An essential role for water in an enzyme reaction mechanism: The crystal structure of the thymidylate synthase mutant E58Q

Biochemistry

Volumn 35, Issue 50, 1996, Pages 16270-16281

  Sage, Carleton R ^a   Rutenber, Earl E ^a   Stout, Thomas J ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE; WATER;

ARTICLE; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; ENZYME INHIBITORS; ESCHERICHIA COLI; FOLIC ACID; GLUTAMIC ACID; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; QUINAZOLINES; RECOMBINANT PROTEINS; THYMIDYLATE SYNTHASE; WATER;

EID: 0030466872     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961269r     Document Type: Article

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