Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1362-1365

  Yu, Aiming ^a   Dong, Haijun ^b   Lang, Dieter ^c   Haining, Robert L ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYMORPHINAN; CYTOCHROME P450 2D6; CYTOCHROME P450 REDUCTASE; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DEMETHYLATION; DRUG BINDING; DRUG STRUCTURE; ENZYME BINDING; ENZYME RECONSTITUTION; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID VESICLE; MICHAELIS CONSTANT; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ANIMALS; BACULOVIRIDAE; CATALYSIS; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; KINETICS; OXIDOREDUCTASES, N-DEMETHYLATING; OXIDOREDUCTASES, O-DEMETHYLATING; RATS; RECOMBINANT PROTEINS;

EID: 0034771887     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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