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Volumn 58, Issue 1, 2003, Pages 28-41

Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction

Author keywords

"uncoupled" NOS; Endothelial dysfunction; Oxidative stress; Tetrahydrobiopterin; Type I diabetes; Type II diabetes

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ACARBOSE; ACETYLCHOLINE; ADENOVIRUS VECTOR; ADVANCED GLYCATION END PRODUCT; ALLOPURINOL; ALPHA TOCOPHEROL; AMINOGUANIDINE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ASCORBIC ACID; BRADYKININ; COPPER ZINC SUPEROXIDE DISMUTASE; GLICLAZIDE; LOSARTAN; MANGANESE SUPEROXIDE DISMUTASE; METFORMIN; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PRAVASTATIN; PROBUCOL; PROTEIN KINASE C; RAXOFELAST; SEROTONIN; SIMVASTATIN; SORBITOL; SUPEROXIDE; TETRAHYDROBIOPTERIN; TROGLITAZONE; UNINDEXED DRUG; ZOPOLRESTAT;

EID: 0037287918     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10127     Document Type: Conference Paper
Times cited : (13)

References (170)
  • 2
    • 0342573147 scopus 로고    scopus 로고
    • Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes
    • Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC. 2000. Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. Cardiovasc Res 47:595-601.
    • (2000) Cardiovasc Res , vol.47 , pp. 595-601
    • Ammar R.F., Jr.1    Gutterman, D.D.2    Brooks, L.A.3    Dellsperger, K.C.4
  • 3
    • 0033567065 scopus 로고    scopus 로고
    • Enzymatic function of nitric oxide synthases
    • Andrew PJ, Mayer B. 1999. Enzymatic function of nitric oxide synthases. Cardiovasc Res 43:521-531.
    • (1999) Cardiovasc Res , vol.43 , pp. 521-531
    • Andrew, P.J.1    Mayer, B.2
  • 5
    • 0028220671 scopus 로고
    • Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
    • Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. 1994. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 368:850-853.
    • (1994) Nature , vol.368 , pp. 850-853
    • Bolotina, V.M.1    Najibi, S.2    Palacino, J.J.3    Pagano, P.J.4    Cohen, R.A.5
  • 6
    • 0026062122 scopus 로고
    • Advanced glycosylation products quench nitric oxide and mediate defective endotheliumdependent vasodilatation in experimental diabetes
    • Bucala R, Tracey KJ, Cerami A. 1991. Advanced glycosylation products quench nitric oxide and mediate defective endotheliumdependent vasodilatation in experimental diabetes. J Clin Invest 87:432-438.
    • (1991) J Clin Invest , vol.87 , pp. 432-438
    • Bucala, R.1    Tracey, K.J.2    Cerami, A.3
  • 7
    • 0034065857 scopus 로고    scopus 로고
    • Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension
    • Butler R, Morris AD, Belch JJ, Hill A, Struthers AD. 2000. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 35:746-751.
    • (2000) Hypertension , vol.35 , pp. 746-751
    • Butler, R.1    Morris, A.D.2    Belch, J.J.3    Hill, A.4    Struthers, A.D.5
  • 8
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. 2000. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 9
    • 0035116150 scopus 로고    scopus 로고
    • Diabetes and endothelial dysfunction: A clinical perspective
    • Calles-Escandon J, Cipolla M. 2001. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 22:36-52.
    • (2001) Endocr Rev , vol.22 , pp. 36-52
    • Calles-Escandon, J.1    Cipolla, M.2
  • 10
    • 0027089884 scopus 로고
    • Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes
    • Calver A, Collier J, Vallance P. 1992. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 90: 2548-2554.
    • (1992) J Clin Invest , vol.90 , pp. 2548-2554
    • Calver, A.1    Collier, J.2    Vallance, P.3
  • 11
    • 0029875833 scopus 로고    scopus 로고
    • High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress
    • Ceriello A, dello RP, Amstad P, Cerutti P. 1996. High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress. Diabetes 45:471-477.
    • (1996) Diabetes , vol.45 , pp. 471-477
    • Ceriello, A.1    Dello, R.P.2    Amstad, P.3    Cerutti, P.4
  • 13
    • 0034332787 scopus 로고    scopus 로고
    • Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes
    • Cheetham C, Collis J, O'Driscoll G, Stanton K, Taylor R, Green D. 2000. Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes. J Am Coll Cardiol 36:1461-1466.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1461-1466
    • Cheetham, C.1    Collis, J.2    O'Driscoll, G.3    Stanton, K.4    Taylor, R.5    Green, D.6
  • 16
    • 0035174557 scopus 로고    scopus 로고
    • Effect of dietary vitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin-diabetic rats
    • Cinar MG, Ulker S, Alper G, Evinc A. 2001. Effect of dietary vitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin-diabetic rats. Pharmacology 62:56-64.
    • (2001) Pharmacology , vol.62 , pp. 56-64
    • Cinar, M.G.1    Ulker, S.2    Alper, G.3    Evinc, A.4
  • 17
    • 0033847954 scopus 로고    scopus 로고
    • Losartan, an angiotensin type 1 receptor inhibitor, and endothelial vasodilator function in Type 1 diabetes mellitus
    • Collis J, Cheetham C, Dembo L, O'Driscoll J, Stanton K, Taylor R, Green D. 2000. Losartan, an angiotensin type 1 receptor inhibitor, and endothelial vasodilator function in Type 1 diabetes mellitus. Diabet Med 17:553-554.
    • (2000) Diabet Med , vol.17 , pp. 553-554
    • Collis, J.1    Cheetham, C.2    Dembo, L.3    O'Driscoll, J.4    Stanton, K.5    Taylor, R.6    Green, D.7
  • 18
    • 0028813306 scopus 로고
    • Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries
    • Cosentino F, Katusic ZS. 1995. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 91:139-144.
    • (1995) Circulation , vol.91 , pp. 139-144
    • Cosentino, F.1    Katusic, Z.S.2
  • 19
    • 0344052668 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and endothelial nitric oxide synthase activity
    • Cosentino F, Luscher TF. 1999, Tetrahydrobiopterin and endothelial nitric oxide synthase activity. Cardiovasc Res 43:274-278.
    • (1999) Cardiovasc Res , vol.43 , pp. 274-278
    • Cosentino, F.1    Luscher, T.F.2
  • 20
    • 0030837996 scopus 로고    scopus 로고
    • High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
    • Cosentino F, Hishikawa K, Katusic ZS, Luscher TF. 1997. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 96:25-28.
    • (1997) Circulation , vol.96 , pp. 25-28
    • Cosentino, F.1    Hishikawa, K.2    Katusic, Z.S.3    Luscher, T.F.4
  • 23
    • 0027054448 scopus 로고
    • Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: New insights on the pathophysiological mechanisms of diabetic vascular complications
    • Curcio F, Ceriello A. 1992. Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol 28A:787-790.
    • (1992) In Vitro Cell Dev Biol , vol.28 A , pp. 787-790
    • Curcio, F.1    Ceriello, A.2
  • 24
    • 0028326484 scopus 로고
    • Serum biopterin - A novel marker for immune activation during prediabetes in the BB rat
    • Davies AJ, Bone AJ, Wilkin TJ, Rokos H, Cole DR. 1994. Serum biopterin - a novel marker for immune activation during prediabetes in the BB rat. Diabetologia 37:466-470.
    • (1994) Diabetologia , vol.37 , pp. 466-470
    • Davies, A.J.1    Bone, A.J.2    Wilkin, T.J.3    Rokos, H.4    Cole, D.R.5
  • 26
    • 0033816515 scopus 로고    scopus 로고
    • The impaired renal vasodilator response attributed to endothelium-derived hypelpolarizing factor in streptozotocin-induced diabetic rats is restored by 5-methyltetrahydrofolate
    • De Vriese An S, Van de Voorde J, Blom HJ, Vanhoutte PM, Verbeke M, Lameire NH. 2000b. The impaired renal vasodilator response attributed to endothelium-derived hypelpolarizing factor in streptozotocin-induced diabetic rats is restored by 5-methyltetrahydrofolate. Diabetologia 43:1116-1125.
    • (2000) Diabetologia , vol.43 , pp. 1116-1125
    • De Vriese An, S.1    Van de Voorde, J.2    Blom, H.J.3    Vanhoutte, P.M.4    Verbeke, M.5    Lameire, N.H.6
  • 27
    • 0028045638 scopus 로고
    • Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: Role of free radicals
    • Diederich D, Skopec J, Diederich A, Dai FX. 1994. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol 266:H1153-H1161.
    • (1994) Am J Physiol , vol.266
    • Diederich, D.1    Skopec, J.2    Diederich, A.3    Dai, F.X.4
  • 28
    • 0035558309 scopus 로고    scopus 로고
    • Relaxing blood vessels: Are there novel endothelium-derived mediators to be found and can their discovery lead to the development of new therapeutic agents?
    • Ding H, Triggle CR. 2002. Relaxing blood vessels: are there novel endothelium-derived mediators to be found and can their discovery lead to the development of new therapeutic agents? Pharmaceut News 8(6):42-49.
    • (2002) Pharmaceut News , vol.8 , Issue.6 , pp. 42-49
    • Ding, H.1    Triggle, C.R.2
  • 31
    • 0027522119 scopus 로고
    • Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependent diabetic patients: Blunted vasoconstriction in patients with microalbuminuria
    • Elliott TG, Cockcroft JR, Groop PH, Viberti GC, Ritter JM. 1993. Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependent diabetic patients: blunted vasoconstriction in patients with microalbuminuria. Clin Sci (Colch) 85:687-693.
    • (1993) Clin Sci (Colch) , vol.85 , pp. 687-693
    • Elliott, T.G.1    Cockcroft, J.R.2    Groop, P.H.3    Viberti, G.C.4    Ritter, J.M.5
  • 32
    • 0033771303 scopus 로고    scopus 로고
    • Endothelial nitric oxide in diabetes mellitus: Too much or not enough?
    • Farkas K, Sannan B, Jermendy G, Somogyi A. 2000. Endothelial nitric oxide in diabetes mellitus: too much or not enough? Diabetes Nutr Metab 13:287-297.
    • (2000) Diabetes Nutr Metab , vol.13 , pp. 287-297
    • Farkas, K.1    Sannan, B.2    Jermendy, G.3    Somogyi, A.4
  • 33
    • 0343986272 scopus 로고    scopus 로고
    • Endothelium-dependent hyperpolarization of vascular smooth muscle cells
    • Feletou M, Vanhoutte PM. 2000 Endothelium-dependent hyperpolarization of vascular smooth muscle cells. Acta Pharmacol Sin 21:1-18.
    • (2000) Acta Pharmacol Sin , vol.21 , pp. 1-18
    • Feletou, M.1    Vanhoutte, P.M.2
  • 34
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF, Zawadzki JV. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373-376.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 35
    • 0027510255 scopus 로고
    • Endothelium-dependent vasodilator responses of the isolated mesenteric bed are preserved in longterm streptozotocin diabetic rats
    • Furman BL, Sneddon P. 1993. Endothelium-dependent vasodilator responses of the isolated mesenteric bed are preserved in longterm streptozotocin diabetic rats. Eur J Pharmacol 232:29-34.
    • (1993) Eur J Pharmacol , vol.232 , pp. 29-34
    • Furman, B.L.1    Sneddon, P.2
  • 36
    • 0015929739 scopus 로고
    • The sorbitol pathway and the complications of diabetes
    • Gabbay KH. 1973. The sorbitol pathway and the complications of diabetes. N Engl J Med 288:831-836.
    • (1973) N Engl J Med , vol.288 , pp. 831-836
    • Gabbay, K.H.1
  • 38
    • 0032757896 scopus 로고    scopus 로고
    • Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus
    • Gazis A, White DJ, Page SR, Cockcroft JR. 1999. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus. Diabet Med 16:304-311.
    • (1999) Diabet Med , vol.16 , pp. 304-311
    • Gazis, A.1    White, D.J.2    Page, S.R.3    Cockcroft, J.R.4
  • 39
    • 85047679406 scopus 로고
    • Influence of experimental diabetes on the mechanical responses of canine coronary arteries: Role of endothelium
    • Gebremedhin D, Koltai MZ, Pogatsa G, Magyar K, Hadhazy P. 1988. Influence of experimental diabetes on the mechanical responses of canine coronary arteries: role of endothelium. Cardiovasc Res 22:537-544.
    • (1988) Cardiovasc Res , vol.22 , pp. 537-544
    • Gebremedhin, D.1    Koltai, M.Z.2    Pogatsa, G.3    Magyar, K.4    Hadhazy, P.5
  • 40
    • 0030048496 scopus 로고    scopus 로고
    • Oxidative stress and diabetic vascular complications
    • Giugliano D, Ceriello A, Paolisso G. 1996. Oxidative stress and diabetic vascular complications. Diabetes Care 19:257-267.
    • (1996) Diabetes Care , vol.19 , pp. 257-267
    • Giugliano, D.1    Ceriello, A.2    Paolisso, G.3
  • 41
    • 0034857939 scopus 로고    scopus 로고
    • Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism
    • Gopaul NK, Manraj MD, Hebe A, Lee Kwai YS, Johnston A, Carrier MJ, Anggard EE. 2001. Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism. Diabetologia 44:706-712.
    • (2001) Diabetologia , vol.44 , pp. 706-712
    • Gopaul, N.K.1    Manraj, M.D.2    Hebe, A.3    Lee Kwai, Y.S.4    Johnston, A.5    Carrier, M.J.6    Anggard, E.E.7
  • 42
    • 0027433608 scopus 로고
    • Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production
    • Gross SS, Levi R, Madera A, Park KH, Vane J, Hattori Y. 1993. Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production. Adv Exp Med Biol 338:295-300.
    • (1993) Adv Exp Med Biol , vol.338 , pp. 295-300
    • Gross, S.S.1    Levi, R.2    Madera, A.3    Park, K.H.4    Vane, J.5    Hattori, Y.6
  • 43
    • 0022640297 scopus 로고
    • Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
    • Gryglewski RJ, Pahner RM, Moncada S. 1986. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320:454-456.
    • (1986) Nature , vol.320 , pp. 454-456
    • Gryglewski, R.J.1    Pahner, R.M.2    Moncada, S.3
  • 44
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in non diabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Ronnemaa T, Pyoralak K, Laakso M. 1998. Mortality from coronary heart disease in subjects with type 2 diabetes and in non diabetic subjects with and without prior myocardial infarction. N Engl J Med 339:229-234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyoralak, K.4    Laakso, M.5
  • 45
    • 0026008802 scopus 로고
    • Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta
    • Hattori Y, Kawasaki H, Abe K, Kanno M. 1991. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 261:H1086-H1094.
    • (1991) Am J Physiol , vol.261
    • Hattori, Y.1    Kawasaki, H.2    Abe, K.3    Kanno, M.4
  • 46
    • 0023217593 scopus 로고
    • A contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit
    • Head RJ, Longhurst PA, Panek RL, Stitzel RE. 1987. A contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit. Br J Pharmacol 91:275-286.
    • (1987) Br J Pharmacol , vol.91 , pp. 275-286
    • Head, R.J.1    Longhurst, P.A.2    Panek, R.L.3    Stitzel, R.E.4
  • 47
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T, Krohn K, Albers S, Meinertz T. 2000. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 43:1435-1438.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 48
    • 0039550848 scopus 로고    scopus 로고
    • L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells
    • Heller R, Munscher-Paulig F, Grabner R, Till U. 1999. L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem 274:8254-8260.
    • (1999) J Biol Chem , vol.274 , pp. 8254-8260
    • Heller, R.1    Munscher-Paulig, F.2    Grabner, R.3    Till, U.4
  • 49
    • 0035808310 scopus 로고    scopus 로고
    • L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
    • Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner ER. 2001. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 276:40-47.
    • (2001) J Biol Chem , vol.276 , pp. 40-47
    • Heller, R.1    Unbehaun, A.2    Schellenberg, B.3    Mayer, B.4    Werner-Felmayer, G.5    Werner, E.R.6
  • 50
    • 0029588302 scopus 로고
    • Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats
    • Heygate KM, Lawrence IG, Bennett MA, Thurston H. 1995. Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats. Br J Pharmacol 116: 3251-3259.
    • (1995) Br J Pharmacol , vol.116 , pp. 3251-3259
    • Heygate, K.M.1    Lawrence, I.G.2    Bennett, M.A.3    Thurston, H.4
  • 54
    • 0033619713 scopus 로고    scopus 로고
    • Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen
    • Hurshman AR, Krebs C, Edmondson DE, Huynh BH, Marletta MA. 1999. Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. Biochemistry 38:15689-15696.
    • (1999) Biochemistry , vol.38 , pp. 15689-15696
    • Hurshman, A.R.1    Krebs, C.2    Edmondson, D.E.3    Huynh, B.H.4    Marletta, M.A.5
  • 55
    • 0032921860 scopus 로고    scopus 로고
    • SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin
    • Ishii M, Shimizu S, Momose K, Yamamoto T. 1999. SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin. J Cardiovasc Pharmacol 33:295-300.
    • (1999) J Cardiovasc Pharmacol , vol.33 , pp. 295-300
    • Ishii, M.1    Shimizu, S.2    Momose, K.3    Yamamoto, T.4
  • 56
    • 0035129395 scopus 로고    scopus 로고
    • Stimulation of tetrahydrobiopterin synthesis induced by insulin: Possible involvement of phosphatidylinositol 3-kinase
    • Ishii M, Shimizu S, Nagai T, Shiota K, Kiuchi Y, Yamamoto T. 2001. Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. Int J Biochem Cell Biol 33:65-73.
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 65-73
    • Ishii, M.1    Shimizu, S.2    Nagai, T.3    Shiota, K.4    Kiuchi, Y.5    Yamamoto, T.6
  • 57
    • 0035726571 scopus 로고    scopus 로고
    • Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production
    • Jaimes EA, Sweeney C, Raij L. 2001. Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production. Hypertension 38:877-883.
    • (2001) Hypertension , vol.38 , pp. 877-883
    • Jaimes, E.A.1    Sweeney, C.2    Raij, L.3
  • 58
    • 0033635176 scopus 로고    scopus 로고
    • Endothelial dysfunction in atherosclerotic mice: Improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin
    • Jiang J, Valen G, Tokuno S, Thoren P, Pernow J. 2000. Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin. Br J Pharmacol 131:1255-1261.
    • (2000) Br J Pharmacol , vol.131 , pp. 1255-1261
    • Jiang, J.1    Valen, G.2    Tokuno, S.3    Thoren, P.4    Pernow, J.5
  • 59
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. 1993. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88:2510-2516.
    • (1993) Circulation , vol.88 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 60
    • 0033663058 scopus 로고    scopus 로고
    • Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
    • Kagota S, Yamaguchi Y, Nakamura K, Kunitomo M. 2000. Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus. Gen Pharmacol 34:201-209.
    • (2000) Gen Pharmacol , vol.34 , pp. 201-209
    • Kagota, S.1    Yamaguchi, Y.2    Nakamura, K.3    Kunitomo, M.4
  • 61
    • 0029835248 scopus 로고    scopus 로고
    • Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes
    • Kamata K and Kobayashi T. 1996. Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes. Br J Pharmacol 119:583-589.
    • (1996) Br J Pharmacol , vol.119 , pp. 583-589
    • Kamata, K.1    Kobayashi, T.2
  • 62
    • 0032801221 scopus 로고    scopus 로고
    • Effects of superoxide dismutase on the acetylcholine-induced relaxation response in cholesterol-fed and streptozotocin-induced diabetic mice
    • Kamata K, Nakajima M, Sugiura M. 1999. Effects of superoxide dismutase on the acetylcholine-induced relaxation response in cholesterol-fed and streptozotocin-induced diabetic mice. J Smooth Muscle Res 35:33-46.
    • (1999) J Smooth Muscle Res , vol.35 , pp. 33-46
    • Kamata, K.1    Nakajima, M.2    Sugiura, M.3
  • 63
    • 0024351774 scopus 로고
    • Endothelium-dependent relaxation to acetylcholine in the aorta of streptozotocin induced diabetic-rat and the BB-diabetic rat
    • Kappagoda T, Jayakody L, Rajotte R, Thomson AB, Senaratne MP. 1989. Endothelium-dependent relaxation to acetylcholine in the aorta of streptozotocin induced diabetic-rat and the BB-diabetic rat. Clin Invest Med 12:187-193.
    • (1989) Clin Invest Med , vol.12 , pp. 187-193
    • Kappagoda, T.1    Jayakody, L.2    Rajotte, R.3    Thomson, A.B.4    Senaratne, M.P.5
  • 64
    • 0029055530 scopus 로고
    • Effects of non-insulin dependent diabetes mellitus on the reactivity of human internal mammary artery and human saphenous vein
    • Karasu C, Soncul H, Altan VM. 1995. Effects of non-insulin dependent diabetes mellitus on the reactivity of human internal mammary artery and human saphenous vein. Life Sci 57:103-112.
    • (1995) Life Sci , vol.57 , pp. 103-112
    • Karasu, C.1    Soncul, H.2    Altan, V.M.3
  • 65
    • 0029942652 scopus 로고    scopus 로고
    • Superoxide anion and endothelial regulation of arterial tone
    • Katusic ZS. 1996. Superoxide anion and endothelial regulation of arterial tone. Free Radic Biol Med 20:443-448.
    • (1996) Free Radic Biol Med , vol.20 , pp. 443-448
    • Katusic, Z.S.1
  • 66
    • 0034837885 scopus 로고    scopus 로고
    • Vascular endothelial dysfunction: Does tetrahydrobiopterin play a role?
    • Katusic ZS. 2001. Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? Am J Physiol Heart Circ Physiol 281:H981-H986.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Katusic, Z.S.1
  • 67
    • 0024397219 scopus 로고
    • Superoxide anion is an endothelium-derived contracting factor
    • Katusic ZS, Vanhoutte PM. 1989. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 257: H33-H37.
    • (1989) Am J Physiol , vol.257
    • Katusic, Z.S.1    Vanhoutte, P.M.2
  • 68
    • 0031984389 scopus 로고    scopus 로고
    • Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells
    • Katusic ZS, Stelter A, Milstien S. 1998. Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 18:27-32.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 27-32
    • Katusic, Z.S.1    Stelter, A.2    Milstien, S.3
  • 69
    • 0026072264 scopus 로고
    • Some metabolic relationships between biopterin and folate: Implications for the methyl trap hypothesis
    • Kaufman S. 1991. Some metabolic relationships between biopterin and folate: implications for the methyl trap hypothesis. Neurochem Res 16:1031-1036.
    • (1991) Neurochem Res , vol.16 , pp. 1031-1036
    • Kaufman, S.1
  • 70
    • 33750688578 scopus 로고    scopus 로고
    • Exogenous tetrahydrobiopterin causes endothelium-dependent contractions in isolated canine basilar artery
    • Kinoshita H, Katusic ZS. 1996. Exogenous tetrahydrobiopterin causes endothelium-dependent contractions in isolated canine basilar artery. Am J Physiol 271:H738-H743.
    • (1996) Am J Physiol , vol.271
    • Kinoshita, H.1    Katusic, Z.S.2
  • 71
    • 33751290467 scopus 로고    scopus 로고
    • Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery
    • Kinoshita H, Milstien S, Wambi C, Katusic ZS. 1997. Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery. Am J Physiol 273:H718-H724.
    • (1997) Am J Physiol , vol.273
    • Kinoshita, H.1    Milstien, S.2    Wambi, C.3    Katusic, Z.S.4
  • 72
    • 0026687419 scopus 로고
    • Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor
    • Klatt P, Heinzel B, Mayer B, Ambach E, Werner-Felmayer G, Wachter H, Werner ER. 1992. Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor. FEBS Lett 305:160-162.
    • (1992) FEBS Lett , vol.305 , pp. 160-162
    • Klatt, P.1    Heinzel, B.2    Mayer, B.3    Ambach, E.4    Werner-Felmayer, G.5    Wachter, H.6    Werner, E.R.7
  • 73
    • 0027292075 scopus 로고
    • Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-Larginine as an intermediate
    • Klatt P, Schmidt K, Uray G, Mayer B. 1993. Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-Larginine as an intermediate. J Biol Chem 268:14781-14787.
    • (1993) J Biol Chem , vol.268 , pp. 14781-14787
    • Klatt, P.1    Schmidt, K.2    Uray, G.3    Mayer, B.4
  • 74
    • 0028302095 scopus 로고
    • The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain
    • Klatt P, Schmid M, Leopold E, Schmidt K, Werner ER, Mayer B. 1994. The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain. J Biol Chem 269: 13861-13866.
    • (1994) J Biol Chem , vol.269 , pp. 13861-13866
    • Klatt, P.1    Schmid, M.2    Leopold, E.3    Schmidt, K.4    Werner, E.R.5    Mayer, B.6
  • 75
    • 0033055194 scopus 로고    scopus 로고
    • Effect of insulin treatment on smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes
    • Kobayashi T, Kamata K. 1999. Effect of insulin treatment on smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes. Br J Pharmacol 127:835-842.
    • (1999) Br J Pharmacol , vol.127 , pp. 835-842
    • Kobayashi, T.1    Kamata, K.2
  • 76
    • 0035098023 scopus 로고    scopus 로고
    • Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats
    • Kobayashi T, Kamata K. 2001. Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats. Atherosclerosis 155:313-320.
    • (2001) Atherosclerosis , vol.155 , pp. 313-320
    • Kobayashi, T.1    Kamata, K.2
  • 77
    • 0033778851 scopus 로고    scopus 로고
    • Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats
    • Kobayashi T, Matsumoto T, Kamata K. 2000. Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats. Br J Pharmacol 131:231-238.
    • (2000) Br J Pharmacol , vol.131 , pp. 231-238
    • Kobayashi, T.1    Matsumoto, T.2    Kamata, K.3
  • 78
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. 1998. Protein kinase C activation and the development of diabetic complications. Diabetes 47:859-866.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 79
    • 0035216224 scopus 로고    scopus 로고
    • Influence of Type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries
    • Lagaud GJ, Masih-Khan E, Kai S, van Breemen C, Dube GP. 2001. Influence of Type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries. J Vasc Res 38:578-589
    • (2001) J Vasc Res , vol.38 , pp. 578-589
    • Lagaud, G.J.1    Masih-Khan, E.2    Kai, S.3    Van Breemen, C.4    Dube, G.P.5
  • 80
    • 0034683051 scopus 로고    scopus 로고
    • Antioxidants, diabetes and endothelial dysfunction
    • Laight DW, Carrier MJ, Anggard EE. 2000. Antioxidants, diabetes and endothelial dysfunction. Cardiovasc Res 47:457-464.
    • (2000) Cardiovasc Res , vol.47 , pp. 457-464
    • Laight, D.W.1    Carrier, M.J.2    Anggard, E.E.3
  • 81
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG. 2001. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103:1282-1288.
    • (2001) Circulation , vol.103 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 82
    • 0034089318 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits
    • Lund DD, Faraci FM, Miller FJ Jr, Heistad DD. 2000. Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits. Circulation 101:1027-1033.
    • (2000) Circulation , vol.101 , pp. 1027-1033
    • Lund, D.D.1    Faraci, F.M.2    Miller F.J., Jr.3    Heistad, D.D.4
  • 85
    • 0035743353 scopus 로고    scopus 로고
    • Insulin action in the vasculature: Physiology and Pathophysiology
    • Mather KJ, Anderson TJ, Verma S. 2001a. Insulin action in the vasculature: Physiology and Pathophysiology. J Vasc Res 38: 415-422.
    • (2001) J Vasc Res , vol.38 , pp. 415-422
    • Mather, K.J.1    Anderson, T.J.2    Verma, S.3
  • 86
    • 0035312620 scopus 로고    scopus 로고
    • Improved endothelial function with metformin in type 2 diabetes mellitus
    • Mather KJ, Verma S, Anderson TJ. 2001b. Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol 37:1344-1350.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1344-1350
    • Mather, K.J.1    Verma, S.2    Anderson, T.J.3
  • 87
    • 0029043644 scopus 로고
    • In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide
    • Mayer B, Werner ER. 1995. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide. Naunym Schmied Arch Pharmacol 351:453-463.
    • (1995) Naunym Schmied Arch Pharmacol , vol.351 , pp. 453-463
    • Mayer, B.1    Werner, E.R.2
  • 88
    • 0028924952 scopus 로고
    • Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide
    • Mayer B, Klatt P, Werner ER, Schmidt K. 1995. Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide. J Biol Chem 270:655-659.
    • (1995) J Biol Chem , vol.270 , pp. 655-659
    • Mayer, B.1    Klatt, P.2    Werner, E.R.3    Schmidt, K.4
  • 89
    • 0029438321 scopus 로고
    • Nitric oxide and cGMP signaling
    • McDonald LJ, Murad F. 1995. Nitric oxide and cGMP signaling. Adv Pharmacol 34:263-275.
    • (1995) Adv Pharmacol , vol.34 , pp. 263-275
    • McDonald, L.J.1    Murad, F.2
  • 90
    • 0034885499 scopus 로고    scopus 로고
    • Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarizing factor(s)
    • McGuire JJ, Ding H, Triggle CR. 2001. Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s). Can J Physiol Pharmacol 79:443-470.
    • (2001) Can J Physiol Pharmacol , vol.79 , pp. 443-470
    • McGuire, J.J.1    Ding, H.2    Triggle, C.R.3
  • 91
    • 0035102966 scopus 로고    scopus 로고
    • Selective enhancement of sensitivity to endothelin-1 despite normal endothelium-dependent relaxation in subcutaneous resistance arteries isolated from patients with Type I diabetes
    • McIntyre CA, Hadoke PW, Williams BC, Lindsay RM, Elliott AI, McKnight JA. 2001. Selective enhancement of sensitivity to endothelin-1 despite normal endothelium-dependent relaxation in subcutaneous resistance arteries isolated from patients with Type I diabetes. Clin Sci (Colch) 100:311-318.
    • (2001) Clin Sci (Colch) , vol.100 , pp. 311-318
    • McIntyre, C.A.1    Hadoke, P.W.2    Williams, B.C.3    Lindsay, R.M.4    Elliott, A.I.5    McKnight, J.A.6
  • 92
    • 0028309655 scopus 로고
    • Impaired contraction and endotheliumdependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus
    • McNally PG, Watt PA, Rimmer T, Burden AC, Hearnshaw JR, Thurston H. 1994. Impaired contraction and endotheliumdependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin Sci (Colch) 87: 31-36.
    • (1994) Clin Sci (Colch) , vol.87 , pp. 31-36
    • McNally, P.G.1    Watt, P.A.2    Rimmer, T.3    Burden, A.C.4    Hearnshaw, J.R.5    Thurston, H.6
  • 93
    • 0028290475 scopus 로고
    • Defective endothelium-dependent relaxation in the JCR:LAcorpulent rat
    • McNamee CJ, Kappagoda CT, Kunjara R, Russell JC. 1994. Defective endothelium-dependent relaxation in the JCR:LAcorpulent rat. Circ Res 74:1126-1132.
    • (1994) Circ Res , vol.74 , pp. 1126-1132
    • McNamee, C.J.1    Kappagoda, C.T.2    Kunjara, R.3    Russell, J.C.4
  • 95
    • 0034235409 scopus 로고    scopus 로고
    • Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
    • Meininger CJ, Marinos RS, Hatakeyama K, Martinez-Zaguilan R, Rojas JD, Kelly KA, Wu G. 2000. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J 349:353-356.
    • (2000) Biochem J , vol.349 , pp. 353-356
    • Meininger, C.J.1    Marinos, R.S.2    Hatakeyama, K.3    Martinez-Zaguilan, R.4    Rojas, J.D.5    Kelly, K.A.6    Wu, G.7
  • 96
    • 0030711558 scopus 로고    scopus 로고
    • Nitric oxide synthases: Which, where, how, and why?
    • Michel T, Feron O. 1997. Nitric oxide synthases: which, where, how, and why? J Clin Invest 100:2146-2152.
    • (1997) J Clin Invest , vol.100 , pp. 2146-2152
    • Michel, T.1    Feron, O.2
  • 97
    • 0033527413 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
    • Milstien S, Katusic Z. 1999. Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochem Biophys Res Commun 263:681-684.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 681-684
    • Milstien, S.1    Katusic, Z.2
  • 98
    • 0016833290 scopus 로고
    • Studies on the phenylalanine hydroxylase system in liver slices
    • Milstien S, Kaufman S. 1975. Studies on the phenylalanine hydroxylase system in liver slices. J Biol Chem 250:4777-4781.
    • (1975) J Biol Chem , vol.250 , pp. 4777-4781
    • Milstien, S.1    Kaufman, S.2
  • 99
    • 0018045665 scopus 로고
    • Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin
    • Moncada S, Vane JR. 1978. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev 30:293-331.
    • (1978) Pharmacol Rev , vol.30 , pp. 293-331
    • Moncada, S.1    Vane, J.R.2
  • 100
    • 0021891891 scopus 로고
    • Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin
    • Nichol CA, Smith GK, Duch DS. 1985. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annu Rev Biochem 54:729-764.
    • (1985) Annu Rev Biochem , vol.54 , pp. 729-764
    • Nichol, C.A.1    Smith, G.K.2    Duch, D.S.3
  • 101
    • 0027216069 scopus 로고
    • Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function
    • Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali JR. 1993. Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 42:1017-1025.
    • (1993) Diabetes , vol.42 , pp. 1017-1025
    • Nitenberg, A.1    Valensi, P.2    Sachs, R.3    Dali, M.4    Aptecar, E.5    Attali, J.R.6
  • 103
    • 0030840915 scopus 로고    scopus 로고
    • Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus
    • O'Driscoll G, Green D, Rankin J, Stanton K, Taylor R. 1997. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. J Clin Invest 100:678-684.
    • (1997) J Clin Invest , vol.100 , pp. 678-684
    • O'Driscoll, G.1    Green, D.2    Rankin, J.3    Stanton, K.4    Taylor, R.5
  • 104
    • 0033133528 scopus 로고    scopus 로고
    • Improvement in endothelial function by angiotensinconverting enzyme inhibition in non-insulin-dependent diabetes mellitus
    • O'Driscoll G, Green D, Maiorana A, Stanton K, Colreavy F, Taylor R. 1999. Improvement in endothelial function by angiotensinconverting enzyme inhibition in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 33:1506-1511.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1506-1511
    • O'Driscoll, G.1    Green, D.2    Maiorana, A.3    Stanton, K.4    Colreavy, F.5    Taylor, R.6
  • 105
    • 0028029346 scopus 로고
    • The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats
    • Otter DJ, Chess-Williams R. 1994. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol 113:576-580.
    • (1994) Br J Pharmacol , vol.113 , pp. 576-580
    • Otter, D.J.1    Chess-Williams, R.2
  • 106
    • 0034574492 scopus 로고    scopus 로고
    • Impaired relaxation in aorta from streptozotocin-diabetic rats: Effect of aminoguanidine (AMNG) treatment
    • Ozyazgan S, Unlucerci Y, Bekpinar S, Akkan AG. 2000. Impaired relaxation in aorta from streptozotocin-diabetic rats: effect of aminoguanidine (AMNG) treatment. Int J Exp Diabetes Res 1:145-153.
    • (2000) Int J Exp Diabetes Res , vol.1 , pp. 145-153
    • Ozyazgan, S.1    Unlucerci, Y.2    Bekpinar, S.3    Akkan, A.G.4
  • 107
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of eiidothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S. 1987. Nitric oxide release accounts for the biological activity of eiidothelium-derived relaxing factor. Nature 327:524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 108
    • 0031935559 scopus 로고    scopus 로고
    • Endothelial dysfunction in streptozotocin-diabetic rats is not reversed by dietary probucol or simvastatin supplementation
    • Palmer AM, Gopaul N, Dhir S, Thomas CR, Poston L, Tribe RM. 1998. Endothelial dysfunction in streptozotocin-diabetic rats is not reversed by dietary probucol or simvastatin supplementation. Diabetologia 41:157-164.
    • (1998) Diabetologia , vol.41 , pp. 157-164
    • Palmer, A.M.1    Gopaul, N.2    Dhir, S.3    Thomas, C.R.4    Poston, L.5    Tribe, R.M.6
  • 109
    • 0036271495 scopus 로고    scopus 로고
    • Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (dbldb-1-) mice: Role of decreased tetrahydrobiopterin bioavailability
    • Pannirselvam M, Verma S, Anderson TJ. 2002. Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (dbldb-1-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol 136:255-263.
    • (2002) Br J Pharmacol , vol.136 , pp. 255-263
    • Pannirselvam, M.1    Verma, S.2    Anderson, T.J.3
  • 111
    • 0031033321 scopus 로고    scopus 로고
    • Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin
    • Pieper GM. 1997. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiovasc Pharmacol 29:8-15.
    • (1997) J Cardiovasc Pharmacol , vol.29 , pp. 8-15
    • Pieper, G.M.1
  • 112
    • 0032950298 scopus 로고    scopus 로고
    • Enhanced, unaltered and impaired nitric oxidemediated endothelium-dependent relaxation in experimental diabetes mellitus: Importance of disease duration
    • Pieper GM. 1999. Enhanced, unaltered and impaired nitric oxidemediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 42:204-213.
    • (1999) Diabetologia , vol.42 , pp. 204-213
    • Pieper, G.M.1
  • 113
    • 0031800116 scopus 로고    scopus 로고
    • Oral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunction
    • Pieper GM, Siebeneich W. 1998. Oral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunction. J Cardiovasc Pharmacol 32:101-105.
    • (1998) J Cardiovasc Pharmacol , vol.32 , pp. 101-105
    • Pieper, G.M.1    Siebeneich, W.2
  • 114
    • 0031953039 scopus 로고    scopus 로고
    • A comparison of spasmogenic and relaxant responses in aortae from C57/BL/KsJ diabetic mice with those from their non-diabetic litter mates
    • Piercy V, Taylor SG. 1998. A comparison of spasmogenic and relaxant responses in aortae from C57/BL/KsJ diabetic mice with those from their non-diabetic litter mates. Pharmacology 56: 267-275.
    • (1998) Pharmacology , vol.56 , pp. 267-275
    • Piercy, V.1    Taylor, S.G.2
  • 115
    • 0033372160 scopus 로고    scopus 로고
    • Endothelial dysfunction in Type 1 diabetes mellitus: Relationship with LDL oxidation and the effects of vitamin E
    • Pinkney JH, Downs L, Hopton M, Mackness MI, Bolton CH. 1999. Endothelial dysfunction in Type 1 diabetes mellitus: relationship with LDL oxidation and the effects of vitamin E. Diabet Med 16:993-999.
    • (1999) Diabet Med , vol.16 , pp. 993-999
    • Pinkney, J.H.1    Downs, L.2    Hopton, M.3    Mackness, M.I.4    Bolton, C.H.5
  • 116
    • 0028946553 scopus 로고
    • Endothelium-mediated vascular function in insulin-dependent diabetes mellitus
    • Glaxo/MRS Young Investigator Prize
    • Poston L, Taylor PD. 1995. Glaxo/MRS Young Investigator Prize. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci (Colch) 88:245-255.
    • (1995) Clin Sci (Colch) , vol.88 , pp. 245-255
    • Poston, L.1    Taylor, P.D.2
  • 117
    • 0026470180 scopus 로고
    • Generation of superoxide by purified brain nitric oxide synthase
    • Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. 1992. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 267:24173-24176.
    • (1992) J Biol Chem , vol.267 , pp. 24173-24176
    • Pou, S.1    Pou, W.S.2    Bredt, D.S.3    Snyder, S.H.4    Rosen, G.M.5
  • 118
    • 0034803984 scopus 로고    scopus 로고
    • Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells
    • Prabhakar SS. 2001. Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells. Am J Physiol Renal Physiol 281:F179-F188.
    • (2001) Am J Physiol Renal Physiol , vol.281
    • Prabhakar, S.S.1
  • 119
    • 0034902045 scopus 로고    scopus 로고
    • Hyperglycemia-induced ascorbic acid deficiency promotes endothelial dysfunction and the development of atherosclerosis
    • Price KD, Price CS, Reynolds RD. 2001. Hyperglycemia-induced ascorbic acid deficiency promotes endothelial dysfunction and the development of atherosclerosis. Atherosclerosis 158:1-12.
    • (2001) Atherosclerosis , vol.158 , pp. 1-12
    • Price, K.D.1    Price, C.S.2    Reynolds, R.D.3
  • 120
    • 0029838582 scopus 로고    scopus 로고
    • Reversing endothelial dysfunction with ACE inhibitors. A new trend
    • Rajagopalan S, Harrison DG. 1996. Reversing endothelial dysfunction with ACE inhibitors. A new trend. Circulation 94:240-243.
    • (1996) Circulation , vol.94 , pp. 240-243
    • Rajagopalan, S.1    Harrison, D.G.2
  • 123
    • 0029085103 scopus 로고
    • Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: Influence of tocopherol as antioxidant
    • Rosen P, Ballhausen T, Bloch W, Addicks K. 1995. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38: 1157-1168.
    • (1995) Diabetologia , vol.38 , pp. 1157-1168
    • Rosen, P.1    Ballhausen, T.2    Bloch, W.3    Addicks, K.4
  • 124
    • 0028196891 scopus 로고
    • Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity
    • Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS. 1994. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 93:2236-2243.
    • (1994) J Clin Invest , vol.93 , pp. 2236-2243
    • Rosenkranz-Weiss, P.1    Sessa, W.C.2    Milstien, S.3    Kaufman, S.4    Watson, C.A.5    Pober, J.S.6
  • 125
    • 0027445164 scopus 로고
    • The role of endothelium in cardiovascular homeostasis and diseases
    • Rubanyi GM. 1993. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 22(Suppl 4):S1-14.
    • (1993) J Cardiovasc Pharmacol , vol.22 , Issue.SUPPL. 4
    • Rubanyi, G.M.1
  • 126
    • 0024559857 scopus 로고
    • Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence
    • Saenz DT, I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. 1989. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320:1025-1030.
    • (1989) N Engl J Med , vol.320 , pp. 1025-1030
    • Saenz, D.T.1    Goldstein, I.2    Azadzoi, K.3    Krane, R.J.4    Cohen, R.A.5
  • 127
    • 0347772237 scopus 로고    scopus 로고
    • Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with noninsulin-dependent diabetes mellitus
    • Sekiya M, Suzuki J, Watanabe K, Funada J, Otani T, Akutsu H. 2001. Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with noninsulin-dependent diabetes mellitus. Jpn Circ J 65:487-490.
    • (2001) Jpn Circ J , vol.65 , pp. 487-490
    • Sekiya, M.1    Suzuki, J.2    Watanabe, K.3    Funada, J.4    Otani, T.5    Akutsu, H.6
  • 128
    • 0033778502 scopus 로고    scopus 로고
    • The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats
    • Sellers DJ, Chess-Williams R. 2000. The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats. J Auton Pharmacol 20:15-22.
    • (2000) J Auton Pharmacol , vol.20 , pp. 15-22
    • Sellers, D.J.1    Chess-Williams, R.2
  • 129
    • 0033512422 scopus 로고    scopus 로고
    • Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta
    • Shinozaki K, Kashiwagi A, Nishio Y, Okamura T, Yoshida Y, Masada M, Toda N, Kikkawa R. 1999. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta. Diabetes 48:2437-2445.
    • (1999) Diabetes , vol.48 , pp. 2437-2445
    • Shinozaki, K.1    Kashiwagi, A.2    Nishio, Y.3    Okamura, T.4    Yoshida, Y.5    Masada, M.6    Toda, N.7    Kikkawa, R.8
  • 130
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulinresistant rats
    • Shinozaki K, Nishio Y, Okamura T, Yoshida Y, Maegawa H, Kojima H, Masada M, Toda N, Kikkawa R, Kashiwagi A. 2000. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulinresistant rats. Circ Res 87:566-573.
    • (2000) Circ Res , vol.87 , pp. 566-573
    • Shinozaki, K.1    Nishio, Y.2    Okamura, T.3    Yoshida, Y.4    Maegawa, H.5    Kojima, H.6    Masada, M.7    Toda, N.8    Kikkawa, R.9    Kashiwagi, A.10
  • 131
    • 0029793534 scopus 로고    scopus 로고
    • Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport
    • Simmons WW, Ungureanu-Longrois D, Smith GK, Smith TW, Kelly RA. 1996. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. J Biol Chem 271:23928-23937.
    • (1996) J Biol Chem , vol.271 , pp. 23928-23937
    • Simmons, W.W.1    Ungureanu-Longrois, D.2    Smith, G.K.3    Smith, T.W.4    Kelly, R.A.5
  • 132
    • 0033910718 scopus 로고    scopus 로고
    • Vitamin E supplementation improves endothelial function in type I diabetes mellitus: A randomized, placebo-controlled study
    • Skyrme-Jones RA, O'Brien RC, Berry KL, Meredith IT. 2000. Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study. J Am Coll Cardiol 36:94-102.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 94-102
    • Skyrme-Jones, R.A.1    O'Brien, R.C.2    Berry, K.L.3    Meredith, I.T.4
  • 133
    • 0027492051 scopus 로고
    • Endothelium-dependent vascular relaxation in patients with type I diabetes
    • Smits P, Kapma JA, Jacobs MC, Lutterman J, Thien T. 1993. Endothelium-dependent vascular relaxation in patients with type I diabetes. Diabetes 42:148-153.
    • (1993) Diabetes , vol.42 , pp. 148-153
    • Smits, P.1    Kapma, J.A.2    Jacobs, M.C.3    Lutterman, J.4    Thien, T.5
  • 134
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfuncton. Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. 1996. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97:2601-2610.
    • (1996) J Clin Invest , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 136
    • 0033304535 scopus 로고    scopus 로고
    • Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes
    • Tan KC, Ai VH, Chow WS, Chau MT, Leong L, Lam KS. 1999. Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes. J Clin Endocrinol Metab 84:3212-3216.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3212-3216
    • Tan, K.C.1    Ai, V.H.2    Chow, W.S.3    Chau, M.T.4    Leong, L.5    Lam, K.S.6
  • 137
    • 0028151070 scopus 로고
    • The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery
    • Taylor PD, Poston L. 1994. The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery. Br J Pharmacol 113:801-808.
    • (1994) Br J Pharmacol , vol.113 , pp. 801-808
    • Taylor, P.D.1    Poston, L.2
  • 138
    • 0026759488 scopus 로고
    • Free radicals mediate endothelial cell dysfunction caused by elevated glucose
    • Tesfamariam B, Cohen RA. 1992. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 263:H321-H326.
    • (1992) Am J Physiol , vol.263
    • Tesfamariam, B.1    Cohen, R.A.2
  • 139
    • 0025832494 scopus 로고
    • Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C
    • Tesfamariam B, Brown ML, Cohen RA. 1991. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 87:1643-1648.
    • (1991) J Clin Invest , vol.87 , pp. 1643-1648
    • Tesfamariam, B.1    Brown, M.L.2    Cohen, R.A.3
  • 140
    • 0027434707 scopus 로고
    • Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta
    • Tesfamariam B, Palacino JJ, Weisbrod RM, Cohen RA. 1993. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol 21:205-211.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 205-211
    • Tesfamariam, B.1    Palacino, J.J.2    Weisbrod, R.M.3    Cohen, R.A.4
  • 141
    • 0034176921 scopus 로고    scopus 로고
    • Tetrahydrobiopterin biosynthesis, regeneration and functions
    • Thony B, Auerbach G, Blau N. 2000. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J 347:1-16.
    • (2000) Biochem J , vol.347 , pp. 1-16
    • Thony, B.1    Auerbach, G.2    Blau, N.3
  • 142
    • 0029833673 scopus 로고    scopus 로고
    • Restoration of endothelium -dependent vasodilation after reperfusion injury by tetrahydrobiopterin
    • Tiefenbacher CP, Chilian WM, Mitchell M, DeFily DV. 1996. Restoration of endothelium -dependent vasodilation after reperfusion injury by tetrahydrobiopterin. Circulation 94:1423-1429.
    • (1996) Circulation , vol.94 , pp. 1423-1429
    • Tiefenbacher, C.P.1    Chilian, W.M.2    Mitchell, M.3    DeFily, D.V.4
  • 143
    • 0034739459 scopus 로고    scopus 로고
    • Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis
    • Tiefenbacher CP, Bleeke T, Vahl C, Amann K, Vogt A, Kubler W. 2000. Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis. Circulation 102:2172-2179.
    • (2000) Circulation , vol.102 , pp. 2172-2179
    • Tiefenbacher, C.P.1    Bleeke, T.2    Vahl, C.3    Amann, K.4    Vogt, A.5    Kubler, W.6
  • 144
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. 1996. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97:22-28.
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 145
    • 0030997880 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia
    • Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P, Creager MA. 1997. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 95:2617-2622.
    • (1997) Circulation , vol.95 , pp. 2617-2622
    • Ting, H.H.1    Timimi, F.K.2    Haley, E.A.3    Roddy, M.A.4    Ganz, P.5    Creager, M.A.6
  • 146
    • 0033673223 scopus 로고    scopus 로고
    • Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: An effect prevented by vitamins C and E
    • Title LM, Cummings PM, Giddens K, Nassar BA. 2000. Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J Am Coll Cardiol 36:2185-2191.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 2185-2191
    • Title, L.M.1    Cummings, P.M.2    Giddens, K.3    Nassar, B.A.4
  • 150
    • 0035887885 scopus 로고    scopus 로고
    • Reaction of tetrahydrobiopterin with superoxide: EPRkinetic analysis and characterization of the pteridine radical
    • Vasquez-Vivar J, Whitsett J, Martasek P, Hogg N, Kalyanaraman B. 2001. Reaction of tetrahydrobiopterin with superoxide: EPRkinetic analysis and characterization of the pteridine radical. Free Radic Biol Med 31:975-985.
    • (2001) Free Radic Biol Med , vol.31 , pp. 975-985
    • Vasquez-Vivar, J.1    Whitsett, J.2    Martasek, P.3    Hogg, N.4    Kalyanaraman, B.5
  • 151
    • 0030009553 scopus 로고    scopus 로고
    • Defective endothelium-dependent relaxation in fructose-hypertensive rats
    • Verma S, Bhanot S, Yao L, McNeill JH. 1996. Defective endothelium-dependent relaxation in fructose-hypertensive rats. Am J Hypertens 9:370-376.
    • (1996) Am J Hypertens , vol.9 , pp. 370-376
    • Verma, S.1    Bhanot, S.2    Yao, L.3    McNeill, J.H.4
  • 152
    • 0032160994 scopus 로고    scopus 로고
    • Insulininduced vasodilation is dependent on tetrahydrobiopterin synthesis
    • Verma S, Arikawa E, Yao L, Laher I, McNeill JH. 1998. Insulininduced vasodilation is dependent on tetrahydrobiopterin synthesis. Metabolism 47:1037-1039.
    • (1998) Metabolism , vol.47 , pp. 1037-1039
    • Verma, S.1    Arikawa, E.2    Yao, L.3    Laher, I.4    McNeill, J.H.5
  • 154
    • 0027049697 scopus 로고
    • Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: A model for diabetic and aging complications
    • Vlassara H, Fuh H, Makita Z, Krungkrai S, Cerami A, Bucala R. 1992. Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications. Proc Natl Acad Sci USA 89:12043-12047.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 12043-12047
    • Vlassara, H.1    Fuh, H.2    Makita, Z.3    Krungkrai, S.4    Cerami, A.5    Bucala, R.6
  • 155
    • 0023110164 scopus 로고
    • Modulation of vascular tonus by the endothelium in experimental diabetes
    • Wakabayashi I, Hatake K, Kimura N, Kakishita E, Nagai K. 1987. Modulation of vascular tonus by the endothelium in experimental diabetes. Life Sci 40:643-648.
    • (1987) Life Sci , vol.40 , pp. 643-648
    • Wakabayashi, I.1    Hatake, K.2    Kimura, N.3    Kakishita, E.4    Nagai, K.5
  • 156
    • 0032701197 scopus 로고    scopus 로고
    • Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase
    • Waldron GJ, Ding H, Lovren F, Kubes P, Triggle CR. 1999. Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase. Br J Pharmacol 128:653-658.
    • (1999) Br J Pharmacol , vol.128 , pp. 653-658
    • Waldron, G.J.1    Ding, H.2    Lovren, F.3    Kubes, P.4    Triggle, C.R.5
  • 158
    • 0035808315 scopus 로고    scopus 로고
    • Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase
    • Wei CC, Wang ZQ, Wang Q, Meade AL, Hemann C, Hille R, Stuehr DJ. 2001. Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase. J Biol Chem 276:315-319.
    • (2001) J Biol Chem , vol.276 , pp. 315-319
    • Wei, C.C.1    Wang, Z.Q.2    Wang, Q.3    Meade, A.L.4    Hemann, C.5    Hille, R.6    Stuehr, D.J.7
  • 159
    • 0026458447 scopus 로고
    • Tetrahydrobiopterin biosynthesis inhibition for diminishing nitric oxide production in cytokine-mediated septic shock
    • Werner-Felmayer G, Werner ER, Weis G, Wachter H. 1992. Tetrahydrobiopterin biosynthesis inhibition for diminishing nitric oxide production in cytokine-mediated septic shock. J Natl Cancer Inst 84:1671-1672.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1671-1672
    • Werner-Felmayer, G.1    Werner, E.R.2    Weis, G.3    Wachter, H.4
  • 161
    • 0031577442 scopus 로고    scopus 로고
    • Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
    • Wever RM, van Dam T, van Rijn HJ, de Groot F, Rabelink TJ. 1997. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase. Biochem Biophys Res Commun 237:340-344.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 340-344
    • Wever, R.M.1    Van Dam, T.2    Van Rijn, H.J.3    De Groot, F.4    Rabelink, T.J.5
  • 162
    • 0032696338 scopus 로고    scopus 로고
    • Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular eontractility
    • Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann RJ. 1999. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular eontractility. J Clin Invest 104:1223-1233.
    • (1999) J Clin Invest , vol.104 , pp. 1223-1233
    • Wiest, R.1    Das, S.2    Cadelina, G.3    Garcia-Tsao, G.4    Milstien, S.5    Groszmann, R.J.6
  • 163
    • 0030863502 scopus 로고    scopus 로고
    • Glucoseinduced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
    • Williams B, Gallacher B, Patel H, Orme C. 1997. Glucoseinduced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 46:1497-1503.
    • (1997) Diabetes , vol.46 , pp. 1497-1503
    • Williams, B.1    Gallacher, B.2    Patel, H.3    Orme, C.4
  • 166
    • 0030032756 scopus 로고    scopus 로고
    • Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase
    • Witteveen CF, Giovanelli J, Kaufman S. 1996. Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase. J Biol Chem 271:4143-4147.
    • (1996) J Biol Chem , vol.271 , pp. 4143-4147
    • Witteveen, C.F.1    Giovanelli, J.2    Kaufman, S.3
  • 167
    • 0023259759 scopus 로고
    • Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes
    • Wolff SP, Dean RT. 1987. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem J 245:243-250.
    • (1987) Biochem J , vol.245 , pp. 243-250
    • Wolff, S.P.1    Dean, R.T.2
  • 168
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
    • Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D. 1994. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269:9889-9897.
    • (1994) J Biol Chem , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.M.3    Zhang, J.4    Brett, J.5    Zou, Y.S.6    Pinsky, D.7    Stern, D.8
  • 169
    • 0034021258 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase alters endothelium-dependent relaxations in aortas from diabetic rabbits
    • Zanetti M, Sato J, Katusic ZS, O'Brien T. 2000. Gene transfer of endothelial nitric oxide synthase alters endothelium-dependent relaxations in aortas from diabetic rabbits. Diabetologia 43:340-347.
    • (2000) Diabetologia , vol.43 , pp. 340-347
    • Zanetti, M.1    Sato, J.2    Katusic, Z.S.3    O'Brien, T.4
  • 170
    • 0034987628 scopus 로고    scopus 로고
    • Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta
    • Zanetti M, Sato J, Katusic ZS, O'Brien T. 2001. Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta. Am J Physiol Heart Circ Physiol 280: H2516-H2523.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Zanetti, M.1    Sato, J.2    Katusic, Z.S.3    O'Brien, T.4


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