ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Current Opinion in Cell Biology

Volumn 14, Issue 1, 2002, Pages 104-109

  Gautreau, Alexis ^a   Louvard, Daniel ^a   Arpin, Monique ^a  

^a INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BRAIN PROTEIN; EZRIN; GENE PRODUCT; MERLIN; MOESIN; RADIXIN;

ACTIN FILAMENT; BRAIN CORTEX; CARCINOGENESIS; CELL GROWTH; CELL MEMBRANE; CYTOSKELETON; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

FALCO COLUMBARIUS; HOMO;

EID: 0036468423     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(01)00300-3     Document Type: Review

References (61)

1. Merlin: The neurofibromatosis 2 tumor suppressor
2. The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association
3. A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding
4. Merlin differentially associates with the microtubule and actin cytoskeleton
5. Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on foldings of its N-terminal domain
6. ERM-merlin and EBP50 protein families in plasma membrane organization and function
7. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
8. Phosphorylation of threonine 558 in the carboxy-terminal actin-binding domain of moesin by thrombin activation of human platelets
9. Phosphorylation of moesin by Rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
10. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
11. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
12. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
13. Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides
14. Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane
15. Protein phosphatase 2C inactivates F-actin binding of human platelet moesin
16. Unopposed phosphatase action initiates ezrin dysfunction: A potential mechanism for anoxic injury
17. ERM (Ezrin/Radixin/Moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis
18. Mutagenesis of the phosphatidylinositol 4,5-biphosphate (PIP2) binding site in the NH2-terminal domain of ezrin correlates with its altered cellular distribution
19. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
20. The 2.7 Å crystal structure of the activated FERM domain of moesin: An analysis of structural changes on activation
21. Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types
22. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
23. Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin
24. Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF
25. Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP
26. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
27. Ezrin is an effector of HGF-mediated migration and morphogenesis in epithelial cells
28. Direct involvement of Ezrin/Radixin/Moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated proteins
29. Ezrin promotes morphogenesis of apical microvilli and basal unfoldings in retinal pigment epithelium
30. In vivo functional analysis of ezrin during mouse blastocyst formation
31. Cytoskeletal rearrangement during migration and activation of T lymphocytes
32. Radixin is involved in lamellipodial stability during nerve growth cone motility
33. Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons
34. Rho- and Rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
35. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
36. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
37. Ezrin-dependent promotion of glioma cell clonogenicity, motility and invasion mediated by BCL-2 and transforming growth factor-β2
38. Ezrin is a downstream effector of trafficking PKC/integrin complexes involved in the control of cell motility
39. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
40. Ezrin interacts with focal adhesion kinase and induces its activation independently of cell matrix adhesion
41. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: A novel regulatory mechanism of the CD95 apoptotic pathway
42. Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain
43. Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading
44. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli
45. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility
46. Interdomain binding mediates tumor growth suppression by the NF2 gene product
47. The Neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation
48. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
49. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
50. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
51. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein
52. High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential
53. Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells
54. Metastasis-associated differences in gene expression in a murine model of osteosarcoma
55. Gene expression patterns associated with the metastatic phenotype in rodent and human tumors
56. Ezrin immunoreactivity is associated with increasing malignancy of astrocytic tumors but is absent in oligodendrogliomas
57. Altered expression of the ERM proteins in lung adenocarcinoma
58. Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma
59. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
60. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation
61. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse