Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B

Journal of Hepatology

Volumn 25, Issue 6, 1996, Pages 803-813

  Krogsgaard, Kim ^f   Marcellin, Patrick ^p   Trepo, Christian ^p   Berthelot, Pierre ^p   Sanchez Tapias, José M ^p   Bassendine, Maggie ^p   Tran, Albert ^p   Ouzan, Denis ^p   Ring Larsen, Helmer ^a   Lindberg, Johan ^p   Enriquez, Jaime ^p   Benhamou, Jean Pierre ^c,d,e   Bindslev, Niels ^b   Bertet, S ^g   Boyer, N ^c   Brind, A ^h   Civeira, M P ⁱ   Housset, C ^e   Lund Laursen, A ^j   Mas, A ^k   Pol, S ^e   Prieto, J ⁱ   Quedens, J ^l   Rampal, P ^m   Schlichting, P ^l   Soriano, G ⁿ   Spacey, B E M ^o   Hawley, S ^o   Brand, C ^o   Howe, I ^o   more..

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BEAUJON HOSPITAL   (France)

^d HÔTEL DIEU   (France)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

^f The Capital Region   (Denmark)

^g INSTITUT ARNAULT TZANCK   (France)

^h FREEMAN HOSPITAL   (United Kingdom)

ⁱ UNIVERSITY CLINIC OF NAVARRA   (Spain)

^j AARHUS UNIVERSITY HOSPITAL   (Denmark)

^k HOSPITAL CLÍNIC   (Spain)

^l FREDERIKSBERG HOSPITAL   (Denmark)

^m CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

ⁿ HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^o WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^p NONE

more..

Author keywords

Chronic hepatitis B; Lymphoblastoid interferon; Prednisolone withdrawal therapy

Indexed keywords

ALPHAN1 INTERFERON; HEPATITIS B SURFACE ANTIGEN; LYMPHOBLAST INTERFERON; PLACEBO; PREDNISOLONE; VIRUS DNA;

ARTICLE; CHRONIC HEPATITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROCONVERSION; SURVIVAL;

EID: 8044234957     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80282-0     Document Type: Article

References (27)

1. 1. Hoofnagle JH, Peters M, Mullen KD, Brian Jones D, Rustgi V, Di Bisceglie A, Hallahan C, Park Y, Meschievitz C, Anthony Jones E. Randomized, controlled trial of recombinant human alpha interferon in patients with chronic hepatitis B. Gastroenterology 1988; 95: 1318-25.
2. 2. Brook MG, McDonald JA, Karayiannis P, Caruso L, Forster G, Harris JRW, Thomas HC et al. Randomised controlled trial of interferon alpha 2A (rbe) (Roferon-A) for the treatment of chronic hepatitis B virus (HBV) infection: factors that influence response. Gut 1989; 30: 1116-22.
3. 3. Saracco G, Mazzella G, Rosina F, Cancellieri C, Lattore V, Raise E, Rocca G, Giorda L, Verme G, Gasbarrini G, Barbara L, Bonino F, Rizzetto M, Roda E. A controlled trial of human lymphoblastoid interferon in chronic hepatitis B in Italy. Hepatology 1989; 10: 336-41.
4. 4. Brook GM, Chan, Yap I, Karayiannis P, Lever AML, Jacyna M, Main J, Thomas HC. Randomised controlled trial of lymphoblastoid interferon alpha in Europid men with chronic hepatitis B virus infection. BMJ 1989; 299: 652-6.
5. 5. Brook MG, Karayiannis P, Thomas HC. Which patients with chronic hepatitis B virus infection will respond to alpha interferon therapy? A statistical analysis of predictive factors. Hepatology 1989; 10: 761-3.
6. 6. Krogsgaard K, Bindslev N, Christensen E Craxi A, Schlichting P, Schalm S, Carreno V, Trepo C, Gerken G, Thomas HC, Kragh Andersen P, Ring-Larsen H, European Concerted Action on Viral Hepatitis. The treatment effect of alpha interferon in chronic hepatitis B is independent of pre-treatment variables. Results of a meta-analysis of individual patient data. J Hepatol 1994; 21: 646-55.
7. 7. Ruiz-Moreno M, Jiminez J, Porres JC, Bartolomé J, Moreno A, Carreno V. A controlled trial of recombinant interferon-al-pha in Caucasian children with chronic hepatitis B. Digestion 1990; 45: 26-33.
8. 8. Lok ASF, Wu PC, Lai CL, Lau JYN, Leung EKY, Wong LSK, Ma OCK, Lauder IJ, Ng CPL, Chung HT. A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 1992; 102: 2091-7.
9. 9. Lok ASF, Lai CL, Wu PC, Leung EKY. Long-term follow-up in a randomised controlled trial of recombinant alpha-interferon in Chinese patients with chronic hepatitis B infection. Lancet 1988; 2: 298-302.
10. 10. Scullard GH, Robinson WS, Merigan TC, Gregory PB. Effect of immunosuppressive therapy on hepatitis B viral infection in patients with chronic hepatitis. Gastroenterology 1979; 7: A40.
11. 11. Müller R, Vido I, Schmidt FW. Rapid withdrawal of immunosuppressive therapy in chronic active hepatitis B infection. Lancet 1981; I: 1323-4.
12. 12. Weller IV, Bassendine MF, Murray AK, Craxi A, Thomas HC, Sherlock S. Effects of prednisolone/azathioprine in chronic hepatitis B viral infection. Gut 1982; 23: 650-5.
13. 13. Nair PV, Tong MJ, Stevenson D, Roskamp D, Boone C. A pilot study on the effects of prednisone withdrawal on serum hepatitis B virus DNA and HBeAg in chronic active hepatitis B. Hepatology 1986; 6: 1319-24.
14. 14. Perrillo RP, Schiff ER, Davis GL, Bodenheimer HC, Lindsay K, Payne J, Dienstag JL, O'Brien C, Tamburro C, Jacobson IM, Sampliner R, Feit D, Lefkowitch J, Kuhns M, Meschievitz C, Sanghvi B, Albrecht J, Gibas A, Hepatitis Interventional Therapy Group. A randomized, controlled trial of interferon alpha 2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323: 295-301.
15. 15. Fevery J, Elewaut A, Michielsen P, Nevens F, Van Eyken P, Adler M, Desmet V. Efficacy of interferon alpha-2b with or without prednisone withdrawal in the treatment of chronic viral hepatitis B. A prospective double-blind Belgian-Dutch study. J Hepatol 1990; 11: S108-12.
16. 16. Krogsgaard K, Wantzin P, Aldershvile J, Kryger P, Andersson P, Nielsen JO. Hepatitis B virus DNA in HBsAg positive blood donors: relation to the HBe system and outcome in recipients. J Infect Dis 1986; 153: 298-303.
17. 17. Brand CM, Leadbeater L, Budiman R, Lechner K, Gisslinger H. Successful retreatment of anti-interferon resistant polycythaemia vera patient with lymphoblastoid interferon-alpha N1 and in vitro studies on the specificity of the antibodies. Br J Haematol 1994; 86: 216-8.
18. 18. Rakela J, Redeker AG, Weliky B. Effect of short-term prednisone therapy on aminotransferase levels and hepatitis B virus markers in chronic type B hepatitis. Gastroenterology 1983; 84: 956-60.
19. 19. Perrillo RP, Regenstein FG, Peters MG, DeSchryver-Kecskemeti K, Bodicky CJ, Campbell CR, Kuhns MC. Prednisone withdrawal followed by recombinant alpha interferon in the treatment of chronic type B hepatitis. A randomised, controlled trial. Ann Intern Med 1988; 109: 95-100.
20. 20. Cohard M, Poynard T, Mathurin P, Zarski JP. Prednisone-interferon combination in the treatment of chronic hepatitis B: direct and indirect meta analysis. Hepatology 1994; 20: 1390-8.
21. 21. Reichen J, Bianchi L, Frei PC, Male PJ, Lavanskhy D, Schmid M. Efficacy of steroid withdrawal and low dose interferon treatment in chronic active hepatitis B. Results of a randomised multicenter trial. J Hepatol 1994; 20: 168-74.
22. 22. Scully LJ, Shein R, Karayiannis P, McDonald JA, Thomas HC. Lymphoblastoid interferon therapy of chronic HBV infection. A comparison of 12 vs. 24 weeks of thrice weekly treatment. J Hepatol 1987; 5: 51-8.
23. 23. Wong DKH, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B and antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med 1993; 119: 312-3.
24. 24. Chou C-K, Wang L-H, Lin H-M, Chi C-W. Glucocorticoid stimulates hepatitis B viral gene expression in cultured human hepatoma cells. Hepatology 1992; 16: 13-8.
25. 25. Thomas HC, Scully LJ, Lever AML, Yap I, Pignatelli M. A review of the efficacy of adenine arabinoside and lymphoblastoid interferon in the Royal Free Hospital studies of hepatitis B virus carrier treatment: identification of factors influencing response rates. Infection 1987; 15: S26-31.
26. 26. Perrillo RP. Factors influencing response to interferon in chronic hepatitis B: implications for Asian and western populations. Hepatology 1990; 12: 1433-5.
27. 27. Janssen HLA, Brouwer JT, Nevens F, Sanchez-Tapias JM, Craxi A, Hadziyannis S. Eurohep. Fatal hepatic decompensation associated with interferon alpha, BMJ 1993; 306: 107-8.