Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 6, 2000, Pages 1757-1760

  Korba, Brent E ^a   Schinazi, R F ^b   Cote, Paul ^a   Tennant, Bud C ^c   Gerin, John L ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMTRICITABINE; LAMIVUDINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; HEPATITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION; WOODCHUCK;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; DEOXYCYTIDINE; HEPATITIS B; HEPATITIS B VIRUS, WOODCHUCK; MARMOTA; VIRUS REPLICATION;

EID: 0034089899     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.6.1757-1760.2000     Document Type: Article

References (21)

1. Abobo, C. V., L. Ni, R. F. Schinazi, D. C. Liotta, and F. D. Boudinot. 1994. Pharmacokinetics of 2′,3′-dideoxy-5-fluoro-3′-thiacytidine in rats. J. Pharm. Sci. 83:96-99.
2. Cote, P. J., C. Roneker, K. Cass, F. Schodel, D. Peterson, B. Tennant, F. DeNoronha, and J. L. Gerin. 1993. New enzyme immunoassays for the serologic detection of woodchuck hepatitis virus infection. Viral Immunol. 6:161-169.
3. Cullen, J. M., S. L. Smith, M. G. Davis, S. E. Dunn, C. Botteron, A. Cecchi, D. Linsey, D. Linzey, L. Frick, M. T. Paff, A. Goulding, and K. Biron. 1997. In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks. Antimicrob. Agents Chemother. 41:2076-2082.
4. Davis, M. G., and R. W. Jansen. 1994. Inhibition of hepatitis B virus in tissue culture by alpha interferon. Antimicrob. Agents Chemother. 38:2921-2924.
5. Furman, P. A., M. Davis, D. C. Liotta, M. Paff, L. W. Frick, D. J. Nelson, R. E. Dornsife, J. A. Wurster, L. J. Wilson, J. A. Fyfe, J. V. Tuttle, W. H. Miller, L. Condreny, D. R. Averett, R. F. Schinazi, and G. R. Painter. 1992. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob. Agents Chemother. 36:2686-2692.
6. Ganem, D. 1996. Hepadnaviridae: the viruses and their replication, p. 2703-2737. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
7. Gerin, J. L. 1990. Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer. Gastroenterol. Jpn. 25(Suppl.): 38-42.
8. Gosselin, G., R. F. Schinazi, J.-P. Sommadossi, C. Mathé, M.-C. Bergogne, A.-M. Aubertin, A. Kirn, and J.-L. Imbach. 1994. Anti-human immunodeficiency virus activities of the β-L enantiomer of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro. Antimicrob. Agents Chemother. 38:1292-1297.
9. Hurwitz, S. J., B. C. Tennant, B. E. Korba, J. L. Gerin, and R. F. Schinazi. 1998. Viral pharmacodynamics of (-)-β-2′,3′-dideoxy-3′-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans. Antimicrob. Agents Chemother. 42:2804-2809.
10. Korba, B., B. Baldwin, W. Hornbuckle, P. Cote, B. Tennant, and J. Gerin. Treatment of chronic WHV infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in man. Hepatology, in press.
11. Korba, B. E., F. Wells, B. C. Tennant, G. H. Yoakum, R. H. Purcell, and J. L. Gerin. 1986. Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis. J. Virol. 58:1-8.
12. Mason, W. S., J. Cullen, G. Moraleda, J. Saputelli, C. E. Aldrich, D. S. Miller, B. Tennant, L. Frick, D. Averett, L. D. Condreay, and A. R. Jilbert. 1998. Lamivudine therapy of WHV-infected woodchucks. Virology 245:18-32.
13. Moraleda, G., J. Saputelli, C. E. Aldrich, D. Averett, L. Condreay, and W. S. Mason. 1997. Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus. J. Virol. 71:9392-9399.
14. National Academy of Sciences. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, D.C.
15. Ponzetto, A., P. J. Cote, E. C. Ford, R. H. Purcell, and J. L. Gerin. 1984. Core antigen and antibody in woodchucks after infection with woodchuck hepatitis virus. J. Virol. 52:70-76.
16. Rajagopalan, P., F. D. Boudinot, C. K. Chu, B. C. Tennant, B. H. Baldwin, and R. F. Schinazi. 1996. Pharmacokinetics of (-)-2′-3′-dideoxy-3′-thiacytidine in woodchucks. Antimicrob. Agents Chemother. 40:642-645.
17. Schinazi, R. F., F. D. Boudinot, S. S. Ibrahim, C. Manning, H. M. McClure, and D. C. Liotta. 1992. Pharmacokinetics and metabolism of racemic 2′,3′-dideoxy-5-fluoro-3′-thiacytidine in rhesus monkeys. Antimicrob. Agents Chemother. 36:2432-2438.
18. Schinazi, R. F., G. Gosselin, A. Faraj, B. E. Korba, D. C. Liotta, C. K. Chu, C. Mathé, J.-L. Imbach, and J.-P. Sommadossi. 1994. Pure nucleoside enantiomers of β-2′,3′-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro. Antimicrob. Agents Chemother. 38:2172-2174.
19. Tennant, B., and J. Gerin. 1994. The woodchuck model of hepatitis B infection, p. 1455-1466. In I. Arias, J. Boyer, N. Fausto, W. Jacoby, D. Schachter, and D. Shafritz (ed.), The liver: biology and pathobiology. Raven Press, New York, N.Y.
20. Tennant, B. C., B. H. Baldwin, L. A. Graham, M. A. Ascenzi, W. E. Hornbuckle, P. H. Rowland, I. A. Tochkov, A. E. Yeager, H. N. Erb, J. M. Colacino, C. Lopez, J. A. Engelhardt, R. R. Bowsher, F. C. Richardson, W. Lewis, P. J. Cote, B. E. Korba, and J. L. Gerin. 1998. Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. Hepatology 28:179-191.
21. Tennant, B. C., W. E. Hornbuckle, B. H. Baldwin, J. M. King, P. Cote, H. Popper, R. H. Purcell, and J. L. Gerin. 1988. Influence of age on the response to experimental woodchuck hepatitis virus infection, p. 462-464. In A. J. Zuckerman (ed.), Viral hepatitis liver disease. Alan R. Liss, Inc., New York, N.Y.