Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein

Cancer Research

Volumn 62, Issue 9, 2002, Pages 2690-2694

  Recio, Juán A ^a   Páez, J Guillermo ^a   Sanders, Sean ^a   Kawakami, Toshiaki ^a   Notario, Vicente ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CISPLATIN; NUCLEOSIDE ANALOG; ONCOPROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LYSATE; CELL SURVIVAL; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA BINDING; GENE ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; IONIZING RADIATION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS; TRANSACTIVATION;

3T3 CELLS; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL SURVIVAL; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FUNGAL PROTEINS; GATA TRANSCRIPTION FACTORS; MAP KINASE KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-FOS; STRESS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0036570081     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Expression of the protein product of the PCPH proto-oncogene in human tumor cell lines
2. Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7, 12-dimethylbenz(a)anthracene
3. The product of the cph oncogene is a truncated, nucleotide binding protein that enhances cellular survival to stress
4. Identity between the PCPH proto-oncogene and the CD39L4(ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene
5. Multiple signaling pathways for the activation of JNK in mast cells: Involvement of Bruton’s tyrosine kinase, protein kinase C, and JNK kinases. SEK1 and MKK7
6. The TAO of MEKK
7. Differential activation of ERK and JNK mitogen-activated protein kinases by raf-1 and MEKK
8. Both normal and transforming PCPH proteins have guanosine diphosphatase activity, but only the oncoprotein co-operates with Ras in activating extracellular signal-regulated kinase ERK1
9. 2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells
10. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
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13. Regulation of human involucrin promoter activity by a protein kinase C. Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway
14. The NTP phosphate donor in kinase reactions: Is ATP a monopolist?
15. Exogenous adenine nucleotides replete endothelial cell adenosine triphosphate after oxidant injury by adenosine uptake
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17. ATP-dependent steps in apoptotic signal transduction
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19. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
20. ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: Fresh insight for a new approach