메뉴 건너뛰기




Volumn 51, Issue 4, 2003, Pages 761-785

Hepatitis B virus: Old, new and future approaches to antiviral treatment

Author keywords

Antivirals; HBV

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; AMINOTRANSFERASE; ANTISENSE OLIGONUCLEOTIDE; APTAMER; BETA INTERFERON; CLEVUDINE; DNA VACCINE; EMTRICITABINE; ENTECAVIR; FAMCICLOVIR; FIALURIDINE; FLUCYTOSINE DEOXYRIBOSIDE; GAMMA INTERFERON; GANCICLOVIR; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; IMMUNOMODULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 2; LAMIVUDINE; NUCLEOSIDE ANALOG; PARACETAMOL; PENCICLOVIR; PREDNISOLONE; RIBOZYME; TENOFOVIR DISOPROXIL; THYMOSIN; UNINDEXED DRUG; VIRUS DNA;

EID: 0037394275     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg163     Document Type: Review
Times cited : (97)

References (300)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee, W. M. (1997). Hepatitis B virus infection. New England Journal of Medicine 337, 1733-45.
    • (1997) New England Journal of Medicine , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 2
    • 10144241676 scopus 로고    scopus 로고
    • 1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody- and hepatitis B virus DNA-positive chronic hepatitis B
    • 1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody- and hepatitis B virus DNA-positive chronic hepatitis B. Hepatology 24, 774-7.
    • (1996) Hepatology , vol.24 , pp. 774-777
    • Andreone, P.1    Cursaro, C.2    Gramenzi, A.3    Zavagliz, C.4    Rezakovic, I.5    Altomare, E.6
  • 4
    • 0035925668 scopus 로고    scopus 로고
    • Immunotherapy of chronic hepatitis B by anti-HBV vaccine: From present to future
    • Michel, M. L., Pol, S., Brechot, C. & Tiollais, P. (2001). Immunotherapy of chronic hepatitis B by anti-HBV vaccine: from present to future. Vaccine 19, 2395-9.
    • (2001) Vaccine , vol.19 , pp. 2395-2399
    • Michel, M.L.1    Pol, S.2    Brechot, C.3    Tiollais, P.4
  • 7
    • 0035144177 scopus 로고    scopus 로고
    • Sequence comparison of an Australian duck hepatitis B virus strain with other avian hepadnaviruses
    • Triyatni, M., Ey, P., Tran, T., Le Mire, M., Qiao, M., Burrell, C. et al. (2000). Sequence comparison of an Australian duck hepatitis B virus strain with other avian hepadnaviruses. Journal of General Virology 82, 373-8.
    • (2000) Journal of General Virology , vol.82 , pp. 373-378
    • Triyatni, M.1    Ey, P.2    Tran, T.3    Le Mire, M.4    Qiao, M.5    Burrell, C.6
  • 9
    • 0001435504 scopus 로고    scopus 로고
    • Hepadnaviridae: The viruses and their replication
    • 4th edn (Knipe, D. M., Griffin, D. E., Lamb, R. A., Martin, M. A., Roizman, B. & Straus, S. E., Eds), Lippincott Williams & Wilkins, Philadelphia, PA, USA
    • Ganem, D. & Schneider, R. J. (2001). Hepadnaviridae: the viruses and their replication. In Fields Virology, 4th edn (Knipe, D. M., Griffin, D. E., Lamb, R. A., Martin, M. A., Roizman, B. & Straus, S. E., Eds), pp. 2923-69. Lippincott Williams & Wilkins, Philadelphia, PA, USA.
    • (2001) Fields Virology , pp. 2923-2969
    • Ganem, D.1    Schneider, R.J.2
  • 10
    • 0022538381 scopus 로고
    • Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus
    • Neurath, A. R., Kent, S. B., Strick, N. & Parker, K. (1986). Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell 46, 429-36.
    • (1986) Cell , vol.46 , pp. 429-436
    • Neurath, A.R.1    Kent, S.B.2    Strick, N.3    Parker, K.4
  • 11
    • 0024347431 scopus 로고
    • Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective
    • Neurath, A. R., Seto, B. & Strick, N. (1989). Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective. Vaccine 7, 234-6.
    • (1989) Vaccine , vol.7 , pp. 234-236
    • Neurath, A.R.1    Seto, B.2    Strick, N.3
  • 12
    • 0035881827 scopus 로고    scopus 로고
    • HBV infection of cell culture: Evidence for multivalent and cooperative attachment
    • Paran, N., Geiger, B. & Shaul, Y. (2001). HBV infection of cell culture: evidence for multivalent and cooperative attachment. EMBO Journal 20, 4443-53.
    • (2001) EMBO Journal , vol.20 , pp. 4443-4453
    • Paran, N.1    Geiger, B.2    Shaul, Y.3
  • 13
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman, J. S., Pourcel, C. & Summers, J. (1986). Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 47, 451-60.
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 14
    • 0032956306 scopus 로고    scopus 로고
    • Antiviral chemotherapy for chronic hepatitis B infection: Lessons learned from treating HIV-infected patients
    • Locarnini, S. & Birch, C. (1999). Antiviral chemotherapy for chronic hepatitis B infection: lessons learned from treating HIV-infected patients. Journal of Hepatology 30, 536-50.
    • (1999) Journal of Hepatology , vol.30 , pp. 536-550
    • Locarnini, S.1    Birch, C.2
  • 17
    • 0036753447 scopus 로고    scopus 로고
    • Hepatitis B treatment: Rational combination chemotherapy based on viral kinetic and animal model studies
    • Lewin, S., Walters, T. & Locarnini, S. (2002). Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies. Antiviral Research 55, 381-96.
    • (2002) Antiviral Research , vol.55 , pp. 381-396
    • Lewin, S.1    Walters, T.2    Locarnini, S.3
  • 18
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers, J. & Mason, W. S. (1982). Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29, 403-15.
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 19
    • 0031771112 scopus 로고    scopus 로고
    • Structure and function of the encapsidation signal of hepadnaviridae
    • Kramvis, A. & Kew, M. C. (1998). Structure and function of the encapsidation signal of hepadnaviridae. Journal of Viral Hepatitis 5, 357-67.
    • (1998) Journal of Viral Hepatitis , vol.5 , pp. 357-367
    • Kramvis, A.1    Kew, M.C.2
  • 20
    • 0030225455 scopus 로고    scopus 로고
    • Hepatitis B virus replication - An update
    • Nassal, M. & Schaller, H. (1996). Hepatitis B virus replication - an update. Journal of Viral Hepatitis 3, 217-26.
    • (1996) Journal of Viral Hepatitis , vol.3 , pp. 217-226
    • Nassal, M.1    Schaller, H.2
  • 21
    • 0028091053 scopus 로고
    • Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase
    • Zoulim, F. & Seeger, C. (1994). Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. Journal of Virology 68, 6-13.
    • (1994) Journal of Virology , vol.68 , pp. 6-13
    • Zoulim, F.1    Seeger, C.2
  • 22
  • 23
    • 0028307177 scopus 로고
    • Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy
    • Crowther, R. A., Kiselev, N. A., Bottcher, B., Berriman, J. A., Borisova, G. P., Ose, V. et al. (1994). Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy. Cell 77, 943-50.
    • (1994) Cell , vol.77 , pp. 943-950
    • Crowther, R.A.1    Kiselev, N.A.2    Bottcher, B.3    Berriman, J.A.4    Borisova, G.P.5    Ose, V.6
  • 24
    • 0029950091 scopus 로고    scopus 로고
    • Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis
    • Gerelsaikhan, T., Tavis, J. E. & Bruss, V. (1996). Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. Journal of Virology 70, 4269-72.
    • (1996) Journal of Virology , vol.70 , pp. 4269-4272
    • Gerelsaikhan, T.1    Tavis, J.E.2    Bruss, V.3
  • 25
    • 0028877043 scopus 로고
    • Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene
    • Magnius, L. O. & Norder, H. (1995). Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 38, 24-34.
    • (1995) Intervirology , vol.38 , pp. 24-34
    • Magnius, L.O.1    Norder, H.2
  • 26
    • 0028265185 scopus 로고
    • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen
    • Yamamoto, K., Horikita, M., Tsuda, F., Itoh, K., Akahane, Y., Yotsumoto, S. et al. (1994). Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. Journal of Virology 68, 2671-6.
    • (1994) Journal of Virology , vol.68 , pp. 2671-2676
    • Yamamoto, K.1    Horikita, M.2    Tsuda, F.3    Itoh, K.4    Akahane, Y.5    Yotsumoto, S.6
  • 27
    • 0028944884 scopus 로고
    • Hepatitis B virus escape mutants: 'Pushing the envelope' of chronic hepatitis B virus infection
    • Mimms, L. (1995). Hepatitis B virus escape mutants: 'pushing the envelope' of chronic hepatitis B virus infection. Hepatology 21, 884-7.
    • (1995) Hepatology , vol.21 , pp. 884-887
    • Mimms, L.1
  • 29
    • 0024427902 scopus 로고
    • Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
    • Carman, W. F., Jacyna, M. R., Hadziyannis, S., Karayiannis, P., McGarvey, M. J., Makris, A. et al. (1989). Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2, 588-91.
    • (1989) Lancet , vol.2 , pp. 588-591
    • Carman, W.F.1    Jacyna, M.R.2    Hadziyannis, S.3    Karayiannis, P.4    McGarvey, M.J.5    Makris, A.6
  • 30
    • 0024383213 scopus 로고
    • Identification of HBV mutants which cannot produce pre-core derived HBeAg and may be responsible for severe hepatitis
    • Brunetto, M. R., Stemler, M., Schodel, F., Will, H., Ottobrelli, A., Rizzetto, M. et al. (1989). Identification of HBV mutants which cannot produce pre-core derived HBeAg and may be responsible for severe hepatitis. Italian Journal of Gastroenterology 2, 151-4.
    • (1989) Italian Journal of Gastroenterology , vol.2 , pp. 151-154
    • Brunetto, M.R.1    Stemler, M.2    Schodel, F.3    Will, H.4    Ottobrelli, A.5    Rizzetto, M.6
  • 31
    • 0027992963 scopus 로고
    • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
    • Okamoto, H., Tsuda, F., Akahane, Y., Sugai, Y., Yoshiba, M., Moriyama, K. et al. (1994). Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. Journal of Virology 68, 8102-10.
    • (1994) Journal of Virology , vol.68 , pp. 8102-8110
    • Okamoto, H.1    Tsuda, F.2    Akahane, Y.3    Sugai, Y.4    Yoshiba, M.5    Moriyama, K.6
  • 32
    • 0001765014 scopus 로고
    • Hepatitis B e antigen negative chronic hepatitis B: From clinical recognition to pathogenesis and treatment
    • Hadziyannis, S. (1995). Hepatitis B e antigen negative chronic hepatitis B: from clinical recognition to pathogenesis and treatment. Viral Hepatitis Reviews 1, 7-36.
    • (1995) Viral Hepatitis Reviews , vol.1 , pp. 7-36
    • Hadziyannis, S.1
  • 33
    • 0030750617 scopus 로고    scopus 로고
    • Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame
    • Scaglioni, P. P., Melegari, M. & Wands, J. R. (1997). Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology 233, 374-81.
    • (1997) Virology , vol.233 , pp. 374-381
    • Scaglioni, P.P.1    Melegari, M.2    Wands, J.R.3
  • 34
    • 0030995314 scopus 로고    scopus 로고
    • Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - Large-scale analysis using a new genotyping method
    • Lindh, M., Andersson, A. S. & Gusdal, A. (1997). Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - large-scale analysis using a new genotyping method. Journal of Infectious Diseases 175, 1285-93.
    • (1997) Journal of Infectious Diseases , vol.175 , pp. 1285-1293
    • Lindh, M.1    Andersson, A.S.2    Gusdal, A.3
  • 35
    • 0029817029 scopus 로고    scopus 로고
    • Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
    • Buckwold, V. E., Xu, Z., Chen, M., Yen, T. S. & Ou, J. H. (1996). Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. Journal of Virology 70, 5845-51.
    • (1996) Journal of Virology , vol.70 , pp. 5845-5851
    • Buckwold, V.E.1    Xu, Z.2    Chen, M.3    Yen, T.S.4    Ou, J.H.5
  • 36
    • 0021803813 scopus 로고
    • Detection of serum HBV-DNA by molecular hybridisation: Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma
    • Karayiannis, P., Fowler, M. J. F., Lok, A. S. F., Greenfield, C., Monjardino, J. & Thomas, H. C. (1985). Detection of serum HBV-DNA by molecular hybridisation: correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma. Journal of Hepatology 1, 99-106.
    • (1985) Journal of Hepatology , vol.1 , pp. 99-106
    • Karayiannis, P.1    Fowler, M.J.F.2    Lok, A.S.F.3    Greenfield, C.4    Monjardino, J.5    Thomas, H.C.6
  • 37
    • 0028217216 scopus 로고
    • Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France
    • French Multicentre Group
    • Zarski, J. P., Marcellin, P., Cohard, M., Lutz, J. M., Bouche, C. & Rais, A. (1994). Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France. French Multicentre Group. Journal of Hepatology 20, 636-40.
    • (1994) Journal of Hepatology , vol.20 , pp. 636-640
    • Zarski, J.P.1    Marcellin, P.2    Cohard, M.3    Lutz, J.M.4    Bouche, C.5    Rais, A.6
  • 39
    • 0025892665 scopus 로고
    • Hepatitis B: Evolving epidemiology and implications for control
    • Margolis, H. S., Alter, M. J. & Hadler, S. C. (1991). Hepatitis B: evolving epidemiology and implications for control. Seminars in Liver Disease 11, 84-92.
    • (1991) Seminars in Liver Disease , vol.11 , pp. 84-92
    • Margolis, H.S.1    Alter, M.J.2    Hadler, S.C.3
  • 40
    • 0023228823 scopus 로고
    • Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal)
    • Corsaget, P., Yvonnet, B., Chotard, J., Vincelot, P., Sarr, M., Diouf, C. et al. (1987). Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal). Journal of Medical Virology 22, 1-5.
    • (1987) Journal of Medical Virology , vol.22 , pp. 1-5
    • Corsaget, P.1    Yvonnet, B.2    Chotard, J.3    Vincelot, P.4    Sarr, M.5    Diouf, C.6
  • 41
    • 0022000510 scopus 로고
    • Acute hepatitis B virus infection: Relation of age to the clinical expression of disease and subsequent development of the carrier state
    • McMahon, B. J., Alward, W. L. M., Hall, D. B., Heyward, W. L., Bender, T. R., Francis, D. P. et al. (1985). Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. Journal of Infectious Diseases 151, 599-603.
    • (1985) Journal of Infectious Diseases , vol.151 , pp. 599-603
    • McMahon, B.J.1    Alward, W.L.M.2    Hall, D.B.3    Heyward, W.L.4    Bender, T.R.5    Francis, D.P.6
  • 43
    • 0000805480 scopus 로고    scopus 로고
    • Epidemiology of hepatitis B
    • (Zuckerman, A. J. & Thoms, H. C., Eds), Churchill Livingstone, London, UK
    • Evans, A. A. & London, W. T. (1998). Epidemiology of hepatitis B. In Viral Hepatitis (Zuckerman, A. J. & Thoms, H. C., Eds), pp. 107-14. Churchill Livingstone, London, UK.
    • (1998) Viral Hepatitis , pp. 107-114
    • Evans, A.A.1    London, W.T.2
  • 44
    • 0027378724 scopus 로고
    • Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Wong, D. K., Cheung, A. M., O'Rourke, K., Naylor, C. D., Detsky, A. S. & Heathcote, J. (1993). Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. Annals of Internal Medicine 119, 312-23.
    • (1993) Annals of Internal Medicine , vol.119 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 45
    • 0023759015 scopus 로고
    • Longterm follow-up in a randomised controlled trial of recombinant alpha 2-interferon in Chinese patients with chronic hepatitis B infection
    • Lok, A. S., Lai, C. L., Wu, P. C. & Leung, E. K. (1988). Longterm follow-up in a randomised controlled trial of recombinant alpha 2-interferon in Chinese patients with chronic hepatitis B infection. Lancet 2, 298-302.
    • (1988) Lancet , vol.2 , pp. 298-302
    • Lok, A.S.1    Lai, C.L.2    Wu, P.C.3    Leung, E.K.4
  • 46
    • 0026602420 scopus 로고
    • A controlled trial of interferon with or without prednisone priming for chronic hepatitis B
    • Lok, A. S., Wu, P. C., Lai, C. L., Lau, J. Y., Leung, E. K., Wong, L. S. et al. (1992). A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 102, 2091-7.
    • (1992) Gastroenterology , vol.102 , pp. 2091-2097
    • Lok, A.S.1    Wu, P.C.2    Lai, C.L.3    Lau, J.Y.4    Leung, E.K.5    Wong, L.S.6
  • 47
    • 0023616670 scopus 로고
    • Placebo-controlled trial of recombinant alpha 2-interferon in Chinese HBsAg-carrier children
    • Lai, C. L., Lok, A. S., Lin, H. J., Wu, P. C., Yeoh, E. K. & Yeung, C. Y. (1987). Placebo-controlled trial of recombinant alpha 2-interferon in Chinese HBsAg-carrier children. Lancet 2, 877-80.
    • (1987) Lancet , vol.2 , pp. 877-880
    • Lai, C.L.1    Lok, A.S.2    Lin, H.J.3    Wu, P.C.4    Yeoh, E.K.5    Yeung, C.Y.6
  • 48
  • 49
    • 0024846323 scopus 로고
    • Treatment of chronic hepatitis B with interferon: Experience in western countries
    • Perrillo, R. P. (1989). Treatment of chronic hepatitis B with interferon: experience in western countries. Seminars in Liver Disease 9, 240-8.
    • (1989) Seminars in Liver Disease , vol.9 , pp. 240-248
    • Perrillo, R.P.1
  • 50
    • 9244231148 scopus 로고    scopus 로고
    • Lymphoblastoid interferon alfa with or without steroid pretreatment in children with chronic hepatitis B: A multicenter controlled trial
    • Gregorio, G. V., Jara, P., Hierro, L., Diaz, C., de la Vega, A., Vegnente, A. et al. (1996). Lymphoblastoid interferon alfa with or without steroid pretreatment in children with chronic hepatitis B: a multicenter controlled trial. Hepatology 23, 700-7.
    • (1996) Hepatology , vol.23 , pp. 700-707
    • Gregorio, G.V.1    Jara, P.2    Hierro, L.3    Diaz, C.4    de la Vega, A.5    Vegnente, A.6
  • 51
    • 0031969612 scopus 로고    scopus 로고
    • Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial
    • Sokal, E. M., Conjeevaram, H. S., Roberts, E. A., Alvarez, F., Bern, E. M., Goyens, P. et al. (1998). Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial. Gastroenterology 114, 988-95.
    • (1998) Gastroenterology , vol.114 , pp. 988-995
    • Sokal, E.M.1    Conjeevaram, H.S.2    Roberts, E.A.3    Alvarez, F.4    Bern, E.M.5    Goyens, P.6
  • 52
    • 0033027690 scopus 로고    scopus 로고
    • Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection
    • Lin, S. M., Sheen, I. S., Chien, R. N., Chu, C. M. & Liaw, Y. F. (1999). Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 29, 971-5.
    • (1999) Hepatology , vol.29 , pp. 971-975
    • Lin, S.M.1    Sheen, I.S.2    Chien, R.N.3    Chu, C.M.4    Liaw, Y.F.5
  • 53
    • 0030730879 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa
    • Lau, D. T., Everhart, J., Kleiner, D. E., Park, Y., Vergalla, J., Schmid, P. et al. (1997). Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa. Gastroenterology 113, 1660-7.
    • (1997) Gastroenterology , vol.113 , pp. 1660-1667
    • Lau, D.T.1    Everhart, J.2    Kleiner, D.E.3    Park, Y.4    Vergalla, J.5    Schmid, P.6
  • 54
    • 0029893146 scopus 로고    scopus 로고
    • Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B
    • Niederau, C., Heintges, T., Lange, S., Goldman, G., Niederau, C. M., Mohr, L. et al. (1996). Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. New England Journal of Medicine 334, 1422-7.
    • (1996) New England Journal of Medicine , vol.334 , pp. 1422-1427
    • Niederau, C.1    Heintges, T.2    Lange, S.3    Goldman, G.4    Niederau, C.M.5    Mohr, L.6
  • 55
    • 0030696048 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa
    • the European Concerted Action of Viral Hepatitis (EUROHEP)
    • Fattovich, G., Giustina, G., Realdi, G., Corroacher, R., Schalm, S. W. & the European Concerted Action of Viral Hepatitis (EUROHEP). (1997). Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. Hepatology 26, 1338-42.
    • (1997) Hepatology , vol.26 , pp. 1338-1342
    • Fattovich, G.1    Giustina, G.2    Realdi, G.3    Corroacher, R.4    Schalm, S.W.5
  • 56
    • 0027142488 scopus 로고
    • Long-term follow-up of chronic hepatitis B patients treated with interferon alfa
    • Lok, A. S., Chung, H. T., Liu, V. W. & Ma, O. C. (1993). Long-term follow-up of chronic hepatitis B patients treated with interferon alfa. Gastroenterology 105, 1833-8.
    • (1993) Gastroenterology , vol.105 , pp. 1833-1838
    • Lok, A.S.1    Chung, H.T.2    Liu, V.W.3    Ma, O.C.4
  • 58
    • 0031769390 scopus 로고    scopus 로고
    • The long-term effect of treatment with interferon-alpha 2a in chronic hepatitis B
    • The Long-Term Follow-up Investigator Group. The European Study Group on Viral Hepatitis (EUROHEP). Executive Team on Anti-Viral Treatment
    • Krogsgaard, K. (1998). The long-term effect of treatment with interferon-alpha 2a in chronic hepatitis B. The Long-Term Follow-up Investigator Group. The European Study Group on Viral Hepatitis (EUROHEP). Executive Team on Anti-Viral Treatment. Journal of Viral Hepatitis 5, 389-97.
    • (1998) Journal of Viral Hepatitis , vol.5 , pp. 389-397
    • Krogsgaard, K.1
  • 59
    • 0035010523 scopus 로고    scopus 로고
    • Management of Hepatitis B 2000, Summary of a Workshop
    • Lok, A. S., Heathcote, E. J. & Hoofnagle, J. H. (2001). Management of Hepatitis B 2000, Summary of a Workshop. Gastroenterology 120, 1828-53.
    • (2001) Gastroenterology , vol.120 , pp. 1828-1853
    • Lok, A.S.1    Heathcote, E.J.2    Hoofnagle, J.H.3
  • 60
    • 0030724692 scopus 로고    scopus 로고
    • A randomized, controlled trial of a 24-month course of interferon alfa 2b in patients with chronic hepatitis B who had hepatitis B virus DNA without hepatitis B e antigen in serum
    • Lampertico, P., Del Ninno, E., Manzin, A., Donato, M. F., Rumi, M. G., Lunghi, G. et al. (1997). A randomized, controlled trial of a 24-month course of interferon alfa 2b in patients with chronic hepatitis B who had hepatitis B virus DNA without hepatitis B e antigen in serum. Hepatology 26, 1621-5.
    • (1997) Hepatology , vol.26 , pp. 1621-1625
    • Lampertico, P.1    Del Ninno, E.2    Manzin, A.3    Donato, M.F.4    Rumi, M.G.5    Lunghi, G.6
  • 61
    • 0026514922 scopus 로고
    • A randomized controlled trial of lymphoblastoid interferon-alpha in patients with chronic hepatitis B lacking HBeAg
    • Fattovich, G., Farci, P., Rugge, M., Brollo, L., Mandas, A., Pontisso, P. et al. (1992). A randomized controlled trial of lymphoblastoid interferon-alpha in patients with chronic hepatitis B lacking HBeAg. Hepatology 15, 584-9.
    • (1992) Hepatology , vol.15 , pp. 584-589
    • Fattovich, G.1    Farci, P.2    Rugge, M.3    Brollo, L.4    Mandas, A.5    Pontisso, P.6
  • 62
    • 0025650982 scopus 로고
    • Interferon alfa-2b treatment of HBeAg negative/serum HBV DNA positive chronic active hepatitis type B
    • Hadziyannis, S., Bramou, T., Makris, A., Moussoulis, G., Zignego, L. & Papaioannou, C. (1990). Interferon alfa-2b treatment of HBeAg negative/serum HBV DNA positive chronic active hepatitis type B. Journal of Hepatology 11, Suppl. 1, S133-6.
    • (1990) Journal of Hepatology , vol.11 , Issue.SUPPL. 1
    • Hadziyannis, S.1    Bramou, T.2    Makris, A.3    Moussoulis, G.4    Zignego, L.5    Papaioannou, C.6
  • 63
    • 0026525117 scopus 로고
    • Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum response to a 6-month course of lymphoblastoid interferon
    • Pastore, G., Santantonio, T., Milella, M., Monno, L., Mariano, N., Moschetta, R. et al. (1992). Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum response to a 6-month course of lymphoblastoid interferon. Journal of Hepatology 14, 221-5.
    • (1992) Journal of Hepatology , vol.14 , pp. 221-225
    • Pastore, G.1    Santantonio, T.2    Milella, M.3    Monno, L.4    Mariano, N.5    Moschetta, R.6
  • 64
    • 0036168816 scopus 로고    scopus 로고
    • Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: A long term cohort study
    • Brunetto, M. R., Oliveri, F., Coco, B., Leandro, G., Colombatto, P., Gorin, J. M. et al. (2002). Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: a long term cohort study. Journal of Hepatology 36, 263-70.
    • (2002) Journal of Hepatology , vol.36 , pp. 263-270
    • Brunetto, M.R.1    Oliveri, F.2    Coco, B.3    Leandro, G.4    Colombatto, P.5    Gorin, J.M.6
  • 65
    • 0035110693 scopus 로고    scopus 로고
    • The long-term outcome of interferon-alfa treated and untreated patients with HBeAg negative chronic hepatitis B
    • Papatheodoridis, G. V., Manesis, E. & Hadziyannis, S. J. (2001). The long-term outcome of interferon-alfa treated and untreated patients with HBeAg negative chronic hepatitis B. Journal of Hepatology 34, 306-13.
    • (2001) Journal of Hepatology , vol.34 , pp. 306-313
    • Papatheodoridis, G.V.1    Manesis, E.2    Hadziyannis, S.J.3
  • 66
    • 0025776440 scopus 로고
    • Treatment with interferon of chronic hepatitis B associated with antibody to hepatitis B e antigen
    • Brunetto, M. R., Oliveri, F., Demartini, A., Calvo, P., Manzini, P., Cerenzia, M. T. et al. (1991). Treatment with interferon of chronic hepatitis B associated with antibody to hepatitis B e antigen. Journal of Hepatology 13, Suppl. 1, S8-11.
    • (1991) Journal of Hepatology , vol.13 , Issue.SUPPL. 1
    • Brunetto, M.R.1    Oliveri, F.2    Demartini, A.3    Calvo, P.4    Manzini, P.5    Cerenzia, M.T.6
  • 67
    • 0033998982 scopus 로고    scopus 로고
    • Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B
    • Erhardt, A., Reineke, U., Blondin, D., Gerlich, W. H., Adams, O., Heintges, T. et al. (2000). Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B. Hepatology 31, 716-25.
    • (2000) Hepatology , vol.31 , pp. 716-725
    • Erhardt, A.1    Reineke, U.2    Blondin, D.3    Gerlich, W.H.4    Adams, O.5    Heintges, T.6
  • 68
    • 0034950006 scopus 로고    scopus 로고
    • Interferon alpha treatment and retreatment of hepatitis B e antigen-negative chronic hepatitis B
    • Manesis, E. K. & Hadziyannis, S. J. (2001). Interferon alpha treatment and retreatment of hepatitis B e antigen-negative chronic hepatitis B. Gastroenterology 121, 101-9.
    • (2001) Gastroenterology , vol.121 , pp. 101-109
    • Manesis, E.K.1    Hadziyannis, S.J.2
  • 69
    • 0033000312 scopus 로고    scopus 로고
    • Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP)
    • Carreno, V., Marcellin, P., Hadziyannis, S., Salmeron, J., Diago, M., Kitis, G. E. et al. (1999). Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP). Hepatology 30, 277-82.
    • (1999) Hepatology , vol.30 , pp. 277-282
    • Carreno, V.1    Marcellin, P.2    Hadziyannis, S.3    Salmeron, J.4    Diago, M.5    Kitis, G.E.6
  • 70
    • 0027414645 scopus 로고
    • Treatment of decompensated viral hepatitis B-induced cirrhosis with low doses of interferon alpha
    • Nevens, F., Goubau, P., Van Eyken, P., Desmyter, J., Desmet, V. & Fevery, J. (1993). Treatment of decompensated viral hepatitis B-induced cirrhosis with low doses of interferon alpha. Liver 13, 15-9.
    • (1993) Liver , vol.13 , pp. 15-19
    • Nevens, F.1    Goubau, P.2    Van Eyken, P.3    Desmyter, J.4    Desmet, V.5    Fevery, J.6
  • 71
    • 0029087266 scopus 로고
    • Low-dose, titratable interferon alfa in decompensated liver disease caused by chronic infection with hepatitis B virus
    • Perrillo, R., Tamburro, C., Regenstein, F., Balart, L., Bodenheimer, H., Silva, M. et al. (1995). Low-dose, titratable interferon alfa in decompensated liver disease caused by chronic infection with hepatitis B virus. Gastroenterology 109, 908-16.
    • (1995) Gastroenterology , vol.109 , pp. 908-916
    • Perrillo, R.1    Tamburro, C.2    Regenstein, F.3    Balart, L.4    Bodenheimer, H.5    Silva, M.6
  • 72
    • 0030634441 scopus 로고    scopus 로고
    • Prolonged interferon-alpha therapy of hepatitis B virus-related decompensated cirrhosis
    • Marcellin, P., Giuily, N., Loriot, M. A., Durand, F., Samuel, D., Bettan, L. et al. (1997). Prolonged interferon-alpha therapy of hepatitis B virus-related decompensated cirrhosis. Journal of Viral Hepatitis 4, Suppl, 1, S21-6.
    • (1997) Journal of Viral Hepatitis , vol.4 , Issue.SUPPL. 1
    • Marcellin, P.1    Giuily, N.2    Loriot, M.A.3    Durand, F.4    Samuel, D.5    Bettan, L.6
  • 73
    • 0031410045 scopus 로고    scopus 로고
    • Recurrence-free long-term survival after liver transplantation for hepatitis B using interferon-alpha pretransplant and hepatitis B immune globulin posttransplant
    • Tchervenkov, J. I., Tector, A. J., Barkun, J. S., Sherker, A., Forbes, C. D., Elias, N. et al. (1997). Recurrence-free long-term survival after liver transplantation for hepatitis B using interferon-alpha pretransplant and hepatitis B immune globulin posttransplant. Annals of Surgery 226, 356-65.
    • (1997) Annals of Surgery , vol.226 , pp. 356-365
    • Tchervenkov, J.I.1    Tector, A.J.2    Barkun, J.S.3    Sherker, A.4    Forbes, C.D.5    Elias, N.6
  • 74
    • 0028105816 scopus 로고
    • Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease
    • Marcellin, P., Samuel, D., Areias, J., Loriot, M. A., Arulnaden, J.L., Gigou, M. et al. (1994). Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease. Hepatology 19, 6-12.
    • (1994) Hepatology , vol.19 , pp. 6-12
    • Marcellin, P.1    Samuel, D.2    Areias, J.3    Loriot, M.A.4    Arulnaden, J.L.5    Gigou, M.6
  • 75
    • 0024448926 scopus 로고
    • Which patients with chronic hepatitis B virus infection will respond to alpha-interferon therapy?
    • Brook, M. G., Karayiannis, P. & Thomas, H. C. (1989). Which patients with chronic hepatitis B virus infection will respond to alpha-interferon therapy? Hepatology 10, 761-3.
    • (1989) Hepatology , vol.10 , pp. 761-763
    • Brook, M.G.1    Karayiannis, P.2    Thomas, H.C.3
  • 76
    • 0025347975 scopus 로고
    • A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B
    • Perrillo, R. P., Schiff, E. R., Davis, G. L., Bodenheimer, H. C., Jr, Lindsay, K., Payne, J. et al. (1990). A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. New England Journal of Medicine 323, 295-301.
    • (1990) New England Journal of Medicine , vol.323 , pp. 295-301
    • Perrillo, R.P.1    Schiff, E.R.2    Davis, G.L.3    Bodenheimer H.C., Jr.4    Lindsay, K.5    Payne, J.6
  • 77
    • 0034761964 scopus 로고    scopus 로고
    • Serum alanine aminotransferase flares during interferon treatment of chronic hepatitis B: Is sustained clearance of HBV DNA dependent on levels of pretreatment viremia?
    • Nair, S. & Perrillo, R. P. (2001). Serum alanine aminotransferase flares during interferon treatment of chronic hepatitis B: is sustained clearance of HBV DNA dependent on levels of pretreatment viremia? Hepatology 34, 1021-6.
    • (2001) Hepatology , vol.34 , pp. 1021-1026
    • Nair, S.1    Perrillo, R.P.2
  • 78
    • 84983726628 scopus 로고    scopus 로고
    • Hepatitis B genotypes and the response to interferon therapy
    • Kao, J. H., Wu, N. H., Chen, P. J., Lai, M. Y. & Chen, D. S. (2000). Hepatitis B genotypes and the response to interferon therapy. Journal of Hepatology 33, 998-1002.
    • (2000) Journal of Hepatology , vol.33 , pp. 998-1002
    • Kao, J.H.1    Wu, N.H.2    Chen, P.J.3    Lai, M.Y.4    Chen, D.S.5
  • 79
    • 0027944159 scopus 로고
    • Prednisone-interferon combination in the treatment of chronic hepatitis B: Direct and indirect metanalysis
    • Cohard, M., Poynard, T., Mathurin, P. & Zarski, J. P. (1994). Prednisone-interferon combination in the treatment of chronic hepatitis B: direct and indirect metanalysis. Hepatology 20, 1390-8.
    • (1994) Hepatology , vol.20 , pp. 1390-1398
    • Cohard, M.1    Poynard, T.2    Mathurin, P.3    Zarski, J.P.4
  • 80
    • 0026602420 scopus 로고
    • A controlled trial of interferon with or without prednisone priming for chronic hepatitis B
    • Lok, A. S., Wu, P. C., Lai, C. L., Lau, J. Y., Leung, E. K., Wong, L. S. et al. (1992). A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 102, 2091-7.
    • (1992) Gastroenterology , vol.102 , pp. 2091-2097
    • Lok, A.S.1    Wu, P.C.2    Lai, C.L.3    Lau, J.Y.4    Leung, E.K.5    Wong, L.S.6
  • 81
    • 8044234957 scopus 로고    scopus 로고
    • Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B
    • INTERPRED Trial Group
    • Krogsgaard, K., Marcellin, P., Trepo, C., Berthelot, P., Sanchez-Tapias, J. M., Bassendine, M. et al. (1996). Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B. INTERPRED Trial Group. Journal of Hepatology 25, 803-13.
    • (1996) Journal of Hepatology , vol.25 , pp. 803-813
    • Krogsgaard, K.1    Marcellin, P.2    Trepo, C.3    Berthelot, P.4    Sanchez-Tapias, J.M.5    Bassendine, M.6
  • 82
    • 0032527967 scopus 로고    scopus 로고
    • Increased risk of autoimmune thyroid disease in hepatitis C vs hepatitis B before, during, and after discontinuing interferon therapy
    • Fernandez-Soto, L., Gonzalez, A., Escobar-Jimenez, F., Vazquez, R., Ocete, E., Olea, N. et al. (1998). Increased risk of autoimmune thyroid disease in hepatitis C vs hepatitis B before, during, and after discontinuing interferon therapy. Archives of Internal Medicine 158, 1445-8.
    • (1998) Archives of Internal Medicine , vol.158 , pp. 1445-1448
    • Fernandez-Soto, L.1    Gonzalez, A.2    Escobar-Jimenez, F.3    Vazquez, R.4    Ocete, E.5    Olea, N.6
  • 83
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari, F. V. (1995). Hepatitis B virus immunopathogenesis. Annual Reviews in Immunology 13, 29-60.
    • (1995) Annual Reviews in Immunology , vol.13 , pp. 29-60
    • Chisari, F.V.1
  • 84
    • 0026650841 scopus 로고
    • A preliminary report of a controlled study of thymosin alpha-1 in the woodchuck model of hepadnavirus infection
    • Gerin, J. L., Korba, B. E., Cote, P. J. & Tennant, B. C. (1992). A preliminary report of a controlled study of thymosin alpha-1 in the woodchuck model of hepadnavirus infection. Advances in Experimental Medicine and Biology 312, 121-3
    • (1992) Advances in Experimental Medicine and Biology , vol.312 , pp. 121-123
    • Gerin, J.L.1    Korba, B.E.2    Cote, P.J.3    Tennant, B.C.4
  • 85
    • 0032585756 scopus 로고    scopus 로고
    • Thymosin alpha 1 treatment of chronic hepatitis B: Results of a phase III multicentre, randomized, double-blind and placebo-controlled study
    • Mutchnick, M. G., Lindsay, K. L., Schiff, E. R., Cummings, G. D., Appelman, H. D., Peleman, R. R. et al. (1999). Thymosin alpha 1 treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double-blind and placebo-controlled study. Journal of Viral Hepatitis 6, 397-403.
    • (1999) Journal of Viral Hepatitis , vol.6 , pp. 397-403
    • Mutchnick, M.G.1    Lindsay, K.L.2    Schiff, E.R.3    Cummings, G.D.4    Appelman, H.D.5    Peleman, R.R.6
  • 86
    • 0035663014 scopus 로고    scopus 로고
    • The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: A meta-analysis
    • Chan, H. L., Tang, J. L., Tam, W. & Sung, J. J. (2001). The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: a meta-analysis. Alimentary Pharmacology and Therapeutics 15, 1899-905.
    • (2001) Alimentary Pharmacology and Therapeutics , vol.15 , pp. 1899-1905
    • Chan, H.L.1    Tang, J.L.2    Tam, W.3    Sung, J.J.4
  • 87
    • 0033951496 scopus 로고    scopus 로고
    • A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B
    • Carreno, V., Zeuzem, S., Hopf, U., Marcellin, P., Cooksley, W. G., Fevery, J. et al. (2000). A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B. Journal of Hepatology 32, 317-24.
    • (2000) Journal of Hepatology , vol.32 , pp. 317-324
    • Carreno, V.1    Zeuzem, S.2    Hopf, U.3    Marcellin, P.4    Cooksley, W.G.5    Fevery, J.6
  • 88
    • 0029094279 scopus 로고
    • Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5′-triphosphate as substrate
    • Focher, F., Maga, G., Bendiscioli, A., Capobianco, M., Colonna, F., Garbesi, A. et al. (1995). Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5′-triphosphate as substrate. Nucleic Acids Research 23, 2840-47.
    • (1995) Nucleic Acids Research , vol.23 , pp. 2840-2847
    • Focher, F.1    Maga, G.2    Bendiscioli, A.3    Capobianco, M.4    Colonna, F.5    Garbesi, A.6
  • 90
    • 0029938508 scopus 로고    scopus 로고
    • DNA polymerase activity of hepatitis B virus particles: Differential inhibition by L-enantiomers of nucleotide analogs
    • Davis, M. G., Wilson, J. E., VanDraanen, N. A., Miller, W. H., Freeman, G. A., Daluge, S. M. et al. (1996). DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs. Antiviral Research 30, 133-45.
    • (1996) Antiviral Research , vol.30 , pp. 133-145
    • Davis, M.G.1    Wilson, J.E.2    VanDraanen, N.A.3    Miller, W.H.4    Freeman, G.A.5    Daluge, S.M.6
  • 91
    • 0030776176 scopus 로고    scopus 로고
    • Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus
    • Moraleda, G., Saputelli, J., Aldrich, C. E., Averett, D., Condreay, L. & Mason, W. S. (1997). Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus. Journal of Virology 71, 9392-9.
    • (1997) Journal of Virology , vol.71 , pp. 9392-9399
    • Moraleda, G.1    Saputelli, J.2    Aldrich, C.E.3    Averett, D.4    Condreay, L.5    Mason, W.S.6
  • 92
    • 0032838507 scopus 로고    scopus 로고
    • Use of the hepatitis B virus recombinant baculovirus-HepG2 system to study the effects of (-)-[beta]-2′,3′-dideoxy-3′-thiacytidine on replication of hepatitis B virus and accumulation of covalently closed circular DNA
    • Delaney, W., Miller, T. & Isom, H. (1999). Use of the hepatitis B virus recombinant baculovirus-HepG2 system to study the effects of (-)-[beta]-2′,3′-dideoxy-3′-thiacytidine on replication of hepatitis B virus and accumulation of covalently closed circular DNA. Anti-microbial Agents and Chemotherapy 43, 2017-26.
    • (1999) Anti-microbial Agents and Chemotherapy , vol.43 , pp. 2017-2026
    • Delaney, W.1    Miller, T.2    Isom, H.3
  • 93
    • 0036109092 scopus 로고    scopus 로고
    • Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication
    • Addison, W. R., Walters, K. A., Wong, W. W., Wilson, J. S., Madej, D., Jewell, L. D. et al. (2002). Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication. Journal of Virology 76, 6356-63.
    • (2002) Journal of Virology , vol.76 , pp. 6356-6363
    • Addison, W.R.1    Walters, K.A.2    Wong, W.W.3    Wilson, J.S.4    Madej, D.5    Jewell, L.D.6
  • 95
    • 0026563976 scopus 로고
    • Biochemical pharmacology of (+)- and (-)-2′,3′-dideoxy-3′-thiacytidine as anti-hepatitis B virus agents
    • Chang, C. N., Skalski, V., Zhou, J. H. & Cheng, Y. C. (1992). Biochemical pharmacology of (+)- and (-)-2′,3′-dideoxy-3′-thiacytidine as anti-hepatitis B virus agents. Journal of Biological Chemistry 267, 22414-20.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 22414-22420
    • Chang, C.N.1    Skalski, V.2    Zhou, J.H.3    Cheng, Y.C.4
  • 97
    • 0033012793 scopus 로고    scopus 로고
    • Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B
    • Lamivudine Precore Mutant Study Group
    • Tassopoulos, N. C., Volpes, R., Pastore, G., Heathcote, J., Buti, M., Goldin, R. D. et al. (1999). Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B. Lamivudine Precore Mutant Study Group. Hepatology 29, 889-96.
    • (1999) Hepatology , vol.29 , pp. 889-896
    • Tassopoulos, N.C.1    Volpes, R.2    Pastore, G.3    Heathcote, J.4    Buti, M.5    Goldin, R.D.6
  • 98
    • 0033754947 scopus 로고    scopus 로고
    • Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy
    • Lok, A. S. F., Hussain, M., Cursano, C., Margotti, M., Gramenzi, A., Grazi, G. L. et al. (2000). Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy. Hepatology 32, 1145-53.
    • (2000) Hepatology , vol.32 , pp. 1145-1153
    • Lok, A.S.F.1    Hussain, M.2    Cursano, C.3    Margotti, M.4    Gramenzi, A.5    Grazi, G.L.6
  • 99
    • 0033760350 scopus 로고    scopus 로고
    • Reversion from precore/core promoter mutants to wild type hepatitis B virus during the course of lamivudine therapy
    • Cho, S. W., Hahm, K. B. & Kim, J. H. (2000). Reversion from precore/core promoter mutants to wild type hepatitis B virus during the course of lamivudine therapy. Hepatology 32, 1163-9.
    • (2000) Hepatology , vol.32 , pp. 1163-1169
    • Cho, S.W.1    Hahm, K.B.2    Kim, J.H.3
  • 100
    • 0033754711 scopus 로고    scopus 로고
    • Is lamivudine effective on precore/core promoter mutants of hepatitis B virus?
    • Zoulim, F. & Trepo, C. (2000). Is lamivudine effective on precore/core promoter mutants of hepatitis B virus? Hepatology 32, 1172-4.
    • (2000) Hepatology , vol.32 , pp. 1172-1174
    • Zoulim, F.1    Trepo, C.2
  • 101
    • 0037221770 scopus 로고    scopus 로고
    • Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro
    • Chen, R. Y., Edwards, R., Shaw, T., Colledge, D., Delaney, W. E., Isom, H. et al. (2003). Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. Hepatology 37, 27-35.
    • (2003) Hepatology , vol.37 , pp. 27-35
    • Chen, R.Y.1    Edwards, R.2    Shaw, T.3    Colledge, D.4    Delaney, W.E.5    Isom, H.6
  • 102
    • 17744383748 scopus 로고    scopus 로고
    • Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy
    • Boni, C., Penna, A., Ogg, G. S., Bertoletti, A., Pilli, M., Cavallo, C. et al. (2001). Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 33, 963-71.
    • (2001) Hepatology , vol.33 , pp. 963-971
    • Boni, C.1    Penna, A.2    Ogg, G.S.3    Bertoletti, A.4    Pilli, M.5    Cavallo, C.6
  • 104
    • 0032499913 scopus 로고    scopus 로고
    • A one-year trial of lamivudine for chronic hepatitis B
    • Asia Hepatitis Lamivudine Study Group
    • Lai, C. L., Chien, R. N., Leung, N. W., Chang, T. T., Guan, R., Tai, D. I. et al. (1998). A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. New England Journal of Medicine 339, 61-8.
    • (1998) New England Journal of Medicine , vol.339 , pp. 61-68
    • Lai, C.L.1    Chien, R.N.2    Leung, N.W.3    Chang, T.T.4    Guan, R.5    Tai, D.I.6
  • 105
    • 0034105307 scopus 로고    scopus 로고
    • Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: A randomised trial
    • Schalm, S. W., Heathcote, J., Cianciara, J., Farrell, G., Sherman, M., Willems, B. et al. (2000). Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial. Gut 46, 562-8.
    • (2000) Gut , vol.46 , pp. 562-568
    • Schalm, S.W.1    Heathcote, J.2    Cianciara, J.3    Farrell, G.4    Sherman, M.5    Willems, B.6
  • 106
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B
    • Liaw, Y. F., Leung, N. W. Y., Chang, T. T., Guan, R., Tai, D. I., Ng, K. Y. et al. (2000). Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Gastroenterology 119, 172-80.
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.Y.2    Chang, T.T.3    Guan, R.4    Tai, D.I.5    Ng, K.Y.6
  • 107
    • 0034993211 scopus 로고    scopus 로고
    • Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen sero-conversion rates: Results after 3 years of therapy
    • Leung, N. W. Y., Lai, C. L., Chang, T. T., Guan, R., Lee, C. M., Ng, K. Y. et al. (2001). Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen sero-conversion rates: results after 3 years of therapy. Hepatology 33, 1527-32.
    • (2001) Hepatology , vol.33 , pp. 1527-1532
    • Leung, N.W.Y.1    Lai, C.L.2    Chang, T.T.3    Guan, R.4    Lee, C.M.5    Ng, K.Y.6
  • 108
    • 0002443164 scopus 로고    scopus 로고
    • Incremental increases in HBeAg seroconversion and continued ALT normalization in Asian chronic HBV (CHB) patients treated with lamivudine for four years
    • (abstract)
    • Chang, T. T., Lai, C. L., Liaw, Y. F., Guan, R., Lim, S. G., Lee, C. M. et al. (2000). Incremental increases in HBeAg seroconversion and continued ALT normalization in Asian chronic HBV (CHB) patients treated with lamivudine for four years (abstract). Antiviral Therapy 5, Suppl. 1, 44.
    • (2000) Antiviral Therapy , vol.5 , Issue.SUPPL. 1 , pp. 44
    • Chang, T.T.1    Lai, C.L.2    Liaw, Y.F.3    Guan, R.4    Lim, S.G.5    Lee, C.M.6
  • 109
    • 0032869876 scopus 로고    scopus 로고
    • Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B
    • Asian Hepatitis Lamivudine Trial Group
    • Chien, R. N., Liaw, Y. F. & Atkins, M. (1999). Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group. Hepatology 30, 770-4.
    • (1999) Hepatology , vol.30 , pp. 770-774
    • Chien, R.N.1    Liaw, Y.F.2    Atkins, M.3
  • 110
    • 0000183272 scopus 로고    scopus 로고
    • Predictors of HBsAg sero-conversion in chronic hepatitis B patients treated with lamivudine
    • (abstract)
    • Perrillo, R. P., Schalm, S. W., Schiff, E. R., Brown, N. A., Woessner, M. A. & Sullivan, M. (1999). Predictors of HBsAg sero-conversion in chronic hepatitis B patients treated with lamivudine (abstract). Hepatology 30, 317A.
    • (1999) Hepatology , vol.30
    • Perrillo, R.P.1    Schalm, S.W.2    Schiff, E.R.3    Brown, N.A.4    Woessner, M.A.5    Sullivan, M.6
  • 111
    • 0037198434 scopus 로고    scopus 로고
    • International Pediatric Lamivudine Investigator Group Clinical trial of lamivudine in children with chronic hepatitis B
    • Jonas, M. M., Kelly, D. A., Mizerski, J., Badia, I. B., Areias, J. A., Schwarz, K. B. et al. (2002). International Pediatric Lamivudine Investigator Group Clinical trial of lamivudine in children with chronic hepatitis B. New England Journal of Medicine 346, 1706-13.
    • (2002) New England Journal of Medicine , vol.346 , pp. 1706-1713
    • Jonas, M.M.1    Kelly, D.A.2    Mizerski, J.3    Badia, I.B.4    Areias, J.A.5    Schwarz, K.B.6
  • 112
    • 0036195781 scopus 로고    scopus 로고
    • Efficacy of lamivudine in HBeAg-negative chronic hepatitis B
    • Rizzetto, M. (2002). Efficacy of lamivudine in HBeAg-negative chronic hepatitis B. Journal of Medical Virology 66, 435-51.
    • (2002) Journal of Medical Virology , vol.66 , pp. 435-451
    • Rizzetto, M.1
  • 113
    • 0033983646 scopus 로고    scopus 로고
    • Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine
    • Santantonio, T., Mazzola, M., Iacovazzi, T., Miglietta, A., Guastadisegni, A. & Pastore, G. (2000). Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine. Journal of Hepatology 32, 300-6.
    • (2000) Journal of Hepatology , vol.32 , pp. 300-306
    • Santantonio, T.1    Mazzola, M.2    Iacovazzi, T.3    Miglietta, A.4    Guastadisegni, A.5    Pastore, G.6
  • 114
    • 0033803799 scopus 로고    scopus 로고
    • Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B
    • Hadziyannis, S. J., Papatheodoridis, G. V., Dimou, E., Laras, A. & Papaioannou, C. (2000). Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Hepatology 32, 847-51.
    • (2000) Hepatology , vol.32 , pp. 847-851
    • Hadziyannis, S.J.1    Papatheodoridis, G.V.2    Dimou, E.3    Laras, A.4    Papaioannou, C.5
  • 115
  • 116
    • 0034091524 scopus 로고    scopus 로고
    • Response of pre-core mutant chronic hepatitis B infection to lamivudine
    • Rizzetto, M., Volpes, R. & Smedile, A. (2000). Response of pre-core mutant chronic hepatitis B infection to lamivudine. Journal of Medical Virology 61, 398-400.
    • (2000) Journal of Medical Virology , vol.61 , pp. 398-400
    • Rizzetto, M.1    Volpes, R.2    Smedile, A.3
  • 117
    • 0036288645 scopus 로고    scopus 로고
    • Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease
    • Papatheodoridis, G. V., Dimou, E., Laras, A., Papadimitropoulos, V. & Hadziyannis, S. J. (2002). Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease. Hepatology 36, 219-26.
    • (2002) Hepatology , vol.36 , pp. 219-226
    • Papatheodoridis, G.V.1    Dimou, E.2    Laras, A.3    Papadimitropoulos, V.4    Hadziyannis, S.J.5
  • 118
    • 0033921765 scopus 로고    scopus 로고
    • Efficacy of treatment with lamivudine in patients with chronic active E-minus variant hepatitis B virus infection: A non-randomized, open label study
    • Scotto, G., Fazio, V., Campanozzi, F. & D'Adduzio, A. (2000). Efficacy of treatment with lamivudine in patients with chronic active E-minus variant hepatitis B virus infection: a non-randomized, open label study. Current Therapeutic Research 61, 321-30.
    • (2000) Current Therapeutic Research , vol.61 , pp. 321-330
    • Scotto, G.1    Fazio, V.2    Campanozzi, F.3    D'Adduzio, A.4
  • 119
    • 0033067028 scopus 로고    scopus 로고
    • Histological changes in liver biopsies after one year of lamivudine treatment in patients with chronic hepatitis B infection
    • Suzuki, Y., Kumada, H., Ikeda, K., Chayama, K., Arase, Y., Saitoh, S. et al. (1999). Histological changes in liver biopsies after one year of lamivudine treatment in patients with chronic hepatitis B infection. Journal of Hepatology 30, 743-8.
    • (1999) Journal of Hepatology , vol.30 , pp. 743-748
    • Suzuki, Y.1    Kumada, H.2    Ikeda, K.3    Chayama, K.4    Arase, Y.5    Saitoh, S.6
  • 120
    • 0035742752 scopus 로고    scopus 로고
    • Decreasing fibrogenesis: An immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B
    • Kweon, Y. O., Goodman, Z. D., Dienstag, J. L., Schiff, E. R., Brown, N. A., Burkhardt, E. et al. (2001). Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. Journal of Hepatology 35, 749-55.
    • (2001) Journal of Hepatology , vol.35 , pp. 749-755
    • Kweon, Y.O.1    Goodman, Z.D.2    Dienstag, J.L.3    Schiff, E.R.4    Brown, N.A.5    Burkhardt, E.6
  • 121
    • 0035123688 scopus 로고    scopus 로고
    • Lamivudine therapy for spontaneously occurring severe acute exacerbation in chronic hepatitis B virus infection: A preliminary study
    • Tsubota, A., Arase, Y., Saitoh, S., Kobayashi, M., Suzuki, Y., Suzuki, F. et al. (2001). Lamivudine therapy for spontaneously occurring severe acute exacerbation in chronic hepatitis B virus infection: a preliminary study. American Journal of Gastroenterology 96, 557-62.
    • (2001) American Journal of Gastroenterology , vol.96 , pp. 557-562
    • Tsubota, A.1    Arase, Y.2    Saitoh, S.3    Kobayashi, M.4    Suzuki, Y.5    Suzuki, F.6
  • 123
    • 2942559300 scopus 로고    scopus 로고
    • A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B
    • Perrillo, R. P., Wright, T., Rakela, J., Levy, G., Schiff, E., Gish, R. et al. (2001). A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. Hepatology 33, 424-32.
    • (2001) Hepatology , vol.33 , pp. 424-432
    • Perrillo, R.P.1    Wright, T.2    Rakela, J.3    Levy, G.4    Schiff, E.5    Gish, R.6
  • 125
    • 0033929544 scopus 로고    scopus 로고
    • Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection
    • Yao, F. Y. & Bass, N. M. (2000). Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection. Journal of Hepatology 33, 301-7.
    • (2000) Journal of Hepatology , vol.33 , pp. 301-307
    • Yao, F.Y.1    Bass, N.M.2
  • 126
    • 0033931789 scopus 로고    scopus 로고
    • Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis
    • Kapoor, D., Guptan, R. C., Wakil, S. M., Kazim, S. N., Kaul, R., Agarwal, S. R. et al. (2000). Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis. Journal of Hepatology 33, 308-12.
    • (2000) Journal of Hepatology , vol.33 , pp. 308-312
    • Kapoor, D.1    Guptan, R.C.2    Wakil, S.M.3    Kazim, S.N.4    Kaul, R.5    Agarwal, S.R.6
  • 127
    • 10544253075 scopus 로고    scopus 로고
    • Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation
    • Bain, V. G., Kneteman, N. M., Ma, M. M., Gutfreund, K., Shapiro, J. A., Fischer, K. et al. (1996). Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation. Transplantation 62, 1456-62.
    • (1996) Transplantation , vol.62 , pp. 1456-1462
    • Bain, G.1    Kneteman, N.M.2    Ma, M.M.3    Gutfreund, K.4    Shapiro, J.A.5    Fischer, K.6
  • 128
    • 16044367618 scopus 로고    scopus 로고
    • Lamivudine prophylaxis against reinfection in liver transplantation for hepatitis B cirrhosis
    • Grellier, L., Mutimer, D., Ahmed, M., Brown, D., Burroughs, A., Rolles, K. et al. (1996). Lamivudine prophylaxis against reinfection in liver transplantation for hepatitis B cirrhosis. Lancet 348, 1212-5.
    • (1996) Lancet , vol.348 , pp. 1212-1215
    • Grellier, L.1    Mutimer, D.2    Ahmed, M.3    Brown, D.4    Burroughs, A.5    Rolles, K.6
  • 129
  • 130
    • 0032572291 scopus 로고    scopus 로고
    • Efficacy of lamivudine in controlling hepatitis B virus recurrence after liver transplantation
    • Nery, J. R., Weppler, D., Rodriguez, M., Ruiz, P., Schiff, E. R. & Tzakis, A. G. (1998). Efficacy of lamivudine in controlling hepatitis B virus recurrence after liver transplantation. Transplantation 65, 1615-21.
    • (1998) Transplantation , vol.65 , pp. 1615-1621
    • Nery, J.R.1    Weppler, D.2    Rodriguez, M.3    Ruiz, P.4    Schiff, E.R.5    Tzakis, A.G.6
  • 131
    • 0030929584 scopus 로고    scopus 로고
    • Histological improvement in patients with chronic hepatitis B virus infection treated with lamivudine
    • Honkoop, P., de Man, R. A., Zondervan, P. E. & Schalm, S. W. (1997). Histological improvement in patients with chronic hepatitis B virus infection treated with lamivudine. Liver 17, 103-6.
    • (1997) Liver , vol.17 , pp. 103-106
    • Honkoop, P.1    de Man, R.A.2    Zondervan, P.E.3    Schalm, S.W.4
  • 132
    • 2942559300 scopus 로고    scopus 로고
    • A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B
    • The Lamivudine North American Transplant Group
    • Perrillo, R. P., Wright, T., Rakela, J., Levy, G., Schiff, E., Gish, R. et al. (2001). The Lamivudine North American Transplant Group. A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. Hepatology 33, 424-32.
    • (2001) Hepatology , vol.33 , pp. 424-432
    • Perrillo, R.P.1    Wright, T.2    Rakela, J.3    Levy, G.4    Schiff, E.5    Gish, R.6
  • 133
    • 17344364991 scopus 로고    scopus 로고
    • Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin
    • Markowitz, J. S., Martin, P., Conrad, A. J., Markmann, J. F., Seu, P., Yersiz, H. et al. (1998). Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin. Hepatology 28, 585-9.
    • (1998) Hepatology , vol.28 , pp. 585-589
    • Markowitz, J.S.1    Martin, P.2    Conrad, A.J.3    Markmann, J.F.4    Seu, P.5    Yersiz, H.6
  • 134
    • 0034954042 scopus 로고    scopus 로고
    • Randomized trial of lamivudine versus hepatitis B immunoglobulin for long-term prophylaxis of hepatitis B recurrence after liver transplantation
    • Naoumov, N. V., Lopes, A. R., Burra, P., Caccamo, L., Lemmolo, R. M., de Man, R. A. et al. (2001). Randomized trial of lamivudine versus hepatitis B immunoglobulin for long-term prophylaxis of hepatitis B recurrence after liver transplantation. Journal of Hepatology 34, 888-94.
    • (2001) Journal of Hepatology , vol.34 , pp. 888-894
    • Naoumov, N.V.1    Lopes, A.R.2    Burra, P.3    Caccamo, L.4    Lemmolo, R.M.5    de Man, R.A.6
  • 135
    • 0035138197 scopus 로고    scopus 로고
    • Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxis
    • Lo, C. M., Cheung, S. T., Lai, C. L., Liu, C. L., Ng, I. O., Yuen, M. F. et al. (2001). Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxis. Annals of Surgery 233, 276-81.
    • (2001) Annals of Surgery , vol.233 , pp. 276-281
    • Lo, C.M.1    Cheung, S.T.2    Lai, C.L.3    Liu, C.L.4    Ng, I.O.5    Yuen, M.F.6
  • 136
    • 0033844153 scopus 로고    scopus 로고
    • Prednisolone priming enhances Th 1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B
    • Liaw, Y. F., Tsai, S. L., Chien, R. N., Yeh, C. T. & Chu, C. M. (2000). Prednisolone priming enhances Th 1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B. Hepatology 32, 604-9.
    • (2000) Hepatology , vol.32 , pp. 604-609
    • Liaw, Y.F.1    Tsai, S.L.2    Chien, R.N.3    Yeh, C.T.4    Chu, C.M.5
  • 137
    • 0033797827 scopus 로고    scopus 로고
    • Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea
    • Song, B. C., Suh, D. J., Lee, H. C., Chung, Y. H. & Lee, Y. S. (2000). Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology 32, 803-6.
    • (2000) Hepatology , vol.32 , pp. 803-806
    • Song, B.C.1    Suh, D.J.2    Lee, H.C.3    Chung, Y.H.4    Lee, Y.S.5
  • 138
    • 0032835661 scopus 로고    scopus 로고
    • Extended lamivudine retreatment for chronic hepatitis B: Maintenance of viral suppression after discontinuation of therapy
    • Dienstag, J. L., Schiff, E. R., Mitchell, M., Casey, D. E., Jr, Gitlin, N., Lissoos, T. et al. (1999). Extended lamivudine retreatment for chronic hepatitis B: maintenance of viral suppression after discontinuation of therapy. Hepatology 30, 1082-7.
    • (1999) Hepatology , vol.30 , pp. 1082-1087
    • Dienstag, J.L.1    Schiff, E.R.2    Mitchell, M.3    Casey D.E., Jr.4    Gitlin, N.5    Lissoos, T.6
  • 139
    • 0000305976 scopus 로고    scopus 로고
    • Durable HBeAg and HBsAg seroconversion after lamivudine for chronic hepatitis B
    • (abstract)
    • Schiff, E., Cianciara, J., Karayalcin, S., Kowdley, K., Woesner, M., McMullen, S. et al. (2000). Durable HBeAg and HBsAg seroconversion after lamivudine for chronic hepatitis B (abstract). Journal of Hepatology 32, Suppl. 2, 99.
    • (2000) Journal of Hepatology , vol.32 , Issue.SUPPL. 2 , pp. 99
    • Schiff, E.1    Cianciara, J.2    Karayalcin, S.3    Kowdley, K.4    Woesner, M.5    McMullen, S.6
  • 140
    • 0032783679 scopus 로고    scopus 로고
    • Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy
    • Liaw, Y. F., Chien, R. N., Yeh, C. T., Tsai, S. L. & Chu, C. M. (1999). Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. Hepatology 30, 567-72.
    • (1999) Hepatology , vol.30 , pp. 567-572
    • Liaw, Y.F.1    Chien, R.N.2    Yeh, C.T.3    Tsai, S.L.4    Chu, C.M.5
  • 141
    • 0031037065 scopus 로고    scopus 로고
    • Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation
    • Bartholomew, M. M., Jansen, R. W., Jeffers, L. J., Reddy, K. R., Johnson, L. C., Bunzendahl, H. et al. (1997). Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet 349, 20-2.
    • (1997) Lancet , vol.349 , pp. 20-22
    • Bartholomew, M.M.1    Jansen, R.W.2    Jeffers, L.J.3    Reddy, K.R.4    Johnson, L.C.5    Bunzendahl, H.6
  • 142
    • 0000126797 scopus 로고    scopus 로고
    • Clinical significance of YMDD mutant hepatitis B virus (HBV) in a large cohort of lamivudine-treated hepatitis B patients
    • [abstract]
    • Atkins, M., Hunt, C. M., Brown, N., Gray, F., Sanathanan, L., Woesser, M. et al. (1998). Clinical significance of YMDD mutant hepatitis B virus (HBV) in a large cohort of lamivudine-treated hepatitis B patients [abstract]. Hepatology 28, 319A.
    • (1998) Hepatology , vol.28
    • Atkins, M.1    Hunt, C.M.2    Brown, N.3    Gray, F.4    Sanathanan, L.5    Woesser, M.6
  • 143
    • 0030586090 scopus 로고    scopus 로고
    • Structure of unliganded HIV-1 reverse transcriptase at 2.7 angstrom resolution: Implications of conformational changes for polymerization and inhibition mechanisms
    • Hsiou, Y., Ding, J., Das, K., Clark, A. D., Hughes, S. H. & Arnold, E. (1996). Structure of unliganded HIV-1 reverse transcriptase at 2.7 angstrom resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure 4, 853-60.
    • (1996) Structure , vol.4 , pp. 853-860
    • Hsiou, Y.1    Ding, J.2    Das, K.3    Clark, A.D.4    Hughes, S.H.5    Arnold, E.6
  • 144
    • 0029807291 scopus 로고    scopus 로고
    • dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog
    • Lavrik, O. I., Prasad, R., Beard, W. A., Safronov, I. V., Dobrikov, M. I., Srivastava, D. K. et al. (1996). dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog. Journal of Biological Chemistry 271, 21891-7.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 21891-21897
    • Lavrik, O.I.1    Prasad, R.2    Beard, W.A.3    Safronov, I.V.4    Dobrikov, M.I.5    Srivastava, D.K.6
  • 146
    • 0034616958 scopus 로고    scopus 로고
    • The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
    • Gao, H.-Q., Boyer, P.L., Sarafianos, S. G., Arnold, E. & Hughes, S. H. (2000). The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. Journal of Biological Chemistry 300, 403-18.
    • (2000) Journal of Biological Chemistry , vol.300 , pp. 403-418
    • Gao, H.-Q.1    Boyer, P.L.2    Sarafianos, S.G.3    Arnold, E.4    Hughes, S.H.5
  • 147
    • 0024784519 scopus 로고
    • Identification of four conserved motifs among the RNA-dependent polymerase encoding elements
    • Poch, O., Sauvaget, I., Delarue, M. & Tordo, N. (1989). Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO Journal 8, 3867-74.
    • (1989) EMBO Journal , vol.8 , pp. 3867-3874
    • Poch, O.1    Sauvaget, I.2    Delarue, M.3    Tordo, N.4
  • 148
    • 0031780935 scopus 로고    scopus 로고
    • Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
    • Allen, M. I., Deslauriers, M., Andrews, C. W., Tipples, G. A., Walters K.-A., Tyrrell, D. L. J. et al. (1998). Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Hepatology 27, 1670-7.
    • (1998) Hepatology , vol.27 , pp. 1670-1677
    • Allen, M.I.1    Deslauriers, M.2    Andrews, C.W.3    Tipples, G.A.4    Walters, K.-A.5    Tyrrell, D.L.J.6
  • 149
    • 0029799423 scopus 로고    scopus 로고
    • Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(-)-beta-L-2′, 3′-dideoxy-3′-thiacytidine] in vitro
    • Fischer, K. P. & Tyrrell, D. L. (1996). Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(-)-beta-L-2′, 3′-dideoxy-3′-thiacytidine] in vitro. Antimicrobial Agents and Chemotherapy 40, 1957-60.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 1957-1960
    • Fischer, K.P.1    Tyrrell, D.L.2
  • 150
    • 17344373482 scopus 로고    scopus 로고
    • Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy
    • Chayama, K., Suzuki, Y., Kobayashi, M., Kobayashi, A., Tsubota, A. & Hashimoto, M. (1998). Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology 27, 1711-6.
    • (1998) Hepatology , vol.27 , pp. 1711-1716
    • Chayama, K.1    Suzuki, Y.2    Kobayashi, M.3    Kobayashi, A.4    Tsubota, A.5    Hashimoto, M.6
  • 151
  • 152
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine
    • Ling, R., Mutimer, D., Ahmed, M., Boxall, E. H., Elias, E., Dusheiko, G. M. et al. (1996). Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 24, 711-3.
    • (1996) Hepatology , vol.24 , pp. 711-713
    • Ling, R.1    Mutimer, D.2    Ahmed, M.3    Boxall, E.H.4    Elias, E.5    Dusheiko, G.M.6
  • 153
    • 0029817898 scopus 로고    scopus 로고
    • Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo
    • Tipples, G. A., Ma, M. M., Fischer, K. P., Bain, V. G., Kneteman, N. M. & Trell, D. L. (1996). Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 24, 714-7.
    • (1996) Hepatology , vol.24 , pp. 714-717
    • Tipples, G.A.1    Ma, M.M.2    Fischer, K.P.3    Bain, V.G.4    Kneteman, N.M.5    Trell, D.L.6
  • 154
    • 0031900989 scopus 로고    scopus 로고
    • Identification of more than one mutation in the hepatitis B virus polymerase arising during prolonged lamivudine treatment
    • Niesters, H. G., Honkoop, P., Haagsma, E. B., de Man, R. A., Schalm, S. W. & Osterhaus, A. D. (1998). Identification of more than one mutation in the hepatitis B virus polymerase arising during prolonged lamivudine treatment. Journal of Infectious Diseases 177, 1382-5.
    • (1998) Journal of Infectious Diseases , vol.177 , pp. 1382-1385
    • Niesters, H.G.1    Honkoop, P.2    Haagsma, E.B.3    de Man, R.A.4    Schalm, S.W.5    Osterhaus, A.D.6
  • 155
    • 17744375593 scopus 로고    scopus 로고
    • Nomenclature for anti-viral-resistant human hepatitis B virus mutations in the polymerase region
    • Stuyver, L. J., Locarnini, S. A., Lok, A., Richman, D. D., Carman, W. F., Dienstag, J. L. et al. (2001). Nomenclature for anti-viral-resistant human hepatitis B virus mutations in the polymerase region. Hepatology 33, 751-7.
    • (2001) Hepatology , vol.33 , pp. 751-757
    • Stuyver, L.J.1    Locarnini, S.A.2    Lok, A.3    Richman, D.D.4    Carman, W.F.5    Dienstag, J.L.6
  • 156
    • 0030905343 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation
    • Aye, T. T., Bartholomeusz, A., Shaw, T., Bowden, S., Breschkin, A., McMillan, J. et al. (1997). Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. Journal of Hepatology 26, 1148-53.
    • (1997) Journal of Hepatology , vol.26 , pp. 1148-1153
    • Aye, T.T.1    Bartholomeusz, A.2    Shaw, T.3    Bowden, S.4    Breschkin, A.5    McMillan, J.6
  • 157
    • 0033067529 scopus 로고    scopus 로고
    • Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation
    • Tillmann, H. L., Trautwein, C., Bock, T., Boker, K. H., Jackel, E., Glowienka, M. et al. (1999). Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. Hepatology 30, 244-56.
    • (1999) Hepatology , vol.30 , pp. 244-256
    • Tillmann, H.L.1    Trautwein, C.2    Bock, T.3    Boker, K.H.4    Jackel, E.5    Glowienka, M.6
  • 158
    • 0034040297 scopus 로고    scopus 로고
    • Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy
    • Yeh, C. T., Chien, R. N., Chu, C. M. & Liaw, Y. F. (2000). Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy. Hepatology 31, 1318-26.
    • (2000) Hepatology , vol.31 , pp. 1318-1326
    • Yeh, C.T.1    Chien, R.N.2    Chu, C.M.3    Liaw, Y.F.4
  • 159
    • 0036071201 scopus 로고    scopus 로고
    • Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy
    • Niesters, H. G. M., De-Man, R. A., Pas, S. D., Fries, E. & Osterhaus, A. D. (2002). Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy. Journal of Medical Microbiology 51, 695-9.
    • (2002) Journal of Medical Microbiology , vol.51 , pp. 695-699
    • Niesters, H.G.M.1    De-Man, R.A.2    Pas, S.D.3    Fries, E.4    Osterhaus, A.D.5
  • 160
    • 0032480010 scopus 로고    scopus 로고
    • The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor
    • Jaeger, J., Restle, T. & Steitz, T. A. (1998). The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. EMBO Journal 17, 4535-42.
    • (1998) EMBO Journal , vol.17 , pp. 4535-4542
    • Jaeger, J.1    Restle, T.2    Steitz, T.A.3
  • 161
    • 0035041976 scopus 로고    scopus 로고
    • Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
    • Das, K., Xiong, X., Yang, H., Westland, C. E., Gibbs, C. S., Sarafianos, S. G. et al. (2001). Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). Journal of Virology 75, 4771-9.
    • (2001) Journal of Virology , vol.75 , pp. 4771-4779
    • Das, K.1    Xiong, X.2    Yang, H.3    Westland, C.E.4    Gibbs, C.S.5    Sarafianos, S.G.6
  • 162
    • 0031938029 scopus 로고    scopus 로고
    • Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
    • Melegari, M., Scaglioni, P. P. & Wands, J. R. (1998). Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology 27, 628-33.
    • (1998) Hepatology , vol.27 , pp. 628-633
    • Melegari, M.1    Scaglioni, P.P.2    Wands, J.R.3
  • 163
    • 0035114188 scopus 로고    scopus 로고
    • The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance
    • Ono, S. K., Kato, N., Shiratori, Y., Kato, J., Goto, T., Schinazi, R. F. et al. (2001). The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance. Journal of Clinical Investigation 107, 449-55.
    • (2001) Journal of Clinical Investigation , vol.107 , pp. 449-455
    • Ono, S.K.1    Kato, N.2    Shiratori, Y.3    Kato, J.4    Goto, T.5    Schinazi, R.F.6
  • 164
    • 0036161381 scopus 로고    scopus 로고
    • Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation
    • Bock, C. T., Tillmann, H. L., Torresi, J., Klempnauer, J., Locarnini, S., Manns, M. P. et al. (2002). Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation. Gastroenterology 122, 264-73.
    • (2002) Gastroenterology , vol.122 , pp. 264-273
    • Bock, C.T.1    Tillmann, H.L.2    Torresi, J.3    Klempnauer, J.4    Locarnini, S.5    Manns, M.P.6
  • 165
    • 0036038911 scopus 로고    scopus 로고
    • Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the 'Fingers' subdomain of the viral polymerase selected as a consequence of mutations in the overlapping s gene
    • Torresi, J., Earnest-Silveira, L., Civitico, G., Walters, T., Lewin, S., Fyfe, J. et al. (2002). Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the 'Fingers' subdomain of the viral polymerase selected as a consequence of mutations in the overlapping s gene. Virology 299, 88-99.
    • (2002) Virology , vol.299 , pp. 88-99
    • Torresi, J.1    Earnest-Silveira, L.2    Civitico, G.3    Walters, T.4    Lewin, S.5    Fyfe, J.6
  • 166
    • 0031793849 scopus 로고    scopus 로고
    • Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro
    • Xiong, X., Flores, C., Yang, H., Toole, J. J. & Gibbs, C. S. (1998). Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro. Hepatology 28, 1669-73.
    • (1998) Hepatology , vol.28 , pp. 1669-1673
    • Xiong, X.1    Flores, C.2    Yang, H.3    Toole, J.J.4    Gibbs, C.S.5
  • 167
    • 0034235905 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants
    • Perrillo, R., Schiff, E., Yoshida, E., Statler, A., Hirsch, K., Wright, T. et al. (2000). Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants. Hepatology 32, 129-34.
    • (2000) Hepatology , vol.32 , pp. 129-134
    • Perrillo, R.1    Schiff, E.2    Yoshida, E.3    Statler, A.4    Hirsch, K.5    Wright, T.6
  • 168
    • 0033017849 scopus 로고    scopus 로고
    • YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection
    • Ono-Nita, S. K., Kato, N., Shiratori, Y., Masaki, T., Lan, K. H., Carrilho, F. J. et al. (1999). YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: a study by in vitro full-length viral DNA transfection. Hepatology 29, 939-45.
    • (1999) Hepatology , vol.29 , pp. 939-945
    • Ono-Nita, S.K.1    Kato, N.2    Shiratori, Y.3    Masaki, T.4    Lan, K.H.5    Carrilho, F.J.6
  • 169
    • 17944372114 scopus 로고    scopus 로고
    • In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2′-fluoro-5-methyl-beta-L-arabinofuranosyluracil
    • Chin, R., Shaw, T., Torresi, J., Sozzi, V., Trautwein, C. & Bock, T. (2001). In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2′-fluoro-5-methyl-beta-L-arabinofuranosyluracil. Antimicrobial Agents and Chemotherapy 45, 2495-501.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 2495-2501
    • Chin, R.1    Shaw, T.2    Torresi, J.3    Sozzi, V.4    Trautwein, C.5    Bock, T.6
  • 170
    • 0036725346 scopus 로고    scopus 로고
    • Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses
    • Seigneres, B., Pichoud, C., Martin, P., Furman, P., Trepo, C. & Zoulim, F. (2002). Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. Hepatology 36, 710-22.
    • (2002) Hepatology , vol.36 , pp. 710-722
    • Seigneres, B.1    Pichoud, C.2    Martin, P.3    Furman, P.4    Trepo, C.5    Zoulim, F.6
  • 171
    • 0034108712 scopus 로고    scopus 로고
    • Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir
    • Ying, C., De Clercq, E., Nicholson, W., Furman, P. & Neyts, J. (2000). Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir. Journal of Viral Hepatitis 7, 161-5.
    • (2000) Journal of Viral Hepatitis , vol.7 , pp. 161-165
    • Ying, C.1    De Clercq, E.2    Nicholson, W.3    Furman, P.4    Neyts, J.5
  • 172
    • 0036147464 scopus 로고    scopus 로고
    • Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2′-fluoro-5-methyl-beta-L-arabinofuranosyluracil
    • Yamamoto, T., Litwin, S., Zhou, T., Zhu, Y., Condreay, L., Furman, P. et al. (2002). Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2′-fluoro-5-methyl-beta-L-arabinofuranosyluracil. Journal of Virology 76, 1213-23.
    • (2002) Journal of Virology , vol.76 , pp. 1213-1223
    • Yamamoto, T.1    Litwin, S.2    Zhou, T.3    Zhu, Y.4    Condreay, L.5    Furman, P.6
  • 173
    • 16044369181 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir
    • Shaw, T., Mok, S. S. & Locarnini, S. A. (1996). Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir. Hepatology 24, 996-1002.
    • (1996) Hepatology , vol.24 , pp. 996-1002
    • Shaw, T.1    Mok, S.S.2    Locarnini, S.A.3
  • 174
    • 0028205505 scopus 로고
    • In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus
    • Shaw, T., Amor, P., Civitico, G., Boyd, M. & Locarnini, S. (1994). In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus. Antimicrobial Agents and Chemotherapy 38, 719-23.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 719-723
    • Shaw, T.1    Amor, P.2    Civitico, G.3    Boyd, M.4    Locarnini, S.5
  • 175
    • 1842293414 scopus 로고    scopus 로고
    • Inhibitory effect of penciclovir-triphosphate on duck hepatitis B virus reverse transcription
    • Dannaoui, E., Trepo, C. & Zoulim, F. (1997). Inhibitory effect of penciclovir-triphosphate on duck hepatitis B virus reverse transcription. Antimicrobial Agents and Chemotherapy 8, 38-46.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.8 , pp. 38-46
    • Dannaoui, E.1    Trepo, C.2    Zoulim, F.3
  • 176
    • 0031879931 scopus 로고    scopus 로고
    • Long-term therapy with the guanine nucleoside analog penciclovir controls chronic duck hepatitis B virus infection in vivo
    • Lin, E., Luscombe, C., Colledge, D., Wang, Y. & Locarnini, S. (1998). Long-term therapy with the guanine nucleoside analog penciclovir controls chronic duck hepatitis B virus infection in vivo. Antimicrobial Agents and Chemotherapy 42, 2132-7.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 2132-2137
    • Lin, E.1    Luscombe, C.2    Colledge, D.3    Wang, Y.4    Locarnini, S.5
  • 177
    • 0028348905 scopus 로고
    • Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo
    • Tsiquaye, K., Slomka, M. & Maung, M. (1994). Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo. Journal of Medical Virology 42, 306-10.
    • (1994) Journal of Medical Virology , vol.42 , pp. 306-310
    • Tsiquaye, K.1    Slomka, M.2    Maung, M.3
  • 178
    • 0029924230 scopus 로고    scopus 로고
    • Antiviral activities and pharmacokinetics of penciclovir and famciclovir in Pekin ducks chronically infected with duck hepatitis B virus
    • Tsiquaye, K., Sutton, D., Maung, M. & Boyd, M. (1996). Antiviral activities and pharmacokinetics of penciclovir and famciclovir in Pekin ducks chronically infected with duck hepatitis B virus. Antiviral Chemistry and Chemotherapy 7, 153-9.
    • (1996) Antiviral Chemistry and Chemotherapy , vol.7 , pp. 153-159
    • Tsiquaye, K.1    Sutton, D.2    Maung, M.3    Boyd, M.4
  • 179
    • 0030179646 scopus 로고    scopus 로고
    • A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection
    • Main, J., Brown, J., Howells, C., Galassini, R., Crossey, M., Karayiannis, P. et al. (1996). A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. Journal of Viral Hepatitis 3, 211-5.
    • (1996) Journal of Viral Hepatitis , vol.3 , pp. 211-215
    • Main, J.1    Brown, J.2    Howells, C.3    Galassini, R.4    Crossey, M.5    Karayiannis, P.6
  • 180
    • 0343674497 scopus 로고    scopus 로고
    • Famciclovir in chronic hepatitis B: Results of a dose-finding study
    • Trepo, C., Jezek, P., Atkinson, G., Boon, R. & Young, C. (2000). Famciclovir in chronic hepatitis B: results of a dose-finding study. Journal of Hepatology 32, 1011-8.
    • (2000) Journal of Hepatology , vol.32 , pp. 1011-1018
    • Trepo, C.1    Jezek, P.2    Atkinson, G.3    Boon, R.4    Young, C.5
  • 181
    • 0033867220 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study to evaluate the efficacy of 12-month famciclovir treatment in patients with chronic hepatitis B e antigen-positive hepatitis B
    • de Man, R. A., Marcellin, P., Habal, F., Desmond, P., Wright, T., Rose, T. et al. (2000). A randomized, placebo-controlled study to evaluate the efficacy of 12-month famciclovir treatment in patients with chronic hepatitis B e antigen-positive hepatitis B. Hepatology 32, 413-7.
    • (2000) Hepatology , vol.32 , pp. 413-417
    • de Man, R.A.1    Marcellin, P.2    Habal, F.3    Desmond, P.4    Wright, T.5    Rose, T.6
  • 182
    • 4243265278 scopus 로고    scopus 로고
    • Famciclovir treatment of decompensated HBV cirrhosis
    • Benner, K., Rosen, H. & Flora, K. (1996). Famciclovir treatment of decompensated HBV cirrhosis. Hepatology 24, A622.
    • (1996) Hepatology , vol.24
    • Benner, K.1    Rosen, H.2    Flora, K.3
  • 183
  • 184
    • 0001228985 scopus 로고    scopus 로고
    • Safety and efficacy of famciclovir for the treatment of recurrent hepatitis B in liver transplant recipients
    • [abstract]
    • Neuhaus, P., Manns, M. & Atkinson, G. (1997). Safety and efficacy of famciclovir for the treatment of recurrent hepatitis B in liver transplant recipients [abstract]. Hepatology 26, 528A.
    • (1997) Hepatology , vol.26
    • Neuhaus, P.1    Manns, M.2    Atkinson, G.3
  • 185
    • 0035128993 scopus 로고    scopus 로고
    • Famciclovir treatment of hepatitis B infection following liver transplantation: A long-term, multi-centre study
    • Famciclovir Liver Transplant Study Group
    • Manns, M. P., Neuhaus, P., Atkinson, G. F., Griffin, K. E., Barnass, S., Vollmar, J. et al. (2001). Famciclovir Liver Transplant Study Group. Famciclovir treatment of hepatitis B infection following liver transplantation: a long-term, multi-centre study. Transplant Infectious Disease 3, 16-23.
    • (2001) Transplant Infectious Disease , vol.3 , pp. 16-23
    • Manns, M.P.1    Neuhaus, P.2    Atkinson, G.F.3    Griffin, K.E.4    Barnass, S.5    Vollmar, J.6
  • 186
    • 0031714143 scopus 로고    scopus 로고
    • Significance of mutations in the hepatitis B virus polymerase selected by nucleoside analogues and implications for controlling chronic disease
    • Bartholmeusz, A., Schinazi, R. F. & Locarnini, S. A. (1998). Significance of mutations in the hepatitis B virus polymerase selected by nucleoside analogues and implications for controlling chronic disease. Viral Hepatitis Reviews 3, 167-87.
    • (1998) Viral Hepatitis Reviews , vol.3 , pp. 167-187
    • Bartholmeusz, A.1    Schinazi, R.F.2    Locarnini, S.A.3
  • 187
    • 0034062371 scopus 로고    scopus 로고
    • Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B
    • Seigneres, B., Pichoud, C., Ahmed, S. S., Hantz, O., Trepo, C. & Zoulim, F. (2000). Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. Journal of Infectious Diseases 181, 1221-33.
    • (2000) Journal of Infectious Diseases , vol.181 , pp. 1221-1233
    • Seigneres, B.1    Pichoud, C.2    Ahmed, S.S.3    Hantz, O.4    Trepo, C.5    Zoulim, F.6
  • 188
    • 0033027088 scopus 로고    scopus 로고
    • Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure
    • Gunther, S., von Breunig, F., Santantonio, T., Jung, M. C., Gaeta, G. B., Fischer, L. et al. (1999). Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure. Journal of Hepatology 30, 749-54.
    • (1999) Journal of Hepatology , vol.30 , pp. 749-754
    • Gunther, S.1    von Breunig, F.2    Santantonio, T.3    Jung, M.C.4    Gaeta, G.B.5    Fischer, L.6
  • 189
    • 0032897955 scopus 로고    scopus 로고
    • Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance
    • Pichoud, C., Seigneres, B., Wang, Z., Trepo, C. & Zoulim, F. (1999). Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance. Hepatology 29, 230-7.
    • (1999) Hepatology , vol.29 , pp. 230-237
    • Pichoud, C.1    Seigneres, B.2    Wang, Z.3    Trepo, C.4    Zoulim, F.5
  • 190
    • 0033977128 scopus 로고    scopus 로고
    • In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
    • Xiong, X., Yang, H., Westland, C. E., Zou, R. & Gibbs, C. S. (2000). In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance. Hepatology 31, 219-24.
    • (2000) Hepatology , vol.31 , pp. 219-224
    • Xiong, X.1    Yang, H.2    Westland, C.E.3    Zou, R.4    Gibbs, C.S.5
  • 191
    • 0027976251 scopus 로고
    • Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates
    • Calio, R., Villani, N., Balestra, E., Sesa, F., Holy, A., Balzarini, J. et al. (1994). Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. Antiviral Research 23, 77-89.
    • (1994) Antiviral Research , vol.23 , pp. 77-89
    • Calio, R.1    Villani, N.2    Balestra, E.3    Sesa, F.4    Holy, A.5    Balzarini, J.6
  • 192
    • 0027253824 scopus 로고
    • Inhibitory effect of 9-(2-phosphonyl-methoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection
    • Heijtink, R. A., De Wilde, G. A., Kruining, J., Berk, L., Balzarini, J., De Clercq, E. et al. (1993). Inhibitory effect of 9-(2-phosphonyl-methoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. Antiviral Research 21, 141-53.
    • (1993) Antiviral Research , vol.21 , pp. 141-153
    • Heijtink, R.A.1    De Wilde, G.A.2    Kruining, J.3    Berk, L.4    Balzarini, J.5    De Clercq, E.6
  • 193
    • 0031728650 scopus 로고    scopus 로고
    • Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue
    • Nicoll, A. J., Colledge, D. L., Toole, J. J., Angus, P. W., Smallwood, R. A. & Locarnini, S. A. (1998). Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue. Antimicrobial Agents and Chemotherapy 42, 3130-5.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 3130-3135
    • Nicoll, A.J.1    Colledge, D.L.2    Toole, J.J.3    Angus, P.W.4    Smallwood, R.A.5    Locarnini, S.A.6
  • 194
    • 0032885698 scopus 로고    scopus 로고
    • A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection
    • Gilson, R. J., Chopra, K. B., Newell, A. M., Murray-Lyon, I. M., Nelson, M. R., Rice, S. J. et al. (1999). A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection. Journal of Viral Hepatitis 6, 387-95.
    • (1999) Journal of Viral Hepatitis , vol.6 , pp. 387-395
    • Gilson, R.J.1    Chopra, K.B.2    Newell, A.M.3    Murray-Lyon, I.M.4    Nelson, M.R.5    Rice, S.J.6
  • 195
    • 0033029334 scopus 로고    scopus 로고
    • Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
    • Tsiang, M., Rooney, J. F., Toole, J. J. & Gibbs, C. (1999). Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy. Hepatology 29, 1863-9.
    • (1999) Hepatology , vol.29 , pp. 1863-1869
    • Tsiang, M.1    Rooney, J.F.2    Toole, J.J.3    Gibbs, C.4
  • 196
    • 0033611144 scopus 로고    scopus 로고
    • Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: Durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin
    • Peters, M. G., Singer, G., Howard, T., Jacobsmeyer, S., Xiong, X., Gibbs, C. S. et al. (1999). Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin. Transplantation 68, 1912-4.
    • (1999) Transplantation , vol.68 , pp. 1912-1914
    • Peters, M.G.1    Singer, G.2    Howard, T.3    Jacobsmeyer, S.4    Xiong, X.5    Gibbs, C.S.6
  • 197
    • 0034806770 scopus 로고    scopus 로고
    • Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks
    • Cullen, J. M., Li, D. H., Brown, C., Eisenberg, E. J., Cundy, K. C., Wolfe, J. et al. (2001). Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks. Antimicrobial Agents and Chemotherapy 45, 2740-5.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 2740-2745
    • Cullen, J.M.1    Li, D.H.2    Brown, C.3    Eisenberg, E.J.4    Cundy, K.C.5    Wolfe, J.6
  • 198
    • 0035449134 scopus 로고    scopus 로고
    • Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: An open-label pilot study
    • Benhamou, Y., Bochet, M., Thibault, V., Calvez, V., Fievet, M. H., Vig, P. et al. (2001). Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study. Lancet 358, 718-23.
    • (2001) Lancet , vol.358 , pp. 718-723
    • Benhamou, Y.1    Bochet, M.2    Thibault, V.3    Calvez, V.4    Fievet, M.H.5    Vig, P.6
  • 199
    • 0035178709 scopus 로고    scopus 로고
    • Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: Rapid resolution during treatment with adefovir
    • Mutimer, D., Feraz-Neto, B. H., Harrison, R., O'Donnell, K., Shaw, J., Cane, P. et al. (2001). Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir. Gut 49, 860-3.
    • (2001) Gut , vol.49 , pp. 860-863
    • Mutimer, D.1    Feraz-Neto, B.H.2    Harrison, R.3    O'Donnell, K.4    Shaw, J.5    Cane, P.6
  • 200
    • 0034862867 scopus 로고    scopus 로고
    • Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus
    • Walsh, K. M., Woodall, T., Lamy, P., Wight, D. G., Bloor, S. & Alexander, G. J. (2001). Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus. Gut 49, 436-40.
    • (2001) Gut , vol.49 , pp. 436-440
    • Walsh, K.M.1    Woodall, T.2    Lamy, P.3    Wight, D.G.4    Bloor, S.5    Alexander, G.J.6
  • 201
    • 18444383362 scopus 로고    scopus 로고
    • Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks
    • Yang, H., Westkand, C. E., Delaney, W. E., Heathcote, E. J., Ho, V., Fry. J. et al. (2002). Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks. Hepatology 36, 464-73.
    • (2002) Hepatology , vol.36 , pp. 464-473
    • Yang, H.1    Westkand, C.E.2    Delaney, W.E.3    Heathcote, E.J.4    Ho, V.5    Fry, J.6
  • 202
    • 0030722272 scopus 로고    scopus 로고
    • The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: A randomized, double-blind, placebo-controlled trial
    • Deeks, S. G., Collier, A., Lalezari, J., Pavia, A., Rodrigue, D., Drew, W. L. et al. (1997). The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. Journal of Infectious Diseases 176, 1517-23.
    • (1997) Journal of Infectious Diseases , vol.176 , pp. 1517-1523
    • Deeks, S.G.1    Collier, A.2    Lalezari, J.3    Pavia, A.4    Rodrigue, D.5    Drew, W.L.6
  • 203
    • 0034234540 scopus 로고    scopus 로고
    • Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA
    • Dandri, M., Burda, M., Will, H. & Petersen, J. (2000). Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA. Hepatology 32, 139-46.
    • (2000) Hepatology , vol.32 , pp. 139-146
    • Dandri, M.1    Burda, M.2    Will, H.3    Petersen, J.4
  • 204
    • 0036148731 scopus 로고    scopus 로고
    • Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro
    • Delmas, J., Schorr, O., Jamard, C., Gibbs, C., Trepo, C., Hantz, O. et al. (2002). Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrobial Agents and Chemotherapy 46, 425-33.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 425-433
    • Delmas, J.1    Schorr, O.2    Jamard, C.3    Gibbs, C.4    Trepo, C.5    Hantz, O.6
  • 205
    • 0031761652 scopus 로고    scopus 로고
    • In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir
    • Seifer, M., Hamatake, R. K., Colonno, R. J. & Standring, D. N. (1998). In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir. Antimicrobial Agents and Chemotherapy 42, 3200-8.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 3200-3208
    • Seifer, M.1    Hamatake, R.K.2    Colonno, R.J.3    Standring, D.N.4
  • 206
    • 0031728652 scopus 로고    scopus 로고
    • Efficacy of the carbocyclic 2′-deoxy-guanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection
    • Genovesi, E. V., Lamb, L., Medina, I., Taylor, D., Seifer, M., Innaimo, S. et al. (1998). Efficacy of the carbocyclic 2′-deoxy-guanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection. Antimicrobial Agents and Chemotherapy 42, 3209-17.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 3209-3217
    • Genovesi, E.V.1    Lamb, L.2    Medina, I.3    Taylor, D.4    Seifer, M.5    Innaimo, S.6
  • 209
    • 0035890097 scopus 로고    scopus 로고
    • Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection
    • Colonno, R. J., Genovesi, E. V., Medina, I., Lamb, L., Durham, S. K., Huang, M. L. et al. (2001). Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection. Journal of Infectious Diseases 184, 1236-45.
    • (2001) Journal of Infectious Diseases , vol.184 , pp. 1236-1245
    • Colonno, R.J.1    Genovesi, E.V.2    Medina, I.3    Lamb, L.4    Durham, S.K.5    Huang, M.L.6
  • 210
    • 0036892435 scopus 로고    scopus 로고
    • Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection
    • Lai, C. L., Rosmawati, M., Lao, J., Van Vlierberghe, H., Anderson, F. H., Thomas, N. et al. (2002). Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. Gastroenterology 123, 1831-8.
    • (2002) Gastroenterology , vol.123 , pp. 1831-1838
    • Lai, C.L.1    Rosmawati, M.2    Lao, J.3    Van Vlierberghe, H.4    Anderson, F.H.5    Thomas, N.6
  • 211
    • 0035991863 scopus 로고    scopus 로고
    • Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro
    • Levine, S., Hernandez, D., Yamanaka, G., Zhang, S., Rose, R., Weinheimer, S. et al. (2002). Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro. Antimicrobial Agents and Chemotherapy 46, 2525-32.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 2525-2532
    • Levine, S.1    Hernandez, D.2    Yamanaka, G.3    Zhang, S.4    Rose, R.5    Weinheimer, S.6
  • 212
    • 0034867425 scopus 로고    scopus 로고
    • Safety and efficacy of oral entecavir given for 28 days in patients with chronic hepatitis B virus infection
    • de Man, R. A., Wolters, L. M., Nevens, F., Chua, D., Sherman, M., Lai, C. L. et al. (2001). Safety and efficacy of oral entecavir given for 28 days in patients with chronic hepatitis B virus infection. Hepatology 34, 578-82.
    • (2001) Hepatology , vol.34 , pp. 578-582
    • de Man, R.A.1    Wolters, L.M.2    Nevens, F.3    Chua, D.4    Sherman, M.5    Lai, C.L.6
  • 213
    • 0026469165 scopus 로고
    • The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
    • Furman, P. A., Davis, M., Liotta, D. C., Paff, M., Frick, L. W., Nelson, D. J. et al. (1992). The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrobial Agents and Chemotherapy 36, 2686-92.
    • (1992) Antimicrobial Agents and Chemotherapy , vol.36 , pp. 2686-2692
    • Furman, P.A.1    Davis, M.2    Liotta, D.C.3    Paff, M.4    Frick, L.W.5    Nelson, D.J.6
  • 214
    • 0034998545 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus by hammerhead ribozyme targeted to the poly(A) signal sequence in cultured cells
    • Feng, Y., Kong, Y. Y., Wang, Y. & Qi, G. R. (2001). Inhibition of hepatitis B virus by hammerhead ribozyme targeted to the poly(A) signal sequence in cultured cells. Biological Chemistry 382, 655-60.
    • (2001) Biological Chemistry , vol.382 , pp. 655-660
    • Feng, Y.1    Kong, Y.Y.2    Wang, Y.3    Qi, G.R.4
  • 215
    • 0030032268 scopus 로고    scopus 로고
    • (-)-cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes
    • Condreay, L., Condreay, J., Jansen, R., Paff, M. & Averett, D. (1996). (-)-cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes. Antimicrobial Agents and Chemotherapy 40, 520-3.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 520-523
    • Condreay, L.1    Condreay, J.2    Jansen, R.3    Paff, M.4    Averett, D.5
  • 216
    • 0028265233 scopus 로고
    • Evaluation of the potent anti-HBV agent (-)cis-5-fluoro-1(2-(hydroxymethyl)-1,3-oxathiolan-5-yl) cytosine in a novel in vivo model
    • Condreay, L., Jansen, R., Powdrill, T., Johnson, L., Selleseth, D., Paff, M. et al. (1994). Evaluation of the potent anti-HBV agent (-)cis-5-fluoro-1(2-(hydroxymethyl)-1,3-oxathiolan-5-yl) cytosine in a novel in vivo model. Antimicrobial Agents and Chemotherapy 38, 616-9.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 616-619
    • Condreay, L.1    Jansen, R.2    Powdrill, T.3    Johnson, L.4    Selleseth, D.5    Paff, M.6
  • 217
    • 0034089899 scopus 로고    scopus 로고
    • Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks
    • Korba, B. E., Schinazi, R. F., Cote, P., Tennant, B. C. & Gerin, J. L. (2000). Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks. Antimicrobial Agents and Chemotherapy 44, 1757-60.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 1757-1760
    • Korba, B.E.1    Schinazi, R.F.2    Cote, P.3    Tennant, B.C.4    Gerin, J.L.5
  • 218
    • 0030754358 scopus 로고    scopus 로고
    • In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl) cytosine in woodchuck hepatitis virus-infected woodchucks
    • Cullen, J. M., Smith, S. L., Davis, M. G., Dunn, S. E., Botteron, C., Cecchi, A. et al. (1997). In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl) cytosine in woodchuck hepatitis virus-infected woodchucks. Antimicrobial Agents and Chemotherapy 41, 2076-82.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , pp. 2076-2082
    • Cullen, J.M.1    Smith, S.L.2    Davis, M.G.3    Dunn, S.E.4    Botteron, C.5    Cecchi, A.6
  • 219
    • 0036093269 scopus 로고    scopus 로고
    • Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection
    • Gish, R. G., Leung, N. W., Wright, T. L., Trinh, H., Lang, W., Kessler, H. A. et al. (2002). Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrobial Agents and Chemotherapy 46, 1734-40.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 1734-1740
    • Gish, R.G.1    Leung, N.W.2    Wright, T.L.3    Trinh, H.4    Lang, W.5    Kessler, H.A.6
  • 220
    • 0031974697 scopus 로고    scopus 로고
    • The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues
    • Ladner, S. K., Miller, T. J., Otto, M. J. & King, R. W. (1998). The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues. Antiviral Chemistry and Chemotherapy 9, 65-72.
    • (1998) Antiviral Chemistry and Chemotherapy , vol.9 , pp. 65-72
    • Ladner, S.K.1    Miller, T.J.2    Otto, M.J.3    King, R.W.4
  • 221
    • 0029799423 scopus 로고    scopus 로고
    • Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(-)-beta-L-2′, 3′-dideoxy-3′-thiacytidine] in vitro
    • Fischer, K. P. & Tyrrell, D. L. (1996). Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(-)-beta-L-2′, 3′-dideoxy-3′-thiacytidine] in vitro. Antimicrobial Agents and Chemotherapy 40, 1957-60.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 1957-1960
    • Fischer, K.P.1    Tyrrell, D.L.2
  • 223
    • 0030061482 scopus 로고    scopus 로고
    • Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients
    • Gish, R. G., Lau, J. Y., Brooks, L., Fang, J. W., Steady, S. L., Imperial, J. C. et al. (1996). Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients. Hepatology 23, 1-7.
    • (1996) Hepatology , vol.23 , pp. 1-7
    • Gish, R.G.1    Lau, J.Y.2    Brooks, L.3    Fang, J.W.4    Steady, S.L.5    Imperial, J.C.6
  • 224
    • 0032789959 scopus 로고    scopus 로고
    • Oral ganciclovir treatment in chronic hepatitis B virus infection: A pilot study
    • Hadziyannis, S. J., Manesis, E. K. & Papakonstantinou, A. (1999). Oral ganciclovir treatment in chronic hepatitis B virus infection: a pilot study. Journal of Hepatology 31, 210-4.
    • (1999) Journal of Hepatology , vol.31 , pp. 210-214
    • Hadziyannis, S.J.1    Manesis, E.K.2    Papakonstantinou, A.3
  • 225
    • 0028111969 scopus 로고
    • Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy
    • Luscombe, C., Pedersen, J., Bowden, S. & Locarnini, S. (1994). Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy. Liver 14, 182-92.
    • (1994) Liver , vol.14 , pp. 182-192
    • Luscombe, C.1    Pedersen, J.2    Bowden, S.3    Locarnini, S.4
  • 226
    • 0029786431 scopus 로고    scopus 로고
    • Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: Effect on intrahepatic-viral DNA, RNA, and protein expression
    • Luscombe, C., Pedersen, J., Uren, E. & Locarnini, S. (1996). Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: effect on intrahepatic-viral DNA, RNA, and protein expression. Hepatology 24, 766-73.
    • (1996) Hepatology , vol.24 , pp. 766-773
    • Luscombe, C.1    Pedersen, J.2    Uren, E.3    Locarnini, S.4
  • 227
    • 0028088920 scopus 로고
    • The in vitro anti-hepatitis B virus activity of FIAU [1-(2′-deoxy-2′fluoro-1-[beta]-D-arabinofuranosyl-5-iodo) uracil] is selective, reversible, and determined, at least in part, by the host cell
    • Statschke, K., Colacino, J., Mabry, T. & Jones, C. (1994). The in vitro anti-hepatitis B virus activity of FIAU [1-(2′-deoxy-2′fluoro-1-[beta]-D-arabinofuranosyl-5-iodo) uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Research 23, 45-61.
    • (1994) Antiviral Research , vol.23 , pp. 45-61
    • Statschke, K.1    Colacino, J.2    Mabry, T.3    Jones, C.4
  • 228
    • 0028606525 scopus 로고
    • Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU triphosphate
    • Lewis, W., Meyer, R. R., Simpson, J. F., Colacino, J. M. & Perrino, F. W. (1994). Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU triphosphate. Biochemistry 33, 14620-4.
    • (1994) Biochemistry , vol.33 , pp. 14620-14624
    • Lewis, W.1    Meyer, R.R.2    Simpson, J.F.3    Colacino, J.M.4    Perrino, F.W.5
  • 229
    • 0028861575 scopus 로고
    • Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells
    • Cui, L., Yoon, S., Schinazi, R. F. & Sommadossi, J. P. (1995). Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells. Journal of Clinical Investigation 95, 555-63.
    • (1995) Journal of Clinical Investigation , vol.95 , pp. 555-563
    • Cui, L.1    Yoon, S.2    Schinazi, R.F.3    Sommadossi, J.P.4
  • 230
    • 0028817865 scopus 로고
    • Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
    • McKenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., Di Bisceglie, A. M., Park, Y. et al. (1995). Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. New England Journal of Medicine 333, 1099-105.
    • (1995) New England Journal of Medicine , vol.333 , pp. 1099-1105
    • McKenzie, R.1    Fried, M.W.2    Sallie, R.3    Conjeevaram, H.4    Di Bisceglie, A.M.5    Park, Y.6
  • 231
    • 0034491961 scopus 로고    scopus 로고
    • Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection
    • Genovesi, E. V., Lamb, L., Medina, I., Taylor, D., Seifer, M., Innaimo, S. et al. (2000). Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection. Antiviral Research 48, 197-203.
    • (2000) Antiviral Research , vol.48 , pp. 197-203
    • Genovesi, E.V.1    Lamb, L.2    Medina, I.3    Taylor, D.4    Seifer, M.5    Innaimo, S.6
  • 232
    • 0030032079 scopus 로고    scopus 로고
    • 2′,3′-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo
    • Zoulim, F., Dannaoui, E., Borel, C., Hantz, O., Lin, T. S., Liu, S. H. et al. (1996). 2′,3′-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo. Antimicrobial Agents and Chemotherapy 40, 448-53.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 448-453
    • Zoulim, F.1    Dannaoui, E.2    Borel, C.3    Hantz, O.4    Lin, T.S.5    Liu, S.H.6
  • 234
    • 0035196639 scopus 로고    scopus 로고
    • Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)
    • Peek, S. F., Cote, P. J., Jacob, J. R., Toshkov, I. A., Hornbuckle, W. E., Baldwin, B. H. et al. (2001). Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax). Hepatology 33, 254-66.
    • (2001) Hepatology , vol.33 , pp. 254-266
    • Peek, S.F.1    Cote, P.J.2    Jacob, J.R.3    Toshkov, I.A.4    Hornbuckle, W.E.5    Baldwin, B.H.6
  • 237
    • 0035991969 scopus 로고    scopus 로고
    • Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus
    • Ono-Nita, S. K., Kato, N., Shiratori, Y., Carrilho, F. J. & Omata, M. (2002). Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrobial Agents and Chemotherapy 46, 2602-5.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 2602-2605
    • Ono-Nita, S.K.1    Kato, N.2    Shiratori, Y.3    Carrilho, F.J.4    Omata, M.5
  • 240
    • 0036096201 scopus 로고    scopus 로고
    • Pharmacology of beta-L-thymidine and beta-L-2′-deoxycytidine in HepG2 cells and primary human hepatocytes: Relevance to chemotherapeutic efficacy against hepatitis B virus
    • Hernandez-Santiago, B., Placidi, L., Cretton-Scott, E., Faraj, A., Bridges, E. G., Bryant, M. L. et al. (2002). Pharmacology of beta-L-thymidine and beta-L-2′-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus. Antimicrobial Agents and Chemotherapy 46, 1728-33.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 1728-1733
    • Hernandez-Santiago, B.1    Placidi, L.2    Cretton-Scott, E.3    Faraj, A.4    Bridges, E.G.5    Bryant, M.L.6
  • 241
    • 0037414988 scopus 로고    scopus 로고
    • An open-label study of tenofovir in HIV-1 and hepatitis B virus co-infected individuals
    • Nelson, M., Portsmouth, S., Stebbing, J., Atkins, M., Barr, A., Matthews, G. et al. (2003). An open-label study of tenofovir in HIV-1 and hepatitis B virus co-infected individuals. AIDS 17, F7-F10.
    • (2003) AIDS , vol.17
    • Nelson, M.1    Portsmouth, S.2    Stebbing, J.3    Atkins, M.4    Barr, A.5    Matthews, G.6
  • 242
    • 0037115019 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed
    • Ristig, M. B., Crippin, J., Aberg, J. A., Powderly, W. G., Lisker Melman, M., Kessels, L. et al. (2002). Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed. Journal of Infectious Diseases 186, 1844-7.
    • (2002) Journal of Infectious Diseases , vol.186 , pp. 1844-1847
    • Ristig, M.B.1    Crippin, J.2    Aberg, J.A.3    Powderly, W.G.4    Lisker-Melman, M.5    Kessels, L.6
  • 243
    • 0036324405 scopus 로고    scopus 로고
    • Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication
    • van Bommel, F., Wunsche, T., Schurmann, D. & Berg, T. (2002). Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication. Hepatology 36, 507-8.
    • (2002) Hepatology , vol.36 , pp. 507-508
    • van Bommel, F.1    Wunsche, T.2    Schurmann, D.3    Berg, T.4
  • 244
    • 0034843958 scopus 로고    scopus 로고
    • Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial
    • Barbaro, G., Zechini, F., Pellicelli, A. M., Francavilla, R., Scotto, G., Bacca, D. et al. (2001). Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial. Journal of Hepatology 35, 406-11.
    • (2001) Journal of Hepatology , vol.35 , pp. 406-411
    • Barbaro, G.1    Zechini, F.2    Pellicelli, A.M.3    Francavilla, R.4    Scotto, G.5    Bacca, D.6
  • 245
    • 0033868988 scopus 로고    scopus 로고
    • Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks
    • Korba, B. E., Cote, P., Hombuckle, W., Schinazi, R., Gangemi, J. D., Tennant, B. C. et al. (2000). Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks. Antiviral Therapy 5, 95-104.
    • (2000) Antiviral Therapy , vol.5 , pp. 95-104
    • Korba, B.E.1    Cote, P.2    Hombuckle, W.3    Schinazi, R.4    Gangemi, J.D.5    Tennant, B.C.6
  • 246
    • 0032101831 scopus 로고    scopus 로고
    • Combination alpha-interferon and lamivudine therapy for alpha-interferon-resistant chronic hepatitis B infection: Results of a pilot study
    • Mutimer, D., Naoumov, N., Honkoop, P., Marinos, G., Ahmed, M., de Man, R. et al. (1998). Combination alpha-interferon and lamivudine therapy for alpha-interferon-resistant chronic hepatitis B infection: results of a pilot study. Journal of Hepatology 28, 923-9.
    • (1998) Journal of Hepatology , vol.28 , pp. 923-929
    • Mutimer, D.1    Naoumov, N.2    Honkoop, P.3    Marinos, G.4    Ahmed, M.5    de Man, R.6
  • 247
    • 0031753523 scopus 로고    scopus 로고
    • Combination therapy with famciclovir and interferon-alpha for the treatment of chronic hepatitis B
    • Marques, A. R., Lau, D. T., McKenzie, R., Straus, S. E. & Hoofnagle, J. H. (1998). Combination therapy with famciclovir and interferon-alpha for the treatment of chronic hepatitis B. Journal of Infectious Diseases 178, 1483-7.
    • (1998) Journal of Infectious Diseases , vol.178 , pp. 1483-1487
    • Marques, A.R.1    Lau, D.T.2    McKenzie, R.3    Straus, S.E.4    Hoofnagle, J.H.5
  • 248
    • 0033854069 scopus 로고    scopus 로고
    • Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: A viral dynamics study
    • Lau, G. K., Tsiang, M., Hou, J., Yuen, S., Carman, W. F., Zhang, L. et al. (2000). Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: a viral dynamics study. Hepatology 32, 394-9.
    • (2000) Hepatology , vol.32 , pp. 394-399
    • Lau, G.K.1    Tsiang, M.2    Hou, J.3    Yuen, S.4    Carman, W.F.5    Zhang, L.6
  • 249
    • 0030926706 scopus 로고    scopus 로고
    • Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro
    • Colledge, D., Locarnini, S. & Shaw, T. (1997). Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology 26, 216-25.
    • (1997) Hepatology , vol.26 , pp. 216-225
    • Colledge, D.1    Locarnini, S.2    Shaw, T.3
  • 250
    • 0033955317 scopus 로고    scopus 로고
    • Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks
    • Korba, B. E., Cote, P., Hornbuckle, W., Schinazi, R., Gerin, J. L. & Tennant, B. C. (2000). Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks. Antiviral Research 45, 19-32.
    • (2000) Antiviral Research , vol.45 , pp. 19-32
    • Korba, B.E.1    Cote, P.2    Hornbuckle, W.3    Schinazi, R.4    Gerin, J.L.5    Tennant, B.C.6
  • 251
    • 0033999389 scopus 로고    scopus 로고
    • In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir
    • Colledge, D., Civitico, G., Locarnini, S. & Shaw, T. (2000). In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir. Antimicrobial Agents and Chemotherapy 44, 551-60.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 551-560
    • Colledge, D.1    Civitico, G.2    Locarnini, S.3    Shaw, T.4
  • 252
    • 0035990778 scopus 로고    scopus 로고
    • Lamivudine and famciclovir combination therapy with or without addition of interferon-alpha-2b for HBeAg-positive chronic hepatitis B: A pilot study
    • Sangfelt, P., Uhnoo, I., Hollander, A., Lindh, G. & Weiland, O. (2002). Lamivudine and famciclovir combination therapy with or without addition of interferon-alpha-2b for HBeAg-positive chronic hepatitis B: a pilot study. Scandinavian Journal of Infectious Diseases 34, 505-11.
    • (2002) Scandinavian Journal of Infectious Diseases , vol.34 , pp. 505-511
    • Sangfelt, P.1    Uhnoo, I.2    Hollander, A.3    Lindh, G.4    Weiland, O.5
  • 253
    • 0343145656 scopus 로고    scopus 로고
    • Placebo-controlled trial of vaccination with hepatitis B virus surface antigen in hepatitis B virus transgenic mice
    • Akbar, S. M., Kajino, K., Tanimoto, K., Kurose, K., Masumoto, T., Michitaka, K. et al. (1997). Placebo-controlled trial of vaccination with hepatitis B virus surface antigen in hepatitis B virus transgenic mice. Journal of Hepatology 26, 131-7.
    • (1997) Journal of Hepatology , vol.26 , pp. 131-137
    • Akbar, S.M.1    Kajino, K.2    Tanimoto, K.3    Kurose, K.4    Masumoto, T.5    Michitaka, K.6
  • 254
    • 0027446378 scopus 로고
    • Induction of anti-hepatitis B surface antigen (HBsAg) antibodies in HBsAg producing transgenic mice: A possible way of circumventing 'nonresponse'to HBsAg
    • Mancini, M., Hadchouel, M., Tiollais, P., Pourcel, C. & Michel, M. L. (1993). Induction of anti-hepatitis B surface antigen (HBsAg) antibodies in HBsAg producing transgenic mice: a possible way of circumventing 'nonresponse'to HBsAg. Journal of Medical Virology 39, 67-74.
    • (1993) Journal of Medical Virology , vol.39 , pp. 67-74
    • Mancini, M.1    Hadchouel, M.2    Tiollais, P.3    Pourcel, C.4    Michel, M.L.5
  • 256
    • 0029047836 scopus 로고
    • Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy
    • Wen, Y. M., Wu, X. H., Hu, D. C., Zhang, Q. P. & Guo, S. Q. (1995). Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy. Lancet 345, 1575-6.
    • (1995) Lancet , vol.345 , pp. 1575-1576
    • Wen, Y.M.1    Wu, X.H.2    Hu, D.C.3    Zhang, Q.P.4    Guo, S.Q.5
  • 257
  • 258
    • 0033575487 scopus 로고    scopus 로고
    • A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant
    • Heineman, T. C., Clements-Mann, M. L., Poland, G. A., Jacobson, R. M., Izu, A. E., Sakamoto, D. et al. (1999). A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant. Vaccine 17, 2769-78.
    • (1999) Vaccine , vol.17 , pp. 2769-2778
    • Heineman, T.C.1    Clements-Mann, M.L.2    Poland, G.A.3    Jacobson, R.M.4    Izu, A.E.5    Sakamoto, D.6
  • 259
    • 0001085330 scopus 로고    scopus 로고
    • Phase 1 study of a potent adjuvanted hepatitis B vaccine (HBV/MF59) for therapy of chronic hepatitis
    • Wright, T. L., Tong, M. J. & Hsu, H. H. (1999). Phase 1 study of a potent adjuvanted hepatitis B vaccine (HBV/MF59) for therapy of chronic hepatitis. Hepatology 30, 421A.
    • (1999) Hepatology , vol.30
    • Wright, T.L.1    Tong, M.J.2    Hsu, H.H.3
  • 260
  • 261
    • 0034991493 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-transgenic mice
    • Malanchere-Bres, E., Payette, P. J., Mancini, M., Tiollais, P., Davis, H. L. & Michel, M. L. (2001). CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-transgenic mice. Journal of Virology 75, 6482-91.
    • (2001) Journal of Virology , vol.75 , pp. 6482-6491
    • Malanchere-Bres, E.1    Payette, P.J.2    Mancini, M.3    Tiollais, P.4    Davis, H.L.5    Michel, M.L.6
  • 263
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus
    • The CY1899 T Cell Vaccine Study Group
    • Heathcote, J., McHutchison, J., Lee, S., Tong, M., Benner, K., Minuk, G. et al. (1999). A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group. Hepatology 30, 531-6.
    • (1999) Hepatology , vol.30 , pp. 531-536
    • Heathcote, J.1    McHutchison, J.2    Lee, S.3    Tong, M.4    Benner, K.5    Minuk, G.6
  • 265
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • Davis, H. L., Michel, M. L. & Whalen, R. G. (1993). DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Molecular Genetics 2, 1847-51.
    • (1993) Human Molecular Genetics , vol.2 , pp. 1847-1851
    • Davis, H.L.1    Michel, M.L.2    Whalen, R.G.3
  • 266
    • 0029051321 scopus 로고
    • DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
    • Michel, M. L., Davis, H. L., Schleef, M., Mancini, M., Tiollais, P. & Whalen, R. G. (1995). DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proceedings of the National Academy of Sciences, USA 92, 5307-11.
    • (1995) Proceedings of the National Academy of Sciences, USA , vol.92 , pp. 5307-5311
    • Michel, M.L.1    Davis, H.L.2    Schleef, M.3    Mancini, M.4    Tiollais, P.5    Whalen, R.G.6
  • 268
    • 0035014396 scopus 로고    scopus 로고
    • Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice
    • Oka, Y., Akbar, S. M., Horiike, N., Joko, K. & Onji, M. (2001). Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology 103, 90-7.
    • (2001) Immunology , vol.103 , pp. 90-97
    • Oka, Y.1    Akbar, S.M.2    Horiike, N.3    Joko, K.4    Onji, M.5
  • 269
    • 0032534059 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization
    • Mancini, M., Hadchouel, M., Tiollais, P. & Michel, M. L. (1998). Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization. Journal of Immunology 161, 5564-70.
    • (1998) Journal of Immunology , vol.161 , pp. 5564-5570
    • Mancini, M.1    Hadchouel, M.2    Tiollais, P.3    Michel, M.L.4
  • 270
    • 0033120573 scopus 로고    scopus 로고
    • Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes
    • Ishioka, G. Y., Fikes, J., Hermanson, G., Livingston, B., Crimi, C., Qin, M. et al. (1999). Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes. Journal of Immunology 162, 3915-25.
    • (1999) Journal of Immunology , vol.162 , pp. 3915-3925
    • Ishioka, G.Y.1    Fikes, J.2    Hermanson, G.3    Livingston, B.4    Crimi, C.5    Qin, M.6
  • 271
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow, Y. H., Huang, W. L., Chi, W. K., Chu, Y. D. & Tao, M. H. (1997). Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. Journal of Virology 71, 169-78.
    • (1997) Journal of Virology , vol.71 , pp. 169-178
    • Chow, Y.H.1    Huang, W.L.2    Chi, W.K.3    Chu, Y.D.4    Tao, M.H.5
  • 272
  • 273
    • 0033042313 scopus 로고    scopus 로고
    • Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein
    • Rollier, C., Sunyach, C., Barraud, L., Madani, N., Jamard, C., Trepo, C. et al. (1999). Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein. Gastroenterology 116, 658-65.
    • (1999) Gastroenterology , vol.116 , pp. 658-665
    • Rollier, C.1    Sunyach, C.2    Barraud, L.3    Madani, N.4    Jamard, C.5    Trepo, C.6
  • 275
    • 7144256527 scopus 로고    scopus 로고
    • Immune response to a hepatitis B DNA vaccine in Aotus monkeys: A comparison of vaccine formulation, route, and method of administration
    • Gramzinski, R. A., Millan, C. L., Obaldia, N., Hoffman, S. L. & Davis, H. L. (1998). Immune response to a hepatitis B DNA vaccine in Aotus monkeys: a comparison of vaccine formulation, route, and method of administration. Molecular Medicine 4, 109-18.
    • (1998) Molecular Medicine , vol.4 , pp. 109-118
    • Gramzinski, R.A.1    Millan, C.L.2    Obaldia, N.3    Hoffman, S.L.4    Davis, H.L.5
  • 276
    • 0030752483 scopus 로고    scopus 로고
    • Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus
    • Prince, A. M., Whalen, R. & Brotman, B. (1997). Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine 15, 916-9.
    • (1997) Vaccine , vol.15 , pp. 916-919
    • Prince, A.M.1    Whalen, R.2    Brotman, B.3
  • 277
    • 0035140812 scopus 로고    scopus 로고
    • DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee
    • Pancholi, P., Lee, D. H., Liu, Q., Tackney, C., Taylor, P., Perkus, M. et al. (2001). DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee. Hepatology 33, 448-54.
    • (2001) Hepatology , vol.33 , pp. 448-454
    • Pancholi, P.1    Lee, D.H.2    Liu, Q.3    Tackney, C.4    Taylor, P.5    Perkus, M.6
  • 278
    • 17344369213 scopus 로고    scopus 로고
    • Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen
    • Sallberg, M., Hughes, J., Javadian, A., Ronlov, G., Hultgren, C., Townsend, K. et al. (1998). Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen. Human Gene Therapy 9, 1719-29.
    • (1998) Human Gene Therapy , vol.9 , pp. 1719-1729
    • Sallberg, M.1    Hughes, J.2    Javadian, A.3    Ronlov, G.4    Hultgren, C.5    Townsend, K.6
  • 279
    • 0034703836 scopus 로고    scopus 로고
    • Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine
    • Roy, M. J., Wu, M. S., Barr, L. J., Fuller, J. T., Tussey, L. G., Speller, S. et al. (2000). Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine 19, 764-78.
    • (2000) Vaccine , vol.19 , pp. 764-778
    • Roy, M.J.1    Wu, M.S.2    Barr, L.J.3    Fuller, J.T.4    Tussey, L.G.5    Speller, S.6
  • 280
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner, R. W. (1994). Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333-5.
    • (1994) Nature , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 281
    • 0023921083 scopus 로고
    • Oligodeoxynucleotides as inhibitors of gene expression: A review
    • Stein, C. A. & Cohen, J. S. (1988). Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Research 48, 2659-68.
    • (1988) Cancer Research , vol.48 , pp. 2659-2668
    • Stein, C.A.1    Cohen, J.S.2
  • 282
    • 84920215637 scopus 로고
    • Inhibition of hepatitis B virus by antisense oligodeoxynucleotides
    • Blum, H. E., Galun, E., von Weizsacker, F. & Wands, J. R. (1991). Inhibition of hepatitis B virus by antisense oligodeoxynucleotides. Lancet 337, 1230.
    • (1991) Lancet , vol.337 , pp. 1230
    • Blum, H.E.1    Galun, E.2    von Weizsacker, F.3    Wands, J.R.4
  • 283
    • 0029437494 scopus 로고
    • Inhibition of hepatitis B viral gene expression by antisense phosphorothioate oligodeoxynucleotides
    • Yao, Z. Q., Zhou, Y. X., Wang, A. L., Bai, X. F. & Yang, W. S. (1995). Inhibition of hepatitis B viral gene expression by antisense phosphorothioate oligodeoxynucleotides. Journal of Viral Hepatitis 2, 85-9.
    • (1995) Journal of Viral Hepatitis , vol.2 , pp. 85-89
    • Yao, Z.Q.1    Zhou, Y.X.2    Wang, A.L.3    Bai, X.F.4    Yang, W.S.5
  • 284
    • 0028840837 scopus 로고
    • Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro
    • Korba, B. E. & Gerin, J. L. (1995). Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro. Antiviral Research 28, 225-42.
    • (1995) Antiviral Research , vol.28 , pp. 225-242
    • Korba, B.E.1    Gerin, J.L.2
  • 285
    • 0029898537 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro
    • Nakazono, K., Ito, Y., Wu, C. H. & Wu, G. Y. (1996). Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro. Hepatology 23, 1297-303.
    • (1996) Hepatology , vol.23 , pp. 1297-1303
    • Nakazono, K.1    Ito, Y.2    Wu, C.H.3    Wu, G.Y.4
  • 287
    • 0029792310 scopus 로고    scopus 로고
    • Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian liver cells
    • Madon, J. & Blum, H. E. (1996). Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian liver cells. Hepatology 24, 474-81.
    • (1996) Hepatology , vol.24 , pp. 474-481
    • Madon, J.1    Blum, H.E.2
  • 289
    • 0031786508 scopus 로고    scopus 로고
    • Biodistribution, stability, and antiviral efficacy of liposome-entrapped phosphorothioate antisense oligodeoxynucleotides in ducks for the treatment of chronic duck hepatitis B virus infection
    • Soni, P. N., Brown, D., Saffie, R., Savage, K., Moore, D., Gregoriadis, G. et al. (1998). Biodistribution, stability, and antiviral efficacy of liposome-entrapped phosphorothioate antisense oligodeoxynucleotides in ducks for the treatment of chronic duck hepatitis B virus infection. Hepatology 28, 1402-10.
    • (1998) Hepatology , vol.28 , pp. 1402-1410
    • Soni, P.N.1    Brown, D.2    Saffie, R.3    Savage, K.4    Moore, D.5    Gregoriadis, G.6
  • 290
    • 0034968241 scopus 로고    scopus 로고
    • Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver
    • Robaczewska, M., Guerret, S., Remy, J. S., Chemin, I., Offensperger, W. B., Chevallier, M. et al. (2001). Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver. Gene Therapy 8, 874-81.
    • (2001) Gene Therapy , vol.8 , pp. 874-881
    • Robaczewska, M.1    Guerret, S.2    Remy, J.S.3    Chemin, I.4    Offensperger, W.B.5    Chevallier, M.6
  • 291
    • 0034708334 scopus 로고    scopus 로고
    • Structure and function of the hairpin ribozyme
    • Fedor, M. J. (2000). Structure and function of the hairpin ribozyme. Journal of Molecular Biology 297, 269-91.
    • (2000) Journal of Molecular Biology , vol.297 , pp. 269-291
    • Fedor, M.J.1
  • 293
    • 0029586990 scopus 로고
    • Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells
    • Beck, J. & Nassal, M. (1995). Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells. Nucleic Acids Research 23, 4954-62.
    • (1995) Nucleic Acids Research , vol.23 , pp. 4954-4962
    • Beck, J.1    Nassal, M.2
  • 294
    • 0030743739 scopus 로고    scopus 로고
    • Intracellular application of hairpin ribozyme genes against hepatitis B virus
    • Welch, P. J., Tritz, R., Yei, S., Barber, J. & Yu, M. (1997). Intracellular application of hairpin ribozyme genes against hepatitis B virus. Gene Therapy 4, 736-43.
    • (1997) Gene Therapy , vol.4 , pp. 736-743
    • Welch, P.J.1    Tritz, R.2    Yei, S.3    Barber, J.4    Yu, M.5
  • 295
    • 0033022041 scopus 로고    scopus 로고
    • Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus
    • zu Putlitz, J., Yu, Q., Burke, J. M. & Wands, J. R. (1999). Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus. Journal of Virology 73, 5381-7.
    • (1999) Journal of Virology , vol.73 , pp. 5381-5387
    • zu Putlitz, J.1    Yu, Q.2    Burke, J.M.3    Wands, J.R.4
  • 297
    • 0034708165 scopus 로고    scopus 로고
    • In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells
    • Passman, M., Weinberg, M., Kew, M. & Arbuthnot, P. (2000). In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells. Biochemical and Biophysical Research Communications 268, 728-33.
    • (2000) Biochemical and Biophysical Research Communications , vol.268 , pp. 728-733
    • Passman, M.1    Weinberg, M.2    Kew, M.3    Arbuthnot, P.4
  • 298
    • 0033917919 scopus 로고    scopus 로고
    • Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells
    • Weinberg, M., Passman, M., Kew, M. & Arbuthnot, P. (2000). Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells. Journal of Hepatology 33, 142-51.
    • (2000) Journal of Hepatology , vol.33 , pp. 142-151
    • Weinberg, M.1    Passman, M.2    Kew, M.3    Arbuthnot, P.4
  • 299
    • 0029953004 scopus 로고    scopus 로고
    • Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents
    • Scaglioni, P., Melegari, M., Takahashi, M., Chowdhury, J. R. & Wands, J. (1996). Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents. Hepatology 24, 1010-7.
    • (1996) Hepatology , vol.24 , pp. 1010-1017
    • Scaglioni, P.1    Melegari, M.2    Takahashi, M.3    Chowdhury, J.R.4    Wands, J.5
  • 300
    • 0035807251 scopus 로고    scopus 로고
    • Peptide aptamers targeting the hepatitis B virus core protein: A new class of molecules with antiviral activity
    • Butz, K., Denk, C., Fitscher, B., Crnkovic-Mertens, I., Ullmann, A., Schroder, C. H. et al. (2001). Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity. Oncogene 20, 6579-86.
    • (2001) Oncogene , vol.20 , pp. 6579-6586
    • Butz, K.1    Denk, C.2    Fitscher, B.3    Crnkovic-Mertens, I.4    Ullmann, A.5    Schroder, C.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.