Host cyclooxygenase-2 modulates carcinoma growth

Journal of Clinical Investigation

Volumn 105, Issue 11, 2000, Pages 1589-1594

  Williams, Christopher S ^a,b   Tsujii, Masahiko ^c   Reese, Jeff ^d   Dey, Sudhansu K ^e   DuBois, Raymond N ^a,b,f  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; CYCLOOXYGENASE 2;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; ENZYME MODIFICATION; EPITHELIUM CELL; FIBROBLAST; GENETIC PREDISPOSITION; LEWIS CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR DENSITY; STROMA CELL; TUMOR GROWTH; TUMOR LOCALIZATION;

EID: 0034089566     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9621     Document Type: Article

References (36)

1. Williams, C.S., Mann, M., and DuBois, R.N. 1999. The role of cyclooxygenases in inflammation, cancer and development. Oncogene. 18:7908-7916.
2. Oshima M., et al. 1996. Suppression of intestinal polyposis in Ape delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 87:803-809.
3. Kawamori, T., Rao, C.V., Seibert, K., and Reddy, B.S. 1998. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58:409-412.
4. Nishimura, G., Yanoma, S., Mizuno, H., Kawakami, K., and Tsukuda, M. 1999. A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells. Jpn. J. Cancer Res. 90:1152-1162.
5. Pentland, A.P., Schoggins, J.W., Scott, G.A., Khan, K.N., and Han, R. 1999. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis. 20:1939-1944.
6. Okajima, E., et al. 1998. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl) nitrosamine. Cancer Res. 58:3028-3031.
7. Achiwa, H., et al. 1999. Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. Clin. Cancer Res. 5:1001-1005.
8. Sheehan, K.M., et al. 1999. The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA. 282:1254-1257.
9. Sheng, H., et al. 1997. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest. 99:2254-2259.
10. Hanif, R., et al. 1996. Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol. 52:237-245.
11. Coffey, R.J., et al. 1997. EGF receptor activation induces nuclear targeting of COX-2, basolateral release of prosraglandins and mitogenesis in polarizing colon cancer cells. Proc. Natl. Acad. Sci. USA. 94:657-662.
12. DuBois, R.N., Awad J., Morrow, J., Roberts, L.J., and Bishop, P.R. 1994. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J. Clin. Invest. 93:493-498.
13. Williams, C.S., et al. 1996. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology. 111:1134-1140.
14. Shao, J., et al. 1999. Coordinate regulation of cyclooxygenase-2 and TGF-β1 in hereditary nonpolyposis colorectal cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis. 20:185-191.
15. Karnes, W.E., et al. 1998. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res. 58:5473-5477.
16. Kutchera, W., et al. 1996. Prostaglandin H synthase-2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc. Natl. Acad. Sci. USA. 93:4816-4820.
17. Sano, H., et al. 1995. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55:3785-3789.
18. Shattuck-Brandt, R.L., Lamps, L.W., Heppner-Goss, K.J., DuBois, R.N., and Matrisian, L.M. 1999. Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Mol. Carcinog. 24:177-187.
19. Chapple, K.S., et al. 2000. Localization of cyclooxygenase-2 in human sporadic colorectal adenoma. Am. J. Pathol. 156:545-553.
20. Shattuck-Brandt, R.L., et al. 2000. Cyclooxygenase-2 expression is increased in the subepithelial myofibroblasts of colon and cecal carcinomas from IL-10 (-/) mice. Gastroenterology. 118:337-345.
21. 2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest. Ophthalmol. Vis. Sci. 39:581-591.
22. Hoper, M.M., et al. 1997. Prostaglandins induce vascular endothelial growth factor in a human monocytic cell line and rat lungs via cAMP. Am. J. Respir. Cell Mol. Biol. 17:748-756.
23. Jones, M.K., et al. 1999. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med 5:1418-1423.
24. Fukumura, D., et al. 1998. Tumor induction of VEGF promoter activity in stromal cells. Cell. 94:715-725.
25. Kinzler, K.W., and Vogelstein, B. 1998. Landscaping the cancer terrain. Science. 280:1036-1037.
26. Dinchuk, J.E., et al. 1995. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 378:406-409.
27. Langenbach, R., et al. 1995. Prostaglandin synthase-1 gene disruption in mice reduces arachidonic acid induced inflammation and indomethacin induced gastric ulceration. Cell. 83:483-492.
28. DuBois, R.N., Shao, J., Sheng, H., Tsujii, M., and Beauchamp, R.D. 1996. G1 delay in intestinal epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 56:733-737.
29. Wang, J., et al. 1995. Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem. 270:22044-22049.
30. Chakraborty, I., Das, S.K., and Dey, S.K. 1995. Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation. J. Endocrinol. 147:339-352.
31. Chakraborty, I., Das, S.K., Wang, J., and Dey, S.K. 1996. Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J. Mol. Endocnnol. 16:107-122.
32. Holash, J., et al. 1999 Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 284:1994-1998.
33. Tsujii, M., et al. 1998. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 93:705-716.
34. 2 is a mediator of cyclooxygenase-2-de pendent endothelial migration and angiogenesis. Cancer Res. 59:4574-4577.
35. Yamada, M., Kawai, M., Kawai, Y., and Mashima, Y. 1999. The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat. Curr. Eye Res. 19:300-304.
36. Chin, L., et al. 1999. Essential role for oncogenic Ras in tumour maintenance. Nature. 400:468-472.