Leptin activation of ATP-sensitive K+ (K(ATP)) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton

Journal of Physiology

Volumn 527, Issue 1, 2000, Pages 95-107

  Harvey, J ^a   Hardy, S C ^a   Irving, A J ^a   Ashford, M L J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACTIN; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; COLCHICINE; CYTOCHALASIN B; DEOXYRIBONUCLEASE I; DIMETHYL SULFOXIDE; INOSITOL PHOSPHATE; INSULIN; LEPTIN; NOCODAZOLE; PACLITAXEL; PHALLOIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; POTASSIUM CHANNEL; RHODAMINE; TOLBUTAMIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; F ACTIN; G ACTIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSKELETON; DIALYSIS; FLUORESCENCE; IMAGING SYSTEM; INSULIN RELEASE; INSULINOMA; MEMBRANE CHANNEL; MICROTUBULE ASSEMBLY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; CELL DISRUPTION; CONCENTRATION RESPONSE; DEPOLYMERIZATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLUORESCENCE IMAGING; HYPERPOLARIZATION; INSULINOMA CELL LINE; PATCH CLAMP TECHNIQUE; POTASSIUM CURRENT; PROTEIN PROTEIN INTERACTION;

EID: 0033845529     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00095.x     Document Type: Article

References (50)

1. Electrophysiology of the pancreatic beta cell
2. A view of SUR/Kir6.x, K(ATP) channels
3. 2 and PIP as determinants for ATP inhibition of KATP channels
4. 12 myotubules: Evidence for a PI 3-kinase mediated effect
5. A disrupter of actin microfilaments impairs sulphonylurea inhibitory gating of cardiac KATP channels
6. Role of actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator
7. + channel activity
8. Five new insulin-producing cell lines with differing secretory properties
9. Insulin-like growth factor 1 stimulates tyrosine phosphorylation of p130(cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(cas).Crk complex
10. Effects of cytochalasin and phalloidin on actin
11. - channel in mouse 3T3 fibroblasts
12. Breakdown of cytoskeletal filaments selectively reduces Na and Ca spikes in cultured mammalian neurones
13. Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function
14. + channel to the actin cytoskeleton
15. Recent advances in the understanding of interleukin-2 signal transduction
16. Growth hormone-induced reorganisation of the actin cytoskeleton is not required for STAT5-mediated transcription
17. Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney
18. + channels in rat CRI-G1 insulin secreting cells
19. Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line
20. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1
21. 2
22. Cytokine receptor signalling
23. The cytoskeleton and cell signalling: Component localisation and mechanical coupling
24. 2+
25. Atomic structure of the actin: DNase 1 complex
26. + channels in pancreatic beta-cells
27. Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-1-mediated cytoskeletal reorganisation
28. + channel present in rat cortical neurones
29. Rho: A connection between membrane receptor signalling and the cytoskeleton
30. Actin cytoskeleton regulates ion channel activity in retinal neurones
31. + current in respiratory brainstem neurons during hypoxia
32. Lipid products of phosphoinositide 3-kinase interact with rac1 GTPase and stimulate GDP dissociation
33. + reabsorption in A6 cells
34. Structure of actin binding proteins: Insights about function at atomic resolution
35. CAMP-independent regulation of CFTR by the actin cytoskeleton
36. Calcium-induced actin depolymerisation reduces NMDA channel activity
37. Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments
38. Getting into shape with Rho
39. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
40. Membrane phospholipid control of nucleotide sensitivity of K(ATP) channels
41. Identification and expression cloning of a leptin receptor, Ob-R
42. Actin microfilament disrupters enhance K(ATP) channel opening in patches from guinea-pig cardiomyocytes
43. + channel
44. Microtubule cytoskeleton involvement in muscarinic suppression of voltage-gated calcium channel current in guinea-pig ileal smooth muscle
45. PDGF induces reorganization of vimentin filaments
46. GABA(A)-receptor-associated proteins links GABA(A) receptors and the cytoskeleton
47. Amatoxins, phallotoxins, phallolysin, and antamanide: The biologically active components of poisonous Amanita mushrooms
48. + channels
49. Signal transduction and actin filament organization