Stress-activated protein kinases are negatively regulated by cell density

EMBO Journal

Volumn 17, Issue 19, 1998, Pages 5615-5626

  Lallemand, Dominique ^a   Ham, Jonathan ^b   Garbay, Serge ^a   Bakiri, Latifa ^a   Traincard, François ^a   Jeannequin, Odile ^a   Pfarr, Curt M ^c   Yaniv, Moshe ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

c Jun; JNK SAPK pathway; Mouse fibroblasts; Protein kinase; Stress activation

Indexed keywords

ACTIN; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN C; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL DENSITY; GENE EXPRESSION; GENETIC TRANSFECTION; MICROFILAMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ULTRAVIOLET IRRADIATION;

ACTINS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CDC42 GTP-BINDING PROTEIN; CELL COUNT; CELL CYCLE PROTEINS; CELL MOVEMENT; CYTOSKELETON; FIBROBLASTS; GROWTH SUBSTANCES; GTP-BINDING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-JUN; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 0032189249     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.19.5615     Document Type: Article

References (69)

1. Almendral, J.M., Sommer, D., Bravo, M.C., Burckhardt, H., Perera, J. and Bravo, R. (1988) Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol. Cell. Biol., 8, 2140-2152.
2. Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R.J., Rahmsdorf, H.J., Jonat, C., Herrlich, P. and Karin, M. (1987) Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell, 49, 729-39.
3. Angel, P., Hattori, K., Smeal, T. and Karin, M. (1988) The jun protooncogene is positively autoregulated by its product, Jun/AP-1. Cell, 55, 875-885.
4. Bereiter, H.J. and Kajstura, J. (1988) Scanning microfluorometric measurement of TRITC-phalloidin labelled F-actin. Dependence of F-actin content on density of normal and transformed cells. Histochemistry, 90, 271-276.
5. Brach, M.A., Herrmann, F. and Kufe, D.W. (1992) Activation of the AP-1 transcription factor by arabinofuranosylcytosine. Blood, 79, 728-734.
6. Buscher, M., Rahmsdorf, H.J., Litfin, M., Karin, M. and Herrlich, P. (1988) Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene, 3, 301-311.
7. Coso, O.A., Chiariello, M., Kalinec, G., Kyriakis, J.M., Woodgett, J. and Gutkind, J.S. (1995a) Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. J. Biol. Chem., 270, 5620-5624.
8. Coso, O.A., Chiariello, M., Yu, J.C. Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J.S. (1995b) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
9. Dalton, S. and Treisman, R. (1992) Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell, 68, 597-612.
10. Derijard, B., Hibi, M., Wu, I.H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R.J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76, 1025-1037.
11. Devary, Y., Gottlieb, R.A., Lau, L.F. and Karin, M. (1991) Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol., 11, 2804-2811.
12. Franklin, C.C., Adler, V. and Kraft, A.S. (1995) Phosphorylation of transcription factors. Methods Enzymol., 254, 550-564.
13. Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78, 1039-1049.
14. Frisch, S.M., Vuori, K., Kelaita, D. and Sicks, S. (1996) A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol., 135, 1377-1382.
15. Gille, H., Kortenjann, M., Thomae, O., Moomaw, C., Slaughter, C., Cobb, M.H. and Shaw, P.E. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J., 14, 951-962.
16. Gille, H., Sharrocks, A.D. and Shaw, P.E. (1992) Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature, 358, 414-417.
17. Gupta, S., Barrett, T., Whitmarsh, A.J., Cavanagh, J., Sluss, H.K., Derijard, B. and Davis, R.J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J., 15, 2760-2770.
18. Gupta, S., Campbell, D., Derijard, B. and Davis, R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science, 267, 389-393.
19. Hall, A. (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol., 10, 31-54.
20. Han, J. and Prywes, R. (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol., 15, 2907-2915.
21. Han, J., Lee, J.D., Bibbs, L. and Ulevitch, R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-811.
22. Han, J., Jiang, Z., Li, V., Kravchenko, V. and Ulevitch, R.J. (1997) Activation of the transcription factor MEF2C by MAP kinase p38 in inflammation. Nature, 386, 296-299.
23. Hattori, K., Angel, P., Le Beau, M.M. and Karin, M. (1988) Structure and chromosomal localization of the functional intronless human jun proto-oncogene. Proc. Natl Acad. Sci. USA, 85, 9148-9152.
24. Hengerer, B., Lindholm, D., Heumann, R., Ruther, U., Wagner, E.F. and Thoenen, H. (1990) Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos. Proc. Natl Acad. Sci. USA, 87, 3899-3903.
25. Herschman, H.R. (1991) Primary responsegenes induced by growth factors and tumor promoters. Annu. Rev. Biochem., 60, 281-319.
26. Hibi, M., Lin, A., Smeal, T., Minden, A. and Karin, M. (1993) Identification of an oncoprotein- and UV-responsive protein kinase that bind and potentiate the c-Jun activation domain. Genes Dev., 7, 2135-2148.
27. Hill, C.S., Wynne, J. and Treisman, R. (1995)The Rho family GTPases RhoA, Rac1 and CDC42Hs regulate transcriptional activation by SRF. Cell, 81, 1159-1170.
28. Hipskind, R.A., Rao, V.N., Mueller, C.G., Reddy, E.S. and Nordheim, A. (1991) Ets-related protein Elk-1 ishomologous to the c-fos regulatory factor p62TCF. Nature, 354, 531-534.
29. Janknecht, R., Ernst, W.H. and Nordheim, A. (1995) SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene, 10, 1209-1216.
30. Janknecht, R., Ernst, W.H., Pingoud, V. and Nordheim, A. (1993) Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J., 12, 5097-5104.
31. Kallunki, T., Su, B., Tsigelny, I., Sluss, H.K., Derijard, B., Moore, G., Davis, R. and Karin, M. (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev., 8, 2996-3007.
32. Kato, Y., Kavchenko, V.V., Tapping, R.I., Han, J., Ulevitch, R.J. and Lee, J-D. (1997) BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J., 16, 7054-7066.
33. Kim, S., Angel, P., Lafyatis, R., Hattori, K., Kim, K.Y., Sporn, M.B., Karin, M. and Roberts, A.N. (1990) Autoinduction of transforming growth factor b1 is mediated by theAP1 complex. Mol. Cell. Biol., 10, 1492-1497.
34. Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995) The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol., 15, 1942-1952.
35. Kyriakis, J.M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.F., Avruch, J. and Woodgett, J.R. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156-160.
36. Lallemand, D., Spyrou, G., Yaniv, M. and Pfarr, C.M. (1997) Variations in Jun and Fos protein expression and AP1activity in cycling, resting and stimulated fibroblasts. Oncogene, 14, 819-830.
37. Lange-Carter, C.A., Pleiman, C.M., Gardner, A.M., Blumer, K.J. and Johnson, G.L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-317.
38. Lau, L.F. and Nathans, D. (1987) Expression of a set of growth-related immediate early genes in Balb/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc. Natl Acad. Sci. USA, 84, 1182-1186.
39. Lee, W., Mitchell, P. and Tjian, R. (1987) Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell, 49, 741-52.
40. Liu, Z.G., Hsu, H., Goeddel, D.V. and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell, 87, 565-576.
41. Livingstone, C., Patel, G. and Jones, N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J., 14, 1785-1797.
42. Martin, J.H., Mohit, A.A. and Miller, C.A. (1996) Developmental expression in the mouse nervous system of the p493F12 SAP kinase. Brain Res. Mol. Brain Res., 35, 47-57.
43. Martin, P., Hopkinson, W.J. and McCluskey, J. (1992) Growth factors and cutaneous wound repair. Prog. Growth Factor Res., 4, 25-44.
44. Martin, P. and Nobes, C.D. (1992) A nearly molecular component of the wound healing response in ratembryos-induction of c-fos protein in cells at the epidermal wound margin. Mech. Dev., 38, 209-215.
45. Martin, P., Nobes, C., McCluskey, J. and Lewis, J. (1994) Repair of excisional wounds in the embryo. Eye, 8, 155-160.
46. Mettouchi, A., Cabon, F., Montreau, N., Vernier, P., Mercier, G., Blangy, D., Tricoire, H., Vigier, P. and Binetruy, B. (1994) SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts. EMBO J., 13, 5668-5578.
47. Mettouchi, A., Cabon, F., Montreau, N., Dejong, V., Vernier, P., Gherzi, R., Mercier, G. and Binetruy, B. (1997) The c-Jun-induced transformation process involves complex regulation of tenascin-C expression. Mol. Cell. Biol., 17, 3202-3209.
48. Minden, A., Lin, A., Claret, F.X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81, 1147-1157.
49. Minden, A., Lin, A., McMahon, M., Lange-Cartier, C., Derijard, B., Davis, R.J., Johnson, G.C. and Karin, M. (1994) Diiferential activation of ERK and JNK mitogen-activated protein kinases by Raf1 and MEKK. Science, 266, 1719-1723.
50. Minden, A., Lin, A., McMahon, M., Lange, C.C., Derijard, B., Davis, R.J., Johnson, G.L. and Karin, M. (1994a) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science, 266, 1719-1723.
51. Minden, A., Lin, A., Smeal, T., Derijard, B., Cobb, M., Davis, R. and Karin, M. (1994b) c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol., 14, 6683-6688.
52. Muegge, K., Williams, T.M., Kant, J., Kann, M., Chiu, R., Schmidt, A., Siebenlist, U., Young, H.A. and Durum, S.K. (1989) Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. Science, 246, 249-251.
53. Norman, C., Runswick, M., Pollock, R. and Treisman, R. (1988) Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell, 55, 989-1003.
54. Okada, Y., Saika, S., Hashizume, N., Kobata, S., Yamanaka, O., Ohnishi, Y. and Senba, E. (1996) Expression of fos family and jun family protooncogenes during corneal epithelial wound healing. Curr. Eye Res., 15, 824-832.
55. Pawar, S., Kartha, S. and Toback, F.G. (1995) Differential gene expression in migrating renal epithelial cells after wounding. J. Cell Physiol., 165, 556-565.
56. Pfarr, C.M., Mechta, F., Spyrou, G., Lallemand, D., Carillo, S. and Yaniv, M. (1994) Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell, 76, 747-760.
57. Price, M.A., Rogers, A.E. and Treisman, R. (1995) Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J., 14, 2589-2601.
58. Pulverer, B.J., Kyriakis, J.M., Avruch, J., Nikolakaki, E. and Woodgett, J.R. (1991) Phosphorylation of c-jun mediated by MAP kinases. Nature, 353, 670-674.
59. Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell, 70, 389-399.
60. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
61. Shaw, P.E., Schroter, H. and Nordheim, A. (1989) The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell 56, 563-572.
62. Treisman, R. (1990) The SRE: a growth factor responsive transcriptional regulator. Semin. Cancer Biol. 1, 47-58.
63. Tsuboi, K., Yamaoka, S., Maki, M., Ohshio, G., Tobe, T. and Hatanaka, M. (1990) Soluble factors including proteinases released from damaged cells may trigger the wound healing process. BBRC, 168, 1163-1170.
64. Unlap, T., Franklin, C.C., Wagner, F. and Kraft, A.D. (1992) Upstream regions of the c-jun promoter regulate phorbol ester-induced transciption in U937 leukemic cells. Nucleic Acids Res., 20, 897-902.
65. van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. and Angel, P. (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J., 14, 1798-1811.
66. Verrier, B., Muller, D., Bravo, R. and Muller, R. (1986) Wounding a fibroblast monolayer results in the rapid induction of the c-fos protooncogene. EMBO J., 5, 913-917.
67. Wagner, B.J., Hayes, T.E., Hoban, C.J. and Cochran, B.H. (1990) The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J., 9, 4477-4484.
68. Waskiewicz, A.J. and Cooper, J.A. (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell Biol., 7, 798-805.
69. Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L.L and Ham, J. (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci., 18, 751-762.