Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors

British Journal of Pharmacology

Volumn 126, Issue 3, 1999, Pages 735-745

  Huang, Xi Ping ^a   Nagy, Peter I ^a   Williams, Frederick E ^a   Peseckis, Steven M ^a   Messer Jr , William S ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

Acetylcholine; Arecoline; Carbachol; G protein coupling; M1 receptor; Molecular modelling; Muscarinic receptors; Oxotremorine M; Phosphatidylinositol turnover; Site directed mutagenesis

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ASPARAGINE; CARBACHOL; DIFENIDOL; HYOSCYAMINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; MUTANT PROTEIN; OTENZEPAD; PIRENZEPINE; QUINUCLIDINYL BENZILATE; SCOPOLAMINE; THREONINE; TRIHEXYPHENIDYL;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; MODELS, MOLECULAR; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PHOSPHATIDYLINOSITOLS; PIRENZEPINE; QUINUCLIDINYL BENZILATE; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; SCOPOLAMINE; THREONINE; TRITIUM;

EID: 0033052408     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702301     Document Type: Article

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