Life without white fat: A transgenic mouse

Genes and Development

Volumn 12, Issue 20, 1998, Pages 3168-3181

  Moitra, Jaideep ^a   Mason, Mark M ^b   Olive, Michelle ^a   Krylov, Dmitry ^a   Gavrilova, Oksana ^b   Marcus Samuels, Bernice ^b   Feigenbaum, Lionel ^e   Lee, Eric ^c   Aoyama, Toshifumi ^f   Eckhaus, Michael ^d   Reitman, Marc L ^b   Vinson, Charles ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e SAIC FREDERICK INC   (United States)

^f SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adipocytes; AP 1; C EBP; Diabetes; Dominant negative proteins; Lipodystrophy

Indexed keywords

DNA BINDING PROTEIN; LEPTIN; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL MODEL; ARTICLE; BODY FAT; DIABETES MELLITUS; DNA BINDING; FEMALE; GENE EXPRESSION; LIPODYSTROPHY; LIPOLYSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE; WHITE ADIPOSE TISSUE;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0032532753     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.20.3168     Document Type: Article

References (77)

1. Ahn, S., M. Olive, S. Aggarwal, D. Krylov, D.D. Ginty, and C. Vinson. 1998. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 18: 967-977.
2. Ailaud, G. and H. Hauner. 1998. Development of white adipose tissue. In Handbook of obesity (ed. G.A. Bray, C. Bouchard, and W.P.T. James), pp. 359-378. Marcel Dekker, New York, NY.
3. Altman, D.G. 1991. Practical statistics for medical research. Chapman & Hall, London, UK.
4. Aoyama, T., M. Souri, T. Kamijo, S. Ushikubo, and T. Hashimoto. 1994. Peroxisomal acyl-coenzyme A oxidase is a rate-limiting enzyme in a very-long-chain fatty acid beta-oxidation system. Biochem. Biophys. Res. Commun. 201: 1541-1547.
5. Aoyama, T., J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, T. Hashimoto, and F.J. Gonzalez. 1998. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J. Biol. Chem. 273: 5678-5684.
6. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1997. Current protocols in molecular biology. Wiley, New York, NY.
7. Barr, V.A., D. Malide, M.J. Zarnowski, S.I. Taylor, and S.W. Cushman. 1997. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138: 4463-4472.
8. Benson, K.F. and K. Chada. 1994. Mini-mouse: Phenotypic characterization of a transgenic insertional mutant allelic to pygmy. Genet. Res. 64: 27-33.
9. Bernlohr, D.A., C.W. Angus, M.D. Lane, M.A. Bolanowski, and T.J. Kelly, Jr. 1984. Expression of specific mRNAs during adipose differentiation: Identification of an mRNA encoding a homologue of myelin P2 protein. Proc. Natl. Acad. Sci. 81: 5468-5472.
10. Bernlohr, D.A., T.L. Doering, T.J. Kelly, Jr., and M.D. Lane. 1985. Tissue specific expression of p422 protein, a putative lipid carrier, in mouse adipocytes. Biochem. Biophys. Res. Commun. 132: 850-855.
11. Bouillaud, F., D. Ricquier, J. Thibault, and J. Weissenbach. 1985. Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc. Natl. Acad. Sci. 82: 445-448.
12. Brunk, C.F., K.C. Jones, and T.W. James. 1979. Assay for nanogram quantities of DNA in cellular homogenates. Anal. Biochem. 92: 497-500.
13. Burant, C.F., S. Sreenan, K. Hirano, T.A. Tai, J. Lohmiller, J. Lukens, N.O. Davidson, S. Ross, and R.A. Graves. 1997. Troglitazone action is independent of adipose tissue. J. Clin. Invent. 100: 2900-2908.
14. Carr, A., K. Samaras, D.J. Chisholm, and D.A. Cooper. 1998. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 351: 1881-1883.
15. Chehab, F.F., M.E. Lim, and R. Lu. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12: 318-320.
16. Chen, H., O. Charlat, L.A. Tartaglia, E.A. Woolf, X. Weng, S.J. Ellis, N.D. Lakey, J. Culpepper, K.J. Moore, R.E. Breitbart, G.M. Duyk, R.I. Tepper, and J.P. Morgenstern. 1996. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495.
17. Christy, R.J., V.W. Yang, J.M. Ntambi, D.E. Geiman, W.H. Landschulz, A.D. Friedmnn, Y. Nakabeppu, T.J. Kelly, and M.D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes & Dev. 3: 1323-1335.
18. Clarke, S.L., C.E. Robinson, and J.M. Gimble. 1997. CAAT/ enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter. Biochem. Biophys. Res. Commun. 240: 99-103.
19. Coleman, D.L. 1978. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14: 141-148.
20. Comuzzie, A.G. and D.B. Allison. 1998. The search for human obesity genes. Science 280: 1374-1377.
21. Cook, J.S., J.J. Lucas, E. Sibley, M.A. Bolanowski, R.J. Christy, T.J. Kelly, and M.D. Lane. 1988. Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. Proc. Natl. Acad. Sci. 85: 2949-2953.
22. Cummings, D.E., E.P. Brandon, J.V. Planas, K. Motamed, R.L. Idzerda, and G.S. McKnight. 1996. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 382: 622-626.
23. Distel, R.J., H.S. Ro, B.S. Rosen, D.L. Groves, and B.M. Spiegelman. 1987. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: Direct participation of c-fos. Cell 49: 835-844.
24. Flier, J.S. 1997. Leptin expression and action: New experimental paradigms. Proc. Natl. Acad. Sci. 94: 4242-4245.
25. Foster, D.W. 1994. The lipodystrophies and other rare disorders of adipose tissue. In Harrison's principles of internal medicine (ed. K.J. Isselbacher, E. Braunwald, J.D. Wilson, J.B. Martin, A.S. Fauci, and D.L. Kasper), pp. 2131-2136. McGraw-Hill, New York, NY.
26. Freytag, S.O., D.L. Paielli, and J.D. Gilbert. 1994. Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes & Dev. 8: 1654-1663.
27. Fukuda, H., N. Iritani, and T. Noguchi. 1997a. Transcriptional regulatory region for expression of the rat ATP citrate-lyase gene. Eur. J. Biochem. 247: 497-502.
28. Fukuda, H., N. Iritani, and T. Noguchi. 1997b. Transcriptional regulatory regions for expression of the rat fatty acid synthase. FEBS Lett. 406: 243-248.
29. Gamble, J. and G.D. Lopaschuk, 1997. Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carhoxylase and inhibition of fatty acid oxidation. Metabolism 46: 1270-1274.
30. Gavrilova, O., V. Barr, B. Marcus-Samuels, and M. Reitman. 1997. Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J. Biol. Chem. 272: 30546-30551.
31. Gorman, C.M., L.F. Moffat, and B.H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2: 1044-1051.
32. He, Y., H. Chen, M.J. Quon, and M. Reitman. 1995. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein α. J. Biol. Chem. 270: 28887-28891.
33. Hill, J.O. and J.C. Peters. 1998. Environmental contributions to the obesity epidemic. Science 280: 1371-1374.
34. Himms-Hagen, J. and D. Ricquier. 1998. Brown adipose tissue. In Handbook of obesity (ed. G.A. Bray, C. Bouchard, and W.P.T. James), pp. 415-441. Marcel Dekker, New York, NY.
35. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
36. Houstek, J., J. Kopecky, Z. Rychter, and T. Soukup. 1988. Uncoupling protein in embryonic brown adipose tissue - existence of nonthermogenic and thermogenic mitochondria. Biochim. Biophys. Acta 935: 19-25.
37. Jacobsson, A., U. Stadler, M.A. Glotzer, and L.P. Kozak. 1985. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J. Biol. Chem. 260: 16250-16254.
38. Kamohara, S., R. Burcelin, J.I. Halaas, J.M. Friedman, and M.J. Charron. 1997. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389: 374-377.
39. Katz, E.B., A.E. Stenbit, K. Hatton, R. DePinho, and M.J. Charron. 1995. Cardiac and adipose tissue abnormalities hut not diabetes in mice deficient in GLUT4. Nature 377: 151-155.
40. Kopecky, J., G. Clarke, S. Enerback, B. Spiegelman, and L.P. Kozak. 1995. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96: 2914-2923.
41. Kozak, L.P., U.C. Kozak, and G.T. Clarke. 1991. Abnormal brown and white fat development in transgenic mice over-expressing glycerol 3-phosphate dehydrogenase. Genes & Dev. 5: 2256-2264.
42. Kozak, L.P., U. Kozak, G. Clarke, S. Enerback, and J. Kopecky. 1996. Genes of energy balance: Modulation in transgenic mice. In Molecular and genetic aspects of obesity (ed. G.A. Bray and D.A. Ryan), pp. 609-623. Louisiana State University Press, Baton Rouge, LA.
43. Krylov, D., M. Olive, and C. Vinson. 1995. Extending dimerization interfaces: The bZIP basic region can form a coiled coil. EMBO J. 14: 5329-5337.
44. Krylov, D., K. Kasai, D.R. Echlin, E.J. Taparowsky, H. Arnheiter, and C. Vinson. 1997. A general method to design dominant negatives to B-HLHZIP proteins that abolish DNA binding. Proc. Natl. Acad. Sci. 94: 12274-12279.
45. Landschulz, W.H., P.F. Johnson, E.Y. Adashi, B.J. Graves, and S.L. McKnight. 1988. Isolation of a recombinant copy of the gene encoding C/EBP. Genes & Dev. 2: 786-800.
46. Levak-Frank, S., H. Radner, A. Walsh, R. Stollberger, G. Knipping, G. Hoefler, W. Sattler, P.H. Weinstock, J.L. Breslow, and R. Zechner. 1995. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J. Clin. Invest. 96: 976-986.
47. Lin, F.T. and M.D. Lane. 1994, CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. 91: 8757-8761.
48. Luetteke, N.C., D.C. Lee, R.D. Palmiter, R.L. Brinster, and E.P. Sandgren. 1993. Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells. Cell Growth Differ. 4: 203-213.
49. Mandrup, S. and M.D. Lane. 1997. Regulating adipogenesis. J. Biol. Chem. 272: 5367-5370.
50. Mason, M.M., Y. He, H. Chen, M.J. Quon, and M. Reitman. 1998. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor. Endocrinology 139: 1013-1022.
51. McGarry, J.D. 1992. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770.
52. McKnight, S.L., M.D. Lane, and S. Gluecksohn-Waelsch. 1989. Is CCAAT/enhancer-binding protein a central regulator of energy metabolism? Genes & Dev. 3:2021-2024.
53. Nicholls, D.G. and R.M. Locke. 1984. Thermogenic mechanisms in brown fat. Physiol. Rev. 64: 1-64.
54. Olive, M., D. Krylov, D.R. Echlin, K. Gardner, E. Taparowsky, and C. Vinson. 1997. A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis. J. Biol. Chem. 272: 18586-18594.
55. O'Shea, E.K., R. Rutkowski, W.F.D. Stafford, and P.S. Kim. 1989. Preferential heterodimer formation by isolated leucine ZIPpers from fos and jun. Science 245: 646-648.
56. O'Shea, E.K., R. Rutkowski, and P.S. Kim. 1992. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell 68: 699-708.
57. Randle, P.J., P.B. Garland, C.N. Hales, and E.A. Hewsholme. 1963. The glucose fatty-acid cycle, its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789.
58. Reitman, M., E. Lee, H. Westphal, and G. Felsenfeld. 1993. An enhancer/locus control region is not sufficient to open chromatin. Mol. Cell. Biol. 13: 3990-3998.
59. Ross, S.R., R.A. Graves, and B.M. Spiegelman. 1993. Targeted expression of a toxin gene to adipose tissue: Transgenic mice resistant to obesity. Genes & Dev. 7: 1318-1324.
60. Rossetti, L., D. Mallillon, N. Barzilai, P. Vuguin, W. Chen, M. Hawkins, J. Wu, and J. Wang. 1997. Short term effect of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 272: 27758-27763.
61. Salmon, D.M. and J.P. Flatt. 1985. Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int. J. Obes. 9: 443-449.
62. Seip, M. and O. Trygstad. 1996. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. (Suppl.) 413: 2-28.
63. Smith, P.J., L.S. Wise, R. Berkowitz, C. Wan, and C.S. Rubin. 1988. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J. Biol. Chem. 263: 9402-9408.
64. Soloveva, V., R.A. Graves, M.M. Raseniek, B.M. Spiegelman, and S.R. Ross. 1997. Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. Mol. Endocrinol. 11: 27-38.
65. Spiegelman, B.M., M. Frank, and H. Green. 1983. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J. Biol. Chem. 258: 10083-10089.
66. Stephens, J.M., M.D. Butts, and P.H. Pekala. 1992. Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-alpha. J. Mol. Endocrinol. 9: 61-72.
67. Taketo, M., A.C. Schroeder, L.E. Mobraaten, K.B. Gunning, G. Hanten, R.R. Fox, T.H. Roderick, C.L. Stewart, F. Lilly, C.T. Hansen, and P.A. Overbeek. 1991. FVB/N: An inbred mouse strain preferable for transgenic analyses. Proc. Natl. Acad. Sci. 88: 2065-2069.
68. Tanaka, T., N. Yoshida, T. Kishimoto, and S. Akira. 1997. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene. EMBO J. 16: 7432-7443.
69. Thomas, P.R. 1995. Weighing the options. National Academy Press, Washington, D.C.
70. Tontonoz, P., E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman. 1994. mPPAR-γ2: Tissue-specific regulator of an adipocyte enhancer. Genes & Dev. 8: 1224-1234.
71. Trayhurn, P. 1986. Brown adipose tissue and energy balance. In Brown adipose tissue (ed. P. Trayhurn and D.G. Nicholls), pp. 299-338. Edward Arnold, London, UK.
72. Vinson, C.R., T. Hai, and S.M. Boyd. 1993. Dimerization specificity of the leucine ZIPper-containing bZIP motif on DNA binding: Prediction and rational design. Genes & Dev. 7: 1047-1058.
73. Wang, N.D., M.J. Finegold, A. Bradley, C.N. Ou, S.V. Abdelsayed, M.D. Wilde, L.R. Taylor, D.R. Wilson, and G.J. Darlington. 1995. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269: 1108-1112.
74. West, D.B., C.N. Boozer, D.L. Moody, and R.L. Atkinson. 1992. Dietary obesity in nine inbred mouse strains. Am. J. Physiol. 262: R1025-R1032.
75. Wu, Z., N.L. Bucher, and S.R. Farmer. 1996. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol. Cell. Biol. 16: 4128-4136.
76. Yubero, P., C. Manchado, A.M. Cassard-Doulcier, T. Mampel, O. Vinas, R. Iglesias, M. Giralt, and F. Villarroya. 1994. CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter. Biochem. Biophys. Res Commun. 198: 653-659.
77. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.