Diclofenac and its derivatives as tools for studying human cytochromones P450 active sites: Particular efficiency and regioselectivity of P450 2Cs

Biochemistry

Volumn 38, Issue 43, 1999, Pages 14264-14270

  Mancy, Annah ^a   Antignac, Marie ^a   Minoletti, Claire ^a   Dijols, Sylvie ^a   Mouries, Virginie ^a   Ha Duong, Nguyet Thanh ^a   Battioni, Pierrette ^a   Dansette, Patrick M ^a   Mansuy, Daniel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXYDICLOFENAC; 5 HYDROXYDICLOFENAC; CYTOCHROME P450; DICLOFENAC; DICLOFENAC DERIVATIVE; IMINE; PORPHYRIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CONTROLLED STUDY; DRUG OXIDATION; ENZYME ACTIVE SITE; HUMAN; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CYCLOOXYGENASE INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; HUMANS; HYDROXYLATION; ISOENZYMES; KINETICS; LIVER; MIXED FUNCTION OXYGENASES; MOLECULAR MIMICRY; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; STEREOISOMERISM; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TERT-BUTYLHYDROPEROXIDE;

FELIS CATUS;

EID: 0033607201     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991195u     Document Type: Article

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