Use of strain in a stereospecific catalytic mechanism: Crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate

Biochemistry

Volumn 36, Issue 15, 1997, Pages 4585-4594

  Hyatt, David C ^a   Maley, Frank ^b   Montfort, William R ^a  

^a University of Arizona   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; METHYLENETETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE;

ARTICLE; CATALYSIS; CHIRALITY; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME ANALYSIS; ENZYME STRUCTURE; ESCHERICHIA COLI; PRIORITY JOURNAL;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; FLUORODEOXYURIDYLATE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTONS; SPECIES SPECIFICITY; STEREOISOMERISM; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE; TYROSINE;

EID: 0030991713     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962936j     Document Type: Article

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