Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells

Molecular Pharmacology

Volumn 59, Issue 2, 2001, Pages 254-262

  Shiah, Shine Gwo ^a   Chuang, Shuang En ^b   Kuo, Min Liang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTYLGLUTAMYLVALYLASPARTIC ACID; CASPASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PACLITAXEL; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0035136965     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.2.254     Document Type: Article

References (38)

1. 2-terminal kinase/activation protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts
2. Cleavage of retinoblastoma protein during apoptesis: An interleukin-1β-converting enzyme-like protease as candidate
3. Raf-1/bcl-2 phosphorylation signal from microtubule damage to cell death
4. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex
5. DNA-dependent protein kinase is one of a subset of auto-antigens specifically cleaved early during apoptosis
6. The role of c-jun-N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation: Duration of JNK activation may determine cell death and proliferation
7. Specific cleavage of α-fodrin during Fas- and TNF-induced apoptosis is mediated by an interleukin-1βconverting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease
8. Proteolytic activation of protein kinase Cd by an ICE-like protease in apoptotic cells
9. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in Jurkat T cell
10. Differential involvement of MEKK1 in the induction of apoptosis in response to microtubule-targeted drugs verus DNA damaging agents
11. Transcription factor ATF2 regulation by the JNK signal transduction pathway
12. Inactivation of Bcl-2 by phosphorylation
13. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-JUN activation domain
14. Mechanism of action of Taxol
15. L inhibits ara-c-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis
16. Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis in mediated by down-regulation of poly(ADP-ribose)-polymerase activity
17. Suppression of apoptesis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis
18. A divergence in the MAP kinase regulatory network defined by MEK kinase and raf
19. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution
20. 2-terminal kinase
21. Phosphorylation of Bcl2 is a marker of M phase events and not a determinant of apoptesis
22. Bcl-2 undergo phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the pressure of the constitutively active GTP-binding protein Racl
23. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
24. Checkpoints of dueling dimers foil death wishes
25. 2-terminal protein kinase pathway in the cellular response to Adriamycin and other chemotherapeutic agents
26. Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein
27. Taxol dose intensification and its clinical implications
28. 2- terminal kinase-mediated activation of interleukin-1-β-converting enzyme/CED-ike protease during anticancer drug-induced apoptesis
29. 2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway
30. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptesis through cyclic AMP-dependent protein kinase
31. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
32. Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis
33. Microtubules dysfunction induced by paclitaxel initiates apoptesis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
34. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both ras and aimptesis signal-regulating kinase pathways
35. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotexin-induced apoptesis
36. 2/M
37. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activation SEKi
38. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption