Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants

Biochemistry

Volumn 39, Issue 10, 2000, Pages 2429-2435

  Variath, Prasanna ^a   Liu, Yaoquan ^a   Lee, Tom T ^a   Stroud, Robert M ^a   Santi, Daniel V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE DERIVATIVE; THYMIDYLATE SYNTHASE;

ARTICLE; BINDING AFFINITY; ENZYME ANALYSIS; KINETICS; LACTOBACILLUS CASEI; MODEL; NONHUMAN; PRIORITY JOURNAL;

ALANINE; ARGININE; CATALYSIS; DEOXYURACIL NUCLEOTIDES; ESCHERICHIA COLI; GLYCINE; KINETICS; LACTOBACILLUS CASEI; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; TETRAHYDROFOLATES; THYMIDINE MONOPHOSPHATE; THYMIDYLATE SYNTHASE; VALINE;

BACTERIA (MICROORGANISMS); LACTOBACILLUS CASEI; POSIBACTERIA;

EID: 0040183813     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991802d     Document Type: Article

References (15)

1. Carreras, C. W., and Santi, D. V. (1995) Annu. Rev. Biochem. 64, 721-762.
2. Barrett, J. E., Maltby, D. A., Santi, D. V., and Schultz, P. G. (1998) J. Am. Chem. Soc. 120, 449-450.
3. Maley, G. F., and Maley, F. (1988) J. Biol. Chem. 263, 7620-7.
4. Climie, S. C., Carreras, C. W., and Santi, D. V. (1992) Biochemistry 31, 6032-6038.
5. Kealey, J. T., Eckstein, J., and Santi, D. V. (1995) Chem. Biol. 2, 609-614.
6. Maniatis, T., Fritsch, E. F., and Sambrook, J. (1982) Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
7. Pogolotti, A. L., and Santi, D. V. (1982) Anal. Biochem. 126, 335-345.
8. Segel, I. H. (1975) Enzyme Kinetics: Behavior and Analysis of Steady-State and Rapid Equilibrium Enzyme Systems, pp 57-58 and 210, Wiley-Interscience, New York.
9. Spencer, H. T., Villafranca, J. E., and Appleman, J. R. (1997) Biochemistry 36, 4212-4222.
10. Sage, C. R., Rutenber, E. E., Stout, T. J., and Stroud, R. M. (1996) Biochemistry 35, 16270-81.
11. Stout, T. J., and Stroud, R. M. (1996) Structure 4, 67-77.
12. Galivan, J. H., Maley, G. F., and Maley, F. (1976) Biochemistry 15, 356-62.
13. Dev, I. K., Dallas, W. S., Ferone, R., Hanlon, M., McKee, D. D., and Yates, B. B. (1994) J. Biol. Chem. 269, 1873-1882.
14. Lockshin, A., Mondal, K., and Danenberg, P. V. (1984) J. Biol. Chem. 259, 11346-11352.
15. FinerMoore, J. S., Liu, L., Birdsall, D. L., Brem, R., Apfeld, J., Santi, D. V., and Stroud, R. M. (1998) J. Mol. Biol. 276, 113-129.