Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: An effect prevented by vitamins C and E

Journal of the American College of Cardiology

Volumn 36, Issue 7, 2000, Pages 2185-2191

  Title, Lawrence M ^a   Cummings, Peter M ^a   Giddens, Karen ^a   Nassar, Bassam A ^a  

^a QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; GLUCOSE;

ADULT; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; ENDOTHELIUM CELL; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

ADULT; ASCORBIC ACID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; OXIDATIVE STRESS; POSTPRANDIAL PERIOD; VASODILATION; VITAMIN E;

EID: 0033673223     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(00)00980-3     Document Type: Article

References (43)

1. Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
2. Dysglycemia and risk of cardiovascular disease
3. Glucose: A continuous risk factor for cardiovascular disease
4. The postprandial state and risk of cardiovascular disease
5. The relationship between glucose and incident cardiovascular events: A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years
6. Coronary heart disease risk and impaired glucose tolerance. The Whitehall study
7. Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry
8. Glucose tolerance and coronary heart disease: Helsinki Policemen study
9. Free radicals mediate endothelial cell dysfunction caused by elevated glucose
10. High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions
11. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
12. Generation of reactive oxygen intermediates, activation of NF-kappaB and induction of apoptosis in human endothelial cells by glucose: Role of nitric oxide synthase?
13. The pathogenesis of atherosclerosis: A perspective for the 1990s
14. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low-density lipoprotein cholesterol levels
15. Impaired nitric oxide-mediated vasodilation in patients with noninsulin-dependent diabetes mellitus
16. Leukocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase and serum and leukocyte vitamin C levels of patients with type II diabetes mellitus
17. Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM
18. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo
19. Endothelium-dependent vasodilation is impaired in both microcirculation and macrocirculation during acute hyperglycemia
20. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery
21. The erythrocyte glutathione levels during oral glucose tolerance test
22. Activity of antioxidant enzymes during hyperglycemia and hypoglycemia in healthy subjects
23. Antioxidant defenses are reduced during the oral glucose tolerance test in normal and noninsulin-dependent diabetic subjects
24. Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in nondiabetic individuals
25. Antioxidants prevent high-D-glucose-enhanced endothelial Ca2+/cGMP response by scavenging superoxide anions
26. Antioxidant and triglyceride-lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin-diabetic rats
27. Vitamin C improves endothelium-dependent vasodilation in patients with noninsulin-dependent diabetes mellitus
28. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal
29. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans
30. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
31. The effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease
32. High-performance liquid chromatographic determination of plasma malondialdehyde level without a solvent extraction procedure
33. Hyperhomocysteinemia induced by folic acid deficiency and methionine load - Applications of a modified HPLC method
34. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo
35. Antioxidant defense: Vitamins E and C and carotenoids
36. Oxidative stress and cardiovascular disease
37. Atherosclerosis, oxidative stress and antioxidant protection in endothelium-derived relaxing factor action
38. Testing endothelial function using ultrasound
39. Assessment and treatment of endothelial dysfunction in humans
40. Noninvasive assessment of brachial artery endothelial vasomotor function: The effect of cuff position on level of discomfort and vasomotor responses
41. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy
42. Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on postprandial endothelial function
43. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle