Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: Triple-labeling immunofluorescent study

Neuroscience Letters

Volumn 273, Issue 2, 1999, Pages 117-120

  Koyano, Shigeru ^a,b   Uchihara, Toshiki ^b   Fujigasaki, Hiroto ^b,c   Nakamura, Ayako ^b   Yagishita, Saburo ^a   Iwabuchi, Kiyoshi ^a  

^a KANAGAWA REHABILITATION CENTER   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL   (Japan)

Author keywords

Neuronal intranuclear inclusions; Spinocerebellar ataxia type 2

Indexed keywords

GLUTAMINE; PROTEIN; UBIQUITIN;

CELL NUCLEUS INCLUSION BODY; CEREBELLAR ATAXIA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; SHORT SURVEY; WESTERN BLOTTING;

EID: 0032840052     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00656-4     Document Type: Article

References (19)

1. Adams J.C. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J. Histochem. Cytochem. 40:1992;1457-1463.
2. Cummings C.J., Mancini M.A., Antalffy B., DeFranco D.B., Orr H.T., Zoghbi H.Y. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat. Genet. 19:1998;148-154.
3. Davis S.W., Turmaine M., Cozens B.A., DiFiglia M., Sharp A.H., Ross C.A., Scherzinger E., Wanker E.E., Mangiarini L., Bates G.P. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 90:1997;537-548.
4. Hayashi Y., Kakita A., Yamada M., Koide R., Igarashi S., Takano H., Ikeuchi T., Wakabayashi K., Egawa S., Tsuji S., Takahashi H. Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain. Acta Neuropathol. 96:1998;547-552.
5. Holmberg M., Duyckaerts C., Dürr A., Cancel G., Gourfinkel-An I., Damier P., Faucheux B., Trottier Y., Hirsch E.C., Agid Y., Brice A. Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions. Hum. Mol. Genet. 7:1998;913-918.
6. Huynh D.P., Del Bigio M.R., Ho D.H., Pulst S.M. Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2. Ann. Neurol. 45:1999;232-241.
7. Imbert G., Saudou F., Yvert G., Devys D., Trottier Y., Garnier J.M., Weber C., Mandel J.L., Cancel G., Abbas N., Dürr A., Didierjean O., Stevanin G., Agid Y., Brice A. Cloning of the gene for spinocerebellar ataxia type 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. Nat. Genet. 14:1996;285-291.
8. Iwabuchi K., Tsuchiya K., Uchihara T., Yagishita S. Autosomal dominant spinocerebellar degenerations. Clinical, pathological, and genetic correlations. Rev. Neurol. 15:1999;255-270.
9. Klement I.A., Skinner P.J., Kaytor M.D., Yi H., Hersch S.M., Clark H.B., Zoghbi H.Y., Orr H.T. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell. 95:1998;41-53.
10. Lettink M., Lewis J.G., Elder P.A. A monoclonal antibody raised against amino acids 497-507 of the human estrogen receptor recognizes human ataxin-2. J. Biochem. Mol. Biol. Biophys. 2:1999;111-119.
11. Li M., Miwa S., Kobayashi Y., Merry D.E., Yamamoto M., Tanaka F., Doyu M., Hashizume Y., Fischbeck K.H., Sobue G. Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy. Ann. Neurol. 44:1998;249-254.
12. Nechiporuk T., Huynh D.P., Figueroa K., Sahba S., Nechiporuk A., Pulst S.M. The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression. Hum. Mol. Genet. 7:1998;1301-1309.
13. Paulson H.L., Perez M.K., Trottier Y., Trojanowski J.Q., Subramony S.H., Das S.S., Vig P., Mandel J.L., Fischbeck K.H., Pittman R.N. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron. 19:1997;333-344.
14. Purst S.M., Neichipork A., Neichipork T., Gispert S., Chen X.N., Cendes I.L., Pealman S., Starkman S., Orozco-Diaz G., Lunkes A., Dejong P., Rouleau G.A., Auburger G., Korenberg J.R., Figueroa C., Sahba S. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Nat. Genet. 14:1996;269-276.
15. Sanpei K., Takano H., Igarashi S., Sato T., Oyake M., Sasaki H., Wakisaka A., Tashiro K., Ishida Y., Ikeuchi T., Koide R., Saito M., Sato A., Tanaka T., Hanyu S., Takiyama Y., Nishizawa M., Shimizu N., Nomura Y., Segawa M., Iwabuchi K., Eguchi Y., Tanaka H., Takahashi H., Tsuji S. Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat. Genet. 14:1996;277-284.
16. Saudou F., Finkbeiner S., Devys D., Greenberg M.E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell. 95:1998;55-66.
17. Skinner P.J., Koshy B.T., Cummings C.J., Klement I.A., Helin K., Servadio A., Zoghbi H.Y., Orr H.T. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature. 389:1997;971-974.
18. Stevanin G., Trottier Y., Cancel G., Dürr A., David G., Didierjean O., Bürk K., Imbert G., Saudou F., Abada-Bendib M., Gourfinkel-An I., Benomar A., Abbas N., Klockgether T., Grid D., Agid Y., Mandel J.L., Brice A. Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias. Hum. Mol. Genet. 5:1996;1887-1892.
19. Trottier Y., Lutz Y., Stevanin G., Imbert G., Devys D., Cancel G., Saudou F., Weber C., David G., Tora T., Agid Y., Brice A., Mandel J.L. Polyglutamine expansion as a pathologic epitope in Huntington's disease and four dominant ataxias. Nature. 378:1995;403-405.