Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 Kinase/Akt

Circulation

Volumn 102, Issue 23, 2000, Pages 2873-2879

  Aikawa, R ^a   Nawano, M ^a   Gu, Y ^a   Katagiri, H ^a   Asano, T ^a   Zhu, W ^a   Nagai, R ^a   Komuro, I ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cardiomyopathy; Heart diseases; Hypertrophy; Insulin; Myocytes

Indexed keywords

INSULIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; INSULIN METABOLISM; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0034610449     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.23.2873     Document Type: Article

References (29)

1. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
2. Apoptosisin the failing human heart
3. Apoptosis in pressure overload-induced heart hypertrophy in the rat
4. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy
5. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion
6. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
7. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
8. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I
9. Oxidative stress activates extracellular signal-regulated kinases through src and ras in cultured cardiac myocytes of neonatal rats
10. The insulin signaling system
11. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidy linositol 3-kinase, and Akt
12. Signal transduction. Regulating S6 kinase
13. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
14. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
15. ERKs: A family of proteinserine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
16. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
17. Stretching cardiac myocytes stimulates proto-oncogene expression
18. Roles of PI 3-kinase and Ras on insulin-stimulated glucose transport in 3T3-L1 adipocytes
19. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
20. Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection
21. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes
22. Regulation of neuronal survival by the serine-threonine protein kinase Akt
23. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes
24. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes
25. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis
26. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
27. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
28. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: An overview of randomized placebo-controlled trials
29. Metabolic modulation of acute myocardial infarction: The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group