Transcriptional control of T cell development

Current Opinion in Immunology

Volumn 12, Issue 3, 2000, Pages 301-306

  Osborne, Barbara A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CELL DEATH; CHROMATIN; LYMPHOCYTE DIFFERENTIATION; REVIEW; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 0034050534     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00091-1     Document Type: Review

References (39)

1. •].
2. •] provide excellent and in-depth coverage of many of the transcription factors mentioned in this review. Furthermore both papers, because of their length, provide more detail than is possible in this review of recent findings during the past year.
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6. -/- blastocysts, the authors were able to demonstrate that c-myb is required for both B cell and immature DN thymocyte differentiation.
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11. ••].
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13. + T cell development, resulting in more γ/δ T cells.
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15. •].
16. ••], a dominant negative Ikaros was used to demonstrate that Ikaros blocks transition from DN to DP T cells. Avitahl et al. show that Ikaros is necessary for mature T cell activation and for appropriate chromosome propagation in cycling mature T cells.
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18. ••].
19. ••].
20. ••] take a different approach and, by targeted deletion of Notch in thymocytes, find that Notch deletion results in a halt in differentiation from DN to DP thymocytes. Lastly, Tomita et al. show that deletion of Hes1, a gene downstream of Notch signaling, prevents the expansion of T cell precursors and blocks cells at the DN stage of development.
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23. Liu Z.G., Smith S.W., McLaughlin K.A., Schwartz L.M., Osborne B.A. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature. 367:1994;281-284.
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28. Amsen D., Revilla Calvo C., Osborne B.A., Kruisbeek A.M. Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci USA. 96:1999;622-627. This paper shows that costimulation is required for the induction of Nur77 activity and further provides evidence that CD28 signals can provide the necessary costimulation.
29. •].
30. •] from the same group of investigators provide data demonstrating that MEF2 is sequestered in T cells by Cabin1 and that, upon TCR signaling, MEF2 is released from Cabin1 and is free to bind to and activate the Nur77 promoter. Additionally, the authors show that overexpression of Cabin1 prevents TCR-mediated apoptosis.
31. •].
32. ••] show that inhibition of NF-κB by a superinhibitory form of IkB prevents DP thymocytes from apoptosis induced through the TCR. Wang et al. find that NF-κB activity correlates with survival and that glucocorticoid-induced apoptosis of DP thymocytes is coupled with an inhibition of NF-κB activity.
33. ••].
34. ••] show that activated Notch expression protects both T cell lines and thymocytes from glucocorticoid induced apoptosis. Jehn et al. show that activated Notch expression protects T cells from TCR-mediated death and further demonstrate that Notch expression inhibits Nur77 activity.
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36. Xu L., Glass C.K., Rosenfeld M.G. Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev. 9:1999;140-147.
37. Kim J., Sif S., Jones B., Jackson A., Koipally J., Heller E., Winandy S., Viel A., Sawyer A., Ikeda T.et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 10:1999;345-355. In this paper, the authors show that Ikaros proteins play a direct role in chromatin remodeling in lymphocytes and suggest that regulation of chromatin structure is an essential feature of lymphocyte differentiation and development.
38. + T cells. Furthermore the authors present data indicating that inhibition of E47 by Id3 induces phenotypic characteristics of positive selection.
39. ••], provide strong evidence for the role of Id3 in positive selection.