Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis

Cancer Research

Volumn 60, Issue 2, 2000, Pages 293-297

  Reddy, Bandaru S ^a   Hirose, Yoshinobu ^a   Lubet, Ronald ^b   Steele, Vernon ^b   Kelloff, Gary ^b   Paulson, Susan ^c   Seibert, Karen ^c   Rao, Chinthalapally V ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CHEMOPROPHYLAXIS; COLON CANCER; GENE OVEREXPRESSION; HISTOPATHOLOGY; INCIDENCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; STEADY STATE; TUMOR PROMOTION;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; AZOXYMETHANE; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DISEASE PROGRESSION; ISOENZYMES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, INBRED F344; SULFONAMIDES; TIME FACTORS;

EID: 0034650771     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Landis, S. H., Murray, T., Bolden, S., and Wingo, P. A. Cancer statistics. 1999. CA Cancer J. Clin., 49: 8-31, 1999.
2. Thun, M. J., Namboodiri, M. M., and Heath, C. W., Jr. Aspirin use and reduced risk of fatal color cancer. N. Engl. J. Med., 325: 1593-1596. 1991.
3. Giovannucci, E., Egan, K. M., Hunter, D. J., Stampfer, M. J., Colditz, G. A., Willett, W. C., and Speizer, F. E. Aspirin and the risk of colorectal cancer in women. N. Engl. J, Med., 333: 609-614, 1995.
4. Giardiello, F. M., Hamilton, S. R., Krush, A. J., Piantoadosi, S., Hylind, L. M., Celano, P., Booker, S. V., Robinson, C. R., and Offerhaus, G. J. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med., 328: 1313-1316, 1993.
5. Reddy, B. S., Rao, C.V., Rivenson, A., and Kelloff, G. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis (Lond.), 14: 1493-1497, 1993.
6. Rao, C. V., Rivenson, A., Simi, B., Zang, E., Kelloff, G., Steele, V., and Reddy, B. S. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res., 55: 1464-1472, 1995.
7. Reddy, B. S., Tokumo, K., Kulkarni, N., Aligia, C., and Kelloff, G. Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds. Carcinogenesis (Lond.). 13: 1019-1023, 1992.
8. Pollard, M., and Luckert, P. H. Effect of piroxicam on primary intestinal tumors induced by N-methylnitrosourea. Cancer Lett., 25: 117-121, 1984.
9. min mouse model by the nonsteroidal anti-inflammatory drug, piroxicam. Cancer Res., 56: 710-714, 1996.
10. Boolbool, S. K., Dannenberg, A. J., Chadburn, A., Martucci, C., Guo, X. J., Ramonetti, J. T., Abreu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., and Bertagnolli, M. M. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res., 56: 2556-2560, 1996.
11. Mahmoud, N. N., Dannenherg, A. J., Mestre, J., Bilinski, R. T., Churchill, M. R., Martucci, C., Newmark, H., and Bertagnolli, M. M. Aspirin prevents tumors in a murine model of adenomatous polyps. Surgery, 124: 225-231, 1998.
12. Jones, D. A., Carlton, D. P., McIntyre, T. M., Zimmerman, G. A., and Prescott, S. M. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem., 268: 9049-9054, 1993.
13. DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Leo, B. A., and Lipsky, P. E. Cyclooxygenase in biology and disease. FASEB J., 12: 1063-1073, 1998.
14. Eberhart, C. E., Coffey, R. J., Radhika, A., Giardiello, F. M., Ferrenbach, S., and DuBois. R. N. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adcnocarcinomas. Gastroenterology, 107: 1183-1188, 1994.
15. Karjman, S. L., O'Neill, G. P., Vickers, P. J., Evans, J. F., Mancini, J. A., and Jothy, S. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res., 55: 2556-2559, 1995.
16. Sano, H., Kawahito, Y., Wilder, R. L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., and Hla, T. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res., 55: 3785-3789, 1995.
17. DuBois, R. N., Radhika, A., Reddy, B. S., and Entingh, A. J. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. Gastroenterology, 110: 1259-1262, 1996.
18. Δ716 knockout mice hy inhibition of cyclooxygenase 2 (COX-2). Cell. 87: 803-809, 1996.
19. Smith, W., Garavito, R., and DeWitt, D. Prostaglandin endoperoxide H synthase (cyclooxygenase)-1 and -2. J. Biol. Chem., 271: 33157-33160, 1996.
20. DuBois, R. N., Tsujii, M., Bishop, P., Awad, J. A., Makita, K., and Lanahan, A. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am. J. Physiol., 266: G822-G827, 1994.
21. Taketo, M. M. Cyclooxygenase-2 inhibitors in tumorigenesis (part I). J. Natl. Cancer Inst., 90: 1529-1536, 1998.
22. Simon, L. B. Biologic effects of nonstcroidal anti-inflammatory drugs. Curr. Opin. Rheumatol., 9: 178-182, 1997.
23. Masferrer, J. I.., Isakson, P. C., and Seibert, K. Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract. Gastroenterol. Clin. N. Am., 25: 363-372, 1996.
24. Tsujii, M., and DuBois, R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83: 493-501, 1995.
25. Taketo, M. M. Cyclooxygenase-2 inhibitors in tumorigenesis (part II). J. Natl. Cancer Inst., 90: 1609-1620, 1998.
26. Penning, T. D., Talley, J. J., Bertenshaw, S. R., Carter, J. S., Collins, P. W., Docter, D. J., Yu, S. S., Anderson G. D., Burton, E. G., Cogburn, J. N., Gregory, S. A., Koboldt, C. M., Perkins, W. E., Seibert, K., Veenhuizen A. W., Shang, Y. Y., and Isakson, P. C. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5(4-methylphenyl)-3-(trifluoromethyl1)-H-pyrazol-1-y1]benzenesulfonamide (SC-58635, celecoxib). J. Med. Chem., 40: 1347-1365, 1997.
27. Seibert, K., Zhang, Y., Leahy, D., Hauser, S., Masferrer, J., Perkins, W., Lee, L., and Isakson, P. C. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA. 91: 12013-12017, 1994.
28. Reddy, B. S., Rao, C V., and Seibert, K. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res., 56: 4566-4569, 1996.
29. Kawamori, T., Rao, C. V., Seibert, K., and Reddy, B. S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res., 58: 409-412, 1998.
30. Reddy, B. S., Maruyama, H., and Kelloff. G. Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal anti-inflammatory drug, during different stages of colon tumor development. Cancer Res., 47: 5340-5346, 1987.
31. Pozharisski, K. M. Tumors of the intestine. In: V. S. Turusov and V. Mohr (eds.), Pathology of Tumors in Laboratory Animals, Vol. 1, pp. 159-198. Lyon, France: IARC, 1990.
32. Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., and Reddy, B. S. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent during the promotion/progression stage of colon cancer. Cancer Res., 59: 597-601, 1999.
33. Tsujii, M., Kawano, S., Tsujii, S., Sawoka, H., Hori, M., and DuBois, R. N. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 93: 705-716, 1998.
34. Sheng, H., Shao, J., Kirkland, S. C., Isakson, P., Coffey, R., Marrow, J., Beauchamp, R. D., and DuBois, R. N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Investig., 99: 2254-2259, 1997.