The 'thrifty genotype' in 1998

Nutrition Reviews

Volumn 57, Issue 5 II, 1999, Pages 2-9

  Neel, James V ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INSULIN; LEPTIN;

AMERICAN INDIAN; CONFERENCE PAPER; DIETARY INTAKE; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; ESSENTIAL HYPERTENSION; GENE ISOLATION; GENE MAPPING; GENE THERAPY; GENETIC ENGINEERING; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; INSULIN METABOLISM; MATURITY ONSET DIABETES MELLITUS; MULTIFACTORIAL INHERITANCE; NOMENCLATURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITION; OBESITY; ONSET AGE; PHYSICAL ACTIVITY; PREVENTIVE MEDICINE; PUBLIC HEALTH; STATISTICAL ANALYSIS; SYNDROME X; TANDEM REPEAT;

EID: 0033000423     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1999.tb01782.x     Document Type: Conference Paper

References (80)

1. Neel JV (1962) Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353-2
2. Vallance-Owen J, Hurlock B, Please NW (1955) Plasma-insulin activity in diabetes mellitus measured by the rat diaphragm technique. Lancet 2:583-7
3. Vallance-Owen J, Lilley MD (1961) Insulin antagonism in the plasma of obese diabetics and prediabetics. Lancet 1:806-7
4. Vallance-Owen J, Lilley MD (1961) An insulin antagonist associated with plasma-albumin. Lancet 1:804-6
5. Neel JV (1982) The thrifty genotype revisited. In Köbberling J, Tattersall R (eds), The Genetics of diabetes mellitus. Academic Press, Amsterdam, pp 137-47
6. Knowler WC, Pettitt DJ, Bennett PH, et al (1983) Diabetes mellitus in the Pima Indians: Genetic and evolutionary considerations. Am J Phys Anthropol 62:107-14
7. Weiss KM, Ferrell RE, Hanis CL (1984) A New World syndrome of metabolic diseases with a genetic and evolutionary basis. Yearbook Phys Anthropol 27:153-78
8. Rosenbaum M, Leibel RL (1988) Pathophysiology of childhood obesity. Adv Pediatr 35:73-137
9. Editorial (1989) Thrifty genotype rendered detrimental by progress? Lancet 2:839-40
10. Ravussin E, Bogardus C (1990) Energy expenditure in the obese: Is there a thrifty gene? Infusionstherapie 17:108-12
11. Zimmet P, Dowse G, Finch C, et al (1990) The epidemiology and natural history of NIDDM-lessons from the South Pacific. Diabetes Metab Rev 6:91-124
12. Zimmet P, O'Dea K (1993) Thrifty genotypes. In Leslie RDG (ed), Causes of diabetes: genetic and environmental factors. John Wiley & Sons, Ltd., Chichester, England, pp 269-90
13. Ravussin E, Valencia ME, Esparza J, et al (1994) Effects of a traditional lifestyle on obesity in Pima Indians. Diabetes Care 17:1067-74
14. Szathmáry EJE (1994) Non-insulin-dependent diabetes mellitus among Aboriginal North Americans. Annu Rev Anthropol 23:457-82
15. Weatherall DJ (1996) The genetics of common diseases: The implications of population variability. In Chadwick D, Cardew G (eds), Variation in the human genome. Wiley & Sons, New York, pp 300-8
16. O'Dea K (1997) Clinical implications of the 'thrifty genotype' hypothesis: Where do we stand now? Nutr Metab Cardiovasc Dis 7:281-4
17. Rosenbaum M, Leibel RL, Hirsch J (1997) Obesity. N Eng J Med 337:396-407
18. Mayberry RH, Lindeman RD (1963) A survey of chronic disease and diet in Seminole Indians in Oklahoma. Am J Clin Nutr 13:127-34
19. Johnson JE, McNutt CW (1964) Diabetes mellitus in an American Indian population isolate. Tex Rep Biol Med 22:110-125
20. Miller M, Burch T, Bennett PH, et al (1965) Prevalence of diabetes mellitus in the American Indians: Results of glucose tolerance in the Cherokee Indians of North Carolina. Arch Intern Med 116:842-5
21. Stein JH, West KM, Robey JM, et al (1965) The high prevalence of abnormal glucose tolerance in the Cherokee Indians of North Carolina. Arch Intern Med 116:843-5
22. Saiki JH, Rimoin DL (1968) Diabetes mellitus among the Navajo. I. Clinical features. Arch Intern Med 122:1-5
23. Henry RE, Burch TA, Bennett PH, et al (1969) Diabetes in the Cocopah Indians. Diabetes 18:33-7
24. Frohman LA, Doeblin TD, Emerling FG (1969) Diabetes in Seneca Indians: Plasma insulin responses to oral carbohydrates. Diabetes 18:38-43
25. Doeblin TD, Evans K, Ingall GB, et al (1969) Diabetes and hyperglycemia in Seneca Indians. Human Hered 19:613-627
26. United States.Congress.Senate.Committee on Government Operations. Permanent Subcommittee on Investigations (1974) Hearings on Indian Health Care. Government Printing Office, Washington, DC
27. Spielman RS, Fajans SS, Neel JV, et al (1982) Glucose tolerance in two unacculturated Indian tribes of Brazil. Diabetologia 23:90-93
28. Tattersall RB (1974) Mild familial diabetes with dominant inheritance. Q J Med 43:339-57
29. Spielman RS, Nussbaum RL (1992) Dual developments in diabetes. Nat Genet 1:82-3
30. Fajans SS, Bell GI, Bowden DW, et al (1994) Maturity-onset diabetes of the young. Life Sci 55:413-422
31. Froguel P, Vaxillaire M, Velho G (1997) Genetic and metabolic heterogeneity of maturity-onset diabetes of the young. Diabetes Rev 5:123-30
32. Horikawa Y, Iwasaki N, Hara M, et al (1997) Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY. Nat Genet 17:384-5
33. Waterworth DM, Bennett ST, Gharani N, et al (1997) Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 349:986-90
34. Raffel LJ, Robbins DC, Norris JM, et al (1996) The GENNID Study. A resource for mapping the genes that cause NIDDM. Diabetes Care 19:864-72
35. Bogardus C, Lillioja S, Nyomba BL, et al (1989) Distribution of in vivo insulin action in Pima Indians as mixture of three normal distributions. Diabetes 38:1423-32
36. Mitchell BD, Kammerer LM, Hixon JE, et al (1995) Evidence for a major gene affecting post-challenge insulin levels in Mexican Americans. Diabetes 44:284-9
37. Hanis CL, Boerwinkle E, Chakraborty R, et al (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 13:161-6
38. Chakraborty R, Ferrell RE, Stern MR et al (1986) Relationship of prevalence of non-insulin-dependent diabetes mellitus with Amerindian admixture in the Mexican Americans of San Antonio, Texas. Genet Epidemiol 3:435-54
39. Schermacher MC, Hasstedt SJ, Hunt SC, et al (1992) Major gene effect for insulin levels in familial NIDDM pedigrees. Diabetes 41:416-23
40. Bell GI, Selby MJ, Rutter WJ (1982) The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature 295:3135
41. Bennett ST, Todd JA (1996) Human type 1 diabetes and the insulin gene: Principles of mapping polygenes. Annu Rev Genet 30:343-370
42. Neel JV, Fajans SS, Conn JW, et al (1965) Diabetes mellitus. In Neel JV, Shaw MW, Schull WJ (eds), Genetics and the epidemiology of chronic diseases. Government Printing Office, Washington, DC, pp 105-32
43. McCance DR, Pettitt DJ, Hanson RL, et al (1994) Glucose insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM. Diabetologia 37:617-23
44. Sims EAH, Berchtold P (1982) Obesity and hypertension: Mechanisms and implications for management. JAMA 24:49-52
45. Kaplan NM (1989) The deadly quartet: Upper body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 149:1514-20
46. Gillum RF (1987) The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women aged 19-79 years. J Chron Dis 40:421-8
47. McKeigue PM, Shah B, Marmot MG (1991) Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337:382-6
48. Landsberg L (1986) Diet, obesity, and hypertension: An hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. QJ Med 61:1081-90
49. Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595-607
50. Björntorp P (1992). Abdominal obesity and the metabolic syndrome. Ann Med 24:465-8
51. Neel JV, Julius S, Weder A, et al (1998) Syndrome X: Is it for real? Genet Epidemiol 15:19-32
52. Barker DJP, Hales CN, Fall CDH, et al (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): Relation to reduced fetal growth. Diabetologia 36:62-7
53. Eaton SB (1999) Where's the beef? Evolution, body composition, and insulin resistance. In preparation.
54. Lee RB (1968) What hunters do for a living, or how to make out on scarce resources. In Lee RB, DeVore I (eds), Man the hunter. Aldine, New York, pp 30-48
55. Hill K, Hawkes K, Hurtado M, et al (1984) Seasonal variance in the diet of Ache hunter-gatherers in eastern Paraguay. Human Ecology 12:101-135
56. Heini AF, Mingholli G, Diaz E, et al (1995) Free-living energy expenditure assessed by two different methods in lean rural Gambian farmers. Am J Clin Nutr 61:893
57. Shimamoto T, Komachi Y, Inada H, et al (1989) Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation 79:503-15
58. Ministry of Agriculture FaF (1995) Household food consumption and expenditure, 1990. With a study of trends over the period 1940-1990. HSMO, London, pp. 55-114
59. Brand Miller JC, Colagiuri S (1994) The carnivore connection: Dietary carbohydrate in the evolution of NIDDM. Diabetologia 37:1280-6
60. Neel JV, Weder A, Julius S (1998) Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis:" The "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med 42:44-74
61. Julius S, Pascual AV, London R (1971 ) Role of parasympathetic inhibition in the hyperkinetic type of borderline hypertension. Circulation 44:413-8
62. Canessa ML, Adragna N, Solomon HS, et al (1980) Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N Eng J Med 302:772-6
63. Clarke WR, Lauer RM (1993) Does childhood obesity track into adulthood? Crit Rev Food Sci Nutr 33:423-30.
64. Guo SS, Roche AF, Chumlea WC, et al (1994) The predictive value of childhood body mass index values for overweight at age 35 y. Am J Clin Nutr 59:810-9
65. Brook CGD (1977) Genetic aspects of obesity. Postgrad Med J. 53:93-9
66. Agras WS, Kraemer HC, Berkowitz RI, et al (1987) Does a vigorous feeding style influence early development of adiposity? J Pediatr 110:799-804
67. Item in Ann Arbor [MI] News, Oct 14, 1996
68. Gortmaker SL, Dietz WH, Sobol AM, et al (1987) Increasing pediatric obesity in the United States. Am J Dis Child 141:535-41
69. Caro JF, Sinha MK, Kolaczynski JW, et al (1996) Leptin: The tale of an obesity gene. Diabetes 45:1455-62
70. Lewontin RC (1992) Biology as ideology/the doctrine of DNA. Harper Perennial, New York
71. Strohman RC (1993) Ancient genomes, wise bodies, unhealthy people: Limits of a genetic paradigm in biology and medicine. Perspect Biol Med 37:112-45
72. Cook-Deegan R (1994) The gene wars. Norton, New York
73. Gest H (1996) Longest and dullest scientific books of the twentieth century. Perspect Biol Med 40:108-17
74. Neel JV (1961) A geneticist looks at modern medicine. Harvey Lectures 36:127-50
75. Neel JV (1994) Physician to the gene pool. John Wiley & Sons, New York
76. Lederberg J. Molecular biology, eugenics, and euphenics. Nature 1963;198:428-9
77. Eaton SB, Shostak M, Konner M (1988) The Paleolithic prescription: a program of diet and exercise and a design for living. Harper & Row, New York
78. Eaton SB, Eaton III SB, Konner MJ (1997) Paleolithic nutrition revisited: A twelve-year retrospective on its nature and implications. Eur J Clin Nutr 51:207-16
79. Wassertheil-Smoller S, Oberman A, Blaufox MD, et al (1992) The Trial of Antihypertensive Interventions and Management (TAIM) study. Final results with regard to blood pressure, cardiovascular risk, and quality of life. Am J Hypertension 5:37-44
80. Appel LJ, Moore TJ, Obarzanek E, et al (1997) A clinical trial of the effects of dietary patterns on blood pressure. N Eng J Med 336:1117-24