Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in Type I diabetes mellitus

Diabetologia

Volumn 43, Issue 12, 2000, Pages 1540-1543

  Araki, S ^a   Makita, Y ^a   Canani, L ^a   Ng, D ^a   Warram, J H ^a   Krolewski, A S ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

Case control study; Diabetic nephropathy; Polymorphism; PON1; Type I diabetes

Indexed keywords

ARGININE; ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; GLYCINE; LEUCINE; METHIONINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE DURATION; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR;

ADULT; AGE OF ONSET; AMINO ACID SUBSTITUTION; ARYLDIALKYLPHOSPHATASE; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; ESTERASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REFERENCE VALUES;

EID: 0034434706     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051566     Document Type: Article

References (10)

1. Genetics of diabetic nephropathy: Evidence for major and minor gene effect
2. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
3. Paraoxonase-gene polymorphisms associated with coronary heart disease: Support for the oxidative damage hypothesis?
4. Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes
5. Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme: A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes
6. Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activites and concentration
7. Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type I diabetes mellitus
8. The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes
9. Paraoxonase genotype (192 Gln-Arg) and serum paraoxonase-arylesterase activity: Relationship with Type I diabetes and nephropathy
10. Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetic mellitus