Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis

Kidney International

Volumn 58, Issue 4, 2000, Pages 1389-1399

  Gupta, S ^a   Clarkson, M R ^a   Duggan, J ^a   Brady, H R ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Cyclic mechanical strain; Diabetic nephropathy; Extracellular matrix; Hyperglycemia; Mesangial cells; Transforming growth factor

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GLUCOSE; TRANSFORMING GROWTH FACTOR BETA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC DISEASE; EARLY RESPONSE GENE; GENE EXPRESSION; GLOMERULOSCLEROSIS; GLOMERULUS; INTERSTITIAL NEPHRITIS; KIDNEY PARENCHYMA; MESANGIUM CELL; PRIORITY JOURNAL; SCAR FORMATION;

EID: 0033802165     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00301.x     Document Type: Article

References (89)

1. Glomerulosclerosis: The final pathway is clarified, but can we deal with the triggers?
2. TGF-β in kidney disease: A target for gene therapy
3. Mechanisms of tubulointerstitial fibrosis
4. Progression of renal damage in human glomerulonephitides: Is there a sleight of hand in the winning game?
5. The transforming growth factor beta system in kidney disease and repair: Recent progress and future directions
6. Therapeutic approaches to organ fibrosis
7. Transforming growth factor-beta: An overview
8. Connective tissue growth factor: A cysteine-rich mitogen secreted by human endothelial cells is related to the SRC-induced immediate early gene product CEF- 10
9. Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein
10. Identification of a gene family regulated by transforming growth factor-beta
11. Expression of cyr61, a growth factor-inducible immediate-early gene
12. Identification of a phorbol ester-repressible v-src-inducible gene
13. Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas
14. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors
15. Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses in vivo tumor growth and metastasis of K- 1735 murine melanoma cells
16. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions
17. Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation
18. Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor
19. Dorsalventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
20. Structural analysis of the human nov proto-oncogene and expression in Wilms tumor
21. The human growth factor-inducible immediate early gene, CYR 61, maps to chromosome 1p
22. Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
23. Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis
24. Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids
25. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily
26. How many insulin-like growth factor binding proteins?
27. Identification of glycosylated 38 kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and upregulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells
28. Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
29. Characterization of cell associated and soluble forms of connective tissue growth factor produced by fibroblast cells in vitro
30. Connective tissue growth factor (IGFBP-rP2) expression and regulation in cultured bovine endothelial cells
31. Localization of connective tissue growth factor during the period of embryo implantation in the mouse
32. Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8)
33. Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-betal and detection in human gingiva
34. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
35. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
36. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
37. Cyr61 and fisp12 are both ECM-associated signaling molecules: Activities, metabolism, and localisation during development
38. Dexamethasone is a novel potent inducer of connective tissue growth factor expression
39. Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells
40. Growth regulation in scleroderma fibroblasts: Increased response to transforming growth factor-bete 1
41. Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells
42. Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA
43. Physiological function of connective tissue growth factor (CTGF/Hcs24): Its roles in the process of endochondral ossification
44. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture
45. Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
46. Differential expression of novH and CTGF in human glioma cell lines
47. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
48. Serial analysis of gene expression to assess the endothelial cell response to an atherogenic stimulus
49. Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene
50. Complexity of the early genetic response to growth factors in mouse fibroblasts
51. Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle
52. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
53. Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells
54. Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF- 7
55. The CCN family of angiogenic regulators: The integrin connection
56. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo
57. Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
58. Transforming growth factor beta induces anchorage independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signalling pathway
59. CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts
60. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions
61. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia
62. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis
63. Expression of connective tissue growth factor in experimental rat and human liver fibrosis
64. Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation
65. Identification of newt connective tissue growth factor as a target of retinoid regulation in limb blastemal cells
66. Immunohistochemical localization of connective tissue growth factor in the rat central nervous system
67. Characterization of 16-20-kilodalton (kDa) connective tissue growth factors (CTGF) and demonstration of proteolytic activity for 38 kDa CTGF in pig uterine luminal flushings
68. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
69. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis
70. Connective tissue growth factor gene expression in tissue sections from localised scleroderma, keloid, and other fibrotic skin disorders
71. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
72. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model
73. Expression of fibrogenic cytokines in desmoplastic malignant melanoma
74. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha (IIb) beta (3)
75. Expression of connective tissue growth factor in human renal fibrosis
76. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
77. Protein kinases C: Potential targets for intervention in diabetic nephropathy
78. Protein kinase C activation and the development of diabetic complications
79. Differential gene expression in migrating renal epithelial cells after wounding
80. Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells
81. Regulation of connective tissue growth factor expression by prostaglandin E (2)
82. Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor beta-simultaneous application with basic fibroblast growth factor causes persistent fibrosis
83. Differential expression of connective tissue growth factor gene in cutaneous fibrohistiocytic and vascular tumors
84. Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors
85. Connective tissue growth factor: A novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?
86. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis
87. Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats
88. Role of transforming growth factor-beta in trans-differentiation and fibrosis of lens epithelial cells
89. Connective tissue growth factor: Friend or foe?