Layilin, a novel integral membrane protein, is a hyaluronan receptor

Molecular Biology of the Cell

Volumn 12, Issue 4, 2001, Pages 891-900

  Bono, P ^a   Rubin, K ^a   Higgins, J M G ^a   Hynes, R O ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GLYCOSAMINOGLYCAN; HYALURONAN RECEPTOR; HYALURONIC ACID; IMMUNOGLOBULIN G; LAYILIN; MEMBRANE PROTEIN; RECEPTOR PROTEIN; SEPHAROSE; TALIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CELL MOTILITY; CELL SHAPE; CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

EID: 0035167035     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.4.891     Document Type: Article

References (57)

1. CD44 is the principal cell surface receptor for hyaluronate
2. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
3. Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic
4. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13
5. Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts
6. Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity
7. Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
8. The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily
9. The talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation
10. Differences between adult and fetal fibroblasts in the regulation of hyaluronate synthesis: Correlation with migratory activity
11. Continuous production of soluble extracellular domain of a type-I transmembrane protein in mammalian cells using an Epstein-Barr virus Ori-P-based expression vector
12. Focal adhesions: The cytoskeletal connection
13. The structure and regulation of hyaluronan-binding proteins
14. CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway
15. Requirement for CD44 in activated T cell extravasation into an inflammatory site
16. Hyaluronan: Fundamental principles and applications in cancer
17. HA receptors: Regulators of signaling to the cytoskeleton
18. Induction of angiogenesis during the transition from hyperplasia to neoplasia
19. Hyaluronic acid: A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing
20. Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains
21. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
22. Rho GTPases and the actin cytoskeleton
23. Heritable formation of pancreatic beta-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
24. Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
25. The transmembrane hyaluronate receptor (CD44): Multiple functions, multiple forms
26. Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2): Regulation by phosphatidylinositol 4,5-bisphosphate
27. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site
28. Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin
29. Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein
30. Effects of hyaluronic acid on fibroblast behavior in peritoneal injury
31. Hyaluronan-binding proteins in development, tissue homeostasis, and disease
32. Stimulation of glycosaminoglycan production in murine tumors
33. Solution structure of the link module: A hyaluronan-binding domain involved in extracellular matrix stability and cell migration
34. A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44
35. Requirements for hyaluronic acid binding by CD44: A role for the cytoplasmic domain and activation by antibody
36. IQGAP and calmodulin modulate E-cadherin function
37. ERM proteins in cell adhesion and membrane dynamics
38. Hyaluronic acid modulates proliferation, collagen and protein synthesis of cultured fetal fibroblasts
39. On the adsorption of hyaluronan and ICAM-1 to modified hydrophobic resins
40. Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion
41. The link proteins
42. Hyaluronan stimulates corneal epithelial migration
43. A novel cadherin cell adhesion molecule: Its expression patterns associated with implantation and organogenesis of mouse embryos
44. Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton
45. Bidirectional signaling between the cytoskeleton and integrins
46. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family
47. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells
48. Affinity chromatography on immobilized hyaluronate and its application to the isolation of hyaluronate binding properties from cartilage
49. Hyaluronan in morphogenesis
50. Hyaluronate and invasiveness of the rabbit V2 carcinoma
51. CD44: The hyaluronan receptor
52. Physical characteristics of hyaluronate binding to the surface of simian virus 40-transformed 3T3 cells
53. The role of hyaluronic acid in inflammation and wound healing
54. Effects of hyaluronan on cell proliferation and collagen synthesis: A study of rabbit flexor tendons in vitro
55. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
56. Ezrin/radixin/moesin (ERM). Proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
57. Biotinylated hyaluronan as a probe for detection of binding proteins in cells and tissues