Essential fatty acids, lipid peroxidation and apoptosis

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 61, Issue 3, 1999, Pages 157-163

  Das, U N ^a  

^a EFA Sciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ARACHIDONIC ACID; CARNITINE PALMITOYLTRANSFERASE; CYTOCHROME P450; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; GAMMA LINOLENIC ACID; GLUTATHIONE; ICOSAPENTAENOIC ACID; LONG CHAIN FATTY ACID; PROTEIN BCL 2; RAS PROTEIN;

APOPTOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; LIPID PEROXIDATION; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; TUMOR CELL;

EID: 0032710389     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.1999.0085     Document Type: Article

References (41)

1. Das U. N. Gammalinolenic acid, arachidonic acid and eicosapentaenoic acid as potential anti-cancer drugs. Nutrition. 6:1990;428-434.
2. Begin M. E., Das U. N., Ells G., Horrobin D. F. Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukotrienes Med. 19:1985;177-186.
3. Leary W. P., Robinson K. M., Booyens J., Dippenar N. Some effect of gamma-linolenic acid on cultured human oesophageal carcinoma cells. S Afr Med J. 82:1984;681-683.
4. Seigal I., Lin T. L., Yaghoubzadch E., Kaskey T. S., Greicher N. Cytotoxic effects of free fatty acids on ascites tumour cells. J Natl Cancer Inst. 78:1987;271-277.
5. Begin M. E., Ells G., Das U. N., Horribin D. F. Differential killing of human carcinoma cells supplementeld with n-3 and n-6 poly unsaturated fatty acids. J Natl Cancer Inst. 177:1986;1053-1062.
6. Das U. N. Cis unsaturated fatty acids as potential anti-mutagenic tumoricidal and anti-metastatic agents. Asia Pacific J Pharmocol. 7:1992;305-327.
7. Das U. N. Essential fatty acids and their metabolites and cancer. Nutrition. 15:1999;239-241.
8. Ramesh G., Das U. N., Koratkar R., Padma M., Sangeetha P. S. Effect of essential fatty acids on tumour cells. Nutrition. 8:1992;342-347.
9. Noguchi M., Rose D. P., Earashi M. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology. 52:1995;265-270.
10. Das U. N. Tumoricidal action of cis-unsaturated fatty acids and its relationship to free radicals and lipid peroxidation. Cancer Lett. 50:1991;235-243.
11. Sangeetha P., Das U. N. Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists. Cancer Lett. 63:1992;189-198.
12. Das U. N., Begin M. E., Ells G., Huang Y. S., Horribin D. F. Polyunsaturated fatty acids augment free radical generation in tumour cells in vitro. Bio Chem Biophys Res Comm. 145:1987;15-24.
13. Das U. N. Selective enhancement of free radicals in tumour cells as a strategy to kill tumour cells both in vitro and in vivo. Reddy C. C. Biological Oxidation Systems. 1990;607-624 Academic Press, New York.
14. Kumar S. G., Das U. N. Free radical dependent suppression of growth of mouse myelomia cells by alpha-linolenic and eicosapentaenoic acid in vitro. Cancer Lett. 92:1995;27-38.
15. Fernandes G., Chandra Sekhar B., Luan X., Troyer D. A. Modulation of antioxidant enzymes and programmed cell death by n-3 fatty acids. Lipids. 31:1996;591-596.
16. Southgate J., Pitt E., Trejdoesiewicz L. K. The Effects of dietary fatty acids on the proliferation of normal human arothelial cells in vitro. Br J Cancer. 74:1996;728-734.
17. Surette M. E., Winkler J. D., Fonten A. N., Chiltoh F. H. Relationship between arachidonate - phospholipid remodelling and apoptosis. Biochemistry. 35:1996;9187-9196.
18. Chen Q., Gallenno M., Cederbaum A. I. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells over expressing human cytochrome p-4502E 1. Alcohol Clin Exp Res. 22:1998;782-784.
19. Colquhoun A. Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitayl transferase I activity in HepG2 cells. Bio Chem Mol Bio Int. 45:1998;331-336.
20. Williams J. R., Leaver H. A., Ironside J. W., Miller E. P., Whittle I. R., Gregor A. Apoptosis in human primary brain tumours. Actions of arachidonic acid. Prostaglandins Leukot Essent Fatty Acids. 58:1998;193-200.
21. Finstad H. S., Myhrstad M. C., Heimli H., Lomo J., Blomhoff K., Kolset S. O., Drevon C. A. Multiplication and death-type of leukemia cell lines exposed to very long chain polyunsaturated fatty acids. Leukemia. 12:1998;921-929.
22. Ramesh G., Das U. N. Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. Prostaglandins Leukot Essent Fatty Acids. 59:1998;155-161.
23. Ramesh G., Das U. N. Effect of free fatty acids on two stage skin carcinogenesis in mice. Cancer Lett. 100:1996;199-209.
24. Ramesh G., Das U. N. Effect of dietary fat on diethylnitrosamine induced hepato carcinogenesis in Wistar rats. Cancer Lett. 95:1995;237-245.
25. Ramesh G., Das U. N. Effect of cis unsaturated fatty acids on meth. A ascitic tumour cells in vitro and in vivo. Cancer Lett. 123:1998;207-214.
26. Calviello G., Palozza O., Piccioni E. Dietary supplementation with eicosapentaenoic and decosahexaenoic acid inhibits growth of morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis. Int J Cancer. 75:1998;699-705.
27. Tang D. G., Guan K. L., Li L. Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids. Int J Cancer. 72:1997;1078-1087.
28. Rotstein N. P., Aveldano M. I., Barrantes F. J., Roccamo A. M., Politi L. E. Apoptosis of retinal photoreceptors during development in vitro. Protective effect of docosahexaenoic acid. J Neurochem. 69:1997;504-513.
29. deVries J. E., Vork M. M., Roemen T. H. Saturated but not monounsaturated fatty acid induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res. 38:1997;1384-1394.
30. Padma M., Das U. N. Effect of cis unsaturated fatty acids on cellular antioxidant stress in macrophage tumour (AK-5) cells in vitro. Cancer Lett. 109:1986;63-75.
31. Sangeetha P. S., Das U. N. Cytotoxic action of cis unsaturated fatty acids on human cervical carcinoma (HeLa) cells in vitro. Prostaglandins Leukot Essent Fatty Acids. 53:1995;287-299.
32. Cheokin R. S., Jiang Y. H., Davidson L. A., Lupton J. R. Modulation of intra cellular second messengers by dietary fat during colonic tumour development. Adv Exp Med Biol. 422:1997;85-96.
33. Shimabukuro M., Wang M. Y., Zhou Y. T., Newgard C. B., Unger R. H. Protection against lipoapoptosis of beta cells through leptin dependent maintenance of BCL-2 expression. Proc Natl Acad Sci USA. 95:1998;9558-9561.
34. Tyurina Y. Y., Tyurina V. A., Certa G., Quinn P. J., Schor N. F., Kagn V. E. Direct evidence for antioxidant effect of BCL-2 in PC 12 rat phacochromocytone cells. Arch Biochem Biophys. 344:1997;413-423.
35. Halder S., Jena N., Croce C. M. Inactivation of BCL-2 by phosphorylation. Proc Natl Acad Sci USA. 92:1995;4507-4511.
36. Padma, M. Das, U. N. Effect of cis unsaturated fatty acids on the activity of protein kinases and protein phosphorylation in macrophage tumour (AK-5) cells in vitro, Prostaglandins Leukot Essent Fatty Acids.
37. Sata M., Walsh K. Oxidised LDL activiates fas mediated endothelial cell apoptosis. J Clin Invest. 102:1998;1682-1689.
38. Kockx M. M., De Meyer G. R., Muhring J., Jacob, Bult H., Herman A. G. Apoptosis and related proteins in different stages of human atherosclerotic plaques. Circulation. 97:1998;2307-2315.
39. Das U. N. Insulin resistance and hyperinsulinemia: are they secondary to an alteration in the metabolism of essential fatty acids. Md Sci Res. 22:1994;243-245.
40. Das U. N. Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heartdisease. Prostaglandins Leukot Essent Fatty Acids. 22:1994;689-692.
41. Das U. N. Can essential fatty acids prevent osteoproses. Med Sci Res. 22:1994;163-165.