Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)

Journal of Virology

Volumn 75, Issue 10, 2001, Pages 4771-4779

  Das, K ^a   Xiong, X ^a   Yang, H ^a   Westland, C E ^a   Gibbs, C S ^a   Sarafianos, S G ^a   Arnold, E ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; DNA POLYMERASE; EMTRICITABINE; ISOLEUCINE; LAMIVUDINE; LEUCINE; LOBUCAVIR; METHIONINE; PENCICLOVIR; RNA DIRECTED DNA POLYMERASE; VALINE;

ANIMAL CELL; ARTICLE; CATALYSIS; DRUG SENSITIVITY; DRUG STRUCTURE; ENANTIOMER; ENZYME ACTIVE SITE; HEPATITIS B; HEPATITIS B VIRUS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY; VIRUS MUTATION; VIRUS RESISTANCE;

ACYCLOVIR; ADENINE; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE; DRUG RESISTANCE, MICROBIAL; GUANINE; HEPATITIS B VIRUS; HUMANS; LAMIVUDINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHONIC ACIDS; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035041976     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.10.4771-4779.2001     Document Type: Article

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