Brain microvascular and metabolic adaptation to prolonged mild hypoxia

Oxygen Sensing: Responses and Adaption to Hypoxia

Volumn , Issue , 2003, Pages 109-121

  Agani, Faton H ^a   Chávez, Juan Carlos ^a   Pichiule, Paola ^a   Lamanna, Joseph C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0037674195     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (79)

1. Siesjö BK, Berntman L, Nilsson B. Regulation of microcirculation in the brain. Microvasc Res 1980; 19:158-170.
2. 2? Brain Res 1976; 108:143-154.
3. LaManna JC, Ven del LM, Farrell RM. Brain adaptation to chronic hypobaric hypoxia in rats. J Appl Physiol 1992; 72:2238-2243.
4. Beck T, Krieglstein J. Cerebral circulation, metabolism, and blood-brain barrier in rats in hypocapnic hypoxia. Am J Physiol 1987; 252:H504-H512.
5. 3redox relationships in rat cerebral cortex in vivo. Brain Res 1981; 218:161-174.
6. Shockley RP, LaManna JC. Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia, and hyperventilation. Brain Res 1988; 454:170-178.
7. 2 pressures. Pflüg Arch 1975; 359:81-95.
8. 2 supply. J Appl Physiol 1971; 31:751-759.
9. Torbati D, Greenberg JH, Lambertsen CJ. Regional cerebral glucose metabolic rate during thirty minutes hypoxia of 7% oxygen in adult conscious rats. Neurosci Lett 1986; 65:253-258.
10. Pulsinelli WA, Duffy TE. Local cerebral glucose metabolism during controlled hypoxemia in rats. Science 1979; 204:626-629.
11. Kuschinsky W, Paulson OB. Capillary circulation in the brain. Cerebrovasc Brain Metab Rev 1992; 4:261-286.
12. Boero JA, Ascher J, Arregui A, Rovainen C, Woolsey TA. Increased brain capillaries in chronic hypoxia. J Appl Physiol 1999; 86(4): 1211-1219.
13. Opitz E. Increased vascularization of the tissue due to acclimatization to high altitude and its significance for the oxygen transport. Exp Med Surg 1951; 9:389-403.
14. Miller AT Jr, Hale DM. Increased vascularity of brain, heart, and skeletal muscle of polycythemic rats. Am J Physiol 1970; 219:702-704.
15. Diemer K, Henn R. Kapillarvermehrung in der hirnrinde der ratte unter chronischem sauerstoffmangel. Die Natur 1965; 52:135-136.
16. Mironov V, Hritz MA, LaManna JC, Hudetz AG, Harik SI. Architectural alterations in rat cerebral microvessels after hypobaric hypoxia. Brain Res 1994; 660:73-80.
17. Harik SI, Hritz MA, LaManna JC. Hypoxia-induced brain angiogenesis in the adult rat. J Physiol (Lond) 1995; 485.2:525-530.
18. Harik N, Harik SI, Kuo N-T, Sakai K, Przybylski RJ, LaManna JC. Time course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density. Brain Res 1996; 737:335-338.
19. Black JE, Sirevaag AM, Greenough WT. Complex experience promotes capillary formation in young rat visual cortex. Neurosci Lett 1987; 83:351-355.
20. Black JE, Zelazny AM, Greenough WT. Capillary and mitochondrial support of neural plasticity in adult rat visual cortex. Exp Neurol 1991; 111:204-209.
21. Isaacs KR, Anderson BJ, Alcantara AA, Black JE, Greenough WT. Exercise and the brain:Angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J Cereb Blood Flow Metab 1992; 12:110-119.
22. 2 homeostasis by hypoxia-inducible factor I. Annu Rev Cell Dev Biol 1999; 15:551-578.
23. Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 2001; 13(2): 167-171.
24. Wenger RH. Mammalian oxygen sensing, signaling and gene regulation. J Exp Biol 2000; 203 Pt 8:1253-1263.
25. Harik SI, Lust WD, Jones SC, Lauro KL, Pundik S, LaManna JC. Brain glucose metabolism in hypobaric hypoxia. J Appl Physiol 1995; 79(1): 136-140.
26. Harik SI, Behmand RA, LaManna JC. Hypoxia increases glucose transport at blood-brain barrier in rats. J Appl Physiol 1994; 77:896-901.
27. LaManna JC, Kutina-Nelson KL, Hritz MA, Huang Z, Wong-Riley MTT. Decreased rat brain cytochrome oxidase activity after prolonged hypoxia. Brain Res 1996; 720:1-6.
28. Lenfant C, Sullivan K. Adaptation to high altitude. N Engl J Med 1971; 284:1298-1309.
29. Dempsey JA, Forster HV Mediation of ventilatory adaptations. Physiol Rev 1982; 62:262-346.
30. Monge C, León-Velarde F. Physiological adaptation to high altitude: Oxygen transport in mammals and birds. Physiol Rev 1991; 71:1135-1172.
31. Boyer SJ, Blume FD. Weight loss and changes in body composition at high altitude. J Appl Physiol 1984; 57:1580-1585.
32. Fregly MJ, Waters IW. Posthypoxic drinking response of rats. Fed Proc 1966; 25:1220-1226.
33. Chávez JC, Pichiule P, Boero J, Arregui A. Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia. Neurosci Lett 1995; 193:169-172.
34. Caceda R, Gamboa JL, Boero JA, Monge C, Arregui A. Energetic metabolism in mouse cerebral cortex during chronic hypoxia. Neurosci Lett 2001; 301(3): 171-174.
35. Lauro KL, LaManna JC. Adequacy of cerebral vascular remodeling following three weeks of hypobaric hypoxia examined by an integrated composite analytical model. In: Nemoto EM, LaManna JC, eds. Oxygen Transport to Tissue XVIII (Advances in Experimental Medicine and Biology, Vol. 411). New York: Plenum Publishing Corp, 1997:369-376.
36. +] regulation in brain tissue during acclimatization to chronic hypoxia. J Appl Physiol 1983; 55:1486-1495.
37. Hochachka PW, Clark CM, Brown WD, Stanley C, Stone CK, Nickles RJ, et al. The brain at high altitude: hypometabolism as a defense against chronic hypoxia? J Cereb Blood Flow Metab 1994; 14(4): 671-679.
38. Mortola JP. Hypoxic hypometabolism in mammals. News in Physiological Sciences 1993; 8:79-82.
39. Wood SC. Interactions between hypoxia and hypothermia. Annu Rev Physiol 1991; 53:71-85.
40. Carlsson C, Hägerdal M, Siesjö BK. Protective effect of hypothermia in cerebral oxygen deficiency caused by arterial hypoxia. Anesthesiology 1976; 44(1): 27-35.
41. LaManna JC, Cordisco BR, Kneuse DE, Hudetz AG. Increased capillary segment length in cerebral cortical microvessels of rats exposed to 3 weeks of hypobaric hypoxia. In: Vaupel P, Zander R, Bruley DF, eds. Oxygen Transport To Tissue XV (Advances in Experimental Medicine and Biology, Vol. 345). New York: Plenum Publishing Corp, 1994:627-632.
42. Stewart PA, Isaacs H, LaManna JC, Harik SI. Ultrastructural concomitants of hypoxia-induced angiogenesis. Acta Neuropathol 1997; 93(6): 579-584.
43. Chávez JC, Agani F, Pichiule P, LaManna JC. Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia. J Appl Physiol 2000; 89:1937-1942.
44. Xu F, Severinghaus JW. Rat brain VEGF expression in alveolar hypoxia: possible role in highaltitude cerebral edema. J Appl Physiol 1998; 85(1): 53-57.
45. Kuo N-T, Benhayon D, Przybylski RJ, Martin RJ, LaManna JC. Prolonged hypoxia increases vascular endothelial growth factor mRNA, and protein in adult mouse brain. J Appl Physiol 1999; 86(1): 260-264.
46. 2 distribution in the living tissue. Kidney Int 1997; 51:372-380.
47. Sick TJ, Lutz PL, LaManna JC, Rosenthal M. Comparative brain oxygenation and mitochondrial redox activity in turtles and rats. J Appl Physiol 1982; 53:1354-1359.
48. Lübbers DW. Oxygen delivery and microcirculation in the brain. In: Manabe H, Zweifach BW, Messmer K, eds. Microcirculation in Circulatory Disorders. Tokyo: Springer-Verlag, 1988:33-50.
49. Dunn JF, Grinberg O, Roche M, Nwaigwe CI, Hou HG, Swartz HM. Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia. J Cereb Blood Flow Metab 2000; 20(12): 1632-1635.
50. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12(12): 5447-5454.
51. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270(3): 1230-1237.
52. Wang GL, Jiang BH. Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92(12): 5510-5514.
53. Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 1991; 252(5008): 954-958.
54. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996; 271(50): 32253-32259.
55. Salceda S, Caro J. Hypoxia-inducible factor 1 alpha (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions-its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997; 272(36): 22642-22647.
56. Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O-2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95(14): 7987-7992.
57. Kallio PJ, Wilson WJ, O’Brien S. Makino Y, Poellinger. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem 1999; 274(10): 6519-6525.
58. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wycoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis. Nature 1999; 399(6733): 271-275.
59. Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000; 2(7): 423-421.
60. Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxiainducible factor-1 alpha by the von Hippel-Lindau tumor suppressor N protein. EMBO J 2000; 19(16): 4298-4309.
61. 2 sensing. Science 2001; 292(5516): 464-468.
62. 2 regulated prolyl hydroxylation. Science 2001; 292(5516): 468-472.
63. Kivirikko KI, Myllyharju J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol 1998; 16(7): 357-368.
64. Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 1988; 242(4884): 1412-1415.
65. Fandrey J, Frede S, Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 1994; 303 (Pt 2):507-510.
66. Agani F, Pichiule P, Chávez JC, LaManna J. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 2000; 275:35863-35867.
67. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 1998; 95(20): 11715-11720.
68. 2 sensing. J Biol Chem 2000; 275(33): 25130-25138.
69. Hirota K, Semenza GL. Rac1 activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem 2001; 276(24): 21166-21172.
70. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 2001; 276(25): 21995-21998.
71. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 2001; 98(2): 296-302.
72. Schroedl C, McClintock D, Budinger GRS, Chandel N. Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species. Am J Physiol 2002; 283:L922-L931.
73. Agani F, and Semenza G. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol 1998; 54(5): 749-754.
74. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999(Aug 15); 59(16):3915-3918.
75. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 1998; 17(17): 5085-5094.
76. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999; 79(4): 1431-1568.
77. Chávez JC, LaManna J. IGF-1 and HIF-1α accumulation induced by transient global ischemia. J Cereb Blood Flow Metab 2001; 21(Suppl 1):S389.
78. Chávez JC, LaManna JC. HIF-1α accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging. ISOTT 2001; 21 Proceedings. In: Wilson DF, Biaglow J, Evans SM, Pastuszko A, eds. New York: Kluwer Academic/Plenum. In press.
79. Frenkel-Denkberg G, Gershon D, Levy AP. The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice. FEBS Lett 1999; 462(3): 341-344.