Functional role of tryptophan residues in the fourth transmembrane domain of the CB2 cannabinoid receptor

Journal of Neurochemistry

Volumn 75, Issue 6, 2000, Pages 2485-2491

  Rhee, Man Hee ^a   Nevo, Igal ^a   Bayewitch, Michael L ^a   Zagoory, Orna ^a   Vogel, Zvi ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Adenylyl cyclase; Cannabinoids; CB2 receptor; G protein; Site directed mutagenesis

Indexed keywords

ADENYLATE CYCLASE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; BINDING, COMPETITIVE; CANNABINOIDS; COS CELLS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCERIDES; HUMANS; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; NAPHTHALENES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROCANNABINOL; TRANSFECTION; TRYPTOPHAN;

ANIMALIA;

EID: 0033773647     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752485.x     Document Type: Article

References (38)

1. Multiple sequence alignment of protein families showing low sequence homology: A methodological approach using database pattern-matching discriminators for G-protein-linked receptors
2. Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gβγ
3. Opioid-induced adenylyl cyclase superactivation is isozyme-specific
4. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
5. Integrated methods for G-protein coupled receptors
6. Role of aromatic transmembrane residues of the δ-opioid receptor in ligand recognition
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1
9. The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor
10. 3H]ketanserin binding to 5-hydroxytryptamine receptors
11. The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/SAPK signalling pathway
12. Cation-π interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
13. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
14. GPCRDB: An information system for G protein-coupled receptors
15. Pharmacology of cannabinoid receptors
16. The CB1 cannabinoid receptor in the brain
17. Methods for introducing DNA into mammalian cells
18. Probing of the location of the allosteric site on the m1 muscarinic receptors by site-directed mutagenesis
19. High-level expression of the human CB2 cannabinoid receptor using a baculovirus system
20. Sequence alignment of the G-protein coupled receptor superfamily
21. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: Insights gained from (E)- and (Z)-naphthylidene indenes
22. Effects of tyrosine289phenylalanine mutation on binding and functional properties of the human tachykinin NK2 receptor stably expressed in Chinese hamster ovary cells
23. Relevance of aromatic residues in transmembrane segments V to VII for binding of peptide and nonpeptide antagonists to the human tachykinin NK2 receptor
24. Cannabinoid derivatives: Binding to cannabinoid receptors and inhibition of adenylyl cyclase
25. Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes
26. Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine(2A) receptors
27. 3H]cAMP in cell monolayers, cell suspensions and tissue slices
28. 1 receptor
29. Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528
30. A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
31. The difference between the CB1 and CB2 cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB2
32. Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling
33. Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): Evidence for subtype specificity
34. Anandamide, a brain endogenous compound, interacts specially with cannabinoid receptors and inhibits adenylate cyclase
35. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
36. Molecular cloning and expression of a novel type V adenylyl cyclase from rabbit myocardium
37. Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation
38. Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor