d-α-Tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity

Diabetes Research and Clinical Practice

Volumn 45, Issue 2-3, 1999, Pages 183-190

  Lee, In Kyu ^a   Koya, Daisuke ^a   Ishi, Hidehiro ^a   Kanoh, Hideo ^a   King, George L ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

DAG kinase; Diacylglycerol (DAG) protein kinase C (PKC) pathway; Vascular smooth muscle; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ANTIOXIDANT; DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; PROBUCOL; PROTEIN KINASE C;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; DIABETIC ANGIOPATHY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; NONHUMAN; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, ABDOMINAL; AORTA, THORACIC; CELLS, CULTURED; DIACYLGLYCEROL KINASE; DIGLYCERIDES; GLUCOSE; HUMANS; HYPERGLYCEMIA; ISOENZYMES; KINETICS; MUSCLE, SMOOTH, VASCULAR; PROBUCOL; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

EID: 0032836472     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(99)00048-0     Document Type: Article

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