Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): Evidence for the role of transcription factor overexpression in determining resistant phenotype

Biochemical Pharmacology

Volumn 63, Issue 9, 2002, Pages 1699-1707

  Pan, Bin ^a   Yao, Kang Shen ^a   Monia, Brett P ^b   Dean, Nicholas M ^b   McKay, Robert A ^b   Hamilton, Thomas C ^c   O'Dwyer, Peter J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Antisense; c Jun; Drug resistance; ISIS 10582; Ovarian cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; ISIS 10582; ISIS 11563; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PROTEIN C JUN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG SENSITIVITY; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; OVARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FOLDING; STEADY STATE; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CISPLATIN; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OVARIAN NEOPLASMS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-JUN; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036569631     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00841-9     Document Type: Article

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