Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47154-47162

  Sinal, Christopher J ^c   Yoon, Michung ^a   Gonzalez, Frank J ^b  

^a Mokwon University   (South Korea)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; FATTY ACIDS; GENES; OXIDATION; SUBSTRATES;

GENE REGULATION;

BIOCHEMISTRY;

BEZAFIBRATE; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLIC ACID; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; TROGLITAZONE; CELL RECEPTOR; DNA BINDING PROTEIN; DNA BINDING PROTEINS; FARNESOID X ACTIVATED RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; GASTROINTESTINAL AGENT; MUTAGENIC AGENT; OXYGEN; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; CONTROLLED STUDY; DIETARY INTAKE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; ENZYME REGULATION; ENZYME SUBSTRATE; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GENE TARGETING; HEPATOMEGALY; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; PLASMID; RNA TRANSLATION; TRANSACTIVATION; TRANSGENIC MOUSE;

ANIMALIA;

ANIMAL; BILE ACIDS AND SALTS; CELL LINE; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL AGENTS; GENE EXPRESSION REGULATION; LIGANDS; MICE; MICE, TRANSGENIC; MUTAGENS; OXYGEN; PLASMIDS; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TRANSLATION, GENETIC;

EID: 0035861625     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107000200     Document Type: Article

References (66)

1. Forman, B. M., Chen, J., and Evans, R. M. (1996) Ann. N. Y. Acad. Sci. 804, 266-275
2. Corton, J. C., Lapinskas, P. J., and Gonzalez, F. J. (2000) Mutat. Res. 448, 139-151
3. Kliewer, S. A., Xu, H. E., Lambert, M. H., and Willson, T. M. (2001) Recent Prog. Horm. Res. 56, 239-263
4. Kersten, S., Desvergne, B., and Wahli, W. (2000) Nature 405, 421-424
5. Fruchart, J. C., Duriez, P., and Staels, B. (1999) Curr. Opin. Lipidol. 10, 245-257
6. Post, S. M., Twisk, J., van der Fits, L., de Wit, E. C., Hoekman, M. F., Mager, W. H., and Princen, H. M. (1999) Biochem. J. 341, 339-346
7. Jump, D. B., and Clarke, S. D. (1999) Annu. Rev. Nutr. 19, 63-90
8. Issemann, I., Prince, R. A., Tugwood, J. D., and Green, S. (1993) J. Mol. Endocrinol. 11, 37-47
9. Varanasi, U., Chu, R., Huang, Q., Castellon, R., Yeldandi, A. V., and Reddy, J. K. (1996) J. Biol. Chem. 271, 2147-2155
10. Gervois, P., Torra, I. P., Fruchart, J. C., and Staels, B. (2000) Clin. Chem. Lab. Med. 38, 3-11
11. Issemann, I., and Green, S. (1990) Nature 347, 645-650
12. Lake, B. G. (1995) Annu. Rev. Pharmacol. Toxicol. 35, 483-507
13. Keller, H., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K., and Wahli, W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2160-2164
14. Gottlicher, M., Widmark, E., Li, Q., and Gustafsson, J. A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4653-4657
15. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992) Cell 68, 879-887
16. Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S., Rachubinski, R. A., and Capone, J. P., (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7541-7545
17. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Mol. Cell. Biol. 15, 3012-3022
18. Motojima, K., Passilly, P., Peters, J. M., Gonzalez, F. J., and Latruffe, N. (1998) J. Biol. Chem. 273, 16710-16714
19. Aldridge, T. C., Tugwood, J. D., and Green, S. (1995) Biochem. J. 306, 473-479
20. Kroetz, D. L., Yook, P., Costet, P., Bianchi, P., and Pineau, T. (1998) J. Biol. Chem. 273, 31581-31589
21. Schoonjans, K., Peinado-Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., and Auwerx, J. (1996) EMBO J. 15, 5336-5348
22. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J. C., Staels, B., and Auwerx, J. (1995) J. Clin. Invest. 96, 741-750
23. Hertz, R., Bishara-Shieban, J., and Bar-Tana, J. (1995) J. Biol. Chem. 270, 13470-13475
24. Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., and Wahli, W. (1999) J. Clin. Invest. 103, 1489-1498
25. Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., and Kelly, D. P. (1998) J. Clin. Invest. 102, 1083-1091
26. Stahlberg, D., Reihner, E., Rudling, M., Berglund, L., Einarsson, K., and Angelin, B. (1995) Hepatology 21, 1025-1030
27. Jelinek, D. F., Andersson, S., Slaughter, C. A., and Russell, D. W. (1990) J. Biol. Chem. 265, 8190-8197
28. Vlahcevic, Z. R., Pandak, W. M., and Stravitz, R. T. (1999) Gastroenterol. Clin. North Am. 28, 1-25
29. Patel, D. D., Knight, B. L., Soutar, A. K., Gibbons, G. F., and Wade, D. P. (2000) Biochem. J. 351, 747-753
30. Marrapodi, M., and Chiang, J. Y. (2000) J. Lipid Res. 41, 514-520
31. Cheema, S. K., and Agellon, L. B. (2000) J. Biol. Chem. 275, 12530-12536
32. Hunt, M. C., Yang, Y. Z., Eggertsen, G., Carneheim, C. M., Gafvels, M., Einarsson, C., and Alexson, S. E. (2000) J. Biol. Chem. 275, 28947-28953
33. Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Cell 102, 731-744
34. Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. (1992) Nature 358, 771-774
35. Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., Parks, D. J., Moore, L. B., Lehmann, J. M., Plunket, K., Miller, A. B., Milburn, M. V., Kliewer, S. A., and Willson, T. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6102-6106
36. Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B. (1999) Science 284, 1362-1365
37. Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., and Lehmann, J. M. (1999) Science 284, 1365-1368
38. Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M. (1999) Mol. Cell 3, 543-553
39. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., and Kliewer, S. A. (2000) Mol. Cell 6, 517-526
40. Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., and Mangelsdorf, D. J. (2000) Mol. Cell 6, 507-515
41. Johansson, L., Thomsen, J. S., Damdimopoulos, A. E., Spyrou, G., Gustafsson, J. A., and Treuter, E. (1999) J. Biol. Chem. 274, 345-353
42. Lee, Y. K., Dell, H., Dowhan, D. H., Hadzopoulou-Cladaras, M., and Moore, D. D. (2000) Mol. Cell. Biol. 20, 187-195
43. Kassam, A., Capone, J. P., and Rachubinski, R. A. (2001) Mol. Cell. Endocrinol. 176, 49-56
44. Ren, B., Thelen, A., and Jump, D. B. (1996) J. Biol. Chem. 271, 17167-17173
45. Aperlo, C., Pognonec, P., Saladin, R., Auwerx, J., and Boulukos, K. E. (1995) Gene (Amst.) 162, 297-302
46. Chiang, J. Y., Kimmel, R., and Stroup, D. (2001) Gene (Amst.) 262, 257-265
47. Onate, S. A., Tsai, S. Y., Tsai, M. J., and O'Malley, B. W. (1995) Science 270, 1354-1357
48. Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. (1997) Mol. Endocrinol. 11, 779-791
49. Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., and Leid, M. (1997) J. Biol. Chem. 272, 33435-33443
50. Dowell, P., Peterson, V. J., Zabriskie, T. M., and Leid, M. (1997) J. Biol. Chem. 272, 2013-2020
51. Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., and Leid, M. (1999) J. Biol. Chem. 274, 15901-15907
52. Chiang, J. Y. L. (1998) Front. Biosci. 3, 176-193
53. Lund, E., Bjorkhem, I., Furster, C., and Wikvall, K. (1993) Biochim. Biophys. Acta 1166, 177-182
54. Johnson, E. F., Palmer, C. N., Griffin, K. J., and Hsu, M. H. (1996) FASEB J. 10, 1241-1248
55. De Fabiani, E., Mitro, N., Anzulovich, A. C., Pinelli, A., Galli, G., and Crestani, M. (2001) J. Biol. Chem. 276, 30708-30716
56. Zhang, M., and Chiang, J. Y. (2001) J. Biol. Chem. 276, 41690-41699
57. Seol, W., Choi, H. S., and Moore, D. D. (1996) Science 272, 1336-1339
58. Seol, W., Chung, M., and Moore, D. D. (1997) Mol. Cell. Biol. 17, 7126-7131
59. Michalik, L., and Wahli, W. (1999) Curr. Opin. Biotechnol. 10, 564-570
60. Lewis, D. F., and Lake, B. G. (1993) Xenobiotica 23, 79-96
61. Cronet, P., Petersen, J. F., Folmer, R., Blomberg, N., Sjoblom, K., Karlsson, U., Lindstedt, E., and Bamberg, K. (2001) Structure 9, 699-706
62. Bertolotti, M., Concari, M., Loria, P., Abate, N., Pinetti, A., Guicciardi, M. E., and Carulli, N. (1995) Arterioscler. Thromb. Vasc. Biol. 15, 1064-1069
63. Li, Y. C., Wang, D. P., and Chiang, J. Y. (1990) J. Biol. Chem. 265, 12012-12019
64. Ramirez, M. I., Karaoglu, D., Haro, D., Barillas, C., Bashirzadeh, R., and Gil, G. (1994) Mol. Cell. Biol. 14, 2809-2821
65. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
66. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140