Pharmacology of β-L-thymidine and β-L-2′-deoxycytidine in HepG2 cells and primary human hepatocytes: Relevance to chemotherapeutic efficacy against hepatitis B virus

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 1728-1733

  Hernandez Santiago, B ^a   Placidi, L ^a   Cretton Scott, E ^a   Faraj, A ^a   Bridges, E G ^a   Bryant, M L ^a   Rodriguez Orengo, J ^a   Imbach, J L ^a   Gosselin, G ^a   Pierra, C ^a   Dukhan, D ^a   Sommadossi, Jean Pierre ^a  

^a Novirio Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BETA LEVO 2' DEOXYCYTIDINE; BETA LEVO THYMIDINE; CHOLINE DERIVATIVE; CYTIDINE DERIVATIVE; DEOXYCYTIDINE DIPHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYURIDINE PHOSPHATE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA POLYMERASE; DRUG METABOLITE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DEAMINATION; DRUG ACCUMULATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; HEPATITIS B VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; PHOSPHORYLATION; PRIORITY JOURNAL; TIME SERIES ANALYSIS;

ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; HALF-LIFE; HEPATITIS B; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; THYMIDINE; TUMOR CELLS, CULTURED;

EID: 0036096201     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.1728-1733.2002     Document Type: Article

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