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Volumn 288, Issue 20, 2002, Pages 2579-2588

Molecular understanding of hyperglycemia's adverse effects for diabetic complications

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; DIACYLGLYCEROL; GLUCOSE; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

EID: 0037184495     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.288.20.2579     Document Type: Article
Times cited : (861)

References (154)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 3
    • 0024430867 scopus 로고
    • The Wisconsin epidemiological study of diabetic retinopathy: A review
    • Klein R, Klein BEK, Moss SE. The Wisconsin epidemiological study of diabetic retinopathy: A review. Diabetes Metab Rev. 1989;5:559-570.
    • (1989) Diabetes Metab Rev , vol.5 , pp. 559-570
    • Klein, R.1    Klein, B.E.K.2    Moss, S.E.3
  • 4
    • 0002451749 scopus 로고
    • Vision disorders in diabetes
    • Hamman R, Harris MWH, eds. Bethesda, Md: National Institutes of Health. US Public Health Service/NIH Publication 85-1468
    • Klein R, Klein BEK. Vision disorders in diabetes. In: Hamman R, Harris MWH, eds. Diabetes in America. Bethesda, Md: National Institutes of Health; 1982. US Public Health Service/NIH Publication 85-1468, vol 13:1-36.
    • (1982) Diabetes in America , vol.13 , pp. 1-36
    • Klein, R.1    Klein, B.E.K.2
  • 5
    • 0030010417 scopus 로고    scopus 로고
    • Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy
    • Bursell SE, Clermont AC, Kinsley BT, et al. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci. 1996;37:886-897.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 886-897
    • Bursell, S.E.1    Clermont, A.C.2    Kinsley, B.T.3
  • 6
    • 0029038779 scopus 로고
    • Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy
    • Kohner EM, Patel V, Rassam SMB. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes. 1995;44:603-607.
    • (1995) Diabetes , vol.44 , pp. 603-607
    • Kohner, E.M.1    Patel, V.2    Rassam, S.M.B.3
  • 7
    • 0025769620 scopus 로고
    • Activated monocytes and granulocytes, capillary non-perfusion, and neovascularization in diabetic retinopathy
    • Schroder S, Palinski W, Schmid-Schonbein GW. Activated monocytes and granulocytes, capillary non-perfusion, and neovascularization in diabetic retinopathy. Am J Pathol. 1991;139:81-100.
    • (1991) Am J Pathol , vol.139 , pp. 81-100
    • Schroder, S.1    Palinski, W.2    Schmid-Schonbein, G.W.3
  • 8
    • 0032833358 scopus 로고    scopus 로고
    • Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy
    • Fortune B, Schneck ME, Adams AJ. Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 1999;40:2638-2651.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2638-2651
    • Fortune, B.1    Schneck, M.E.2    Adams, A.J.3
  • 10
    • 0031006861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy
    • Miller JW, Adamis AP, Aiello LP, Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev. 1997;13:37-50.
    • (1997) Diabetes Metab Rev , vol.13 , pp. 37-50
    • Miller, J.W.1    Adamis, A.P.2    Aiello, L.P.3
  • 11
    • 0033895534 scopus 로고    scopus 로고
    • Retinal and choroidal neovascularization
    • Campochiaro PA. Retinal and choroidal neovascularization. J Cell Physiol. 2000;184:301-310.
    • (2000) J Cell Physiol , vol.184 , pp. 301-310
    • Campochiaro, P.A.1
  • 12
    • 0032800916 scopus 로고    scopus 로고
    • Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus
    • Shinoda K, Ishida S, Kawashima S, et al. Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus. Br J Ophthalmol. 1999;83:834-837.
    • (1999) Br J Ophthalmol , vol.83 , pp. 834-837
    • Shinoda, K.1    Ishida, S.2    Kawashima, S.3
  • 13
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331:1480-1487.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 14
    • 0033538517 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
    • Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science. 1999;285:245-248.
    • (1999) Science , vol.285 , pp. 245-248
    • Dawson, D.W.1    Volpert, O.V.2    Gillis, P.3
  • 15
    • 0034880565 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment
    • Ogata N, Tombran-Tink J, Nishikawa M, et al. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Ophthalmol. 2001;132:378-382.
    • (2001) Am J Ophthalmol , vol.132 , pp. 378-382
    • Ogata, N.1    Tombran-Tink, J.2    Nishikawa, M.3
  • 16
    • 0025892104 scopus 로고
    • Early photocoagulation for diabetic retinopathy: ETDRS report number 9
    • Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy: ETDRS report number 9. Ophthalmology. 1991;98:766-785.
    • (1991) Ophthalmology , vol.98 , pp. 766-785
  • 17
    • 0027466546 scopus 로고
    • The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort
    • Dyck PJ, Kratz KM, Karnes JL, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort. Neurology. 1993;43:817-824.
    • (1993) Neurology , vol.43 , pp. 817-824
    • Dyck, P.J.1    Kratz, K.M.2    Karnes, J.L.3
  • 18
    • 0029954190 scopus 로고    scopus 로고
    • Pathologic alterations in the diabetic neuropathies of humans
    • Dyck PJ, Giannini C. Pathologic alterations in the diabetic neuropathies of humans. J Neuropathol Exp Neurol. 1996;55:1181-1193.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 1181-1193
    • Dyck, P.J.1    Giannini, C.2
  • 20
    • 0000792964 scopus 로고    scopus 로고
    • Foot problems in patients with diabetes mellitus
    • Pickup J, Williams G, eds. London, England: Blackwell Science
    • Boulton AJM. Foot problems in patients with diabetes mellitus. In: Pickup J, Williams G, eds. Textbook of Diabetes. London, England: Blackwell Science; 1997:1-58.
    • (1997) Textbook of Diabetes , pp. 1-58
    • Boulton, A.J.M.1
  • 21
    • 0027322099 scopus 로고
    • Endoneurial localisation of microvascular damage in human diabetic neuropathy
    • Malik RA, Tesfaye S, Thompson SD, et al. Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetoiogia. 1993;36:454-459.
    • (1993) Diabetoiogia , vol.36 , pp. 454-459
    • Malik, R.A.1    Tesfaye, S.2    Thompson, S.D.3
  • 22
    • 0029954190 scopus 로고    scopus 로고
    • Pathologic alterations in the diabetic neuropathies of humans
    • Dyck PJ, Giannini C. Pathologic alterations in the diabetic neuropathies of humans. J Neuropathol Exp Neurol. 1996;55:1181-1193.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 1181-1193
    • Dyck, P.J.1    Giannini, C.2
  • 24
    • 0035195970 scopus 로고    scopus 로고
    • Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy
    • Cameron NE, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001;44:1973-1988.
    • (2001) Diabetologia , vol.44 , pp. 1973-1988
    • Cameron, N.E.1    Eaton, S.E.2    Cotter, M.A.3    Tesfaye, S.4
  • 25
    • 0026469097 scopus 로고
    • Complications: Neuropathy, pathogenetic considerations
    • Greene DA, Sima AAF, Stevens MJ, et al. Complications: Neuropathy, pathogenetic considerations. Diabetes Care. 1992;15:1902-1925.
    • (1992) Diabetes Care , vol.15 , pp. 1902-1925
    • Greene, D.A.1    Sima, A.A.F.2    Stevens, M.J.3
  • 26
    • 0033760829 scopus 로고    scopus 로고
    • Diabetic peripheral neuropathy: Evidence for apoptosis and associated mitochondrial dysfunction
    • Srinivasan S, Stevens M, Wiley JW. Diabetic peripheral neuropathy: Evidence for apoptosis and associated mitochondrial dysfunction. Diabetes. 2000;49:1932-1938.
    • (2000) Diabetes , vol.49 , pp. 1932-1938
    • Srinivasan, S.1    Stevens, M.2    Wiley, J.W.3
  • 27
    • 0023757221 scopus 로고
    • Diabetic neuropathy: Structural analysis of nerve hydration by magnetic resonance spectroscopy
    • Griffey RH, Eaton RP, Sibbitt RR, et al. Diabetic neuropathy: Structural analysis of nerve hydration by magnetic resonance spectroscopy. JAMA. 1988;260:2872-2878.
    • (1988) JAMA , vol.260 , pp. 2872-2878
    • Griffey, R.H.1    Eaton, R.P.2    Sibbitt, R.R.3
  • 28
    • 0001740717 scopus 로고
    • Capillary number and percentage closed in human diabetic sural nerve
    • Dyck PJ, Hansen S, Karnes J, et al. Capillary number and percentage closed in human diabetic sural nerve. Proc Natl Acad Sci U S A. 1985;82:2513-2517.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 2513-2517
    • Dyck, P.J.1    Hansen, S.2    Karnes, J.3
  • 29
    • 0021742187 scopus 로고
    • Galactose neuropathy: Impact of chronic endoneurial edema on nerve blood flow
    • Myers RR, Powell HC. Galactose neuropathy: Impact of chronic endoneurial edema on nerve blood flow. Ann Neurol. 1984;16:587-594.
    • (1984) Ann Neurol , vol.16 , pp. 587-594
    • Myers, R.R.1    Powell, H.C.2
  • 30
    • 0033548514 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats
    • Samii A, Unger J, Lange W. Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats. Neurosci Lett. 1999;262:159-162.
    • (1999) Neurosci Lett , vol.262 , pp. 159-162
    • Samii, A.1    Unger, J.2    Lange, W.3
  • 31
    • 0035023584 scopus 로고    scopus 로고
    • Reversal of experimental diabetic neuropathy by VEGF gene transfer
    • Schratzberger P, Walter DH, Rittig K, et al. Reversal of experimental diabetic neuropathy by VEGF gene transfer. J Clin Invest. 2001;107:1083-1092.
    • (2001) J Clin Invest , vol.107 , pp. 1083-1092
    • Schratzberger, P.1    Walter, D.H.2    Rittig, K.3
  • 32
    • 0029011459 scopus 로고
    • Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy
    • Kihara M, Low PA. Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol. 1995;132:180-185.
    • (1995) Exp Neurol , vol.132 , pp. 180-185
    • Kihara, M.1    Low, P.A.2
  • 33
  • 34
    • 0033406221 scopus 로고    scopus 로고
    • Endothelin: Emerging role in diabetic vascular complications
    • Hopfner RL, Gopalakrishnan V. Endothelin: Emerging role in diabetic vascular complications. Diabetologia. 1999;42:1383-1394.
    • (1999) Diabetologia , vol.42 , pp. 1383-1394
    • Hopfner, R.L.1    Gopalakrishnan, V.2
  • 35
    • 0343825168 scopus 로고
    • Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy
    • Low PA, Tuck RR, Dyck PJ, et al. Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy. Proc Natl Acad Sci U S A. 1984;81:6894-6898.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 6894-6898
    • Low, P.A.1    Tuck, R.R.2    Dyck, P.J.3
  • 36
    • 0030432243 scopus 로고    scopus 로고
    • Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats
    • Cameron NE, Cotter MA. Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats. J Pharmacol Exp Ther. 1996;278:1262-1268.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1262-1268
    • Cameron, N.E.1    Cotter, M.A.2
  • 37
    • 0028095119 scopus 로고
    • Vascular factors in diabetic neuropathy
    • Tesfaye S, Malik R, Ward JD, Vascular factors in diabetic neuropathy. Diabetologia. 1994;37:847-854.
    • (1994) Diabetologia , vol.37 , pp. 847-854
    • Tesfaye, S.1    Malik, R.2    Ward, J.D.3
  • 38
    • 0033533807 scopus 로고    scopus 로고
    • Nephropathy in patients with type 2 diabetes mellitus
    • Ritz E, Orth SR. Nephropathy in patients with type 2 diabetes mellitus. N Engl J Med. 1999;341:1127-1133.
    • (1999) N Engl J Med , vol.341 , pp. 1127-1133
    • Ritz, E.1    Orth, S.R.2
  • 39
    • 0023099831 scopus 로고
    • Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats
    • Craven PA, Caines MA, DeRubertis FR. Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats. Metabolism. 1987;36:95-103.
    • (1987) Metabolism , vol.36 , pp. 95-103
    • Craven, P.A.1    Caines, M.A.2    DeRubertis, F.R.3
  • 40
    • 0026696584 scopus 로고
    • Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperfusion of diabetic rats
    • Perico N, Benignim A, Gabanelli M, et al. Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperfusion of diabetic rats. Diabetes. 1992;41:533-538.
    • (1992) Diabetes , vol.41 , pp. 533-538
    • Perico, N.1    Benignim, A.2    Gabanelli, M.3
  • 41
    • 0028899528 scopus 로고
    • Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels
    • Sharma K, Danoff TM, DePiero A, Ziyadeh FN. Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels. Biochem Biophys Res Commun. 1995;207:80-88.
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 80-88
    • Sharma, K.1    Danoff, T.M.2    DePiero, A.3    Ziyadeh, F.N.4
  • 43
    • 0032712434 scopus 로고    scopus 로고
    • Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    • Cooper ME, Vranes D, Youssef S, et al. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes. 1999;48:2229-2239.
    • (1999) Diabetes , vol.48 , pp. 2229-2239
    • Cooper, M.E.1    Vranes, D.2    Youssef, S.3
  • 44
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • Senger DR, Perruzzi CA, Feder J, Dvorak HF. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 1986;46:5629-5632.
    • (1986) Cancer Res , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.F.4
  • 45
    • 0027379945 scopus 로고
    • Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy
    • Min W, Yamanak N. Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy, Virchows Arch A Pathol Anat Histopathol. 1993;423:201-207.
    • (1993) Virchows Arch A Pathol Anat Histopathol , vol.423 , pp. 201-207
    • Min, W.1    Yamanak, N.2
  • 46
    • 0027452124 scopus 로고
    • The extracellular matrix in diabetic nephropathy
    • Ziyadeh FN. The extracellular matrix in diabetic nephropathy. Am J Kidney Dis. 1993;22:736-744.
    • (1993) Am J Kidney Dis , vol.22 , pp. 736-744
    • Ziyadeh, F.N.1
  • 47
    • 0023710779 scopus 로고
    • A strong correlation between glomerular filtration rate and surface in diabetic nephropathy
    • Osterby R, Parving HH, Nyberg G, et al. A strong correlation between glomerular filtration rate and surface in diabetic nephropathy. Diabetologia. 1988;31:265-270.
    • (1988) Diabetologia , vol.31 , pp. 265-270
    • Osterby, R.1    Parving, H.H.2    Nyberg, G.3
  • 48
    • 0029878746 scopus 로고    scopus 로고
    • Quantification of glomerular TGF-beta 1 mRNA in patients with diabetes mellitus
    • Iwano M, Kubo A, Nishino T, et al. Quantification of glomerular TGF-beta 1 mRNA in patients with diabetes mellitus. Kidney Int. 1996;49:1120-1126.
    • (1996) Kidney Int , vol.49 , pp. 1120-1126
    • Iwano, M.1    Kubo, A.2    Nishino, T.3
  • 49
    • 0033802165 scopus 로고    scopus 로고
    • Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
    • Gupta S, Clarkson MR, Duggan J, Brady HR. Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int. 2000;58:1389-1399.
    • (2000) Kidney Int , vol.58 , pp. 1389-1399
    • Gupta, S.1    Clarkson, M.R.2    Duggan, J.3    Brady, H.R.4
  • 50
    • 0027375770 scopus 로고
    • Transforming growth factor-β1 enhances glomerular collagen synthesis in diabetic rats
    • Bollineni JS, Reddi AS. Transforming growth factor-β1 enhances glomerular collagen synthesis in diabetic rats. Diabetes. 1993;42:1673-1677.
    • (1993) Diabetes , vol.42 , pp. 1673-1677
    • Bollineni, J.S.1    Reddi, A.S.2
  • 51
    • 0027263332 scopus 로고
    • The glomerular mesangium in diabetes mellitus
    • Kreisberg JI, Ayo SH. The glomerular mesangium in diabetes mellitus. Kidney Int. 1993;43:109-113.
    • (1993) Kidney Int , vol.43 , pp. 109-113
    • Kreisberg, J.I.1    Ayo, S.H.2
  • 52
    • 0028218461 scopus 로고
    • Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β
    • Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β. Clin Invest. 1994;93:536-542.
    • (1994) Clin Invest , vol.93 , pp. 536-542
    • Ziyadeh, F.N.1    Sharma, K.2    Ericksen, M.3    Wolf, G.4
  • 53
    • 0035882440 scopus 로고    scopus 로고
    • Regulation of mesangial cell function by vasodilatory signaling molecules
    • Buschhausen L, Seibold S, Gross O, et al. Regulation of mesangial cell function by vasodilatory signaling molecules. Cardiovasc Res. 2001;51:463-469
    • (2001) Cardiovasc Res , vol.51 , pp. 463-469
    • Buschhausen, L.1    Seibold, S.2    Gross, O.3
  • 55
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345:851-860.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 56
    • 0027319870 scopus 로고
    • Pericyte physiology
    • Shepro D, Morel NML. Pericyte physiology. FASEB J. 1993;7:1031-1038.
    • (1993) FASEB J , vol.7 , pp. 1031-1038
    • Shepro, D.1    Morel, N.M.L.2
  • 58
    • 0029808361 scopus 로고    scopus 로고
    • The genetics of complex ophthalmic disorders
    • Evans K, Bird AC. The genetics of complex ophthalmic disorders. Br J Ophthalmol. 1996;80:763-768.
    • (1996) Br J Ophthalmol , vol.80 , pp. 763-768
    • Evans, K.1    Bird, A.C.2
  • 59
    • 0016243140 scopus 로고
    • Mechanisms initiating cataract formation: Proctor lecture
    • Kinoshita JH. Mechanisms initiating cataract formation: Proctor lecture. Invest Ophthalmol. 1974;13:713-724.
    • (1974) Invest Ophthalmol , vol.13 , pp. 713-724
    • Kinoshita, J.H.1
  • 60
    • 0016411408 scopus 로고
    • Hyperglycemia, polyol metabolism, and complications of diabetes mellitus
    • Gabbay KH. Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annu Rev Med. 1975;26:521-536.
    • (1975) Annu Rev Med , vol.26 , pp. 521-536
    • Gabbay, K.H.1
  • 61
    • 0029032001 scopus 로고
    • Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism
    • Van den Enden MK, Nyengaard JR, Ostrow E, et al. Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Invest Ophthalmol Vis Sci. 1995;36:1675-1685.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1675-1685
    • Van den Enden, M.K.1    Nyengaard, J.R.2    Ostrow, E.3
  • 62
    • 0028274304 scopus 로고
    • Free radicals in diabetic endothelial cell dysfunction
    • Tesfamariam B. Free radicals in diabetic endothelial cell dysfunction. Free Radic Biol Med. 1994;16:383-391.
    • (1994) Free Radic Biol Med , vol.16 , pp. 383-391
    • Tesfamariam, B.1
  • 63
    • 0027318772 scopus 로고
    • Hyperglycemic pseudohypoxia and diabetic complications
    • Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42:801-813.
    • (1993) Diabetes , vol.42 , pp. 801-813
    • Williamson, J.R.1    Chang, K.2    Frangos, M.3
  • 64
    • 0024388765 scopus 로고
    • Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor
    • Robison WG Jr, Nagata M, Laver N, et al. Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor. Invest Ophthalmol Vis Sci. 1989;30:2285-2292.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 2285-2292
    • Robison W.G., Jr.1    Nagata, M.2    Laver, N.3
  • 65
    • 0025140713 scopus 로고
    • Prevention of retinal vessel changes associated with diabetic retinoathy in galactose-fed dogs by aldose reductase inhibitors
    • Kador PF, Akagi Y, Takahashi Y, et al. Prevention of retinal vessel changes associated with diabetic retinoathy in galactose-fed dogs by aldose reductase inhibitors. Arch Ophthalmol. 1990;108:1301-1309.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1301-1309
    • Kador, P.F.1    Akagi, Y.2    Takahashi, Y.3
  • 66
    • 0024821312 scopus 로고
    • Effects of sorbinil on glomerular structure and function in long-term-diabetic rats
    • Mauer SM, Steffes MW, Azar S, Brown DM. Effects of sorbinil on glomerular structure and function in long-term-diabetic rats. Diabetes. 1989;38:839-846.
    • (1989) Diabetes , vol.38 , pp. 839-846
    • Mauer, S.M.1    Steffes, M.W.2    Azar, S.3    Brown, D.M.4
  • 67
    • 0019965361 scopus 로고
    • The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats
    • Yue DK, Hanwell MA, Satchell PM, Turtle JR. The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. Diabetes. 1982;31:789-794.
    • (1982) Diabetes , vol.31 , pp. 789-794
    • Yue, D.K.1    Hanwell, M.A.2    Satchell, P.M.3    Turtle, J.R.4
  • 68
    • 0022640893 scopus 로고
    • The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat
    • Cameron NE, Leonard MB, Ross IS, Whiting PH. The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat. Diabetologia. 1986;29:168-174.
    • (1986) Diabetologia , vol.29 , pp. 168-174
    • Cameron, N.E.1    Leonard, M.B.2    Ross, I.S.3    Whiting, P.H.4
  • 69
    • 0025073693 scopus 로고
    • A randomized trial of Sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group. A randomized trial of Sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch Ophthalmol. 1990;108:1234-1244.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1234-1244
  • 70
    • 0029085097 scopus 로고
    • Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy
    • Goto Y, Hotta N, Shigeta Y, et al. Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Biomed Pharmacother. 1995;49:269-277.
    • (1995) Biomed Pharmacother , vol.49 , pp. 269-277
    • Goto, Y.1    Hotta, N.2    Shigeta, Y.3
  • 71
    • 0035486938 scopus 로고    scopus 로고
    • Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy
    • Hotta N, Toyota T, Matsuoka K, et al. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy. Diabetes Care. 2001;24:1776-1782.
    • (2001) Diabetes Care , vol.24 , pp. 1776-1782
    • Hotta, N.1    Toyota, T.2    Matsuoka, K.3
  • 72
    • 0001430544 scopus 로고
    • Accelerated age-related browning of human collagen in diabetes mellitus
    • Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Nati Acad Sci U S A. 1984;81:583-587.
    • (1984) Proc Natl Acad Nati Acad Sci U S A , vol.81 , pp. 583-587
    • Monnier, V.M.1    Kohn, R.R.2    Cerami, A.3
  • 73
    • 0021231172 scopus 로고
    • Nonenzymatic glycosylation and the pathogenesis of diabetic complications
    • Brownlee M, Vlassara H, Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med. 1984;101:527-537.
    • (1984) Ann Intern Med , vol.101 , pp. 527-537
    • Brownlee, M.1    Vlassara, H.2    Cerami, A.3
  • 74
    • 0028908348 scopus 로고
    • Advanced protein glycosylation in diabetes and aging
    • Brownlee M. Advanced protein glycosylation in diabetes and aging Annu Rev Med. 1995;46:223-234.
    • (1995) Annu Rev Med , vol.46 , pp. 223-234
    • Brownlee, M.1
  • 75
    • 0028304845 scopus 로고
    • Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity
    • Giardino I, Edelstein D, Brownlee M. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. J Clin Invest. 1994;94:110-117.
    • (1994) J Clin Invest , vol.94 , pp. 110-117
    • Giardino, I.1    Edelstein, D.2    Brownlee, M.3
  • 76
    • 0033073704 scopus 로고    scopus 로고
    • Intracellular protein glycation in cultured retinal capillary pericytes and endothelial cells exposed to high-glucose concentration
    • Chibber R, Molinatti PA, Kohner EM. Intracellular protein glycation in cultured retinal capillary pericytes and endothelial cells exposed to high-glucose concentration. Cell Mol Biol (Noisy-le-grand). 1999;45:47-57.
    • (1999) Cell Mol Biol (Noisy-le-grand) , vol.45 , pp. 47-57
    • Chibber, R.1    Molinatti, P.A.2    Kohner, E.M.3
  • 77
    • 0033779614 scopus 로고    scopus 로고
    • RAGE a new target for the prevention and treatment of the vascular and inflammatory complications of diabetes
    • Schmidt AM, Stern DM. RAGE: a new target for the prevention and treatment of the vascular and inflammatory complications of diabetes. Trends Endocrinol Metab. 2000;11:368-375.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 368-375
    • Schmidt, A.M.1    Stern, D.M.2
  • 78
    • 0028364606 scopus 로고
    • Macrophages adhere to glucose-modified basement membrane via their scavenger receptors
    • el Khoury J, Thomas CA, Loike JD, et al. Macrophages adhere to glucose-modified basement membrane via their scavenger receptors. J Biol Chem. 1994;269:10197-10200.
    • (1994) J Biol Chem , vol.269 , pp. 10197-10200
    • El Khoury, J.1    Thomas, C.A.2    Loike, J.D.3
  • 79
    • 0029366113 scopus 로고
    • Galectin-2 as a high affinity binding protein for AGE
    • Vlassara H, Li YM, Imani F, et al. Galectin-2 as a high affinity binding protein for AGE. Mol Med 1995;1:634-646.
    • (1995) Mol Med , vol.1 , pp. 634-646
    • Vlassara, H.1    Li, Y.M.2    Imani, F.3
  • 80
    • 0022644227 scopus 로고
    • Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
    • Brownlee M, Vlassara H, Kooney A, et al. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science. 1986;232:1629-1632.
    • (1986) Science , vol.232 , pp. 1629-1632
    • Brownlee, M.1    Vlassara, H.2    Kooney, A.3
  • 81
    • 0032971837 scopus 로고    scopus 로고
    • Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications
    • Friedman E. Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications. Diabetes Care. 1999;22(suppl 2): B65-B71.
    • (1999) Diabetes Care , vol.22 , Issue.SUPPL. 2
    • Friedman, E.1
  • 82
    • 0032697984 scopus 로고    scopus 로고
    • Biological effects of aminoguanidine
    • Nilsson BO. Biological effects of aminoguanidine. Inflamm Res. 1999;48:509-515.
    • (1999) Inflamm Res , vol.48 , pp. 509-515
    • Nilsson, B.O.1
  • 83
    • 0030061699 scopus 로고    scopus 로고
    • Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy
    • Wautier JL, Zoukourian C, Chappey O, et al. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. J Clin Invest. 1996;97:238-243.
    • (1996) J Clin Invest , vol.97 , pp. 238-243
    • Wautier, J.L.1    Zoukourian, C.2    Chappey, O.3
  • 84
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-790.
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Edelstein, D.2    Du, X.L.3
  • 85
    • 0023708392 scopus 로고
    • Hydroxyl radical production and autoxidative glycosylation
    • Hunt JV, Dean RT, Wolff SP. Hydroxyl radical production and autoxidative glycosylation. Biochem J. 1988;256:205-212.
    • (1988) Biochem J , vol.256 , pp. 205-212
    • Hunt, J.V.1    Dean, R.T.2    Wolff, S.P.3
  • 86
    • 0032882037 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA and its relationship to diabetic complications
    • Suzuki S, Hinokio Y, Komatu K, et al. Oxidative damage to mitochondrial DNA and its relationship to diabetic complications. Diabetes Res Clin Pract. 1999;45:161-168.
    • (1999) Diabetes Res Clin Pract , vol.45 , pp. 161-168
    • Suzuki, S.1    Hinokio, Y.2    Komatu, K.3
  • 87
    • 0027957212 scopus 로고
    • Selective impairment of endothelium-dependent relaxation by prostaglandin endoperoxides
    • Tesfamariam B. Selective impairment of endothelium-dependent relaxation by prostaglandin endoperoxides. J Hypertens. 1994;12:41-47.
    • (1994) J Hypertens , vol.12 , pp. 41-47
    • Tesfamariam, B.1
  • 88
    • 0030048496 scopus 로고    scopus 로고
    • Oxidative stress and diabetic vascular complications
    • Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care. 1996;19:257-267.
    • (1996) Diabetes Care , vol.19 , pp. 257-267
    • Giugliano, D.1    Ceriello, A.2    Paolisso, G.3
  • 89
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991;40:405-412
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 90
    • 0035023063 scopus 로고    scopus 로고
    • Oxidant stress and endothelial cell dysfunction
    • Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001;280:C719-C741.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Lum, H.1    Roebuck, K.A.2
  • 91
    • 0035461381 scopus 로고    scopus 로고
    • Overexpression of Cu/Zn superoxide dismutase protects against early diabetic glomerular injury in transgenic mice
    • Craven PA, Melhem MF, Phillips SL, DeRubertis FR. Overexpression of Cu/Zn superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes. 2001;50:2114-2125.
    • (2001) Diabetes , vol.50 , pp. 2114-2125
    • Craven, P.A.1    Melhem, M.F.2    Phillips, S.L.3    DeRubertis, F.R.4
  • 92
    • 0028273785 scopus 로고
    • Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients
    • Jain SK, McVie R. Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients. Metabolism. 1994;43:306-309.
    • (1994) Metabolism , vol.43 , pp. 306-309
    • Jain, S.K.1    McVie, R.2
  • 93
    • 0023470581 scopus 로고
    • Vitamin C metabolites and microangiopathy in diabetes mellitus
    • Jennings PE, Chirico S, Jones AF, et al. Vitamin C metabolites and microangiopathy in diabetes mellitus. Diabetes Res. 1987;6:151-154.
    • (1987) Diabetes Res , vol.6 , pp. 151-154
    • Jennings, P.E.1    Chirico, S.2    Jones, A.F.3
  • 94
    • 0021809959 scopus 로고
    • Production of 12 HETE and vitamin E status in platelets from type 1 human diabetic subjects
    • Karpen CW, Cataland S, D'Orisio TM, Panganamala RV. Production of 12 HETE and vitamin E status in platelets from type 1 human diabetic subjects. Diabetes. 1985;34:526-531.
    • (1985) Diabetes , vol.34 , pp. 526-531
    • Karpen, C.W.1    Cataland, S.2    D'Orisio, T.M.3    Panganamala, R.V.4
  • 95
    • 0023770113 scopus 로고
    • Free radicals and diabetes
    • Obedey LW. Free radicals and diabetes. Free Radic Biol Med. 1988;5:113-124.
    • (1988) Free Radic Biol Med , vol.5 , pp. 113-124
    • Obedey, L.W.1
  • 96
    • 0033779967 scopus 로고    scopus 로고
    • Cardiovascular disease in diabetes mellitus type 2
    • Hayden JM, Reaven PD. Cardiovascular disease in diabetes mellitus type 2. Curr Opin Lipidol. 2000;11:519-528.
    • (2000) Curr Opin Lipidol , vol.11 , pp. 519-528
    • Hayden, J.M.1    Reaven, P.D.2
  • 97
    • 0034781641 scopus 로고    scopus 로고
    • Divergence between LDL oxidative susceptibility and urinary F(2)-isoprostanes as measures of oxidative stress in type 2 diabetes
    • Devaraj S, Hirany SV, Burk RF, Jialal I. Divergence between LDL oxidative susceptibility and urinary F(2)-isoprostanes as measures of oxidative stress in type 2 diabetes. Clin Chem. 2001;47:1974-1979.
    • (2001) Clin Chem , vol.47 , pp. 1974-1979
    • Devaraj, S.1    Hirany, S.V.2    Burk, R.F.3    Jialal, I.4
  • 98
    • 0029082815 scopus 로고
    • Neurovascular dysfunction in diabetic rats
    • Cameron NE, Cotter MA. Neurovascular dysfunction in diabetic rats. J Clin Invest. 1995;96:1159-1163.
    • (1995) J Clin Invest , vol.96 , pp. 1159-1163
    • Cameron, N.E.1    Cotter, M.A.2
  • 99
    • 0028207046 scopus 로고
    • Antioxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats
    • Cameron NE, Cotter MA, Archibald V, et al. Antioxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia. 1994;37:449-459.
    • (1994) Diabetologia , vol.37 , pp. 449-459
    • Cameron, N.E.1    Cotter, M.A.2    Archibald, V.3
  • 100
    • 0029090976 scopus 로고
    • Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy
    • Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.
    • (1995) Diabetes Care , vol.18 , pp. 1160-1167
    • Nagamatsu, M.1    Nickander, K.K.2    Schmelzer, J.D.3
  • 101
    • 0033861609 scopus 로고    scopus 로고
    • Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats
    • Lal MA, Korner A, Matsuo Y, et al. Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats. Diabetes. 2000;49:1381-1389.
    • (2000) Diabetes , vol.49 , pp. 1381-1389
    • Lal, M.A.1    Korner, A.2    Matsuo, Y.3
  • 102
    • 0035434119 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes and experimental galactosemia
    • Kowluru RA, Tang J, Kern TS. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. Diabetes. 2001;50:1938-1942.
    • (2001) Diabetes , vol.50 , pp. 1938-1942
    • Kowluru, R.A.1    Tang, J.2    Kern, T.S.3
  • 103
    • 0032813888 scopus 로고    scopus 로고
    • High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes
    • Bursell SE, Clermont AC, Aiello LP, et al. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care. 1999;22:1245-1251.
    • (1999) Diabetes Care , vol.22 , pp. 1245-1251
    • Bursell, S.E.1    Clermont, A.C.2    Aiello, L.P.3
  • 104
    • 0034688195 scopus 로고    scopus 로고
    • Vitamin E supplementation and cardiovascular events in high-risk patients
    • Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med. 2000;342:154-160.
    • (2000) N Engl J Med , vol.342 , pp. 154-160
    • Yusuf, S.1    Dagenais, G.2    Pogue, J.3
  • 105
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1992;258:607-614.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 106
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats
    • Inoguchi T, Battan R, Handler E, et al. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats. Proc Natl Acad Sci U S A 1992;89:11059-11063.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3
  • 107
    • 0031883161 scopus 로고    scopus 로고
    • Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus
    • Ishii H, Koya D, King GL. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med. 1998;76:21-31.
    • (1998) J Mol Med , vol.76 , pp. 21-31
    • Ishii, H.1    Koya, D.2    King, G.L.3
  • 108
    • 0030053505 scopus 로고    scopus 로고
    • Protein kinase C β1 overexpression augments phorbol ester-induced increase in endothelial permeability
    • Nagpala PG, Malik AB, Vuong PT, Lum H. Protein kinase C β1 overexpression augments phorbol ester-induced increase in endothelial permeability. J Cell Physiol. 1996;166:249-255.
    • (1996) J Cell Physiol , vol.166 , pp. 249-255
    • Nagpala, P.G.1    Malik, A.B.2    Vuong, P.T.3    Lum, H.4
  • 109
    • 0034651949 scopus 로고    scopus 로고
    • Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo
    • Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo. Circulation. 2000;101:676-681.
    • (2000) Circulation , vol.101 , pp. 676-681
    • Kuboki, K.1    Jiang, Z.Y.2    Takahara, N.3
  • 110
    • 0035008602 scopus 로고    scopus 로고
    • Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced betall PKC activation
    • Bohlen HG, Nase GP. Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced betall PKC activation. Am J Physiol Heart Circ Physiol. 2001;280:H621-H627.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Bohlen, H.G.1    Nase, G.P.2
  • 111
    • 0033868806 scopus 로고    scopus 로고
    • PKC-β inhibitor (Ruboxistaurin mesylate) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats
    • Nonaka A, Kiryu J, Tsujikawa A, et al. PKC-β inhibitor (Ruboxistaurin mesylate) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 2000;41:2702-2706.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2702-2706
    • Nonaka, A.1    Kiryu, J.2    Tsujikawa, A.3
  • 112
    • 0027454103 scopus 로고
    • Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation
    • Shiba T, Inoguchi T, Sportsman JR, et al. Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993;265:E783-E793.
    • (1993) Am J Physiol , vol.265
    • Shiba, T.1    Inoguchi, T.2    Sportsman, J.R.3
  • 113
    • 0030863502 scopus 로고    scopus 로고
    • Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
    • Williams B, Gallagher B, Patel H, Orme C. Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes. 1997;46:1497-1503.
    • (1997) Diabetes , vol.46 , pp. 1497-1503
    • Williams, B.1    Gallagher, B.2    Patel, H.3    Orme, C.4
  • 114
    • 0030760729 scopus 로고    scopus 로고
    • Characterization of protein kinase β-isoform activation on the gene expression of transforming growth factor β, extracellular matrix components and prostanoids in the glomeruli of diabetic rats
    • Koya D, Jirousek MR, Lin YW, et al. Characterization of protein kinase β-isoform activation on the gene expression of transforming growth factor β, extracellular matrix components and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997;100:115-126.
    • (1997) J Clin Invest , vol.100 , pp. 115-126
    • Koya, D.1    Jirousek, M.R.2    Lin, Y.W.3
  • 115
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes. 1997;46:1473-1480.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3
  • 117
    • 0032728365 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases as glucose transducers for diabetic complications
    • Tomlinson DR. Mitogen-activated protein kinases as glucose transducers for diabetic complications. Diabetologia. 1999;42:1271-1281.
    • (1999) Diabetologia , vol.42 , pp. 1271-1281
    • Tomlinson, D.R.1
  • 118
    • 0032104245 scopus 로고    scopus 로고
    • The extended protein kinase C superfamily
    • Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J. 1998;332:281-292.
    • (1998) Biochem J , vol.332 , pp. 281-292
    • Mellor, H.1    Parker, P.J.2
  • 119
    • 0027454103 scopus 로고
    • Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation
    • Shiba T, Inoguchi T, Sportsman JR, et al. Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993;265:E783-E793.
    • (1993) Am J Physiol , vol.265
    • Shiba, T.1    Inoguchi, T.2    Sportsman, J.R.3
  • 120
    • 0031898614 scopus 로고    scopus 로고
    • Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells
    • Babazono T, Kapor-Drezgic J, Dlugosz JA, Whiteside C. Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells. Diabetes. 1998;47:668-676.
    • (1998) Diabetes , vol.47 , pp. 668-676
    • Babazono, T.1    Kapor-Drezgic, J.2    Dlugosz, J.A.3    Whiteside, C.4
  • 121
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase C activation and its pharmacological inhibition in vascular disease
    • Meier M, King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000;5:173-185.
    • (2000) Vasc Med , vol.5 , pp. 173-185
    • Meier, M.1    King, G.L.2
  • 122
    • 13344293711 scopus 로고    scopus 로고
    • Ameliouration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
    • Ishii H, Jirousek, MR, Koya D, et al. Ameliouration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor. Science. 1996;272:728-731.
    • (1996) Science , vol.272 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3
  • 123
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes. 1997;46:1473-1480.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3
  • 124
    • 0031964664 scopus 로고    scopus 로고
    • Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCbeta inhibition with LY333531
    • Danis RP, Bingaman DP, Jirousek M, Yang Y. Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCbeta inhibition with LY333531. Invest Ophthatmol Vis Sci. 1998;39:171-179.
    • (1998) Invest Ophthatmol Vis Sci , vol.39 , pp. 171-179
    • Danis, R.P.1    Bingaman, D.P.2    Jirousek, M.3    Yang, Y.4
  • 125
    • 0032836509 scopus 로고    scopus 로고
    • A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
    • Nakamura J, Kato K, Hamada Y, et al. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes. 1999;48:2090-2095.
    • (1999) Diabetes , vol.48 , pp. 2090-2095
    • Nakamura, J.1    Kato, K.2    Hamada, Y.3
  • 126
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • Koya D, Haneda M, Nakagawa H, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000;14:439-447.
    • (2000) FASEB J , vol.14 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3
  • 127
    • 0030581630 scopus 로고    scopus 로고
    • Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway
    • Hamada Y, Araki N, Koh N, et al. Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway. Biochem Biophys Res Comm. 1996;228:539-543.
    • (1996) Biochem Biophys Res Comm , vol.228 , pp. 539-543
    • Hamada, Y.1    Araki, N.2    Koh, N.3
  • 128
    • 0028951461 scopus 로고
    • Mechanism of autoxidative glycosylation: Identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose
    • Wells-Knecht KJ, Zyzak DV, Litchfield LE, et al. Mechanism of autoxidative glycosylation: Identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose. Biochemistry. 1995;34:3702-3709.
    • (1995) Biochemistry , vol.34 , pp. 3702-3709
    • Wells-Knecht, K.J.1    Zyzak, D.V.2    Litchfield, L.E.3
  • 129
    • 0028826628 scopus 로고
    • Pathways of formation of glycoxidation products during glycation of collagen
    • Wells-Knecht MC, Thorpe SR, Baynes JW. Pathways of formation of glycoxidation products during glycation of collagen. Biochemistry. 1995;34:15134-15141.
    • (1995) Biochemistry , vol.34 , pp. 15134-15141
    • Wells-Knecht, M.C.1    Thorpe, S.R.2    Baynes, J.W.3
  • 130
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/ binding proteins
    • Yan SD, Schmidt AM, Anderson GM, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/ binding proteins. J Biol Chem. 1994;269:9889-9897.
    • (1994) J Biol Chem , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.M.3
  • 131
    • 0026714689 scopus 로고
    • Anti-oxidant status in an in vitro model for hyperglycaemic lens cataract formation
    • Hothersall JS, Muirhead RP, Taylaur CE, Jones RH. Anti-oxidant status in an in vitro model for hyperglycaemic lens cataract formation. Biochem Int. 1992;27:945-952.
    • (1992) Biochem Int , vol.27 , pp. 945-952
    • Hothersall, J.S.1    Muirhead, R.P.2    Taylaur, C.E.3    Jones, R.H.4
  • 132
    • 0030854361 scopus 로고    scopus 로고
    • Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients
    • Bravi MC, Pietrangeli P, Laurenti O, et al. Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients. Metabolism. 1997;46:1194-1198.
    • (1997) Metabolism , vol.46 , pp. 1194-1198
    • Bravi, M.C.1    Pietrangeli, P.2    Laurenti, O.3
  • 133
    • 0029002394 scopus 로고
    • Impaired activation of glucose oxidation and NADPH supply in human endothelial cells exposed to H2O2 in high-glucose medium
    • Asahina T, Kashiwagi A, Nishio Y, et al. Impaired activation of glucose oxidation and NADPH supply in human endothelial cells exposed to H2O2 in high-glucose medium. Diabetes. 1995;44:520-526.
    • (1995) Diabetes , vol.44 , pp. 520-526
    • Asahina, T.1    Kashiwagi, A.2    Nishio, Y.3
  • 134
    • 0032694683 scopus 로고    scopus 로고
    • The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins
    • Anderson MM, Requena JR, Crowley JR, et al. The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins. J Clin Invest. 1999;104:103-113.
    • (1999) J Clin Invest , vol.104 , pp. 103-113
    • Anderson, M.M.1    Requena, J.R.2    Crowley, J.R.3
  • 135
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000;49:1939-1945.
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3
  • 136
    • 0034957822 scopus 로고    scopus 로고
    • Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor-beta
    • Kim YS, Kim BC, Song CY, et al. Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor-beta. J Lab Clin Med. 2001;138:59-68.
    • (2001) J Lab Clin Med , vol.138 , pp. 59-68
    • Kim, Y.S.1    Kim, B.C.2    Song, C.Y.3
  • 137
    • 0030859290 scopus 로고    scopus 로고
    • Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress
    • Lander HM, Tauras JM, Ogiste JS, et al. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem. 1997;272:17810-17814.
    • (1997) J Biol Chem , vol.272 , pp. 17810-17814
    • Lander, H.M.1    Tauras, J.M.2    Ogiste, J.S.3
  • 138
    • 0027231627 scopus 로고
    • Hydroperoxide-induced diacylglycerol formation and protein kinase C activation in vascular endothelial cells
    • Taher MM, Garcia JGN, Natarajan V. Hydroperoxide-induced diacylglycerol formation and protein kinase C activation in vascular endothelial cells. Arch Biochem Biophys. 1993;303:260-266.
    • (1993) Arch Biochem Biophys , vol.303 , pp. 260-266
    • Taher, M.M.1    Garcia, J.G.N.2    Natarajan, V.3
  • 139
    • 0028973482 scopus 로고
    • Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
    • Sundaresan M, Yu ZX, Ferrans VJ, et al. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995;270:296-299.
    • (1995) Science , vol.270 , pp. 296-299
    • Sundaresan, M.1    Yu, Z.X.2    Ferrans, V.J.3
  • 140
    • 0029020218 scopus 로고
    • Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes
    • Lo YY, Cruz TF. Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes J Biol Chem. 1995;270:11727-11730
    • (1995) J Biol Chem , vol.270 , pp. 11727-11730
    • Lo, Y.Y.1    Cruz, T.F.2
  • 141
    • 0033851574 scopus 로고    scopus 로고
    • Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose
    • Ha H, Lee HB. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int. 2000;58(suppl 77): S19-S25. The journal name is valid, but no match was found at PubMed
    • (2000) Kidney Int , vol.58 , Issue.SUPPL. 77
    • Ha, H.1    Lee, H.B.2
  • 142
    • 0035958913 scopus 로고    scopus 로고
    • Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival
    • Wang XT, McCullough KD, Wang XJ, et al. Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival. J Biol Chem. 2001;276:28364-28371.
    • (2001) J Biol Chem , vol.276 , pp. 28364-28371
    • Wang, X.T.1    McCullough, K.D.2    Wang, X.J.3
  • 144
    • 0034434706 scopus 로고    scopus 로고
    • Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type 1 diabetes mellitus
    • Araki S, Makita Y, Canani L, et al. Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type 1 diabetes mellitus. Diabetologia. 2000;43:1540-1543.
    • (2000) Diabetologia , vol.43 , pp. 1540-1543
    • Araki, S.1    Makita, Y.2    Canani, L.3
  • 145
    • 0029925181 scopus 로고    scopus 로고
    • Randomised controlled trial of vitamin E in patients with coronary disease
    • Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease. Lancet. 1996;347:781-786.
    • (1996) Lancet , vol.347 , pp. 781-786
    • Stephens, N.G.1    Parsons, A.2    Schofield, P.M.3
  • 146
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction
    • Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction. Lancet. 1999;354:447-455.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 147
    • 0032836472 scopus 로고    scopus 로고
    • d-alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity
    • Lee IK, Koya D, Ishi H, et al. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. 1999;45:183-190.
    • (1999) Diabetes Res Clin Pract , vol.45 , pp. 183-190
    • Lee, I.K.1    Koya, D.2    Ishi, H.3
  • 148
    • 0030838053 scopus 로고    scopus 로고
    • Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells
    • Studer RK, Craven PA, DeRubertis FR. Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells. Metabolism. 1997;46:918-925.
    • (1997) Metabolism , vol.46 , pp. 918-925
    • Studer, R.K.1    Craven, P.A.2    DeRubertis, F.R.3
  • 149
    • 0035851210 scopus 로고    scopus 로고
    • Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase
    • Soriano FG, Pacher P, Mabley J, et al. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res. 2001;89:684-691.
    • (2001) Circ Res , vol.89 , pp. 684-691
    • Soriano, F.G.1    Pacher, P.2    Mabley, J.3
  • 150
    • 0035434130 scopus 로고    scopus 로고
    • Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C
    • Ido Y, Chang KC, Lejeune WS, et al. Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation. 2001;8:251-263.
    • (2001) Microcirculation , vol.8 , pp. 251-263
    • Ido, Y.1    Chang, K.C.2    Lejeune, W.S.3
  • 151
    • 0034004141 scopus 로고    scopus 로고
    • Protein kinase C-beta mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells
    • Ren S, Shatadal S, Shen GX. Protein kinase C-beta mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells. Am J Physiol Endocrinol Metab. 2000;278:E656-E662.
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Ren, S.1    Shatadal, S.2    Shen, G.X.3
  • 152
    • 0034177184 scopus 로고    scopus 로고
    • Protein kinase C-beta contributes to NADPH-oxidase activation in neutrophils
    • Dekker LV, Leitges M, Altschuler G, et al. Protein kinase C-beta contributes to NADPH-oxidase activation in neutrophils. Biochem J. 2000;347(pt 1):285-289.
    • (2000) Biochem J , vol.347 , Issue.PART 1 , pp. 285-289
    • Dekker, L.V.1    Leitges, M.2    Altschuler, G.3
  • 153
    • 0033894543 scopus 로고    scopus 로고
    • Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced permeability in endothelial cells
    • Chen S, Apostolova MD, Cherian MG, Chakrobarti S. Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced permeability in endothelial cells. Lab Invest. 2000;80:1311-1321.
    • (2000) Lab Invest , vol.80 , pp. 1311-1321
    • Chen, S.1    Apostolova, M.D.2    Cherian, M.G.3    Chakrobarti, S.4
  • 154
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P, Aiello LP, Ishii H, et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996;98:2018-2026.
    • (1996) J Clin Invest , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3


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