Antisense therapy of hepatitis B virus infection

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 9, Issue 2, 1998, Pages 161-170

  Offensperger, Wolf Bernhard ^a   Offensperger, Silke ^a   Blum, Hubert E ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Antisense oligodeoxynucleotides; Antiviral substances; Duck hepatitis B virus

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY DNA;

ANIMAL MODEL; ARTICLE; DUCK; HEPATITIS B; HEPATITIS B VIRUS; NONHUMAN; VIRUS INHIBITION;

ANAS PLATYRHYNCHOS; ANAS SP.; ANIMALIA; DUCK HEPATITIS B VIRUS; HEPATITIS B VIRUS;

EID: 0031715924     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02760817     Document Type: Article

References (63)

1. Anderson, W. F. (1992) Human gene therapy. Science 256, 808-813.
2. Morgan, R. A. and Anderson, W. F. (1993) Human gene therapy. Ann. Rev. Biochem. 62, 191-217.
3. Agrawal, S. (1992) Antisense oligonucleotides as antiviral agents. Trends Biotechnol. 10, 281-287.
4. Helene, C. (1991) Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides. Eur. J. Cancer 27, 1466-1471.
5. Helene, C. and Toulme, J. J. (1990) Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim. Biophys. Acta 1049, 99-125.
6. Uhlmann, H. and Peyman, A. (1990) Antisense oligonucleotides: a new therapeutic principle. Chem. Rev. 90, 544-583.
7. Wickstrom, E. (1992) Strategies for administering targeted therapeutic oligodeoxynucleotides. A review. Trends Biotechnol. 10, 281-287.
8. Calabretta, B. (1991) Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications. Cancer Res. 51, 4505-4510.
9. Ma, D. D. F. and le Doan, T. (1994) Antisense oligonucleotide therapies: are they the "magic bullets"? Ann. Intern. Med. 120, 161-163.
10. Stein, C. A. and Cohen, J. S. (1988) Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res. 48, 2659-2668.
11. Becker, D., Meier, C. B., and Herlyn, M. (1989) Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor. EMBO J. 8, 3685-3691.
12. Harel-Bellan, A., Ferris, D. K., Vinocour, M., Holt, J. T., and Farrar, W. L. (1988) Specific inhibition of c-myc protein biosynthesis using an antisense synthetic deoxyoligonucleotide in human T lymphocytes. J. Immunol. 140, 2431-2435.
13. Holt, J. T., Redner, R. L., and Nienhuis, A. W. (1988) An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol. Cell. Biol. 8, 963-973.
14. McManaway, M. E., Neckers, L. M., Loke, S. L., Al-Nasser, A. A., Redner, R. L., Shiramizu, B. T., Goldschmidts, W. L., Huber, B. E., Bhatia, K., and Magrath, I. T. (1990) Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet 335, 808-811.
15. Melani, C., Rivoltini, L., Parmiani, G., Calabretta, B., and Colombo, M. P. (1991) Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. Cancer Res. 51, 2897-2901.
16. Reed, J. C., Stein, C., Subasinghe, C., Haldar, S., Croce, C. M., Yum, S., and Cohen, J. (1990) Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res. 50, 6565-6570.
17. Rivera, R. T., Pasion, S. G., Wong, D. T., Fei, Y. B., and Biswas, D. K. (1989) Loss of tumorigenic potential by human lung tumor cells in the presence of antisense RNA specific to the ectopically synthesized alpha subunit of human chorionic gonadotropin. J. Cell Biol. 108, 2423-2434.
18. Saison-Behmoaras, T., Tocque, B., Rey, I., Chassignol, M., Thuong, N. T., and Helene, C. (1991) Short modified antisense oligonucleotides directed against Haras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. EMBO J. 10, 1111-1118.
19. Szczylik, C., Skorski, T., Nicolaides, N. C., Manzella, L., Malaguarnera, L., Venturelli, D., Gewirtz, A. M., and Calabretta, B. (1991) Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides. Science 253, 562-565.
20. von Rüden, T. and Gilboa, E. (1989) Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA. J. Virol. 63, 677-682.
21. Kabanov, A. V., Vinogradov, S. V., Ovcharenko, A. V., Krivonos, A. V., Melik, N. N. S., Kiselev, V. I., and Severin, E. S. (1990) A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells. FEBS Lett. 259, 327-330.
22. Chang, L. J. and Stoltzfus, C. M. (1987) Inhibition of Rous sarcoma virus replication by antisense RNA. J. Virol. 61, 921-924.
23. Zamecnik, P. C. and Stephenson, M. L. (1978) Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 75, 280-284.
24. Agrawal, S., Goodchild, J., Civeira, M. P., Thornton, A. H., Sarin, P. S., and Zamecnik, P. C. (1988) Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 85, 7079-7083.
25. Matsukura, M., Shinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J. S., and Broder, S. (1987) Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 84, 7706-7710.
26. Renneisen, K., Leserman, L., Matthes, E., Schröder, H. C., and Müller, W. E. (1990) Inhibition of expression of human immunodeficiency virus-1 in vitro by antibody-targeted liposomes containing antisense RNA to the env region. J. Biol. Chem. 265, 16,337-16,342.
27. Zamecnik, P. C., Goodchild, J., Taguchi, Y., and Sarin, P. S. (1986) Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA. Proc. Natl. Acad. Sci. USA 83, 4143-4146.
28. Lemaitre, M., Bayard, B., and Lebleu, B. (1987) Specific antiviral activity of a poly-lysine-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc. Natl. Acad. Sci. USA 84, 648-652.
29. Smith, C. C., Aurelian, L., Reddy, M. P., Miller, P. S., and Ts'o, P. O. P. (1986) Antiviral effect of an oligo (nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc. Natl. Acad. Sci. USA 83, 2787-2791.
30. Bergman, P., Ustav, M., Moreno-Lopez, J., Vennstroem, B., and Pettersson, U. (1986) Replication of the bovine papillomavirus type 1 genome; antisense transcripts prevent episomal replication. Gene 50, 185-193.
31. Gupta, K. C. (1987) Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs. J. Biol. Chem. 262, 7492-7496.
32. Blum, H. E., Galun, E., von Weizsäcker, F., and Wands, J. R. (1991) Inhibition of hepatitis B virus by antisense oligodeoxynucleotides (letter). Lancet 337, 1230.
33. Goodarzi, G., Gross, S. C., Tewari, A., and Watabe, K. (1990) Antisense oligodeoxyribonucleotides inhibit the expression of the gene for hepatitis B virus surface antigen. J. Gen. Virol. 71, 3021-3025.
34. Wu, G. Y. and Wu, C. H. (1992) Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J. Biol. Chem. 267, 12,436-12,439.
35. Wands, J. R. and Blum, H. E. (1991) Primary hepatocellular carcinoma. N. Engl. J. Med. 325, 729-731.
36. Tiollais, P., Pourcel, C., and Dejean, A. (1985) The hepatitis B virus. Nature 317, 489-495.
37. Summers, J., Smolec, J. M., and Snyder, R. (1978) A virus similar to hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc. Natl. Acad. Sci. USA 75, 4533-4537.
38. Marion, P. L., Oshiro, L. S., Regnery, D. C., Scullard, G. H., and Robinson, W. S. (1980) A virus in Beechey ground squirrels that is related to hepatitis B virus of humans. Proc. Natl. Acad. Sci. USA 77, 2941-2945.
39. Mason, W. S., Seal, G., and Summers, J. (1980) Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J. Virol. 36, 829-836.
40. Sprengel, R., Kaleta, E. F., and Will, H. (1988) Isolation and characterization of a hepatitis B virus endemic in herons. J. Virol. 62, 3832-3839.
41. Summers, J. W. and Mason, W. S. (1982) Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29, 403-415.
42. Carman, W., Thomas, H., and Domingo, E. (1993) Viral genetic variation: hepatitis B virus as a clinical example. Lancet, 341, 349-353.
43. Tuttleman, J. S., Pugh, J. C. and Summers, J. W. (1986) In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis B virus. J. Virol. 58, 17-25.
44. Suzuki, S., Lee, B., Luo, W., Tovell, D., Robins, M. J., and Tyrrell, D. L. (1988) Inhibition of duck hepatitis B virus replication by purine 2′,3′- dideoxynucleosides. Biochem. Biophys. Res. Commun. 156, 1144-1151.
45. Fourel, I., Gripon, P., Hantz, O., Cova, L., Lambert, V., Jacquet, C., Watanabe, K., Fox, J., Guillouzo, C., and Trepo, C. (1989) Prolonged duck hepatitis B virus replication in duck hepatocytes cocultivated with rat epithelial cells: a useful system for antiviral testing. Hepatolagy 10, 186-191.
46. Civitico, G., Wang, Y. Y., Luscombe, C., Bishop, N., Tachedjian, G., Gust, I., and Locarnini, S. (1990) Antiviral strategies in chronic hepatitis B virus infection: II. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds. J. Med. Virol. 31, 90-97.
47. Hirota, K., Sherker, A. H., Omata, M., Yokosuka, O., and Okuda, K. (1987) Effects of adenine arabinoside on serum and intrahepatic replicative forms of duck hepatitis B virus in chronic infection. Hepatology 7, 24-28.
48. Kassianides, C., Hoofnagle, J. H., Miller, R. H., Doo, E., Ford, H., Broder, S., and Mitsuya, H. (1989) Inhibition of duck hepatitis B virus replication by 2′,3′-dideoxycytidine. A potent inhibitor of reverse transcriptase. Gastroenterology 97, 1275-1280.
49. Sherker, A. H., Hirota, K., Omata, M., and Okuda, K. (1986) Foscarnet decreases serum and liver duck hepatitis B virus DNA in chronically infected ducks. Gastroenterology 91, 818-824.
50. Iyer, R. P., Philips, L. R., Egan, W., Regan, J. B., and Beaucage, S. L. J. (1990) The automated synthesis of sulphur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulphur-transfer reagent. Org. Chem. 55, 4693-4698.
51. Leonetti, J. P., Mechti, N., Degols, G., Gagnor, C., and Lebleu, B. (1991) Intracellular distribution of microinjected antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 88, 2702-2706.
52. Stein, C. A. and Cheng, Y. C. (1993) Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261, 1004-1012.
53. Hanvey, J. C., Peffer, N. J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Hassman, C. F., Bonham, M. A., Au, K. G., et al. (1992) Antisense and antigene properties of peptide nucleic acids. Science 258, 1481-1485.
54. Wagner, R. W., Matteucci, M. D., Lewis, J. G., Gutierrez, A. J., Moulds, C., and Froehler, B. C. (1993) Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science 260, 1510-1513.
55. Duval-Valentin, G., Thuong, N. T., and Helene, C. (1992) Specific inhibition of transcription by triple helix-forming oligonucleotides. Proc. Natl. Acad. Sci. USA 89, 504-508.
56. Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., and Danielsen, M. (1987) Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84, 7413-7417.
57. Leonetti, J. P., Machy, P., Degols, G., Lebleu, B., and Leserman, L. (1990) Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication. Proc. Natl. Acad. Sci. USA 87, 2448-2451.
58. Liang, T. J., Makdisi, W. J., Sun, S., Hasegawa, K., Zhang, Y., Wands, J. R., Wu, C. H., and Wu, G. Y. (1993) Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells. J. Clin. Invest. 91, 1241-1246.
59. Cotten, M., Wagner, E., Zatloukal, K., Phillips, S., Curiel, D. T., and Birnstiel, M. L. (1992) High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc. Natl. Acad. Sci. USA 89, 6094-6098.
60. Cristiano, R. J., Smith, L. C., and Woo, S. L. (1993) Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. Proc. Natl. Acad. Sci. USA 90, 2122-2126.
61. Wagner, E., Zenke, M., Cotten, M., Beug, H., and Birnstiel, M. L. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. USA 87, 3410-3414.
62. Kay, M. A., Baley, P., Rothenberg, S., Leland, F., Fleming, L., Ponder, K. P., Liu, T., Finegold, M., Darlington, G., Pokorny, W., and Woo, S. L. C. (1992) Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc. Natl. Acad. Sci. USA 89, 89-93.
63. Ledley, F. D., Darlington, G. J., Hahn, T., and Woo, S. L. (1987) Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions. Proc. Natl. Acad. Sci. USA 84, 5335-5339.