A crucial role for CD44 in inflammation

Trends in Molecular Medicine

Volumn 7, Issue 5, 2001, Pages 213-221

  Puré, Ellen ^a   Cuff, Carolyn A ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN;

APOPTOSIS; CELL PROLIFERATION; DOWN REGULATION; IMMUNOCOMPETENT CELL; INFLAMMATION; PARENCHYMA; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD44; CELL ADHESION; CELL DIVISION; GENE EXPRESSION REGULATION; HUMANS; HYALURONIC ACID; INFLAMMATION; LEUKOCYTES; MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC;

EID: 0034852360     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)01963-3     Document Type: Review

References (79)

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2. Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan
3. Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium
4. Identification of a polymorphism in human CD44
5. CD44 is the principal cell surface receptor for hyaluronate
6. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin
7. A chondroitin/dermatan sulfate form of CD44 is a receptor for collagen XIV (undulin)
8. Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
9. Heparan sulfate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action
10. N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding
11. Identification of hyaluronic acid binding sites in the extracellular domain of CD44
12. Identification of CD44 residues important for hyaluronan binding and delineation of the binding site
13. Glycosylation of CD44 negatively regulates its recognition of hyaluronan
14. Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation
15. Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan
16. Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain
17. TNF-α induction of CD44-mediated leukocyte adhesion by sulfation
18. Oncostatin M and transforming growth factor-β1 induce post-translational modification and hyaluronan binding to CD44 in lung-derived epithelial tumor cells
19. CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation
20. CD44 positive macrophages take up hyaluronan during lung development
21. Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-α and is inhibited by IL-4 and IL-13
22. Induction of IL-12 and chemokines by hyaluronan requires adhesion dependent priming of resident but not elicited macrophages
23. Characterization of CD44 induction by IL-1: A critical role for Egr-1
24. Characterization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growth
25. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
26. Distinction of virgin and memory T lymphocytes: Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
27. Regulation of CD44 gene expression by the pro-inflammatory cytokine interleukin-1β in vascular smooth muscle cells
28. Therapeutic effects of antibodies against adhesion molecules in murine collagen type II-induced arthritis
29. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation
30. Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
31. Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2
32. Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis
33. CD44 regulates hematopoietic progenitor distribution, granuloma formation and tumorigenicity
34. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets
35. Abrogation of experimental colitis correlates with increased apotosis in mice deficient for CD44 variant exon 7 (CD44v7)
36. Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury
37. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis
38. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
39. CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway
40. Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity
41. Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44
42. Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: Hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-κB and activating protein-1
43. Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1
44. LFA-3, CD44, and CD45: Physiologic triggers of human monocyte TNF and IL-1 release
45. Antibodies against the CD44 p80 lymphocyte homing receptor molecule augment human peripheral blood T cell activation
46. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-α dependent mechanism in murine macrophages
47. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44
48. Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages
49. Hyaluronan fragments induce nitric oxide synthase in murine macrophages through a nuclear factor κB-dependent mechanism
50. Inhibition of IFN-γ induced IL-12 production: A potential mechanism for the anti-inflammatory activities of TNF
51. CD3-mediated T cell activation is inhibited by anti-CD44 monoclonal antibodies directed to the hyaluronan-binding region
52. Dual role of the CD44 molecule in T cell adhesion and activation
53. Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16
54. Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages
55. Hyaluronan fragments activate an NF-κB/I-κBα autoregulatory loop in murine macrophages
56. 2+-dependent signal transduction pathways
57. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton
58. + T cells
59. Ras, protein kinase Cζ, and IκB kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-κB by hyaluronic acid fragments in T-24 carcinoma cells
60. Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
61. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
62. CD44 interaction with Tiam 1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
63. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β
64. The integrin αvβ 6 binds and activates latent TGF-β 1: A mechanism for regulating pulmonary inflammation and fibrosis
65. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
66. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix
67. Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes
68. CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages
69. Hyaluronan: Its nature, distribution, functions and turnover
70. Versican, a hyaluronate-binding proteoglycan of embryonal precartilaginous mesenchyma, is mainly expressed postnatally in rat brain
71. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression. Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy
72. Degradation of hyaluronic acid, poly- and monosaccharides, and model compounds by hypochlorite: Evidence for radical intermediates and fragmentation
73. Degradation of hyaluronan by peroxynitrite
74. CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma
75. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specfic receptor for hyaluronan
76. TSG-6: An Il-1/TNF-inducible protein with anti-inflammatory activity
77. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo
78. Characterization of hyaluronate binding proteins isolated from 3T3 and murine sarcoma virus transformed 3T3 cells
79. Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking