메뉴 건너뛰기




Volumn 169, Issue 8, 2002, Pages 4124-4128

Neonatal tolerance in the absence of Stat4- and Stat6-dependent Th cell differentiation

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 5; STAT4 PROTEIN; STAT6 PROTEIN;

EID: 0037108508     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.8.4124     Document Type: Article
Times cited : (15)

References (55)
  • 1
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham, R. E., L. Brent, and P. B. Medawar. 1953. Actively acquired tolerance of foreign cells. Nature 172:603.
    • (1953) Nature , vol.172 , pp. 603
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 2
    • 0018762616 scopus 로고
    • Maturation of the lymphoid system. I. Induction of tolerance in neonates with a T-dependent antigen that is an obligate immunogen in adults
    • Etlinger, H. M., and J. M. Chiller. 1979. Maturation of the lymphoid system. I. Induction of tolerance in neonates with a T-dependent antigen that is an obligate immunogen in adults. J. Immunol. 122:2558.
    • (1979) J. Immunol. , vol.122 , pp. 2558
    • Etlinger, H.M.1    Chiller, J.M.2
  • 3
    • 0018761866 scopus 로고
    • Maturation of the lymphoid system. II. Characterization of the cellular levels of unresponsiveness induced in neonates by a T-dependent antigen that is an obligate immunogen in adults
    • Etlinger, H. M., and J. M. Chiller. 1979. Maturation of the lymphoid system. II. Characterization of the cellular levels of unresponsiveness induced in neonates by a T-dependent antigen that is an obligate immunogen in adults. J. Immunol. 122:2564.
    • (1979) J. Immunol. , vol.122 , pp. 2564
    • Etlinger, H.M.1    Chiller, J.M.2
  • 4
    • 0028922933 scopus 로고
    • Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance
    • Chen, N., and E. H. Field. 1995. Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation 59:933.
    • (1995) Transplantation , vol.59 , pp. 933
    • Chen, N.1    Field, E.H.2
  • 5
    • 0029670540 scopus 로고    scopus 로고
    • Induction of Th1 and Th2 immunity in neonatal mice
    • Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 271:1728.
    • (1996) Science , vol.271 , pp. 1728
    • Forsthuber, T.1    Yip, H.C.2    Lehmann, P.V.3
  • 6
    • 0022635695 scopus 로고
    • Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation
    • Gammon, G., K. Dunn, N. Shastri, A. Oki, S. Wilbur, and E. E. Sercarz. 1986. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature 319:413.
    • (1986) Nature , vol.319 , pp. 413
    • Gammon, G.1    Dunn, K.2    Shastri, N.3    Oki, A.4    Wilbur, S.5    Sercarz, E.E.6
  • 7
    • 0030012251 scopus 로고    scopus 로고
    • Induction of protective CTL responses in newborn mice by a murine retrovirus
    • Sarzotti, M., D. S. Robbins, and P. M. Hoffman. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
    • (1996) Science , vol.271 , pp. 1726
    • Sarzotti, M.1    Robbins, D.S.2    Hoffman, P.M.3
  • 9
    • 0025014494 scopus 로고
    • Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells
    • Powell, T. J., Jr., and J. W. Streilein. 1990. Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J. Immunol. 144:854.
    • (1990) J. Immunol. , vol.144 , pp. 854
    • Powell T.J., Jr.1    Streilein, J.W.2
  • 10
    • 0029664599 scopus 로고    scopus 로고
    • Prevention of Th1 response is critical for tolerance
    • Chen, N., Q. Gao, and E. H. Field. 1996. Prevention of Th1 response is critical for tolerance. Transplantation 61:1076.
    • (1996) Transplantation , vol.61 , pp. 1076
    • Chen, N.1    Gao, Q.2    Field, E.H.3
  • 13
    • 0030470416 scopus 로고    scopus 로고
    • The role of interleukin-4 in the induction phase of allogeneic neonatal tolerance
    • Gao, Q., N. Chen, T. M. Rouse, and E. H. Field. 1996. The role of interleukin-4 in the induction phase of allogeneic neonatal tolerance. Transplantation 62:1847.
    • (1996) Transplantation , vol.62 , pp. 1847
    • Gao, Q.1    Chen, N.2    Rouse, T.M.3    Field, E.H.4
  • 14
    • 0030002897 scopus 로고    scopus 로고
    • Neonatal peptide exposure can prime T cells and upon subsequent immunization, induce their immune deviation: Implications for antibody vs. T cell-mediated autoimmunity
    • Singh, R. R., B. H. Hahn, and E. E. Sercarz. 1996. Neonatal peptide exposure can prime T cells and upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J. Exp. Med. 183:1613.
    • (1996) J. Exp. Med. , vol.183 , pp. 1613
    • Singh, R.R.1    Hahn, B.H.2    Sercarz, E.E.3
  • 17
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
    • (1995) J. Exp. Med. , vol.181 , pp. 1755
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell J.E., Jr.6    Murphy, K.M.7
  • 18
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Y.-L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
    • (1996) Nature , vol.382 , pp. 174
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 20
    • 0032519993 scopus 로고    scopus 로고
    • Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
    • Kaplan, M. H., J. R. Whitfield, D. L. Boros, and M. J. Grusby. 1998. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J. Immunol. 160:1850.
    • (1998) J. Immunol. , vol.160 , pp. 1850
    • Kaplan, M.H.1    Whitfield, J.R.2    Boros, D.L.3    Grusby, M.J.4
  • 21
    • 0032785433 scopus 로고    scopus 로고
    • STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
    • Stamm, L. M., A. A. Satoskar, S. K. Ghosh, J. R. David, and A. R. Satoskar. 1999. STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur. J. Immunol. 29:2524.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2524
    • Stamm, L.M.1    Satoskar, A.A.2    Ghosh, S.K.3    David, J.R.4    Satoskar, A.R.5
  • 22
    • 0034254417 scopus 로고    scopus 로고
    • Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    • Tarleton, R. L., M. J. Grusby, and L. Zhang. 2000. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol. 165:1520.
    • (2000) J. Immunol. , vol.165 , pp. 1520
    • Tarleton, R.L.1    Grusby, M.J.2    Zhang, L.3
  • 23
    • 0034283962 scopus 로고    scopus 로고
    • Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
    • Cai, G., T. Radzanowski, E. N. Villegas, R. Kastelein, and C. A. Hunter. 2000. Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii. J. Immunol. 165:2619.
    • (2000) J. Immunol. , vol.165 , pp. 2619
    • Cai, G.1    Radzanowski, T.2    Villegas, E.N.3    Kastelein, R.4    Hunter, C.A.5
  • 24
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
    • Simpson, S. J., S. Shah, M. Comiskey, Y. P. de Jong, B, Wang, E. Mizoguchi, A. K. Bhan, and C. Terhorst. 1998. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med. 187:1225.
    • (1998) J. Exp. Med. , vol.187 , pp. 1225
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3    De Jong, Y.P.4    Wang, B.5    Mizoguchi, E.6    Bhan, A.K.7    Terhorst, C.8
  • 25
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T., N. Najafian, C. Benou, A. D. Salama, M. J. Grusby, M. H. Sayegh, and S. J. Khoury. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108:739.
    • (2001) J. Clin. Invest. , vol.108 , pp. 739
    • Chitnis, T.1    Najafian, N.2    Benou, C.3    Salama, A.D.4    Grusby, M.J.5    Sayegh, M.H.6    Khoury, S.J.7
  • 26
    • 0032555904 scopus 로고    scopus 로고
    • A Stat4-independent pathway for the development of Th1 cells
    • Kaplan, M. H., A. L. Wurster, and M. J. Grusby. 1998. A Stat4-independent pathway for the development of Th1 cells. J. Exp. Med. 188:1191.
    • (1998) J. Exp. Med. , vol.188 , pp. 1191
    • Kaplan, M.H.1    Wurster, A.L.2    Grusby, M.J.3
  • 27
    • 0345422708 scopus 로고    scopus 로고
    • Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
    • Holz, A., A. Bot, B. Coon, T. Wolfe, M. J. Grusby, and M. G. von Herrath. 1999. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J. Immunol. 163:5374.
    • (1999) J. Immunol. , vol.163 , pp. 5374
    • Holz, A.1    Bot, A.2    Coon, B.3    Wolfe, T.4    Grusby, M.J.5    Von Herrath, M.G.6
  • 28
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
    • (1990) J. Exp. Med. , vol.172 , pp. 921
    • Le Gros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 29
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
    • (1990) J. Immunol. , vol.145 , pp. 3796
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 31
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4:313.
    • (1996) Immunity , vol.4 , pp. 313
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 34
    • 0032007351 scopus 로고    scopus 로고
    • IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    • Urban, J. F., Jr., N. Noben-Trauth, D. D. Donaldson, K. B. Madden, S. C. Morris, M. Collins, and F. D. Finkelman. 1998. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8:255.
    • (1998) Immunity , vol.8 , pp. 255
    • Urban J.F., Jr.1    Noben-Trauth, N.2    Donaldson, D.D.3    Madden, K.B.4    Morris, S.C.5    Collins, M.6    Finkelman, F.D.7
  • 36
    • 0036533539 scopus 로고    scopus 로고
    • Cutting edge: Susceptibility to the larval stage of the helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling
    • Rodriguez-Sosa, M., J. R. David, R. Bojalil, A. R. Satoskar, and L. I. Terrazas. 2002. Cutting edge: susceptibility to the larval stage of the helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling. J. Immunol. 168:3135.
    • (2002) J. Immunol. , vol.168 , pp. 3135
    • Rodriguez-Sosa, M.1    David, J.R.2    Bojalil, R.3    Satoskar, A.R.4    Terrazas, L.I.5
  • 37
    • 0032715407 scopus 로고    scopus 로고
    • Stat6-dependent and -independent pathways for IL-4 production
    • Kaplan, M. H., A. L. Wurster, S. T. Smiley, and M. J. Grusby. 1999. Stat6-dependent and -independent pathways for IL-4 production. J. Immunol. 163:6536.
    • (1999) J. Immunol. , vol.163 , pp. 6536
    • Kaplan, M.H.1    Wurster, A.L.2    Smiley, S.T.3    Grusby, M.J.4
  • 38
  • 43
    • 0033566955 scopus 로고    scopus 로고
    • BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major
    • Dent, A. L., T. M. Doherty, W. E. Paul, A. Sher, and L. M. Staudt. 1999. BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J. Immunol. 163:2098.
    • (1999) J. Immunol. , vol.163 , pp. 2098
    • Dent, A.L.1    Doherty, T.M.2    Paul, W.E.3    Sher, A.4    Staudt, L.M.5
  • 45
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman, D., B. Schofield, M. Wills-Karp, and M. J. Grusby. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:939.
    • (1998) J. Exp. Med. , vol.187 , pp. 939
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 46
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducer and activator of transcription (STAT)6-deficient mice
    • Akimoto, T., F. Numata, M. Tamura, Y. Takata, N. Higashida, T. Takashi, K. Takeda, and S. Akira. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducer and activator of transcription (STAT)6-deficient mice. J. Exp. Med. 187:1537.
    • (1998) J. Exp. Med. , vol.187 , pp. 1537
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7    Akira, S.8
  • 47
    • 0035821221 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
    • Mathew, A., J. A. MacLean, E. DeHaan, A. M. Tager, F. H. Y. Green, and A. D. Luster. 2001. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 193:1087.
    • (2001) J. Exp. Med. , vol.193 , pp. 1087
    • Mathew, A.1    MacLean, J.A.2    DeHaan, E.3    Tager, A.M.4    Green, F.H.Y.5    Luster, A.D.6
  • 49
    • 0031859134 scopus 로고    scopus 로고
    • STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination
    • Linehan, L. A., W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton. 1998. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J. Immunol. 161:302.
    • (1998) J. Immunol. , vol.161 , pp. 302
    • Linehan, L.A.1    Warren, W.D.2    Thompson, P.A.3    Grusby, M.J.4    Berton, M.T.5
  • 50
    • 0034695876 scopus 로고    scopus 로고
    • T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance: The response in the "tolerant" mouse within the residual repertoire is quantitatively similar but qualitatively different
    • Maverakis, E., J. T. Beech, S. S. Wilson, A. Quinn, B. Pedersen, and E. E. Sercarz. 2000. T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance: the response in the "tolerant" mouse within the residual repertoire is quantitatively similar but qualitatively different. J. Exp. Med. 191:695.
    • (2000) J. Exp. Med. , vol.191 , pp. 695
    • Maverakis, E.1    Beech, J.T.2    Wilson, S.S.3    Quinn, A.4    Pedersen, B.5    Sercarz, E.E.6
  • 51
    • 0035879195 scopus 로고    scopus 로고
    • Failure to induce neonatal tolerance in mice that lack both IL-4 and IL-13 but not in those that lack IL-4 alone
    • Inoue, Y., B. T. Konieczny, M. E. Wagener, A. N. McKenzie, and F. G. Lakkis. 2001. Failure to induce neonatal tolerance in mice that lack both IL-4 and IL-13 but not in those that lack IL-4 alone. J. Immunol. 167:1125.
    • (2001) J. Immunol. , vol.167 , pp. 1125
    • Inoue, Y.1    Konieczny, B.T.2    Wagener, M.E.3    McKenzie, A.N.4    Lakkis, F.G.5
  • 55
    • 0344690179 scopus 로고    scopus 로고
    • Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells
    • Shi, H. N., M. J. Grusby, and C. Nagler-Anderson. 1999. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. J. Immunol. 162:5143.
    • (1999) J. Immunol. , vol.162 , pp. 5143
    • Shi, H.N.1    Grusby, M.J.2    Nagler-Anderson, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.