Notch signalling in the regulation of peripheral T-cell function

Seminars in Cell and Developmental Biology

Volumn 14, Issue 2, 2003, Pages 127-134

  Mckenzie, Grahame J ^a   Young, Lesley L ^a   Briend, Emmanuel ^a   Lamb, Jonathan R ^b   Dallman, Margaret J ^c   Champion, Brian R ^a  

^a Celldex Therapeutics Inc   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cell fate; Notch; T cell; Treg; Tolerance

Indexed keywords

NOTCH RECEPTOR;

CELL FATE; EMBRYO DEVELOPMENT; IMMUNE SYSTEM; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE;

EID: 0037375918     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-9521(02)00181-7     Document Type: Review

References (50)

1. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signalling: cell fate control and signal integration in development. Science. 284:1999;770-776.
2. Artavanis-Tsakonas S., Delidakis C., Fehon R.G. The Notch locus and the cell biology of neuroblast segregation. Ann. Rev. Cell Biol. 7:1991;427-452.
3. Fleming R.J. Structural conservation of Notch receptors and ligands. Semin. Cell Dev. Biol. 9:1998;599-607.
4. Rauskolb C., Correia T., Irvine K.D. Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing. Nature. 401:1999;476-480.
5. Munro S., Freeman M. The Notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr. Biol. 10:2000;813-820.
6. Ju B.G., Jeong S., Bae E., Hyun S., Carroll S.B., Yim J.et al. Fringe forms a complex with Notch. Nature. 405:2000;191-195.
7. Weinmaster G. Notch signaling: direct or what? Curr. Opin. Genet Dev. 8:1998;436-442.
8. Fowlkes B.J., Robey E.A. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J. Immunol. 169:2002;1817-1821.
9. Robson MacDonald H., Wilson A., Radtke F. Notch1 and T-cell development: insights from conditional knockout mice. Trends Immunol. 22:2001;155-160.
10. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
11. Roncarolo M.G., Bacchetta R., Bordignon C., Narula S., Levings M.K. Type 1 T regulatory cells. Immunol. Rev. 182:2001;68-79.
12. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:1997;737-742.
13. Sakaguchi S., Sakaguchi N., Shimizu J., Yamazaki S., Sakihama T., Itoh M.et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:2001;18-32.
14. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:2002;389-400.
15. Weiner H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182:2001;207-214.
16. Kronenberg M., Gapin L. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:2002;557-568.
17. Walker L.S., Abbas A.K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2:2002;11-19.
18. Mason D., Powrie F. Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 10:1998;649-655.
19. Zhai Y., Li J., Hammer M., Busuttil R.W., Volk H.D., Kupiec-Weglinski J.W. Evidence of T cell clonality in the infectious tolerance pathway: implications toward identification of regulatory T cells. Transplantation. 71:2001;1701-1708.
20. + regulatory T cell function. J. Exp. Med. 196:2002;851-857.
21. Davies J.D., Martin G., Phillips J., Marshall S.E., Cobbold S.P., Waldmann H. T cell regulation in adult transplantation tolerance. J. Immunol. 157:1996;529-533.
22. Bluestone J.A. Is CTLA-4 a master switch for peripheral T cell tolerance? J. Immunol. 158:1997;1989-1993.
23. + T cells. J. Exp. Med. 183:1996;2669-2674.
24. Asseman C., Mauze S., Leach M.W., Coffman R.L., Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:1999;995-1004.
25. Kojika S., Griffin J.D. Notch receptors and hematopoiesis. Exp. Hematol. 29:2001;1041-1052.
26. (+) T cells. Int. Immunol. 12:2000;177-185.
27. (+) cells: a naturally occurring population of regulatory T cells. Blood. 98:2001;2736-2744.
28. Dallman MJ, Champion BR, Lamb JR. Notch signalling in the peripheral immune system. Novartis Symp Regul T-cells 2003, in press.
29. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Ann. Rev. Immunol. 19:2001;683-765.
30. Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:1993;263-274.
31. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:2001;1285-1294.
32. (+) T regulatory cells suppress naïve and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:2001;1295-1302.
33. Dieckmann D., Bruett C.H., Ploettner H., Lutz M.B., Schuler G. Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196:2002;247-253.
34. Shevach E.M., McHugh R.S., Piccirillo C.A., Thornton A.M. Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol. Rev. 182:2001;58-67.
35. (+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194:2001;629-644.
36. (+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196:2002;237-246.
37. Baeuerle P.A., Baltimore D. NF-kappa B: ten years after. Cell. 87:1996;13-20.
38. Guan E., Wang J., Laborda J., Norcross M., Baeuerle P.A., Hoffman T. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J. Exp. Med. 183:1996;2025-2032.
39. Radtke F., Wilson A., Ernst B., MacDonald H.R. The role of Notch signaling during hematopoietic lineage commitment. Immunol. Rev. 187:2002;65-74.
40. Gonzalo J.A., Tian J., Delaney T., Corcoran J., Rottman J.B., Lora J.et al. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2:2001;597-604.
41. Akbari O., Freeman G.J., Meyer E.H., Greenfield E.A., Chang T.T., Sharpe A.H.et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8:2002;1024-1032.
42. Zelenika D., Adams E., Humm S., Graca L., Thompson S., Cobbold S.P.et al. Regulatory T cells overexpress a subset of Th2 gene transcripts. J. Immunol. 168:2002;1069-1079.
43. + thymocytes by modulating TCR signal strength. Immunity. 14:2001;253-264.
44. Jehn B.M., Bielke W., Pear W.S., Osborne B.A. Cutting edge: protective effects of Notch-1 on TCR-induced apoptosis. J. Immunol. 162:1999;635-638.
45. (+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity. 16:2002;311-323.
46. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:2002;135-142.
47. Lombardi G., Sidhu S., Batchelor R., Lechler R. Anergic T cells as suppressor cells in vitro. Science. 264:1994;1587-1589.
48. Hoyne G.F., Dallman M.J., Champion B.R., Lamb J.R. Notch signalling in the regulation of peripheral immunity. Immunol. Rev. 182:2001;215-227.
49. Lai E.C. Protein degradation: four E3s for the Notch pathway. Curr. Biol. 12:2002;R74-R78.
50. Heitzler P., Bourouis M., Ruel L., Carteret C., Simpson P. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development. 122:1996;161-171.