c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents

Molecular and Cellular Biology

Volumn 20, Issue 2, 2000, Pages 575-582

  Kolbus, Andrea ^a,b   Herr, Ingrid ^a   Schreiber, Martin ^b,c   Debatin, Klaus Michael ^a   Wagner, Erwin F ^b   Angel, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c Abt Signaltransduktion W ^*  (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; FAS ANTIGEN; MESYLIC ACID METHYL ESTER; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FETUS; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 2; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALKYLATING AGENTS; ANIMALS; ANTIBODIES; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FAS LIGAND PROTEIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLASTS; GENE DELETION; GENE EXPRESSION; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; METHYL METHANESULFONATE; MICE; PROTO-ONCOGENE PROTEINS C-JUN; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0033961711     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.2.575-582.2000     Document Type: Article

References (57)

1. Angel, P., I. Baumann, B. Stein, H. Delius, H. J. Rahmsdorf, and P. Herrlich. 1987. 12-O-Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol. Cell. Biol. 7:2256-2266.
2. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
3. Angel, P., K. Hattori, T. Smeal, and M. Karin. 1988. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55:875-885.
4. Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072:129-157.
5. Ashkenazi, A., and V. M. Dixit. 1998. Death receptors: signaling and modulation. Science 281:1305-1308.
6. Basu, S., and R. Kolesnick. 1998. Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 17:3277-3285.
7. Beg, A. A., and D. Baltimore. 1996. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274:782-784.
8. Behrens, A., M. Sibilia, and E. F. Wagner. 1999. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21:326-329.
9. Benbrook, D. M., and N. C. Jones. 1990. Heterodimer formation between CREB and JUN proteins. Oncogene 5:295-302.
10. Bossy-Wetzel, E., L. Bakiri, and M. Yaniv. 1997. Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16:1695-1709.
11. Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936.
12. Chinnaiyan, A. M., C. G. Tepper, M. F. Seldin, K. O'Rourke, F. C. Kischkel, S. Hellbardt, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FADD/ MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271:4961-4965.
13. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol/chloroform extraction. Anal. Biochem. 162:156-159.
14. Dhein, J., H. Walczak, C. Baumler, K. M. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373: 438-441.
15. Estus, S., W. J. Zaks, R. S. Freeman, M. Gruda, R. Bravo, and E. M. Johnson. 1994. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127:1717-1727.
16. Evan, G., and T. Littlewood. 1998. A matter of life and cell death. Science 281:1317-1322.
17. Faris, M., K. M. Latinis, S. J. Kempiak, G. A. Koretzky, and A. Nel. 1998. Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol. Cell. Biol. 18:5414-5424.
18. Faris, M., N. Kokot, K. Latinis, S. Kasibhatla, D. R. Green, G. A. Koretzky, and A. Nel. 1998. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J. Immunol. 160:134-144.
19. Gack, S., R. Vallon, J. Schaper, U. Rüther, and P. Angel. 1994. Phenotypic alterations in Fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. J. Biol. Chem. 269:10363-10369.
20. Green, D. R. 1998. Apoptotic pathways: the roads to ruin. Cell 94:695-698.
21. Hafezi, F., J. P. Steinbach, A. Marti, K. Munz, Z. Q. Wang, E. F. Wagner, A. Aguzzi, and C. E. Reme. 1997. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat. Med. 3:346-349.
22. Hai, T. A., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720-3724.
23. Ham, J., C. Babij, J. Whitfield, C. M. Pfarr, D. Lallemand, M. Yaniv, and L. L. Rubin. 1995. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927-939.
24. Herdegen, T., F.-X. Claret, T. Kallunki, M. A. Villalba, T. Hunter, and M. Karin. 1998. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci. 18:5124-5135.
25. Herr, I., D. Wilhelm, T. Bohler, P. Angel, and K. M. Debatin. 1997. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16:6200-6208.
26. Herr, I., D. Wilhelm, T. Bohler, P. Angel, and K. M. Debatin. 1999. JNK/ SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha. Int. J. Cancer 80:417-424.
27. Herr, I., M. A. Villalba, E. Kurz, P. Roncaioli, J. Schenkel, M. G. Cifone, and K. M. Debatin. 1999. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res. 826:210-219.
28. Herrlich, P., C. Blattner, A. Knebel, K. Bender, and H. J. Rahmsdorf. 1997. Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants. Biol. Chem. 378:1217-1229.
29. Hu, E., E. Mueller, S. Oliviero, V. E. Papaioannou, R. Johnson, and B. M. Spiegelman. 1994. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 13:3094-3103.
30. Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10:205-219.
31. Ivashkiv, L. B., H. C. Liou, C. J. Kara, W. W. Lamph, I. M. Verma, and L. H. Glimcher. 1990. mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element. Mol. Cell. Biol. 10:1609-1621.
32. Johnson, R. S., B. van Lingen, V. E. Papaioannou, and B. M. Spiegelman. 1993. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7:1309-1317.
33. Kasibhatla, S., T. Brunner, L. Genestier, F. Echeverri, A. Mahboubi, and D. R. Green. 1998. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappaB and AP-1. Mol. Cell 1:543-551.
34. Krammer, P. H. 1999. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol. 71:163-210.
35. Kuan, C.-Y., D. Yang, D. R. Samata Roy, R. J. Davis, P. Rakic, and R. A. Flavell. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22:667-676.
36. Lenczowski, J. M., L. Dominiguez, A. M. Eder, L. B. King, C. M. Zacharchuk, and J. D. Ashwell. 1997. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol. Cell. Biol. 17:170-181.
37. Le-Niculescu, H., E. Bonfoco, Y. Kasuya, F. X. Claret, D. R. Green, and M. Karin. 1999. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to fas ligand induction and cell death. Mol. Cell. Biol. 19:751-763.
38. Liu, Z. G., R. Baskaran, E. T. Lea Chou, L. D. Wood, Y. Chen, K. Karin, and J. Y. Wang. 1996. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384:273-276.
39. Liu, Z. G., H. Hsu, D. V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87:565-576.
40. Minden, A., and M. Karin. 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333:85-104.
41. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355-365.
42. Reichardt, H. M., K. H. Kaestner, T. Tuckermann, O. Kretz, O. Wessely, R. Bock, P. Gass, W. Schmid, P. Herrlich, P. Angel, and G. Schütz. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531-541.
43. Sabapathy, K., Y. Hu, T. Kallunki, M. Schreiber, J.-P. David, W. Jochum, E. F. Wagner, and M. Karin. 1999. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr. Biol. 9:116-125.
44. Schreiber, M., B. Baumann, M. Cotten, P. Angel, and E. F. Wagner. 1995. Fos is an essential component of the mammalian UV response. EMBO J. 14:5338-5349.
45. Schreiber, M., A. Kolbus, F. Piu, A. Szabowski, U. Möhle-Steinlein, F. Tian, M. Karin, P. Angel, and E. F. Wagner. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607-613.
46. Schulze-Osthoff, K., D. Ferrari, M. Los, S. Wesselborg, and M. E. Peter. 1998. Apoptosis signaling by death receptors. Eur. J. Biochem. 254:439-459.
47. Stein, B., P. Angel, H. van Dam, H. Ponta, P. Herrlich, A. van der Eb, and H. J. Rahmsdorf. 1992. UV induced c-Jun gene transcription: two AP-1 like binding sites mediate the response. Photochem. Photobiol. 55:409-415.
48. Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274:787-789.
49. van Dam, H., M. Duyndam, R. Rottier, A. Bosch, L. de Vries Smits, P. Herrlich, A. Zantema, P. Angel, and A. van der Eb. 1993. Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J. 12:479-487.
50. van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and P. Angel. 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1798-1811.
51. van Dam, H., S. Huguier, K. Kooistra, J. Baguet, E. Vial, A. van der Eb, P. Herrlich, and M. Castellazzi. 1998. Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. Genes Dev. 12:1227-1239.
52. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedmann, Z. Fuks, and R. N. Kolesnick. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75-79.
53. Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274:784-787.
54. Wilhelm, D., K. Bender, A. Knebel, and P. Angel. 1997. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol. Cell. Biol. 17:4792-4800.
55. Wisdom, R., R. S. Johnson, and C. Moore. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18:188-197.
56. Yang, D. D., C. Y. Kuan, A. J. Whitmarsh, M. Rincon, T. S. Zheng, R. J. Davis, P. Rakic, and R. A. Flavell. 1997. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389: 865-870.
57. Zanke, B. W., K. Boudreau, E. Rubie, E. Winnett, L. A. Tibbles, L. Zon, J. Kyriakis, F. F. Liu, and J. R. Woodgett. 1996. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr. Biol. 6:606-613.