Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death

Human Molecular Genetics

Volumn 12, Issue 13, 2003, Pages 1485-1496

  Huynh, Duong P ^a,b   Yang, Hai Tao ^a,b   Vakharia, Hema ^a,b   Nguyen, Dung ^a,b   Pulst, Stefan M ^a,b  

^a BURNS AND ALLEN RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 2; CASPASE 3; GENE PRODUCT; GLUTAMINE; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL NUCLEUS INCLUSION BODY; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EXPERIMENTAL MODEL; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENE TARGETING; GOLGI COMPLEX; IN VITRO STUDY; NERVE CELL; NICK END LABELING; NONHUMAN; NUCLEOTIDE REPEAT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PURKINJE CELL; RAT; SIGNAL TRANSDUCTION; SPINOCEREBELLAR DEGENERATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREFELDIN A; CASPASE 3; CASPASES; CELL DEATH; CELL DIVISION; COS CELLS; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUMINESCENT PROTEINS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PC12 CELLS; PEPTIDES; PLASMIDS; PROTEIN SYNTHESIS INHIBITORS; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION;

ANIMALIA; ATAXIA;

EID: 0037767510     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg175     Document Type: Article

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