., Rudolph,B. and Littlewood,T. (2000) Action of Myc in vivo-proliferation and apoptosis. Curr. Opin. Genet. Dev., 10, 100-105.
8. McDonald,E.R., III and El Deiry,W.S. (2001) Checkpoint genes in cancer. Ann. Med, 33, 113-122.
9. Evan,G.I. and Vousden,K.H. (2001) Proliferation, cell cycle and apoptosis in cancer. Nature, 411, 342-348.
10. Makin,G. and Dive,C. (2001) Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy? Breast Cancer Res., 3, 150-153.
11. Lewis,T.S., Shapiro,P.S. and Ahn,N.G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res., 74, 49-139.
12. Robinson,M.J. and Cobb,M.H. (1997) Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol., 9, 180-186.
13. Merlino,G.T., Xu,Y.H., Ishii,S., Clark,A.J., Semba,K., Toyoshima,K., Yamamoto,T. and Pastan,I. (1984) Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science, 224, 417-419.
14. Schwarz,E., Freese,U.K., Gissmann,L., Mayer,W., Roggenbuck,B., Stremlau,A. and Zur,H.H. (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature, 314, 111-114.
15. Vousden,K. (1993) Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. FASEB J., 7, 872-879.
16. Teixeira,C., Reed,J.C. and Pratt,M.A. (1995) Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res., 55, 3902-3907.
17. Rowinsky,E.K. and Donehower,R.C. (1995) Paclitaxel (taxol). N. Engl. J. Med, 332, 1004-1014.
18. Hande,K.R. (1998) Etoposide: four decades of development of a topoisomerase II inhibitor. Eur. J. Cancer, 34, 1514-1521.
19. Kolesnick,R.N. and Kronke,M. (1998) Regulation of ceramide production and apoptosis. Annu. Rev. Physiol., 60, 643-665.
20. Duriez,P.J. and Shah,G.M. (1997) Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem. Cell Biol., 75, 337-349.
21. Budman,D.R., Igwemezie,L.N., Kaul,S. et al. (1994) Phase I evaluation of a water-soluble etoposide prodrug, etoposide phosphate, given as a 5-minute infusion on days 1, 3, and 5 in patients with solid tumors. J. Clin. Oncol., 12, 1902-1909.
22. Lowis,S.P., Price,L., Pearson,A.D., Newell,D.R. and Cole,M. (1998) A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. Br. J. Cancer, 77, 2318-2323.
23. Blagosklonny,M.V. and Fojo,T. (1999) Molecular effects of paclitaxel: myths and reality (a critical review). Int. J. Cancer, 83, 151-156.
24. Affar,E.B., Germain,M., Winstall,E., Vodenicharov,M., Shah,R.G., Salvesen,G.S. and Poirier,G.G. (2001) Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis. J. Biol. Chem., 276, 2935-2942.
25. Adams,J.M. and Cory,S. (2001) Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci., 26, 61-66.
26. Xia,Z., Dickens,M., Raingeaud,J., Davis,R.J. and Greenberg,M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 270, 1326-1331.
27. Marshall,C.J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-185.
28. Rouse,J., Cohen,P., Trigon,S., Morange,M., Alonso-Llamazares,A., Zamanillo,D., Hunt,T. and Nebreda,A.R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell, 78, 1027-1037.
29. Fujita,K., Lazarovici,P. and Guroff,G. (1989) Regulation of the differentiation of PC12 pheochromocytoma cells. Environ. Health Perspect., 80, 127-142.
30. Marshall,C. (1999) How do small GTPase signal transduction pathways regulate cell cycle entry? Curr. Opin. Cell Biol., 11, 732-736.
31. Cheng,M., Sexl,V., Sherr,C.J. and Roussel,M.F. (1998) Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl Acad. Sci. USA, 95, 1091-1096.
32. Lavoie,J.N., L'Allemain,G., Brunet,A., Muller,R. and Pouyssegur,J. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem., 271, 20608-20616.
33. Kawada,M., Yamagoe,S., Murakami,Y., Suzuki,K., Mizuno,S. and Uehara,Y. (1997) Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene, 15, 629-637.
34. Lenferink,A.E., Busse,D., Flanagan,W.M., Yakes,F.M. and Arteaga,C.L. (2001) ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res., 61, 6583-6591.
35. Tran,S.E., Holmstrom,T.H., Ahonen,M., Kahari,V.M. and Eriksson,J.E. (2001) MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J. Biol. Chem., 276, 16484-16490.
36. Erhardt,P., Schremser,E.J. and Cooper,G.M. (1999) B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway (in process citation). Mol. Cell Biol., 19, 5308-5315.
37. Rytomaa,M., Lehmann,K. and Downward,J. (2000) Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not raf signalling (in process citation). Oncogene, 19, 4461-4468.
38. Townsend,K.J., Trusty,J.L., Traupman,M.A., Eastman,A. and Craig,R.W. (1998) Expression of the antiapoptotic MCL1 gene product is regulated by a mitogen activated protein kinase-mediated pathway triggered through microtubule disruption and protein kinase C. Oncogene, 17, 1223-1234.
39. Yang,Y.L. and Li,X.M. (2000) The IAP family: endogenous caspase inhibitors with multiple biological activities. Cell Res., 10, 169-177.
40. Bonni,A., Brunet,A., West,A.E., Datta,S.R., Takasu,M.A. and Greenberg,M.E. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 286, 1358-1362.
41. Mayo,M.W., Norris,J.L. and Baldwin,A.S. (2001) Ras regulation of NF-kappa B and apoptosis. Methods Enzymol., 333, 73-87.
42. van den Brink,M.R., Kapeller,R., Pratt,J.C., Chang,J.H. and Burakoff,S.J. (1999) The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells. J. Biol. Chem., 274, 11178-11185.
43. Basu,S., Bayoumy,S., Zhang,Y, Lozano,J. and Kolesnick,R. (1998) BAD enables ceramide to signal apoptosis via ras and raf-1 (in process citation). J. Biol. Chem., 273, 30419-30426.
44. Ghose,A., Fleming,J. and Harrison,P.R. (2001) Selenium and signal transduction: roads to cell death and anti-tumour activity. Biofactors, 14, 127-133.
45. Mielke,K. and Herdegen,T. (2000) JNK and p38 stress kinases - degenerative effectors of signal-transduction-cascades in the nervous system. Prog. Neurobiol., 61, 45-60.
46. Yamamoto,K., Ichijo,H. and Korsmeyer,S.J. (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol. Cell Biol., 19, 8469-8478.
47. Herrmann,J.L., Menter,D.G., Beham,A., von Eschenbach,A. and McDonnell,T.J. (1997) Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. Exp. Cell Res., 234, 442-451.
48. Leppa,S. and Bohmann,D. (1999) Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene, 18, 6158-6162.
49. Nishina,H., Vaz,C., Billia,P., et al. (1999) Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development, 126, 505-516.
50. Nishina,H., Radvanyi,L., Raju,K., Sasaki,T., Kozieradzki,I. and Penninger,J.M. (1998) Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J. Immunol., 161, 3416-3420.
51. Yujiri,T., Fanger,G.R., Garrington,T.P., Schlesinger,T.K., Gibson,S. and Johnson,G.L. (1999) MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton. J. Biol. Chem., 274, 12605-12610.
52. Kwan,R., Burnside,J., Kurosaki,T. and Cheng,G. (2001) MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption. Mol. Cell Biol., 21, 7183-7190.
53. Lee,J.C., Laydon,J.T., McDonnell,P.C., et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-746.
54. Bulavin,D.V., Higashimoto,Y., Popoff,I.J., Gaarde,W.A., Basrur,V., Potapova,O., Appella,E. and Fornace,A.J., Jr. (2001) Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature, 411, 102-107.
55. Stadheim,T.A., Xiao,H. and Eastman,A. (2001) Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells. Cancer Res., 61, 1533-1540.
56. MacKeigan,J.P., Collins,T.S. and Ting,J.P. (2000) MEK inhibition enhances paclitaxel-induced tumor apoptosis. J. Biol. Chem., 275, 38953-38956.
57. McDaid,H.M. and Horwitz,S.B. (2001) Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. Mol. Pharmacol., 60, 290-301.
58. Seidman,R., Gitelman,I., Sagi,O., Horwitz,S.B. and Wolfson,M. (2001) The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells. Exp. Cell Res., 268, 84-92.
59. Ding,A., Chen,B., Fuortes,M. and Blum,E. (1996) Association of mitogen-activated protein kinases with microtubules in mouse macrophages. J. Exp. Med., 183, 1899-1904.
60. Morgan,M.A., Dolp,O. and Reuter,C.W. (2001) Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood, 97, 1823-1834.
61. Tamemoto,H., Kadowaki,T., Tobe,K., et al. (1992) Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. J. Biol. Chem., 267, 20293-20297.
62. Fan,M., Du,L., Stone,A.A., Gilbert,K.M. and Chambers,T.C. (2000) Modulation of mitogen-activated protein kinases and phosphorylation of Bcl-2 by vinblastine represent persistent forms of normal fluctuations at G2-M1. Cancer Res., 60, 6403-6407.