Signal transduction: Imposing specificity on kinases

Science

Volumn 299, Issue 5609, 2003, Pages 1025-1027

  Ptashne, Mark ^a   Gann, Alexander ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

SIGNALING;

BINDING SITE; BIOCHEMISTRY; CATALYSIS; CELL SURFACE; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; MATING; MOLECULAR EVOLUTION; OSMOLARITY; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; SHORT SURVEY; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CARRIER PROTEINS; CELL MEMBRANE; EVOLUTION, MOLECULAR; GTP-BINDING PROTEIN BETA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0037436144     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081519     Document Type: Short Survey

References (9)

1. S.-H. Park, A. Zarrinpar, W. A. Lim, Science 299, 1061 (2003); published ontine 2 January 2003 (10.1126/science.1076979).
2. E. A. Elion, J. Cell Sci. 114, 3967 (2001).
3. P. Pryciak, F. A. Huntress, Genes Dev. 12, 2684 (1998).
4. K. Harris et al., Curr. Biol. 11, 1815 (2001).
5. C. Sette et al., Mol. Biol. Cell 11, 4033 (2000).
6. M. Ptashne, A. Gann, Genes and Signals (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2002).
7. M. Lei et al., Cell 102, 387 (2000).
8. R. E. Lamson et al., Mol. Cell. Biol. 22, 2939 (2002).
9. We thank E. A. Elion.