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Volumn 13, Issue 1, 2003, Pages 70-76

Telomeres and cancer: A tale with many endings

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; TELOMERASE INHIBITOR;

EID: 0037309155     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00011-4     Document Type: Review
Times cited : (52)

References (57)
  • 1
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell. 106:2001;661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 2
    • 0037148270 scopus 로고    scopus 로고
    • New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromation
    • Chan S.W.L., Blackburn E.H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromation. Oncogene. 21:2002;553-563.
    • (2002) Oncogene , vol.21 , pp. 553-563
    • Chan, S.W.L.1    Blackburn, E.H.2
  • 3
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • De Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 5
    • 0037148330 scopus 로고    scopus 로고
    • Many ways to telomere dysfunction: In vivo studies using mouse models
    • Goytisolo F.A., Blasco M.A. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene. 21:2002;584-591.
    • (2002) Oncogene , vol.21 , pp. 584-591
    • Goytisolo, F.A.1    Blasco, M.A.2
  • 7
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature. 31:1990;458-460.
    • (1990) Nature , vol.31 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 8
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins K., Mitchell J.R. Telomerase in the human organism. Oncogene. 21:2002;564-579.
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 13
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated to telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E., Samper E., Martín-Caballero J., Flores J.M., Lee H.-W., Blasco M.A. Disease states associated to telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18:1999;2950-2960.
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martín-Caballero, J.3    Flores, J.M.4    Lee, H.-W.5    Blasco, M.A.6
  • 14
    • 0034769105 scopus 로고    scopus 로고
    • -/- mice with short telomeres
    • In this paper, we demonstrate that it is possible to elongate short telomeres in the context of the telomerase-deficient mouse by re-introducing telomerase. Rescue of the population of short telomeres prevents chromosome fusions and loss of viability in these mice. These findings encourage the use of telomerase in the therapy of age-related diseases or premature aging syndromes that are characterized by critical telomere shortening
    • -/- mice with short telomeres. EMBO Rep. 2:2001;800-807 In this paper, we demonstrate that it is possible to elongate short telomeres in the context of the telomerase-deficient mouse by re-introducing telomerase. Rescue of the population of short telomeres prevents chromosome fusions and loss of viability in these mice. These findings encourage the use of telomerase in the therapy of age-related diseases or premature aging syndromes that are characterized by critical telomere shortening.
    • (2001) EMBO Rep. , vol.2 , pp. 800-807
    • Samper, E.1    Flores, J.M.2    Blasco, M.A.3
  • 16
    • 0037148326 scopus 로고    scopus 로고
    • Clinical utility of telomerase in cancer
    • Hiyama E., Hiyama K. Clinical utility of telomerase in cancer. Oncogene. 21:2001;643-649.
    • (2001) Oncogene , vol.21 , pp. 643-649
    • Hiyama, E.1    Hiyama, K.2
  • 17
    • 0033553516 scopus 로고    scopus 로고
    • P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L., Artandi S.E., Shen Q., Tam A., Lee S.L., Gottlieb G.J., Greider C.W., DePinho R.A. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:1999;527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 18
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • González-Suárez E., Samper E., Flores J.M., Blasco M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26:2000;114-117.
    • (2000) Nat. Genet. , vol.26 , pp. 114-117
    • González-Suárez, E.1    Samper, E.2    Flores, J.M.3    Blasco, M.A.4
  • 19
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:2000;641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 20
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph K.L., Millard M., Bosenberg M.W., DePinho R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28:2001;155-159.
    • (2001) Nat. Genet. , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 22
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • This elegant paper dissects the tumor suppressor pathways that mediate telomere dysfunction in mouse and human cells. Whereas in the mouse p53 is the main mediator of telomere dysfunction, both p53 and Rb/p16 pathways are important in human cells
    • Smogorzewska A., de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21:2002;4338-4348 This elegant paper dissects the tumor suppressor pathways that mediate telomere dysfunction in mouse and human cells. Whereas in the mouse p53 is the main mediator of telomere dysfunction, both p53 and Rb/p16 pathways are important in human cells.
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    De Lange, T.2
  • 23
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B., Smogorzewska A., de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:1998;401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 24
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    • Samper E., Goytisolo F., Slijepcevic P., van Buul P., Blasco M.A. Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1:2000;244-252.
    • (2000) EMBO Rep. , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.2    Slijepcevic, P.3    Van Buul, P.4    Blasco, M.A.5
  • 25
    • 0035023139 scopus 로고    scopus 로고
    • Absence of DNA-PKcs in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • Goytisolo F., Samper E., Edmonson S., Taccioli G.E., Blasco M.A. Absence of DNA-PKcs in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell Biol. 21:2001;3642-3651.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3642-3651
    • Goytisolo, F.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 27
    • 0035964864 scopus 로고    scopus 로고
    • Strand-specific postreplicative processing of mammalian telomeres
    • cs in telomere capping. The paper shows that abrogation of either activity results in end-to-end fusions preferentially involving telomeres produced by leading-strand synthesis. The authors argue that these telomere-binding proteins could have a role in the post-replicative processing of telomeres
    • cs in telomere capping. The paper shows that abrogation of either activity results in end-to-end fusions preferentially involving telomeres produced by leading-strand synthesis. The authors argue that these telomere-binding proteins could have a role in the post-replicative processing of telomeres.
    • (2001) Science , vol.293 , pp. 2462-2465
    • Bailey, S.M.1    Conforth, M.N.2    Kurimasa, A.3    Chen, D.J.4    Goodwin, E.H.5
  • 28
    • 0036352911 scopus 로고    scopus 로고
    • Identification of telomere-dependent 'senescence-like' arrest in mouse embryonic fibroblasts
    • The senescence-like arrest shown by MEFs in culture is not likely to be mediated by telomere loss because MEFs have telomerase activity and very long telomeres. In this paper, we demonstrate that it is possible to trigger a telomere-mediated senescence-like arrest in MEFs by either short telomeres in the absence of telomerase (telomerase-deficient mice) or by deletion of the telomere-binding protein Ku86 (Ku86-deficient mice). Hence, telomere dysfunction produced by either short telomeres or altered telomere capping leads to senescence-like arrest in mouse cells
    • Espejel S., Blasco M.A. Identification of telomere-dependent 'senescence-like' arrest in mouse embryonic fibroblasts. Exp. Cell Res. 276:2001;242-248 The senescence-like arrest shown by MEFs in culture is not likely to be mediated by telomere loss because MEFs have telomerase activity and very long telomeres. In this paper, we demonstrate that it is possible to trigger a telomere-mediated senescence-like arrest in MEFs by either short telomeres in the absence of telomerase (telomerase-deficient mice) or by deletion of the telomere-binding protein Ku86 (Ku86-deficient mice). Hence, telomere dysfunction produced by either short telomeres or altered telomere capping leads to senescence-like arrest in mouse cells.
    • (2001) Exp. Cell Res. , vol.276 , pp. 242-248
    • Espejel, S.1    Blasco, M.A.2
  • 31
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • The paper shows that altering the telomere state using a dominant negative mutant of the telomere-binding protein TRF2, it is possible to alter the average length at which telomeres trigger senescence in human cells. Therefore, by altering the telomere state it is possible to induce senescence
    • Karlseder J., Smogorzewska A., de Lange T. Senescence induced by altered telomere state, not telomere loss. Science. 295:2002;2446-2449 The paper shows that altering the telomere state using a dominant negative mutant of the telomere-binding protein TRF2, it is possible to alter the average length at which telomeres trigger senescence in human cells. Therefore, by altering the telomere state it is possible to induce senescence.
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    De Lange, T.3
  • 32
    • 0033605145 scopus 로고    scopus 로고
    • P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 283:1999;1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 37
    • 0036241994 scopus 로고    scopus 로고
    • Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
    • The authors elegantly dissect the roles of TRF1 and TRF2 by tagging these proteins to the telomeres. They show that TRF1 interferes with telomerase-dependent telomere elongation, and that TRF2, however seems to promote telomere degradation by unknown mechanisms
    • Ancelin K., Brunori M., Bauwens S., Koering C.E., Brun C., Ricoul M., Pommier J.P., Sabatier L., Gilson E. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell Biol. 22:2002;3474-3487 The authors elegantly dissect the roles of TRF1 and TRF2 by tagging these proteins to the telomeres. They show that TRF1 interferes with telomerase-dependent telomere elongation, and that TRF2, however seems to promote telomere degradation by unknown mechanisms.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 3474-3487
    • Ancelin, K.1    Brunori, M.2    Bauwens, S.3    Koering, C.E.4    Brun, C.5    Ricoul, M.6    Pommier, J.P.7    Sabatier, L.8    Gilson, E.9
  • 38
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis
    • Blasco M.A., Rizen M., Greider C.W., Hanahan D. Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis. Nat. Genet. 12:1996;200-204.
    • (1996) Nat. Genet. , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 39
    • 0029941676 scopus 로고    scopus 로고
    • Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation
    • Broccoli D., Godley L.A., Donehower L.A., Varmus H.E., de Lange T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell Biol. 16:1996;3765-3772.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 3765-3772
    • Broccoli, D.1    Godley, L.A.2    Donehower, L.A.3    Varmus, H.E.4    De Lange, T.5
  • 40
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E., Samper E., Ramirez A., Flores J.M., Martin-Caballero J., Jorcano J.L., Blasco M.A. Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20:2001;2619-2630.
    • (2001) EMBO J. , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3    Flores, J.M.4    Martin-Caballero, J.5    Jorcano, J.L.6    Blasco, M.A.7
  • 41
    • 0036787840 scopus 로고    scopus 로고
    • Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
    • This paper is a continuation of a previous work in which we showed that constitutive transgenic telomerase expression increased the frequency of carcinogen-induced tumors in mice [40]. This implied that telomerase could have a role in promoting tumorigenesis independently of telomere length. In this paper, we demonstrate that constitutive telomerase expression also increases spontaneous tumorigenesis with age. In addition, the authors generate a new mouse model with constitutive telomerase expression in the context of p53 deficiency. These double mutant mice show an increased frequency of spontaneous tumors at young ages, suggesting cooperation between telomerase activity and p53 mutation in accelerating tumorigenesis
    • González-Suárez E., Flores J.M., Blasco M.A. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell Biol. 22:2002;7291-7301 This paper is a continuation of a previous work in which we showed that constitutive transgenic telomerase expression increased the frequency of carcinogen-induced tumors in mice [40]. This implied that telomerase could have a role in promoting tumorigenesis independently of telomere length. In this paper, we demonstrate that constitutive telomerase expression also increases spontaneous tumorigenesis with age. In addition, the authors generate a new mouse model with constitutive telomerase expression in the context of p53 deficiency. These double mutant mice show an increased frequency of spontaneous tumors at young ages, suggesting cooperation between telomerase activity and p53 mutation in accelerating tumorigenesis.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7291-7301
    • González-Suárez, E.1    Flores, J.M.2    Blasco, M.A.3
  • 44
    • 0035978922 scopus 로고    scopus 로고
    • Emerging roles for telomerase in regulating cell differentiation and survival: A neuroscientist's perspective
    • Mattson M.P., Fu W., Zhang P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech. Aging Dev. 122:2001;659-671.
    • (2001) Mech. Aging Dev. , vol.122 , pp. 659-671
    • Mattson, M.P.1    Fu, W.2    Zhang, P.3
  • 45
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco M.A. Telomerase beyond telomeres. Nat. Rev. Cancer. 2:2002;627-633.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 46
    • 0037047068 scopus 로고    scopus 로고
    • The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    • This paper compares genome-wide gene expression changes in yeast containing telomerase activity versus yeast where telomerase is deleted. The fact that many genes show expression changes as a consequence of abrogation of telomerase also supports the notion that telomerase may impact processes other than telomere length maintenance
    • Nautiyal S., DeRisi J.L., Blackburn E.H. The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 99:2002;9316-9321 This paper compares genome-wide gene expression changes in yeast containing telomerase activity versus yeast where telomerase is deleted. The fact that many genes show expression changes as a consequence of abrogation of telomerase also supports the notion that telomerase may impact processes other than telomere length maintenance.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 9316-9321
    • Nautiyal, S.1    DeRisi, J.L.2    Blackburn, E.H.3
  • 51
    • 0035197010 scopus 로고    scopus 로고
    • Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line
    • Finnon P., Wong H.P., Silver A.R., Slijepcevic P., Bouffler S.D. Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line. Int. J. Radiat. Biol. 77:2001;1151-1162.
    • (2001) Int. J. Radiat. Biol. , vol.77 , pp. 1151-1162
    • Finnon, P.1    Wong, H.P.2    Silver, A.R.3    Slijepcevic, P.4    Bouffler, S.D.5
  • 52
    • 0037081078 scopus 로고    scopus 로고
    • Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres
    • Franco S., Segura I., Riese H.H., Blasco M.A. Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res. 62:2002;552-559.
    • (2002) Cancer Res. , vol.62 , pp. 552-559
    • Franco, S.1    Segura, I.2    Riese, H.H.3    Blasco, M.A.4
  • 53
    • 0037148329 scopus 로고    scopus 로고
    • Telomerase inhibition, oligonucleotides, and clinical trials
    • Corey D.R. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene. 21:2002;631-637.
    • (2002) Oncogene , vol.21 , pp. 631-637
    • Corey, D.R.1
  • 56
    • 0035878750 scopus 로고    scopus 로고
    • Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells
    • Sachsinger J., Gonzalez-Suarez E., Samper E., Heicappell R., Muller M., Blasco M.A. Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells. Cancer Res. 61:1999;5580-5586.
    • (1999) Cancer Res. , vol.61 , pp. 5580-5586
    • Sachsinger, J.1    Gonzalez-Suarez, E.2    Samper, E.3    Heicappell, R.4    Muller, M.5    Blasco, M.A.6
  • 57
    • 0037148281 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in mammalian cells
    • Henson J.D., Neumann A.A., Yeager T.R., Reddel R.R. Alternative lengthening of telomeres in mammalian cells. Oncogene. 21:2002;598-610.
    • (2002) Oncogene , vol.21 , pp. 598-610
    • Henson, J.D.1    Neumann, A.A.2    Yeager, T.R.3    Reddel, R.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.