Leptin in the CNS: Much more than a satiety signal

Neuropharmacology

Volumn 44, Issue 7, 2003, Pages 845-854

  Harvey, J ^a   Ashford, M L J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cognitive function; Hippocampus; Hypothalamus; Ion channels; Leptin; Neuronal excitability; Satiety signal; Signalling pathways

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AGOUTI RELATED PROTEIN; GENE PRODUCT; GONADORELIN; ISOPROTEIN; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; LUTEINIZING HORMONE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RECOMBINANT LEPTIN; STAT3 PROTEIN; TYROSINE; WORTMANNIN;

BODY WEIGHT; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN REGION; CENTRAL NERVOUS SYSTEM; ENERGY BALANCE; FEEDING BEHAVIOR; GENETIC TRANSCRIPTION; GONADORELIN RELEASE; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS NUCLEUS; IMMUNOREACTIVITY; LONG TERM POTENTIATION; LUTEINIZING HORMONE RELEASE; MUTATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; OBESITY; OSSIFICATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SATIETY; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 0037410414     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00076-5     Document Type: Short Survey

References (95)

1. Ahima R.S. Leptin and the neuroendocrinology of fasting. Frontiers in Hormone Research. 26:2000;42-56.
2. Ahima R.S., Bjorbaek C., Osei S., Flier J.S. Regulation of neuronal and glial proteins by leptin: Implications for brain development. Endocrinology. 140:1999;2755-2762.
3. Ahima R.S., Dushay J., Flier S.N., Prabakaran D., Flier J.S. Leptin accelerates the onset of puberty in normal female mice. Journal of Clinical Investigation. 99:1997;391-395.
4. Ahima R.S., Flier J.S. Leptin. Annual Review of Physiology. 62:2000;413-437.
5. Ahima R.S., Saper C.B., Flier J.S., Elmquist J.K. Leptin regulation of neuroendocrine systems. Frontiers in Neuroendocrinology. 21:2000;263-307.
6. Aiston S., Agius L. Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin. Diabetes. 48:1999;15-20.
7. Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. Journal of Biological Chemistry. 275:2000;14653-15472.
8. Banks W.A., Kastin A.J., Huang W., Jaspan J.P., Maness L.M. Leptin enters the brain by a saturable transport system independent of insulin. Peptides. 17:1996;305-311.
9. Barash I.A., Cheung C.C., Weigle D.S., Ren H., Kabigting E.B., Kuijper J.L., Clifton D.K., Steiner R.A. Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:1996;3144-3147.
10. Baskin D.G., Schwartz M.W., Seeley R.J., Woods S.C., Porte D. Jr., Breininger J.F., Jonak Z., Schaefer J., Krouse M., Burghardt C., Campfield L.A., Burn P., Kochan J.P. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. Journal of Histochemical Cytochemistry. 47:1999;353-362.
11. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H., Lai C.F., Tartaglia L.A. The full length leptin receptor has signalling capabilities of interleukin 6-type cytokine receptors. Proceedings National Academy of Science. 93:1996;8374-8378.
12. Bereiter D.A., Jeanrenaud B. Altered neuroanatomical organisation in the central nervous system of the genetically obese (ob/ob) mouse. Brain Research. 165:1979;249-260.
13. Bereiter D.A., Jeanrenaud B. Altered dendritic orientation of hypothalamic neurons from genetically obese (ob/ob) mice. Brain Research. 202:1980;201-206.
14. 12 myotubes: evidence for a PI 3-kinase mediated effect. Diabetologia. 40:1997;606-609.
15. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signalling capacities of the long and short isoforms of the leptin receptor. Journal of Biological Chemistry. 272:1997;32686-32695.
16. Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signalling and leptin resistance. Journal of Biological Chemistry. 274:1999;30059-30065.
17. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell. 1:1998;619-625.
18. Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davies S.M., Flier J.S., Myers M.G. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. Journal of Biological Chemistry. 275:2000;40649-40657.
19. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
20. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
21. Carpenter L.R., Farruggella T.J., Symes A., Karow M.L., Yancopoulos G.D., Stahl N. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proceedings National Academy Sciences. 95:1998;6061-6066.
22. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lake N.D., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495.
23. Chehab F.F., Mounzin K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science. 275:1997;88-90.
24. Clement K., Vaisse C., Lahlous N., Cabroll S., Pelloux V. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:1998;398-401.
25. Cohen B., Novick D., Rubenstein M. Modulation of insulin activities by leptin. Science. 274:1996;1185-1188.
26. Cowley M.A., Smart J.L., Rubenstein M., Cerdan M.C., Diano S., Horvath T.L., Cone R.D., Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484.
27. Da Silva B.A., Bjorbaek C., Uotani S., Flier J.S. Functional properties of leptin receptor isoforms containing the gln> pro extracellular domain mutation of the fatty rat. Endocrinology. 139:1998;3681-3690.
28. Dawson R., Pelleymounter M., Millard W., Liu S., Eppler B. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage. American Journal of Physiology. 273:1997;E202-E206.
29. Di Marzo V., Goparaju S.K., Wang L., Liu J., Batkai S., Jarai Z., Fezza F., Muira G.I., Palmiter R.D., Sugiura T., Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 410:2001;822-825.
30. Ducy P., Amling M., Takeda S., Priemel M., Schilling A.F., Beil F.T., Shen J., Vinson C., Rueger J.M., Karsenty G. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone formation. Cell. 100:2000;197-207.
31. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., Saper C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. Journal of Comparative Neurology. 395:1998;535-547.
32. Elmquist J.K., Maratos-Flier E., Saper C.B., Flier J.S. Unravelling the central nervous system pathways underlying responses to leptin. Nature Neuroscience. 1:1998;445-450.
33. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: Hypothalamic control of food intake and body weight. Neuron. 22:1999;221-232.
34. Ghilardi N., Skoda R.C. The leptin receptor activates janus tyrosine kinase 2 and signals for proliferation in a factor-dependent cell line. Molecular Endocrinology. 11:1997;393-399.
35. Gispen W.H., Biessels G.-J. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci. 23:2000;542-549.
36. Gonzalez L.C., Pinilla L., Tena-Sempere M., Aguilar E. Leptin (116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats. Neuroendocrinology. 70:1999;213-220.
37. Hakansson M.-L., Hulting A.L., Meister B. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus- relationship with NPY neurones. Neuroreport. 7:1996;3087-3092.
38. Hakansson M.-L., Brown H., Guilardi N., Skoda R.C., Meister B.J. Leptin receptor immunoreactivity in chemically-defined target neurons of the hypothalamus. Journal of Neuroscience. 18:1998;559-572.
39. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:1995;543-546.
40. + channels in rat CRI-G1 insulin-secreting cells. Journal of Physiology. 511:1998;695-706.
41. Harvey J., Hardy S.C., Ashford M.L. Leptin activation of KATP channels in CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. Journal of Physiology. 527:2000;95-107.
42. Harvey J., McKenna F., Herson P.S., Spanswick D., Ashford M.L.J. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. Journal of Physiology. 504:1997;527-535.
43. ATP channel activation in the rat CRI-G1 insulinoma cell line. Journal of Biological Chemistry. 275:2000;4660-4669.
44. Hileman S.M., Pierroz D.D., Masuzaki H., Bjorbaek C., El-Haschimi K., Banks W.A., Flier J.S. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology. 143:2002;775-783.
45. Hoggard N., Hunter L., Duncan J.S., Williams L.M., Trayhurn P., Mercer J.G. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proceedings National Academy Sciences. 94:1997;11073-11078.
46. Hübschle T., Thom E., Watson A., Roth J., Klaus S., Meyerhof W. Leptin-induced translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. Journal of Neuroscience. 21:2001;2413-2424.
47. Ihle J.N. Cytokine receptor signalling. Nature. 377:1995;591-594.
48. Janmey P.A. The cytoskeleton and cell signalling: component localisation and mechanical coupling. Physiological Reviews. 78:1998;763-781.
49. Karsenty G. Leptin controls bone formation through a hypothalamic relay. Recent Progress in Hormone Research. 56:2001;401-415.
50. + channels in pancreatic beta cells. Diabetes. 46:1997;1087-1093.
51. Kile B.T., Alexander W.S. The suppressors of cytokine signalling (SOCS). Cellular & Molecular Life Sciences. 58:2001;1627-1635.
52. Lee G.H., Proenca R., Montez J.M., Carroll K., Darvishzadeh J.G. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
53. ATP channels composed of Kir 6.1 and SUR1 subunits. Journal of Physiology. 515:1999;439-452.
54. Li C., Freidman J.M. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proceedings National Academy Sciences. 96:1999;9677-9682.
55. Li X.L., Aou S., Oomura Y., Hori N., Fukunaga K., Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience. 113:2002;607-615.
56. Masuzaki H., Ogawa Y., Sagawa N., Horoda I., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanake I., Mori T., Nakao K. Nonadipose production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Medicine. 3:1997;1029-1033.
57. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localisation of leptin receptor mRNA and the long form slice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridisation. FEBS Letters. 387:1996;113-116.
58. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nature Neuroscience. 4:2001;507-512.
59. Mirshami S., Ashford M.L.J. PI 3-Kinase mediates leptin activation of KATP channels in rat acutely dispersed hypothalamic neurons. Journal of Physiology. 536:2001;18.
60. Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., Sewter C.P., Digby J.E., Mohammed S.N., Hurst J.A., Cheetham C.H., Earley A.R., Barnett A.H., Prins J.B., O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:1997;903-908.
61. Morton N.M., Emilsson V., Liu Y.L., Cawthorne M.A. Leptin action in intestinal cells. Journal of Biological Chemistry. 273:1999;26194-26201.
62. Myers M.G., White M.F. Insulin signal transduction and the IRS proteins. Annual Review Pharmacology & Toxicology. 36:1996;615-658.
63. Niswender K.D., Morton G.J., Stearns W.H., Rhodes C.J., Myers M.G., Schwartz M.W. Key enzyme in leptin-induced anorexia. Nature. 413:2001;794-795.
64. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
65. Powis J.E., Bains J., Ferguson A.V. Leptin depolarises rat hypothalamic paraventricular nucleus neurones. American Journal of Physiology. 274:1998;R1468-R1472.
66. Sahu A. Evidence suggesting the galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide y (NPY) are targets of leptin signalling in the hypothalamus. Endocrinology. 139:1998;795-798.
67. Sahu A. Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology. 139:1998;4739-4742.
68. Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D. Cerebrospinal fluid leptin concentrations: relationship to plasma leptin and to adiposity in humans. Nature Medicine. 2:1996;589-593.
69. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation. 98:1996;1101-1106.
70. Seeley R.J., Van Dijk G., Campfield L.A., Smith F.J., Burn P., et al. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res. 28:1996;664-668.
71. Sena A., Sarlieve L.L., Rebel G. Brain myelin of genetically obese mice. Journal of Neurological Science. 68:1985;233-243.
72. Shanley L.J., O'Malley D., Irving A.J., Ashford M.L.J., Harvey J. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. Journal of Physiology. 545:2002;933-944.
73. Shanley L.J., Irving A.J., Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. Journal of Neuroscience. RC186:2001;1-6.
74. + channels. Nature Neuroscience. 5:2002;299-300.
75. Shepherd P.R., Withers D.J., Siddle K. Phosphoinositide 3-kinase: the key switch in insulin signalling. Biochemical Journal. 333:1998;471-490.
76. Sinha M.K., Opentanova I., Ohannesian J.P., Kolaczynski J.W., Heiman M.L., Hale J., Becker G.W., Bowsher R.R., Stephens T.W., Caro J.F. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short term fasting. Journal of Clinical Investigation. 98:1996;1277-1282.
77. Smith F.J., Campfield L.A., Moschera J.A., Bailon P.S., Burn P. Feeding inhibition by neuropeptide Y. Nature. 382:1996;307.
78. Spanswick D., Smith M.A., Groppi V., Logan S.D., Ashford M.L.J. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525.
79. + channels in hypothalamic neurons of lean, but not obese rats. Nature Neuroscience. 3:2000;757-758.
80. Steppan C.M., Swick A.G. A role for leptin in brain development. Biochemical & Biophysical Research Communications. 24:1999;600-602.
81. Strobel A., Issad T., Camoin L., Ozata M., Strosberg A.D. A leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genetics. 18:1998;213-215.
82. Swerdloff R.S., Batt R.A., Bray G.A. Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology. 98:1976;1359-1364.
83. Szanto I., Khan C.R. Selective interaction between leptin and insulin signalling pathways in a hepatic cell line. Proceedings National Academy Science. 97:2000;2355-2360.
84. Takahashi Y., Okimura Y., Mizuno I., Iida K., Takahashi T., Kaji H., Abe H., Chihara K. Leptin induces mitogen-activated protein kinase -dependent proliferation of C1H10T1/2 cells. Journal of Biological Chemistry. 272:1997;12897-12900.
85. Tanabe K., Okuya S., Tanizawa Y., Matsutani A., Oka Y. Leptin induces proliferation of pancreatic beta cell line, MIN6 through activation of mitogen activated protein kinase. Biochemical & Biophysical Research Communications. 241:1997;765-768.
86. Tang-Christensen M., Holst J., Hartmann B., Vrang N. The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin. Neuroreport. 10:1999;1183-1187.
87. Tartaglia L.A., Dempski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolfe E.A., Monroe C.A., Tepper R.T. Identification and expression cloning of a leptin receptor, Ob-R. Cell. 83:1995;1263-1271.
88. Tritos N.A., Mastiatis J.W., Kokkotou E., Maratos-Flier E. Characterization of melanin concentrating hormone and preprorexin expression in the murine hypothalamus. Brain Research. 895:2001;160-166.
89. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E., Stoffel M., Friedman J.M. Leptin activation of STAT3 in the hypothalamus of wild type and ob/ob mice but not db/db mice. Nature Genetics. 14:1996;95-97.
90. Wanatobe H. Leptin directly acts within the hypothalamus to stimulate gonadotrophin-releasing hormone secretion in vivo in rats. Journal of Physiology. 545:2002;255-268.
91. Wang M.-Y., Zhou Y.T., Newgard C.B., Unger R.H. A novel leptin receptor isoform in rat. FEBS Letters. 392:1998;87-90.
92. Yamashita T., Murakami T., Otani S., Kuwajima M., Shima K. Leptin receptor signal transduction: ObRa and ObRb of fa type. Biochemical & Biophysical Research Communications. 246:1998;752-759.
93. Yura S., Ogawa Y., Sagawa N., Masuzaki H., Itoh H., Ebihara K., Aizawa-Abe M., Fujii S., Nakao K. Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. Journal of Clinical Investigation. 105:2000;749-755.
94. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
95. Zhao A.Z., Shinohara M.M., Huang D., Shimizu M., Eldar-Finkelman H., Krebs E.G., Beavo J.A., Bornfeldt K.A. Leptin induces insulin-like signalling that antagonises cAMP elevation by glucagon in hepatocytes. Journal of Biological Chemistry. 275:2000;11348-11354.