Amino acid 305 determines catalytic center accessibility in CYP3A4

Biochemistry

Volumn 39, Issue 15, 2000, Pages 4406-4414

  Fowler, Stephen M ^a,b   Riley, Robert J ^a   Pritchard, Michael P ^b   Sutcliffe, Michael J ^c   Friedberg, Thomas ^b   Wolf, C Roland ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; CLOTRIMAZOLE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DIAZEPAM; ECONAZOLE; ERYTHROMYCIN; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; MICONAZOLE; N DEMETHYLASE; NIFEDIPINE; PHENYLALANINE; SERINE; TESTOSTERONE;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STEREOSPECIFICITY;

ALANINE; AMINO ACID SUBSTITUTION; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYSIS; CLOTRIMAZOLE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; ECONAZOLE; ERYTHROMYCIN; HUMANS; IMIDAZOLES; KETOCONAZOLE; KINETICS; MICONAZOLE; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; MUTATION; NIFEDIPINE; OXIDOREDUCTASES, N-DEMETHYLATING; SUBSTRATE SPECIFICITY; TESTOSTERONE;

EID: 0034681944     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992372u     Document Type: Article

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