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Volumn 32, Issue 1, 1998, Pages 101-105

Oral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunction

Author keywords

Diabetes mellitus; Endothelium; Hydroxyl radical; N Acetylcysteine; Nitric oxide; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HYDROXYL RADICAL; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

EID: 0031800116     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199807000-00016     Document Type: Article
Times cited : (77)

References (35)
  • 2
    • 0027230446 scopus 로고
    • Dysfunction of vascular endothelium in diabetes mellitus
    • Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation 1993;87 Suppl V:V67-76.
    • (1993) Circulation , vol.87 , Issue.5 SUPPL.
    • Cohen, R.A.1
  • 3
    • 0026583353 scopus 로고
    • Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus
    • Kamata K, Miyata N, Abirut T, Kasuya Y. Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus. Life Sci 1995;50:1379-87.
    • (1995) Life Sci , vol.50 , pp. 1379-1387
    • Kamata, K.1    Miyata, N.2    Abirut, T.3    Kasuya, Y.4
  • 4
    • 0028946553 scopus 로고
    • Endothelium-mediated vascular function in insulin-dependent diabetes mellitus
    • Poston L, Taylor PD. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci 1995;88:245-55.
    • (1995) Clin Sci , vol.88 , pp. 245-255
    • Poston, L.1    Taylor, P.D.2
  • 5
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993;88:2510-6.
    • (1993) Circulation , vol.88 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 6
    • 0026684462 scopus 로고
    • Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35: 771-6.
    • (1992) Diabetologia , vol.35 , pp. 771-776
    • McVeigh, G.E.1    Brennan, G.M.2    Johnston, G.D.3
  • 7
    • 0026008802 scopus 로고
    • Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta
    • Heart Circ Physiol 30
    • Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 1991;261 (Heart Circ Physiol 30):H1086-94.
    • (1991) Am J Physiol , vol.261
    • Hattori, Y.1    Kawasaki, H.2    Abe, K.3    Kanno, M.4
  • 8
    • 0026736722 scopus 로고
    • Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals
    • Heart Circ Physiol 32
    • Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol 1992;263 (Heart Circ Physiol 32):H257-65.
    • (1992) Am J Physiol , vol.263
    • Langenstroer, P.1    Pieper, G.M.2
  • 9
    • 0026736729 scopus 로고
    • Bioassay of endothelium-derived relaxing factor in diabetic rat aorta
    • Heart Circ Physiol 32
    • Pieper GM, Mei DA, Langenstroer P, O'Rourke ST. Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. Am J Physiol 1992;263(Heart Circ Physiol 32):H676-80.
    • (1992) Am J Physiol , vol.263
    • Pieper, G.M.1    Mei, D.A.2    Langenstroer, P.3    O'Rourke, S.T.4
  • 10
    • 0026759488 scopus 로고
    • Free radicals mediate endothelial cell dysfunction caused by elevated glucose
    • Heart Circ Physiol 32
    • Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 1992; 263(Heart Circ Physiol 32):H321-6.
    • (1992) Am J Physiol , vol.263
    • Tesfamariam, B.1    Cohen, R.A.2
  • 11
    • 0028045638 scopus 로고
    • Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: Role of free radicals
    • Heart Circ Physiol 35
    • Diederich D, Skopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol 1994;266(Heart Circ Physiol 35):H1153-61.
    • (1994) Am J Physiol , vol.266
    • Diederich, D.1    Skopec, J.2    Diederich, A.3    Dai, F.X.4
  • 12
    • 0029085103 scopus 로고
    • Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: Influence of tocopherol as antioxidant
    • Rösen P, Ballhausen T, Bloch W, Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 1995;38:1157-68.
    • (1995) Diabetologia , vol.38 , pp. 1157-1168
    • Rösen, P.1    Ballhausen, T.2    Bloch, W.3    Addicks, K.4
  • 13
    • 0030058769 scopus 로고    scopus 로고
    • Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat
    • Pieper GM, Moore-Hilton G, Roza AM. Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat. Life Sci 1996;58:PL147-52.
    • (1996) Life Sci , vol.58
    • Pieper, G.M.1    Moore-Hilton, G.2    Roza, A.M.3
  • 14
    • 0030900360 scopus 로고    scopus 로고
    • Diabetic-induced endothelial dysfunction in rat aorta: Role of hydroxyl radicals
    • Pieper GM, Langenstroer P, Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res 1997;34:145-56.
    • (1997) Cardiovasc Res , vol.34 , pp. 145-156
    • Pieper, G.M.1    Langenstroer, P.2    Siebeneich, W.3
  • 15
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97:22-8.
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 16
    • 0029798152 scopus 로고    scopus 로고
    • Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction
    • Pieper GM, Siebeneich W, Roza AM, Jordan M, Adams MB. Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction. J Cardiovasc Pharmacol 1996;28:27-31.
    • (1996) J Cardiovasc Pharmacol , vol.28 , pp. 27-31
    • Pieper, G.M.1    Siebeneich, W.2    Roza, A.M.3    Jordan, M.4    Adams, M.B.5
  • 17
    • 0021219610 scopus 로고
    • Evidence for increased peroxidative activity in muscles from streptozotocin-diabetic rats
    • Lammi-Keefe CJ, Swan PB, Hegarty PVJ. Evidence for increased peroxidative activity in muscles from streptozotocin-diabetic rats. Proc Soc Exp Biol Med 1984;176:27-31.
    • (1984) Proc Soc Exp Biol Med , vol.176 , pp. 27-31
    • Lammi-Keefe, C.J.1    Swan, P.B.2    Hegarty, P.V.J.3
  • 18
    • 0023601973 scopus 로고
    • Starvation-related alteration in free radical tissue defense mechanisms in rats
    • Wohaieb SA, Godin DV. Starvation-related alteration in free radical tissue defense mechanisms in rats. Diabetes 1987;36:169-73.
    • (1987) Diabetes , vol.36 , pp. 169-173
    • Wohaieb, S.A.1    Godin, D.V.2
  • 19
    • 0029992423 scopus 로고    scopus 로고
    • N-Acetylcysteine inhibits loss of diaphragm function in streptozotocin-treated rats
    • Hida W, Shindoh C, Satoh J, et al. N-Acetylcysteine inhibits loss of diaphragm function in streptozotocin-treated rats. Am J Respir Crit Care Med 1996;153:1875-9.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1875-1879
    • Hida, W.1    Shindoh, C.2    Satoh, J.3
  • 20
    • 0030022084 scopus 로고    scopus 로고
    • Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine
    • Sagara M, Satoh J, Wada R, et al. Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine. Diabetologia 1996;39:263-9.
    • (1996) Diabetologia , vol.39 , pp. 263-269
    • Sagara, M.1    Satoh, J.2    Wada, R.3
  • 21
    • 0028790808 scopus 로고
    • Chronic vitamin e treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
    • Keegan A, Walbank H, Cotter MA, Cameron NE. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia 1995;38:1475-8.
    • (1995) Diabetologia , vol.38 , pp. 1475-1478
    • Keegan, A.1    Walbank, H.2    Cotter, M.A.3    Cameron, N.E.4
  • 22
    • 0000489612 scopus 로고
    • Oxidative stress in diabetic blood vessels
    • Pieper GM. Oxidative stress in diabetic blood vessels [Abstract]. FASEB J 1995;9:A891.
    • (1995) FASEB J , vol.9
    • Pieper, G.M.1
  • 23
    • 0028951141 scopus 로고
    • Hydroxyl radical formation in diabetic rats induced by streptozotocin
    • Ohkuwa T, Sato Y, Naoi M. Hydroxyl radical formation in diabetic rats induced by streptozotocin. Life Sci 1995;56:1789-98.
    • (1995) Life Sci , vol.56 , pp. 1789-1798
    • Ohkuwa, T.1    Sato, Y.2    Naoi, M.3
  • 24
    • 0026629803 scopus 로고
    • Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat
    • Bravenboer B, Kappelle AC, Hamers FPT, van Buren T, Erkelens DW, Gispen WH. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Diabetologia 1992;35:813-7.
    • (1992) Diabetologia , vol.35 , pp. 813-817
    • Bravenboer, B.1    Kappelle, A.C.2    Hamers, F.P.T.3    Van Buren, T.4    Erkelens, D.W.5    Gispen, W.H.6
  • 25
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7.
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 26
    • 0026443163 scopus 로고
    • Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients
    • Ghiselli A, Laurenti O, De Mattia G, Maiani G, Ferro-Luzzi A. Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients. Free Radic Biol Med 1992;13:621-6.
    • (1992) Free Radic Biol Med , vol.13 , pp. 621-626
    • Ghiselli, A.1    Laurenti, O.2    De Mattia, G.3    Maiani, G.4    Ferro-Luzzi, A.5
  • 27
    • 0031425142 scopus 로고    scopus 로고
    • Diabetes-induced endothelial dysfunction is prevented by chronic treatment with the modified iron chelator, hydroxyethyl starch-conjugated deferoxamine
    • Pieper GM, Siebeneich W. Diabetes-induced endothelial dysfunction is prevented by chronic treatment with the modified iron chelator, hydroxyethyl starch-conjugated deferoxamine. J Cardiovasc Pharmacol 1997;30:734-8.
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 734-738
    • Pieper, G.M.1    Siebeneich, W.2
  • 28
    • 0030938698 scopus 로고    scopus 로고
    • Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells
    • Pieper GM, Dondlinger L. Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells. Cardiovasc Res 1997;34:169-78.
    • (1997) Cardiovasc Res , vol.34 , pp. 169-178
    • Pieper, G.M.1    Dondlinger, L.2
  • 29
    • 24244435354 scopus 로고    scopus 로고
    • Increases in extracellular glucose diminish bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells via an intracellular redox-sensitive pathway
    • Pieper GM, Dondlinger L. Increases in extracellular glucose diminish bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells via an intracellular redox-sensitive pathway. Circulation 1996;94 Suppl I:I-41.
    • (1996) Circulation , vol.94 , Issue.1 SUPPL.
    • Pieper, G.M.1    Dondlinger, L.2
  • 30
    • 0023791398 scopus 로고
    • Nonenzymatic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione
    • Huby R, Harding JJ. Nonenzymatic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione. Exp Eye Res 1988;47:53-9.
    • (1988) Exp Eye Res , vol.47 , pp. 53-59
    • Huby, R.1    Harding, J.J.2
  • 31
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and ageing
    • Wolff SP, Jiany ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med 1991;10: 339-52.
    • (1991) Free Radic Biol Med , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jiany, Z.Y.2    Hunt, J.V.3
  • 32
    • 0027447676 scopus 로고
    • No effect of deferoxamine therapy on glucose homeostasis and insulin secretion in individuals with NIDDM and elevated serum ferritin
    • Redmon JB, Pyzdrowski KL, Robertson RP. No effect of deferoxamine therapy on glucose homeostasis and insulin secretion in individuals with NIDDM and elevated serum ferritin. Diabetes 1993;42:544-9.
    • (1993) Diabetes , vol.42 , pp. 544-549
    • Redmon, J.B.1    Pyzdrowski, K.L.2    Robertson, R.P.3
  • 33
    • 0029820473 scopus 로고    scopus 로고
    • Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human hemoglobin: Possible mechanisms involved
    • Angulo J, Sánchez-Ferrer CP, Peiró C, Marín J, Rodríquez-Mañas L. Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human hemoglobin: possible mechanisms involved. Hypertension 1996;28:583-92.
    • (1996) Hypertension , vol.28 , pp. 583-592
    • Angulo, J.1    Sánchez-Ferrer, C.P.2    Peiró, C.3    Marín, J.4    Rodríquez-Mañas, L.5
  • 35
    • 0026062122 scopus 로고
    • Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes
    • Bucala R, Tracey K, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991;87: 432-8.
    • (1991) J Clin Invest , vol.87 , pp. 432-438
    • Bucala, R.1    Tracey, K.2    Cerami, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.