Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits

Circulation

Volumn 101, Issue 9, 2000, Pages 1027-1033

  Lund, D D ^a   Faraci, F M ^a   Miller Jr , F J ^a   Heistad, D D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Acetylcholine; Diabetes mellitus; Gene therapy; Nitric oxide; Viruses

Indexed keywords

NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; VIRUS VECTOR;

ACETYLCHOLINE RELEASE; ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL FUNCTION; CAROTID ARTERY; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC TRANSFECTION; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT;

EID: 0034089318     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.9.1027     Document Type: Article

References (35)

1. Nabel EG. Gene therapy for cardiovascular disease. Circulation. 1995; 91:541-548.
2. Heistad DD, Faraci FM. Gene therapy for cerebral vascular disease. Stroke. 1996;27:1688-1693.
3. Ooboshi H, Toyoda K, Faraci FM, Lang MG, Heistad DD. Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 1998;18: 1752-1758.
4. Ooboshi H, Chu Y, Rios CD, Faraci FM, Davidson BL, Heistad DD. Altered vascular function following adenovirus-mediated overexpression of endothelial nitric oxide synthase. Am J Physiol. 1997;273:H265-H270.
5. Onoue H, Tsutsui M, Smith L, Stelter A, O'Brien T, Katusic ZS. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage. Stroke. 1998;29:1959-1966.
6. Channon KM, Qian H, Neplioueva V, Blazing MA, Olmez E, Shetty GA, Youngblood SA, Pawloski J, McMohon T, Stamler JS, George SE. In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-fed rabbits. Circulation. 1998;98:1905-1911.
7. Von de Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A. 1995;92:1137-1141.
8. McNally PG, Watt PAC, Rimmer T, Burden AC, Hearnshaw JR, Thurston H. Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin Sci. 1994;87:31-36.
9. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW. Hayes JR. Impaired endothelium-dependent and independent vasodilatation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetohgia. 1992;35:771-776.
10. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 1993;87(suppl V):V67-V76.
11. Pieper GM, Gross GJ. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol. 1988;255: H825-H833.
12. Kamata K, Miyata N, Kasuya Y. Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br J Phamacol. 1989;97:614-618.
13. Meraji S, Joakody L, Senaratene MP, Thomson ABR, Kappagoda T. Endothelium-dependent relaxation in aorta of BB rat. Diabetes. 1987;36: 978-981.
14. Pieper GM, Siebeneich W, Moore-Hilton G, Roza AM. Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in endothelium of the genetic diabetic BB rat. Diabetologia. 1997;40:910-915.
15. Diederich D, Scopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol. 1994;266:H1153-H1161.
16. Chang KC, Chung SY, Chong WS, Suh JS, Kim SH, Noh HK, Seong BW, Ko HJ, Chun KW. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther. 1993;266:992-1000.
17. Pieper GM, Mei DA, Langenstroer P, O'Rourke. Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. Am J Physiol. 1988;263: H676-H680.
18. Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol. 1991;261:H1086-H1094.
19. Lund DD, Faraci FM, Ooboshi H, Davidson BL, Heistad DD. Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits. Stroke. 1998;29:120-125.
20. Ooboshi H, Rios CD, Chu Y, Christensen SD, Faraci FM, Davidson BL, Heistad DD. Augmented adenovirus-mediated gene transfer in atherosclerotic vessels. Arterioscler Thromb Vasc Biol. 1997;17:1786-1792.
21. Miller FJ, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res. 1998; 82:1298-1305.
22. Rajogopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest. 1996;97:1916-1923.
23. Chen AFY, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS. Expression and function of recombinant endothelial nitric oxide synthase in canine basilar artery. Circ Res. 1997;80: 327-335.
24. Pieper GM, Siebeneich W, Rosa AM, Jordan M, Adams MB. Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction. J Cardiovasc Pharmacol 1996;28:741-745.
25. Pieper G. Divergent actions of chronic insulin treatment in vivo versus acute treatment ex vivo on diabetic-induced endothelial dysfunction. Life Sci. 1997;60:371-376.
26. Haddad EB, Rousell J, Mak JC, Barns PJ. Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptor but not m2 receptor mRNA in human lung cell line. Br J Pharmacol. 1995;116: 2027-2032.
27. Koenig JA, Edwardson JM. Intracellular trafficking of muscarinic acetylcholine receptor: importance of subtype and cell type. Mol Pharmacol. 1996;49:351-359.
28. Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic Z. Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium. Anerioscler Thromb Vasc Biol. 1998;18: 1231-1241.
29. Pagano PJ, Griswold MC, Ravel D, Cohen RA. Vascular action of the hypoglycaemic agent gliclazide in diabetic rabbits. Diabetologia. 1998; 41:9-15.
30. Marshall J, Wei EP, Kontos HA. Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide. Am J Physiol. 1988;255: H847-H854.
31. Rubanyi GM, Vanhoutte PM. Oxygen-derived free radicals, endothelium and responsiveness of vascular smooth muscle. Am J Physiol. 1986;250: H815-H821.
32. Heygate KM, Lawrence IG, Bennett MA, Thurston H. Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats. Br J Pharmacol. 1995;116:3251-3259.
33. Tesfamariam B, Jakubowski JA, Cohen RA. Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2. Am J Physiol. 1989;257:H1327-H1333.
34. Pieper GM. Enhanced, unaltered and impaired nitric oxide mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia. 1999;42:204-213.
35. Bindokas VP, Jordan J, Lee CC, Miller RJ. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci. 1996;156:1324-1336.