Rat brain VEGF expression in alveolar hypoxia: Possible role in high- altitude cerebral edema

Journal of Applied Physiology

Volumn 85, Issue 1, 1998, Pages 53-57

  Fengping, X U ^a,b   Severinghaus, John W ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute mountain sickness; Angiogenesis; Brain capillary leak; Cytokines

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

ALTITUDE DISEASE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CAPILLARY; BRAIN CORTEX; BRAIN EDEMA; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; LUNG ALVEOLUS OXYGEN TENSION; MALE; NONHUMAN; OXYGEN CONCENTRATION; PRIORITY JOURNAL; RAT;

EID: 14444283112     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.1.53     Document Type: Article

References (24)

1. Banai, S., M. T. Jacklitsch, and M. Shou. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dog. Circulation 89: 2183-2189, 1994.
2. Berkman, R. A., M. J. Merill, W. C. Reinhold, W. T. Tonacci, A. Saxena, W. C. Clark, J. T. Robertson, I. U. Ali, and E. H. Oldfield. Expression of the vascular permeability/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. 91: 153-159, 1993.
3. Breier, G., U. Albrecht, S. Sterrer, and W. Risau. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114: 521-532, 1992.
4. ++ and von Willebrand factor release in human endothelial cells. Am. J. Pathol. 138: 213-221, 1991.
5. Brogi, E., G. Schatteman, T. Wu, E. A. Kim, L. Varticovski, B. Keyt, and J. M. Isner. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J. Clin. Invest. 97: 469-476, 1996.
6. Charnock-Jones, D. S. C., A. M. Sharkey, and J. Raiput-Williams. Identification and localization of alternately spliced mRNA for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol. Reprod. 48: 1120-1128, 1993.
7. Clauss, M., M. Gerlach, H. Gerlach, J. Brett, F. Wang, P. C. Familletti, Y.-C. E. Pan, J. V. Olander, D. T. Connolly, and D. Stern. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172: 1535-1545, 1990.
8. De Vries, C., J. A. Escobedo, H. Ueno, H. K. Houck, N. Ferrara, and L. T. Williams. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991, 1991.
9. Harik, S. I., M. A. Hritz, and J. C. LaManna. Hypoxia-induced brain angiogenesis in the adult rat. J. Physiol. (Lond.) 485: 525-530, 1995.
10. Hashimoto, E., T. Ogita, T. Nakaoka, R. Matsuoka, A. Takao, and Y. Kira. Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1948-H1954, 1994.
11. Houck, K. A., N. Ferrara, J. Winer, G. Cachianes, B. Li, and D. W. Leung. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5: 1806-1814, 1991.
12. Keck, P. J., S. D. Hauser, G. Krivi, K. Sanzo, T. Warren, J. Feder, and D. T. Connolly. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312, 1989.
13. Kim, K. J., B. Li, J. Winer, M. Armanini, N. Gillett, H. S. Phillips, and N. Ferrara. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362: 841-844, 1993.
14. LaManna, J. C., K. D. Boehm, V. Mironov, A. G. Hudetz, M. A. Hritz, J. K. Yun, and S. I. Harik. Increased basic fibroblastic growth factor mRNA in the brains of rats exposed to hypobaric hypoxia. Adv. Exp. Med. Biol. 361: 497-502, 1994.
15. LaManna, J. C., B. R. Cordisco, D. E. Knuese, and A. G. Hudetz. Increased capillary segment length in cerebral cortical microvessels of rats exposed to 3 weeks of hypobaric hypoxia. Adv. Exp. Med. Biol. 345: 627-631, 1994.
16. Monacci, W. T., M. J. Merrill, and E. H. Oldfield. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J. Physiol. 264 (Cell Physiol. 33): C995-C1002, 1993.
17. Plate, K. H., G. Breier, B. Millauer, A. Ullrich, and W. Risau. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat-glioma model of tumor angiogenesis. Cancer Res. 53: 5822-5827, 1993.
18. Plate, K. H., G. Breier, H. A. Weich, and W. Risau. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
19. Robertson, P. L., M. Du Bois, P. D. Bowman, and G. W. Goldstein. Angiogenesis in developing rat brain: an in vivo and in vitro study. Dev. Brain Res. 23: 219-223, 1985.
20. 2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50: 572-578, 1990.
21. Severinghaus, J. W. Hypothetical roles of angiogenesis, osmotic swelling, and ischemia in high-altitude cerebral edema. J. Appl. Physiol. 79: 375-379, 1995.
22. Shibuya, M., S. Yamaguchi, A. Yamane, T. Ikeda, A. Toji, H. Matushime, and M. Sato. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5: 519-524, 1990.
23. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
24. Tuder, R. M., B. E. Flook, and N. F. Voelkel. Increased gene expression for VEGF and the VEGF receptors KDR/flk and fit in lungs exposed to acute or to chronic hypoxia. J. Clin. Invest. 95: 1798-1807, 1995.